- 2019
- Published
Metformin-induced changes of the gut microbiota in healthy young men: results of a non-blinded, one-armed intervention study
Bryrup, T., Thomsen, C. W., Kern, T., Allin, K. H., Brandslund, I., Jørgensen, Niklas Rye, drb459, drb459, Hansen, Torben, Hansen, T. H., Pedersen, Oluf Borbye & Nielsen, T., 2019, In: Diabetologia. 62, 6, p. 1024-1035Research output: Contribution to journal › Journal article › Research › peer-review
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Does genetic predisposition to higher fat expandability attenuate the impact of weight gain on cardiometabolic risk?
Carrasquilla, Germán D., Linneberg, Allan René, Jørgensen, T., Grarup, N., Pedersen, Oluf Borbye, Hansen, Torben, Sørensen, Thorkild I.A. & Kilpeläinen, Tuomas O., 2019, In: European Journal of Human Genetics. 27, Suppl. 2, p. 1764 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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Dietary Fat and the Genetic Risk of Type 2 Diabetes
Carrasquilla, Germán D., Jakupovic, Hermina & Kilpeläinen, Tuomas O., 2019, In: Current Diabetes Reports. 19, 6 p., 109.Research output: Contribution to journal › Review › Research › peer-review
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Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography
Chen, S., Lu, M., Liu, D., Yang, L., Yi, C., Ma, L., Zhang, H., Liu, Q., Frimurer, Thomas Michael, Wang, M., Schwartz, Thue W., Stevens, R. C., Wu, B., Wuthrich, K. & Zhao, Q., 2019, In: Nature Communications. 10, 8 p., 638.Research output: Contribution to journal › Journal article › Research › peer-review
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GIP and GLP-1 Potentiate Sulfonylurea-Induced Insulin Secretion in HNF1A Diabetes
Christensen, A. S., Haedersdal, S., Storgaard, H., Rose, K., Hansen, N. L., Holst, Jens Juul, Hansen, Torben, Knop, Filip Krag & Vilsbøll, Tina, 2019, In: Diabetes. 68, Suppl. 1, 1 p., 981-P.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Benefit-Risk Assessment of Obesity Drugs: Focus on Glucagon-like Peptide-1 Receptor Agonists
Christensen, R. M., Juhl, C. R. & Torekov, Signe Sørensen, 2019, In: Drug Safety. 42, 8, p. 957-971 15 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents
Christiansen, Charlotte Bayer, Trammell, Sam, Albrechtsen, Nicolai Jacob Wewer, Schoonjans, K., Albrechtsen, Reidar, Gillum, M. P., Kuhre, Rune Ehrenreich & Holst, Jens Juul, 2019, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 316, 5, p. G574-G584 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of Acute GLP-1 Infusion on Pulmonary and Systemic Hemodynamics in Patients With Heart Failure: A Pilot Study
Clarke, S. J., Pettit, S., Giblett, J. P., Zhao, T., Kydd, A. C., Albrechtsen, Nicolai Jacob Wewer, Deacon, Carolyn F., Parameshwar, J. & Hoole, S. P., 2019, In: Clinical Therapeutics. 41, 1, p. 118-127 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases
Clemmensen, Christoffer, Finan, B., Müller, T. D., DiMarchi, R. D., Tschöp, M. H. & Hofmann, S. M., 2019, In: Nature Reviews Endocrinology. 15, p. 90-104Research output: Contribution to journal › Review › Research › peer-review
- Published
Gut microbiota composition in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives
Coello, K., Hansen, T. H., Sørensen, N., Munkholm, K., Kessing, Lars Vedel, Pedersen, Oluf Borbye & Vinberg, Maj, 2019, In: Brain, Behavior, and Immunity. 75, p. 112-118Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polygenic predisposition to breast cancer and the risk of coronary artery disease
D'Souza, M., Schou, Morten, Skals, R., Weeke, P. E., Lee, C., Smedegaard, L., Madelaire, C., Gerds, Thomas Alexander, Poulsen, Henrik Enghusen, Hansen, Torben, Grarup, N., Pedersen, Oluf Borbye, Stender, Steen, Engstrøm, Thomas, Fosbøl, E., Nielsen, D., Gislason, Gunnar Hilmar, Køber, Lars Valeur, Torp-Pedersen, C. & Andersson, C., 2019, In: International Journal of Cardiology. 291, p. 145-151 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Voluntary wheel running in the late dark phase ameliorates diet-induced obesity in mice without altering insulin action
Kellezi, Emilie Dalbram, Basse, A. L., Zierath, Juleen R & Treebak, Jonas Thue, 2019, In: Journal of Applied Physiology. 126, 4, p. 993-1005 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity
Dall, M., Trammell, Sam, Asping, M., Hassing, Anna Skab, Agerholm, M., Vienberg, S. G., Gillum, M. P., Larsen, Steen & Treebak, Jonas Thue, 2019, In: The Journal of Biological Chemistry. 294, 36, p. 13304-13326 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity
Dallner, O. S., Marinis, J. M., Lu, Y., Birsoy, K., Werner, E., Fayzikhodjaeva, G., Dill, B. D., Molina, H., Moscati, A., Kutalik, Z., Marques-Vidal, P., Kilpeläinen, Tuomas O., Grarup, N., Linneberg, Allan René, Zhang, Y., Vaughan, R., Loos, Ruth, Lazar, M. A. & Friedman, J. M., 2019, In: Nature Medicine. 25, 3, p. 507-530 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes
Davegardh, C., Wedin, E. H., Broholm, C., Henriksen, T. I., Pedersen, M., Pedersen, Bente Klarlund, Schéele, Camilla Charlotte Nielsen & Ling, C., 2019, In: Stem Cell Research & Therapy. 10Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLP-1/dexamethasone inhibits food reward without inducing mood and memory deficits in mice
Decarie-Spain, L., Fisette, A., Zhu, Z., Yang, B., DiMarchi, R. D., Tschoep, M. H., Finan, B., Fulton, S. & Clemmensen, Christoffer, 2019, In: Neuropharmacology. 151, p. 55-63Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A meta-analysis of genome-wide association studies identifies multiple longevity genes
Deelen, J., Evans, D. S., Arking, D. E., Tesi, N., Nygaard, M., Liu, X., Wojczynski, M. K., Biggs, M. L., van Der Spek, A., Atzmon, G., Ware, E. B., Sarnowski, C., Smith, A. V., Seppala, I., Cordell, H. J., Dose, J., Amin, N., Arnold, A. M., Ayers, K. L., Barzilai, N. & 64 others, , 2019, In: Nature Communications. 10, 14 p., 3669.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Liraglutide preserved insulin secretion in adults with newly diagnosed type 1 diabetes: the NewLira trial: [Meeting Abstract}
Dejgaard, T. F., Frandsen, C., Kielgast, U., Andersen, H. U., Thorsteinsson, B., Krarup, T., Holst, Jens Juul & Madsbad, Sten, 2019, In: Diabetologia. 62, Supl. 1/SI, p. S75-S75 145.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine
Deshmukh, A. S., Peijs, L., Beaudry, J. L., Jespersen, N. Z., Nielsen, C. H., Ma, T., Brunner, A. D., Larsen, T. J., Bayarri-Olmos, R., Prabhakar, B. S., Helgstrand, C., Severinsen, M. C. K., Holst, B., Kjaer, A., Tang-Christensen, M., Sanfridson, A., Garred, P., Privé, G. G., Pedersen, B. K., Gerhart-Hines, Z. & 4 others, , 2019, In: Cell Metabolism. 30, 5, p. 963-975.e7 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mucosal Metabolomic Profiling and Pathway Analysis Reveal the Metabolic Signature of Ulcerative Colitis
Diab, J., Hansen, T., Goll, R., Stenlund, H., Jensen, E., Moritz, Thomas, Florholmen, J. & Forsdahl, G., 2019, In: Metabolites. 9, 12, 15 p., 291.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Energy intake, gastrointestinal transit, and gut hormone release in response to oral triglycerides and fatty acids in men with and without severe obesity
Dirksen, C., Graff, J., Fuglsang, S., Rehfeld, Jens Frederik, Holst, Jens Juul & Madsen, J. L., 2019, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 316, 3, p. G332-G337Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Underpowered or negative? A crucial distinction
Dollerup, O. L., Treebak, Jonas Thue & Jessen, N., 2019, In: Diabetologia. 62, 6, p. 1094-1095 2 p.Research output: Contribution to journal › Comment/debate › Research
- Published
Effects of Nicotinamide Riboside on Endocrine Pancreatic Function and Incretin Hormones in Nondiabetic Men With Obesity
Dollerup, O. L., Trammell, Sam, Hartmann, Bolette, Holst, Jens Juul, Christensen, B., Møller, N., Gillum, M. P., Treebak, Jonas Thue & Jessen, N., 1 Nov 2019, In: The Journal of clinical endocrinology and metabolism. 104, 11, p. 5703-5714 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interplay between diet, exercise and the molecular circadian clock in orchestrating metabolic adaptations of adipose tissue
Dollet, L. & Zierath, Juleen R, 2019, In: Journal of Physiology. 597, 6, p. 1439-1450Research output: Contribution to journal › Review › Research › peer-review
- Published
Associations between thyroid-stimulating hormone, blood pressure and adiponectin are attenuated in children and adolescents with overweight or obesity
Drivsholm, A., Lund, Morten Asp Vonsild, Hedley, P. L., Jespersen, Thomas, Christiansen, M., Hansen, Torben & Holm, Jens-Christian, 2019, In: Journal of Pediatric Endocrinology and Metabolism. 32, 12, p. 1351-1358Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide-1 is a marker of systemic inflammation in patients treated with high-dose chemotherapy and autologous stem cell transplantation
Ebbesen, M. S., Kissow, Hannelouise, Hartmann, Bolette, Grell, Kathrine, Gørløv, J. S., Kielsen, K., Holst, Jens Juul & Muller, Klaus, 2019, In: Biology of Blood and Marrow Transplantation. 25, 6, p. 1085-1091 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Molecular Diversity of Vagal Afferents Revealed
Egerod, Kristoffer Lihme, Schwartz, Thue W. & Gautron, L., 2019, In: Trends in Neurosciences. 42, 10, p. 663-666Research output: Contribution to journal › Editorial › Research › peer-review
- Published
Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments
Ehmann, D., Wendler, J., Koeninger, L., Larsen, I. S., Klag, T., Berger, J., Marette, A., Schaller, M., Stange, E. F., Malek, N. P., Jensen, Benjamin Anderschou Holbech & Wehkamp, J., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3746-3751Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic determinants of blood pressure traits are associated with carotid arterial thickening and plaque formation in patients with type 2 diabetes
pjx571, pjx571, Appel, V. E., Schnurr, T. M., Lundby-Christensen, L., Skaaby, T., Linneberg, Allan René, Drivsholm, Thomas, Witte, D. R., Jørgensen, M. E., Grarup, N., Pedersen, Oluf Borbye, Hansen, Torben & drb459, drb459, 2019, In: Diabetes and Vascular Disease Research. 16, 1, p. 13-21 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Non-alcoholic fatty liver disease alters expression of genes governing hepatic nitrogen conversion
Eriksen, P. L., Vilstrup, H., Rigbolt, K., Suppli, M. P., Sørensen, M., Heebøll, S., Veidal, S. S., Knop, Filip Krag & Thomsen, K. L., 2019, In: Liver International. 39, 11, p. 2094-2101Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bone Status in Obese, Non-diabetic, Antipsychotic-Treated Patients, and Effects of the Glucagon-Like Peptide-1 Receptor Agonist Exenatide on Bone Turnover Markers and Bone Mineral Density
Eriksson, R., Broberg, B. V., Ishoy, P. L., Bak, N., Andersen, U. B., Jorgensen, N. R., Knop, Filip Krag & Ebdrup, Bjørn, 2019, In: Frontiers in Psychiatry. 9, 7 p., 781.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
O12.4. EFFECTS OF THE GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONIST EXENATIDE ON BONE STATUS IN OBESE, NON-DIABETIC, ANTIPSYCHOTIC-TREATED SCHIZOPHRENIA SPECTRUM PATIENTS
Eriksson, R., Broberg, B. V., Ishoy, P. L., Bak, N., Andersen, U. B., Jørgensen, Niklas Rye, Knop, Filip Krag & Ebdrup, Bjørn, 2019, In: Schizophrenia Bulletin. 45, Suppl. 2, p. S198-S199 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Assessment of mouse liver [1-13C]pyruvate metabolism by dynamic hyperpolarized MRS
Faarkrog Høyer, K., Laustsen, C., Ringgaard, S., Qi, H., Mariager, C. Ø., Nielsen, Thomas Svava, Sundekilde, U. K., Treebak, Jonas Thue, Jessen, N. & Stødkilde-Jørgensen, H., 2019, In: Journal of Endocrinology. 242, 3, p. 251-260 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chronic high dose P2X7 receptor inhibition exacerbates cancer-induced bone pain
Falk, S., Appel, C. K., Bennedbæk, H. B., Al-Dihaissy, T., Unger, A., Dinkel, K. & Heegaard, Anne-Marie, 15 Feb 2019, In: European Journal of Pharmacology. 845, p. 48-55 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Benchmarker: An Unbiased, Association-Data-Driven Strategy to Evaluate Gene Prioritization Algorithms
Fine, R. S., Pers, Tune H, Amariuta, T., Raychaudhuri, S. & Hirschhorn, J. N., 2019, In: American Journal of Human Genetics. 104, 6, p. 1025-1039Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Haploinsufficiency of ARHGAP42 is associated with hypertension
Fjorder, A. S., Rasmussen, Malene Bøgehus, Mehrjouy, M. M., Nazaryan-Petersen, L., Hansen, C., Bak, M., Grarup, N., Nørremølle, Anne, Larsen, Lars Allan, drb459, drb459, Hansen, Torben, Tommerup, Niels & Bache, Iben, 2019, In: European Journal of Human Genetics. 27, 8, p. 1296-1303 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls
Broad Genomics Platform, B. G. P., Jun 2019, In: Nature. 570, 7759, p. 71-76 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucose metabolism in patients with psoriasis
Friis, N. U., Hoffmann, N., Gyldenlove, M., Skov, Lone, Vilsbøll, Tina, Knop, Filip Krag & Storgaard, H., 2019, In: British Journal of Dermatology. 180, 2, p. 264-271Research output: Contribution to journal › Review › Research › peer-review
- Published
Glucose metabolism in children and adolescents: Population-based reference values and comparisons to children and adolescents enrolled in obesity treatment
Frithioff-Bøjsøe, C., Lund, Morten Asp Vonsild, Kloppenborg, J. T., Nielsen, T. T. H., Fonvig, Cilius Esmann, Lausten-Thomsen, U., Hedley, P. L., Hansen, T., Pedersen, Oluf Borbye, Christiansen, M., Baker, J. L., Hansen, Torben & Holm, Jens-Christian, 2019, In: Pediatric Diabetes. 20, 5, p. 538-548Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Circadian rhythms and exercise - re-setting the clock in metabolic disease
Gabriel, B. M. & Zierath, Juleen R, 2019, In: Nature Reviews Endocrinology. 15, 4, p. 197-206Research output: Contribution to journal › Review › Research › peer-review
- Published
Obesity-induced CYP2E1 activity in children
Gade, C., Dalhoff, Kim, Petersen, Tonny Studsgaard, Riis, T., Schmeltz, C., Chabanova, E., Christensen, H. R., Mikus, G., Burhenne, J., Holm, Jens-Christian & Holst, H., 2019, In: British Journal of Clinical Pharmacology. 85, 2, p. 458-459 2 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
- Published
Glucose and Amino Acid Metabolism in Mice Depend Mutually on Glucagon and Insulin Receptor Signaling
Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Pedersen, Jens, Kjeldsen, Sasha Alexandra Sampson, Rosenkilde, Mette, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 316, 4, p. E660-E673Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Separate and Combined Glucometabolic Effects of Endogenous Glucose-Dependent Insulinotropic Polypeptide and Glucagon-like Peptide 1 in Healthy Individuals
Gasbjerg, Lærke Smidt, Helsted, M. M., Hartmann, Bolette, Jensen, M. H., Gabe, M. B. N., wbf943, wbf943, Veedfald, Simon, Stensen, S., Lanng, A. R., Bergmann, N. C., Christensen, Mikkel Bring, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, 2019, In: Diabetes. 68, 3, p. 906-917Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New Avenues in the Regulation of Gallbladder Motility: Implications for the Use of Glucagon-Like Peptide-Derived Drugs
Gether, I. M., Nexøe-Larsen, C. & Knop, Filip Krag, 2019, In: Journal of Clinical Endocrinology and Metabolism. 104, 7, p. 2463-2472Research output: Contribution to journal › Review › Research › peer-review
- Published
Extracellular Vesicle Encapsulated MicroRNAs in Patients with Type 2 Diabetes Are Affected by Metformin Treatment
Ghai, V., Kim, T., Etheridge, A., Nielsen, T., Hansen, Torben, Pedersen, Oluf Borbye, Galas, D. & Wang, K., 2019, In: Journal of Clinical Medicine. 8, 17 p., 617.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Early Life Body Size in Relation to First Intracerebral or Subarachnoid Hemorrhage
Gjærde, L. K., Truelsen, Thomas Clement, Sørensen, Thorkild I.A. & Baker, J. L., 2019, In: Journal of Stroke. 21, 1, p. 60-68 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MR-proANP Associated with Body Mass Index in Patients with Anorexia Nervosa
Goetze, J. P., Gustafsson, Finn, Pedersen, Oluf Borbye & Støving, R. K., 2019, In: The journal of applied laboratory medicine. 4, 1, p. 132-134Research output: Contribution to journal › Letter › Research › peer-review
- Published
ADAMTS9 regulates skeletal muscle insulin sensitivity through extracellular matrix alterations
Graae, A-S., Grarup, N., Ribel-Madsen, R., Lystbæk, S. H., Boesgaard, T., Staiger, H., Fritsche, A., Wellner, N., Sulek, K., Kjølby, M. F., Backe, M. B., Chubanava, S., Prats, C., Serup, A. K. L., Birk, J. B., Dubail, J., Gillberg, L., Vienberg, S. G., Nykjær, A., Kiens, B. & 10 others, , 2019, In: Diabetes. 68, 3, p. 502-514Research output: Contribution to journal › Journal article › Research › peer-review
- Published
N-acyl taurines are endogenous lipid messengers that improve glucose homeostasis
Grevengoed, Trisha Jean, Trammell, Sam, McKinney, M. K., Petersen, N., Cardone, R. L., Svenningsen, J. S., Ogasawara, D., Nexøe-Larsen, C. C., Knop, Filip Krag, Schwartz, Thue W., Kibbey, R. G., Cravatt, B. F. & Gillum, M. P., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 49, p. 24770-24778Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bio art and the end of philosophy (Feuerstein & Hegel)
Grünfeld, Martin, 21 May 2019, 1 p.Research output: Other contribution › Net publication - Internet publication › Research › peer-review
- Published
Tracing the origin of adult intestinal stem cells
Guiu, J., Hannezo, E., Yui, S., Demharter, S., Ulyanchenko, Svetlana, Maimets, Martti, Jørgensen, A., Perlman, S., Lundvall, L., Mamsen, L. S., Larsen, A., Olesen, R. H., Andersen, C. Y., Thuesen, L. L., Hare, Kristine Juul, Pers, Tune H, Khodosevich, Konstantin, Simons, B. D. & Jensen, Kim Bak, 2019, In: Nature. 570, 7759, p. 107-111Research output: Contribution to journal › Letter › Research › peer-review
- Published
Reference values for fasting serum concentrations of thyroid-stimulating hormone and thyroid hormones in healthy Danish/North-European white children and adolescents
Gunapalasingham, G., Frithioff-Bojsoe, C., Lund, Morten Asp Vonsild, Hedley, P. L., Fonvig, Cilius Esmann, Dahl, M., Pedersen, Oluf Borbye, Christiansen, M., Hansen, Torben, Lausten-Thomsen, U. & Holm, Jens-Christian, 2019, In: Scandinavian Journal of Clinical & Laboratory Investigation. 79, 1-2, p. 129-135Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A cost analysis of intensified vs conventional multifactorial therapy in individuals with type 2 diabetes: a post hoc analysis of the Steno-2 study
Gæde, J., Oellgaard, J., Ibsen, R., Gæde, P., Nortoft, E., Parving, H., Kjellberg, J. & Pedersen, Oluf Borbye, 2019, In: Diabetologia. 62, 1, p. 147-155Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Beneficial impact of intensified multifactorial intervention on risk of stroke: outcome of 21 years of follow-up in the randomised Steno-2 Study
Gæde, P., Oellgaard, J., Kruuse, Christina Rostrup, Rossing, Peter, Parving, H. & Pedersen, Oluf Borbye, 2019, In: Diabetologia. 62, 9, p. 1575-1580Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Longitudinal Associations of Fitness, Motor Competence, and Adiposity with Cognition
Haapala, E. A., Lintu, N., Vaisto, J., Tompuri, T., Soininen, S., Viitasalo, A., Eloranta, A., Venalainen, T., Saakslahti, A., Laitinen, T. & Lakka, T. A., 2019, In: Medicine and Science in Sports and Exercise. 51, 3, p. 465-471Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Liraglutide-Induced Weight Loss May be Affected by Autonomic Regulation in Type 1 Diabetes
Hansen, C. S., Frandsen, C. S., Fleischer, J., Vistisen, D., Holst, Jens Juul, Tarnow, L., Knop, Filip Krag, Madsbad, Sten, Andersen, H. U. & Dejgaard, T. F., 2019, In: Frontiers in Endocrinology. 10, 9 p., 242.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors
Hansen, T. F., Banasik, K., Erikstrup, C., Pedersen, O. B., Westergaard, D., Chmura, P. J., Nielsen, K., Thørner, L., Hjalgrim, H., Paarup, H., Larsen, M. A. H., Petersen, M., Jennum, P., Andersen, S., Nyegaard, M., Jemec, G. B. E., Olesen, J., Werge, T., Johansson, P. I., Sørensen, E. & 3 others, , 9 Jun 2019, In: BMJ Open. 9, 6, p. 1-7 7 p., e028401.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia
Harold, D., Connolly, S., Riley, B. P., Kendler, K. S., McCarthy, S. E., McCombie, W. R., Richards, A., Owen, M. J., O'Donovan, M. C., Walters, J., Donnelly, P., Bates, L., Barroso, I., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Deloukas, P., Duncanson, A. & 32 others, , 2019, In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 180, 3, p. 223-231 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis
Hartwig, F. P., Davies, N. M., Horta, B. L., Ahluwalia, T. S., Bisgaard, H., Bønnelykke, K., Caspi, A., Moffitt, T. E., Poulton, R., Sajjad, A., Tiemeier, H. W., Dalmau-Bueno, A., Guxens, M., Bustamante, M., Santa-Marina, L., Parker, N., Paus, T., Pausova, Z., Lauritzen, L., Schnurr, T. M. & 7 others, , 2019, In: International Journal of Epidemiology. 48, 1, p. 45-57 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dysregulated autophagy in muscle precursor cells from humans with type 2 diabetes
Henriksen, T. I., Wigge, L. V., Nielsen, J., Pedersen, Bente Klarlund, Sandri, M. & Schéele, Camilla Charlotte Nielsen, 2019, In: Scientific Reports. 9, 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise
Henriquez-Olguín, Carlos, Knudsen, Jonas Roland, Raun, Steffen Henning, Li, Z., Kellezi, Emilie Dalbram, Treebak, Jonas Thue, Sylow, Lykke, Holmdahl, R., Richter, Erik A., Jaimovich, E. & Jensen, Thomas Elbenhardt, 2019, In: Nature Communications. 10, 11 p., 4623.Research output: Contribution to journal › Journal article › Research › peer-review
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Epigenetic reprogramming of immune cells in women with PCOS impact genes controlling reproductive function
Hiam, D., Simar, D., Laker, R., Altıntaş, Ali, Gibson-Helm, M., Fletcher, E., Moreno-Asso, A., Trewin, A. J., Barrès, Romain & Stepto, N. K., 2019, In: Journal of Clinical Endocrinology and Metabolism. 104, 12, p. 6155-6170Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of two microRNA nodes as potential cooperative modulators of liver metabolism
Hochreuter, Mette Yde, Altıntaş, Ali, Garde, C., Emanuelli, Brice, Kahn, C. R., Zierath, Juleen R, Vienberg, S. & Barrès, Romain, 2019, In: Hepatology Research. 49, 12, p. 1451-1465Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Methods and Guidelines for Measurement of Glucagon in Plasma
Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2019, In: International Journal of Molecular Sciences (Online). 20, 10 p., 5416.Research output: Contribution to journal › Review › Research › peer-review
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Physiology of the Incretin Hormones, GIP and GLP-1-Regulation of Release and Posttranslational Modifications
Holst, Jens Juul, Albrechtsen, Nicolai Jacob Wewer, Rosenkilde, Mette & Deacon, Carolyn F., 2019, In: Comprehensive Physiology. 9, 4, p. 1339-1381Research output: Contribution to journal › Journal article › Research › peer-review
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From the Incretin Concept and the Discovery of GLP-1 to Today's Diabetes Therapy
Holst, Jens Juul, 2019, In: Frontiers in Endocrinology. 10, 10 p., 260.Research output: Contribution to journal › Review › Research › peer-review
- Published
Long-acting glucagon-like peptide-1 receptor agonist-status December 2018
Holst, Jens Juul, 2019, In: Annals of Translational Medicine. 7, 5, 6 p., 83 .Research output: Contribution to journal › Editorial › Research
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The incretin system in healthy humans: The role of GIP and GLP-1
Holst, Jens Juul, 2019, In: Metabolism. 96, p. 46-55Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Which to choose, an oral or an injectable glucagon-like peptide-1 receptor agonist?
Holst, Jens Juul, 2019, In: The Lancet. 394, 10192, p. 4-6Research output: Contribution to journal › Editorial › Research › peer-review
- Published
PAIRUP-MS: Pathway analysis and imputation to relate unknowns in profiles from mass spectrometry-based metabolite data
Hsu, Y. H., Churchhouse, C., Pers, Tune H, Mercader, J. M., Metspalu, A., Fischer, K., Fortney, K., Morgen, E. K., Gonzalez, C., Gonzalez, M. E., Esko, T. & Hirschhorn, J. N., 2019, In: PLOS Computational Biology. 15, 1, 26 p., e1006734.Research output: Contribution to journal › Journal article › Research › peer-review
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Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study
Huang, T., Wang, T., Zheng, Y., Ellervik, C., Li, X., Gao, M., Fang, Z., Chai, J-F., Ahluwalia, T. V. S., Wang, Y., Voortman, T., Noordam, R., Frazier-Wood, A., Scholz, M., Sonestedt, E., Akiyama, M., Dorajoo, R., Zhou, A., Kilpeläinen, T. O., Kleber, M. E. & 31 others, , 2019, In: JAMA Network Open. 2, 9, 18 p., e1910915.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dairy Intake and Body Composition and Cardiometabolic Traits among Adults: Mendelian Randomization Analysis of 182041 Individuals from 18 Studies
Huang, T., Sun, D., Heianza, Y., Bergholdt, H. K. M., Gao, M., Fang, Z., Ding, M., Frazier-Wood, A. C., North, K. E., Marouli, E., Graff, M., Smith, C. E., Varbo, A., Lemaitre, R. N., Corella, D., Wang, C. A., Tjønneland, A., Overvad, K., Sørensen, T. I. A., Feitosa, M. F. & 36 others, , 2019, In: Clinical Chemistry. 65, 6, p. 751-760 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association between fat mass, adipose tissue, fat fraction per adipose tissue, and metabolic risks: a cross-sectional study in normal, overweight, and obese adults
Huebers, M., Geisler, C., Bosy-Westphal, A., Braun, W., Pourhassan, M., Sørensen, Thorkild I.A. & Mueller, M. J., 2019, In: European Journal of Clinical Nutrition. 73, 1, p. 62-71 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dietary Fiber is Essential to Maintain L Cell Secretion and Intestinal Weight
Dal, Jenna Elizabeth Hunt, Hartmann, Bolette, Holst, Jens Juul & Kissow, Hannelouise, 1 May 2019, In: Gastroenterology. 156, 6 (S1), p. S-477Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Intestinal Growth in Glucagon Receptor Knockout Mice is Not Associated with the Formation of Aom/DSS-Induced Tumours
Dal, Jenna Elizabeth Hunt, Yassin, M., Olsen, Jørgen, Windeløv, Johanne Agerlin, Galsgaard, Katrine Douglas, Holst, Jens Juul & Kissow, Hannelouise, 1 May 2019, In: Gastroenterology. 156, 6 (S1), 1 p., S-692.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
The diurnal variation of bone formation is attenuated in adult patients with type 2 diabetes
Hygum, K., Starup-Linde, J., Harslor, T., Jørgensen, Niklas Rye, Hartmann, Bolette, Holst, Jens Juul & Langdahl, B. L., 2019, In: European Journal of Endocrinology. 181, 3, p. 221-231Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epigenetic and Transcriptomic Characterization of Pure Adipocyte Fractions From Obese Pigs Identifies Candidate Pathways Controlling Metabolism
Jacobsen, M. J., Havgaard, Jakob Hull, Anthon, Christian, Mentzel, Caroline M. Junker, Cirera, Susanna, Krogh, P. M., Pundhir, Sachin, Karlskov-Mortensen, Peter, Bruun, C. S., Lesnik, P., Guerin, M., Gorodkin, Jan, Jørgensen, Claus Bøttcher, Fredholm, Merete & Barrès, Romain, 2019, In: Frontiers in Genetics. 10, 13 p., 1268.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epigenetic changes in healthy human skeletal muscle following exercise - a systematic review
Jacques, M., Hiam, D., Craig, J., Barrès, Romain, Eynon, N. & Voisin, S., 2019, In: Epigenetics. 14, 7, p. 633-648Research output: Contribution to journal › Review › Research › peer-review
- Published
Obesity and unfavourable lifestyle increase type 2 diabetes-risk independent of genetic predisposition
Jakupovic, Hermina, Schnurr, T. M., Carrasquilla, Germán D., Grarup, N., Sørensen, Thorkild I.A., Tjønneland, Anne, Overvad, K., Pedersen, Oluf Borbye, Hansen, Torben & Kilpeläinen, Tuomas O., 2019, In: Diabetologia. 62, Suppl. 1, p. S188 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Pirt deficiency has subtle female-specific effects on energy and glucose metabolism in mice
Jall, S., Finan, B., Collden, G., Fischer, K., Dong, X., Tschoep, M. H., Mueller, T. D. & Clemmensen, Christoffer, 2019, In: Molecular Metabolism. 23, p. 75-81Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon Receptor Signaling and Glucagon Resistance
Janah, L., Kjeldsen, Sasha Alexandra Sampson, Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Stojanovska, E., Pedersen, Jens, Knop, Filip Krag, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2019, In: International Journal of Molecular Sciences. 20, 13, 27 p., 3314.Research output: Contribution to journal › Review › Research › peer-review
- Published
Habitual activity associates with lower fasting and greater glucose-induced GLP-1 response in men
Janus, C., Vistisen, D., Amadid, H., Witte, D. R., Lauritzen, T., Brage, S., Bjerregaard, A., Hansen, Torben, Holst, Jens Juul, Jørgensen, M. E., Pedersen, Oluf Borbye, Færch, K. & Torekov, Signe Sørensen, 2019, In: Endocrine Connections. 8, 12, p. 1607–1617 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protocol for a randomised controlled trial of the combined effects of the GLP-1 receptor agonist liraglutide and exercise on maintenance of weight loss and health after a very low-calorie diet
Jensen, Simon Birk Kjær, Lundgren, J. R., Janus, C., Juhl, C. R., Olsen, L. M., Rosenkilde, M., Holst, Jens Juul, Stallknecht, Bente Merete, Madsbad, Sten & Torekov, Signe Sørensen, 2019, In: BMJ Open. 9, 11, 10 p., e031431.Research output: Contribution to journal › Journal article › Research › peer-review
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Paracrine Crosstalk between Intestinal L- and D-cells Controls Secretion of Glucagon-Like Peptide-1 in mice
Jepsen, Sara Lind, Grunddal, Kaare Villum, Albrechtsen, Nicolai Jacob Wewer, Engelstoft, M. S., Gabe, M. B. N., Jensen, E. P., Ørskov, Cathrine, Poulsen, Steen Seier, Rosenkilde, M. M., Pedersen, J., Gribble, F. M., Reimann, F., Deacon, Carolyn F., Schwartz, Thue W., Christ, A. D., Martin, R. E. & Holst, Jens Juul, 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 317, 6, p. E1081-E1093Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Heterogeneity in the perirenal region of humans suggests presence of dormant brown adipose tissue that contains brown fat precursor cells
Jespersen, N. Z., Feizi, A., Andersen, E. S., Heywood, S., Hattel, H. B., Daugaard, S., Peijs, Lone, Bagi, P., Feldt-Rasmussen, Bo, Schultz, H. S., Hansen, N. S., Krogh-Madsen, Rikke, Pedersen, Bente Klarlund, Petrovic, N., Nielsen, S. & Schéele, Camilla Charlotte Nielsen, 2019, In: Molecular Metabolism. 24, p. 30-43 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antibiotic use during pregnancy and childhood overweight: A population-based nationwide cohort study
Jess, T., Morgen, C. S., Harpsoe, M. C., Sørensen, Thorkild I.A., Ajslev, T. A., Antvorskov, J. C. & Allin, K. H., 2019, In: Scientific Reports. 9, 9 p., 11528 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7
Jørgensen, Astrid Sissel, Larsen, Olav, Uetz-von Allmen, E., Lückmann, Michael, Legler, D. F., Frimurer, Thomas Michael, Veldkamp, C. T., Hjortø, Gertrud Malene & Rosenkilde, Mette, 2019, In: Frontiers in Immunology. 10, 14 p., 2156.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Investigating Intestinal Glucagon after Roux-en-Y Gastric Bypass Surgery
Jorsal, T., Wewer Albrechtsen, N. J., Christensen, M. M., Mortensen, B., Wandall, E., Langholz, E., Friis, S., Worm, D., Ørskov, C., Støving, R. K., Andries, A., Juhl, C. B., Sørensen, F., Forman, J. L., Falkenhahn, M., Musholt, P. B., Theis, S., Larsen, P. J., Holst, J. J., Vrang, N. & 3 others, , 2019, In: Journal of Clinical Endocrinology and Metabolism. 104, 12, p. 6403–6416 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
Justice, A. E., Karaderi, T., Highland, H. M., Young, K. L., Graff, M., Lu, Y., Turcot, V., Auer, P. L., Fine, R. S., Guo, X., Schurmann, C., Lempradl, A., Marouli, E., Mahajan, A., Winkler, T. W., Locke, A. E., Medina-Gomez, C., Esko, T., Vedantam, S., Giri, A. & 31 others, , 2019, In: Nature Genetics. 51, 3, p. 452-469 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pros and cons of Roux en-Y gastric bypass surgery in obese patients with type 2 diabetes
Justinussen, T., Madsbad, Sten, Holst, Jens Juul & Bojsen-Moller, K. N., 2019, In: Expert Review of Endocrinology & Metabolism. 14, 4, p. 243-257Research output: Contribution to journal › Review › Research › peer-review
- Published
Sustained Improvements in Glucose Metabolism Late After Roux-En-Y Gastric Bypass Surgery in Patients with and Without Preoperative Diabetes
Jørgensen, N. B., Bojsen-Møller, K. N., Dirksen, C., Martinussen, C., Svane, M. S., Kristiansen, V. B., Holst, Jens Juul & Madsbad, Sten, 2019, In: Scientific Reports. 9, 1, 10 p., 15154.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased leptin, decreased adiponectin and FGF21 concentrations in adolescent offspring of women with gestational diabetes
Kampmann, F. B., Thuesen, Anne Cathrine Baun, Hjort, L., Bjerregaard, A. A., Chavarro, J., Frystyk, J., Bjerre, M., Tetens, Inge , Olsen, S. F., Vaag, A., Damm, Peter & Grunnet, Louise Groth, 2019, In: European Journal of Endocrinology. 181, 6, p. 691-700Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanisms of action of a carbohydrate-reduced, high-protein diet in reducing the risk of postprandial hypoglycemia after Roux-en-Y gastric bypass surgery
Kandel, D., Bojsen-Møller, K. N., Svane, M. S., Samkani, A., Astrup, A., Holst, Jens Juul, Madsbad, Sten & Krarup, T., 2019, In: American Journal of Clinical Nutrition. 110, 2, p. 296-304 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Disentangling the genetics of lean mass
Karasik, D., Zillikens, M. C., Hsu, Y. H., Aghdassi, A., Akesson, K., Amin, N., Barroso, I., Bennett, D. A., Bertram, L., Bochud, M., Borecki, I. B., Broer, L., Buchman, A. S., Byberg, L., Campbell, H., Campos-Obando, N., Cauley, J. A., Cawthon, P. M., Chambers, J. C., Chen, Z. & 137 others, , 2019, In: American Journal of Clinical Nutrition. 109, 2, p. 276-287Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
Karlsson Linnér, R., Biroli, P., Kong, E., Meddens, S. F. W., Wedow, R., Fontana, M. A., Lebreton, M., Tino, S. P., Abdellaoui, A., Hammerschlag, A. R., Nivard, M. G., Okbay, A., Rietveld, C. A., Timshel, P. N., Trzaskowski, M., Vlaming, R. D., Zünd, C. L., Bao, Y., Buzdugan, L., Caplin, A. H. & 31 others, , 2019, In: Nature Genetics. 51, 2, p. 245-257Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impaired glucose metabolism and altered gut microbiome despite calorie restriction of ob/ob mice
Kashani, A., Brejnrod, A. D., Jin, C., Kern, T., Madsen, A. N., Holm, L. A., Gerber, G. K., Holm, Jens-Christian, Hansen, Torben, Holst, Birgitte & Arumugam, Mani, 2019, In: Animal Microbiome. 1, 1, 16 p., 11.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Diabetic cats have decreased gut microbial diversity and a lack of butyrate producing bacteria
Kieler, Ida Nordang, Osto, M., Hugentobler, L., Puetz, Lara Christine, Gilbert, M Thomas P, Hansen, Torben, Pedersen, Oluf Borbye, Reusch, C. E., Zini, E., Lutz, T. A. & Bjørnvad, Charlotte Reinhard, 2019, In: Scientific Reports. 9, p. 1-13 13 p., 4822.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Variations in microbiome composition of sewer biofilms due to ferrous and ferric iron dosing
Kiilerich, B., Brejnrod, A. D., Vollertsen, J. & Kiilerich, P., 2019, In: Cogent Environmental Science. 5Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
Kilpeläinen, T. O., Bentley, A. R., Noordam, R., Sung, Y. J., Schwander, K., Winkler, T. W., Jakupović, H., Chasman, D. I., Manning, A., Ntalla, I., Aschard, H., Brown, M. R., de las Fuentes, L., Franceschini, N., Guo, X., Vojinovic, D., Aslibekyan, S., Feitosa, M. F., Kho, M., Musani, S. K. & 32 others, , 2019, In: Nature Communications. 10, 11 p., 376.Research output: Contribution to journal › Journal article › Research › peer-review
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Natural selection affects multiple aspects of genetic variation at putatively peutral sites across the human genome
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Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets
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The isoenzyme pattern of LDH does not play a physiological role; except perhaps during fast transitions in energy metabolism
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