- Published
Nanopore sequencing reveals methylation changes associated with obesity in circulating cell-free DNA from Göttingen Minipigs
Drag, Markus Hodal, Debes, Karina Poulsdóttir, Franck, C. S., Flethøj, M., Lyhne, Mille Kronborg, Møller, J. E., Ludvigsen, Trine Pagh, Jespersen, Thomas, Olsen, Lisbeth Høier & Kilpeläinen, Tuomas O., 2023, In: Epigenetics. 18, 1, 17 p., 2199374.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of ferritin-guided iron supplementation among Danish female first-time blood donors
Drechsler, L. Ø., Boldsen, J. K., Hindhede, L., Aagaard, B., Harritshøj, Lene Holm, Mikkelsen, Christina, Brodersen, T., Brøns, N., Schwinn, M., Hjalgrim, Henrik, Rostgaard, K., Topholm Bruun, M., Ostrowski, Sisse Rye, Pedersen, Ole Birger Vesterager, Mikkelsen, S. & Erikstrup, C., 2023, In: Transfusion. 63, 9, p. 1710-1718 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human P2Y11 expression level affects human P2X7 receptor-mediated cell death
Dreisig, K., Sund, L., Dommer, M. W., Kristensen, N. P., Boddum, K., Viste, R., Fredholm, S., Ødum, Niels, Jäättelä, M., Skov, Søren & Kornum, Birgitte Rahbek, 2018, In: Frontiers in Immunology. 9, JUN, 12 p., 1159.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Associations between thyroid-stimulating hormone, blood pressure and adiponectin are attenuated in children and adolescents with overweight or obesity
Drivsholm, A., Lund, Morten Asp Vonsild, Hedley, P. L., Jespersen, Thomas, Christiansen, M., Hansen, Torben & Holm, Jens-Christian, 2019, In: Journal of Pediatric Endocrinology and Metabolism. 32, 12, p. 1351-1358Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Heritability of optic disc diameters: a twin study
Drobnjak, D., Taarnhøj, N. C., Mitchell, P., Wang, J. J., Tan, A., Kessel, Line, Hougaard, J., Sørensen, Thorkild I.A. & Larsen, Michael, 1 Mar 2011, In: Acta Ophthamologica (Online). 89, 2, p. e193-8Research output: Contribution to journal › Journal article › Research
- Published
Discovery, characterization, and clinical development of the glucagon-like peptides
Drucker, D. J., Habener, J. F. & Holst, Jens Juul, 1 Dec 2017, In: The Journal of Clinical Investigation. 127, 12, p. 4217-4227 11 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
The expanding incretin universe: from basic biology to clinical translation
Drucker, D. J. & Holst, Jens Juul, 2023, In: Diabetologia. 66, p. 1765-1779Research output: Contribution to journal › Review › Research › peer-review
- Published
Genetic polymorphisms in the hypothalamic pathway in relation to subsequent weight change--the DiOGenes study
Du, H., Ängquist, Lars, Vimaleswaran, K. S., Hansen, R. D., van der, D. L., Holst, C., Tjønneland, A., Overvad, K., Jakobsen, M. U., Boeing, H., Meidtner, K., Palli, D., Masala, G., Bouatia-Naji, N., Saris, W. H. M., Feskens, E. J. M., Wareham, N. J., Sørensen, Thorkild I.A. & Loos, R. J. F., 2011, In: P L o S One. 6, 2, p. e17436Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dietary fiber and subsequent changes in body weight and waist circumference in European men and women
Du, H., van der A, D. L., Boshuizen, H. C., Forouhi, N. G., Wareham, N. J., Halkjaer, J., Tjønneland, A., Overvad, K., Jakobsen, M. U., Boeing, H., Buijsse, B., Masala, G., Palli, D., Sørensen, Thorkild I.A., Saris, W. H. M. & Feskens, E. J. M., 1 Feb 2010, In: American Journal of Clinical Nutrition. 91, 2, p. 329-36 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic
Duncan, C. J. A., Skouboe, M. K., Howarth, S., Hollensen, A. K., Chen, R., Børresen, M. L., Thompson, B. J., Spegarova, J. S., Hatton, C. F., Stæger, F. F., Andersen, M. K., Whittaker, J., Paludan, S. R., Jørgensen, S. E., Thomsen, M. K., Mikkelsen, J. G., Heilmann, C., Buhas, D., Øbro, N. F., Bay, J. T. & 17 others, , 2022, In: Journal of Experimental Medicine. 219, 6, 26 p., e20212427.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Atrial natriuretic peptide-like immunoreactive material (ANP-L1) is released from the adrenal gland by splanchnic nerve stimulation
Duntas, L., Bornstein, S. R., Scherbaum, W. & Holst, Jens Juul, 1994, In: Exp.Clin.Endocrinol.. 101, p. 371-373Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism
Duparc, T., Plovier, H., Marrachelli, V. G., Van Hul, M., Essaghir, A., Ståhlman, M., Matamoros, S., Geurts, L., Pardo-Tendero, M. M., Druart, C., Delzenne, N. M., Demoulin, J., van der Merwe, S. W., van Pelt, J., Bäckhed, G. F., Monleon, D., Everard, A. & Cani, P. D., 2017, In: Gut. 66, 4, p. 620-632 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A. U., Wheeler, E., Glazer, N. L., Bouatia-Naji, N., Gloyn, A. L., Lindgren, C. M., Mägi, R., Morris, A. P., Randall, J., Johnson, T., Elliott, P., Rybin, D., Thorleifsson, G., Steinthorsdottir, V., Henneman, P. & 31 others, , 1 Feb 2010, In: Nature Genetics. 42, 2, p. 105-16 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Circulating Soluble CD163, Associations With Cardiovascular Outcomes and Mortality, and Identification of Genetic Variants in Older Individuals: The Cardiovascular Health Study
Durda, P., Raffield, L. M., Lange, E. M., Olson, N. C., Jenny, N. S., Cushman, M., Deichgraeber, P., Grarup, N., Jonsson, Anna Elisabet, Hansen, Torben, Mychaleckyj, J. C., Psaty, B. M., Reiner, A. P., Tracy, R. P. & Lange, L. A., 2022, In: Journal of the American Heart Association. 11, 21, 14 p., e024374.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lessons from whole-exome sequencing in MODYX families
Dusatkova, P., Fang, M., Pruhova, S., Gjesing, A. P., Cinek, O., Hansen, Torben, Pedersen, Oluf Borbye, Xu, X. & Lebl, J., Jun 2014, In: Diabetes Research and Clinical Practice. 104, 3, p. e72-4 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nationwide prediction of type 2 diabetes comorbidities
Dworzynski, P., Aasbrenn, M., Rostgaard, K., Melbye, M., Gerds, Thomas Alexander, Hjalgrim, H. & Pers, Tune H, 2020, In: Scientific Reports. 10, 13 p., 1776.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide-1 is a marker of systemic inflammation in patients treated with high-dose chemotherapy and autologous stem cell transplantation
Ebbesen, M. S., Kissow, Hannelouise, Hartmann, Bolette, Grell, Kathrine, Gørløv, J. S., Kielsen, K., Holst, Jens Juul & Muller, Klaus, 2019, In: Biology of Blood and Marrow Transplantation. 25, 6, p. 1085-1091 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-Like Peptide-1 Is Associated With Systemic Inflammation in Pediatric Patients Treated With Hematopoietic Stem Cell Transplantation
Sørum, Maria Ebbesen, Kissow, Hannelouise, Hartmann, Bolette, Kielsen, K., Sørensen, K., Stinson, Sara, Frithioff-Bojsoe, C., Fonvig, Cilius Esmann, Holm, Jens-Christian, Hansen, Torben, Holst, Jens Juul & Müller, K. G., 2021, In: Frontiers in Immunology. 12, 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
'No cognitive-enhancing effect of GLP-1 receptor agonism in antipsychotic-treated, obese patients with schizophrenia': authors' response
Ebdrup, Bjørn, Ishøy, P. L., Fagerlund, Birgitte, Broberg, B. V., Bak, N., Knop, Filip Krag & Glenthøj, Birte Yding, Nov 2017, In: Acta Psychiatrica Scandinavica. 136, 5, p. 526-527Research output: Contribution to journal › Comment/debate › Research
- Published
Glucometabolic hormones and cardiovascular risk markers in antipsychotic-treated patients
Ebdrup, Bjørn, Knop, Filip Krag, Madsen, A., Mortensen, H. B., Søgaard, B., Holst, Jens Juul, Szecsi, P. B. & Lublin, H., Sep 2014, In: Journal of Clinical Psychiatry. 75, 9, p. e899-905 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity
Echwald, S. M., Bjørbaek, C., Hansen, Torben, Clausen, J. O., drb459, drb459, Zierath, Juleen R, Printz, R. L., Granner, D. K. & Pedersen, Oluf Borbye, Mar 1995, In: Diabetes. 44, 3, p. 347-53 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutation analysis of NR0B2 among 1545 Danish men identifies a novel c.278G>A (p.G93D) variant with reduced functional activity
Echwald, S. M., Andersen, K. L., Sørensen, Thorkild I.A., Larsen, L. H., Andersen, T., Tonooka, N., Tomura, H., Takeda, J. & Pedersen, Oluf Borbye, 2004, In: Human Mutation. 24, 5, p. 381-387 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fedmens genetik
Echwald, S. M., Larsen, P. J., Pedersen, Oluf Borbye & Sørensen, Thorkild I.A., 2006, In: Ugeskrift for læger. 168, 2, p. 150-152 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transcriptional profiling of extracellular amino acid sensing in Saccharomyces cerevisiae and the role of Stp 1 p and Stp2p
Eckert-Boulet, N., Nielsen, P. S., Friis, Carsten, Moreira dos Santos, M., Nielsen, J., Kielland-Brandt, M. C. & Regenberg, Birgitte, 1 Jun 2004, In: Yeast. 21, 8, p. 635-648 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Prospective Cohort Study in Patients with Type 2 Diabetes Mellitus for Validation of Biomarkers (PROVALID) - Study Design and Baseline Characteristics
Eder, S., Leierer, J., Kerschbaum, J., Rosivall, L., Wiecek, A., de Zeeuw, D., Mark, P. B., Heinze, G., Rossing, Peter, Heerspink, H. L. & Mayer, G., 2018, In: Kidney and Blood Pressure Research. 43, 1, p. 181-190Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis
Edholm, T., Degerblad, M., Grybäck, P., Hilsted, Linda, Holst, Jens Juul, Jacobsson, H., Efendic, S., Schmidt, P. T. & Hellström, P. M., 1 Nov 2010, In: Neurogastroenterology and Motility Online. 22, 11, p. 1191-200, e315 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Difference in postprandial GLP-1 response despite similar glucose kinetics after consumption of wheat breads with different particle size in healthy men
Eelderink, C., Noort, M. W. J., Sozer, N., Koehorst, M., Holst, Jens Juul, Deacon, Carolyn F., Rehfeld, Jens Frederik, Poutanen, K., Vonk, R. J., Oudhuis, L. & Priebe, M. G., 2017, In: European Journal of Nutrition. 56, 3, p. 1063-1076 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The structure of wheat bread influences the postprandial metabolic response in healthy men
Eelderink, C., Noort, M. W. J., Sozer, N., Koehorst, M., Holst, Jens Juul, Deacon, Carolyn F., Rehfeld, Jens Frederik, Poutanen, K., Vonk, R. J., Oudhuis, L. & Priebe, M. G., Oct 2015, In: Food & Function. 6, 10, p. 3236-48 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Limited availability of childhood overweightand obesity treatment programmes in Danish paediatric departments
Eg, M., Cortes, Dina, Johansen, A., Frederiksen, K., Lorentzen, V., Larsen, L. M., Holm, Jens-Christian & Vámosi, M., Sep 2016, In: Danish Medical Journal. 63, 9, p. 1-5 5 p., A5269.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Accelerated food source location in aging Drosophila.
Egenriether, S., Chow, E., Krauth, Nathalie & Giebultowicz, J., 23 Jun 2015, In: Aging Cell.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Major Lineage of Enteroendocrine Cells Coexpress CCK, Secretin, GIP, GLP-1, PYY, and Neurotensin but Not Somatostatin
Egerod, Kristoffer Lihme, Engelstoft, M. S., Grunddal, Kaare Villum, Nøhr, M. K., Secher, A., Sakata, I., Pedersen, Jens, Windeløv, Johanne Agerlin, Füchtbauer, E., Olsen, Jørgen, Sundler, F., Christensen, Jan Pravsgaard, Wierup, N., Olsen, Jesper Velgaard, Holst, Jens Juul, Zigman, J. M., Poulsen, Steen Seier & Schwartz, Thue W., 1 Dec 2012, In: Endocrinology. 153, 12, p. 5782-95 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transcriptional and Functional Characterization of the G Protein-Coupled Receptor Repertoire of Gastric Somatostatin Cells
Egerod, Kristoffer Lihme, Engelstoft, M. S., Lund, M. L., Grunddal, Kaare Villum, Zhao, M., Barir-Jensen, D., Nygaard, E. B., Petersen, N., Holst, Jens Juul & Schwartz, Thue W., Nov 2015, In: Endocrinology. 156, 11, p. 3909-23 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms
Egerod, Kristoffer Lihme, Petersen, N., Timshel, P. N., Rekling, Jens Christian, Wang, Y., Liu, Q., Schwartz, Thue W. & Gautron, L., 2018, In: Molecular Metabolism. 12, p. 62-75 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Molecular Diversity of Vagal Afferents Revealed
Egerod, Kristoffer Lihme, Schwartz, Thue W. & Gautron, L., 2019, In: Trends in Neurosciences. 42, 10, p. 663-666Research output: Contribution to journal › Editorial › Research › peer-review
- Published
Pregnancy loss is associated with type 2 diabetes: a nationwide case-control study
Egerup, P., Mikkelsen, A. P., Kolte, A. M., Westergaard, D., Rasmussen, S., Knop, Filip Krag, Lidegaard, Øjvind & Nielsen, Henriette Svarre, 2020, In: Diabetologia. 63, 8, p. 1521-1529Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments
Ehmann, D., Wendler, J., Koeninger, L., Larsen, I. S., Klag, T., Berger, J., Marette, A., Schaller, M., Stange, E. F., Malek, N. P., Jensen, Benjamin Anderschou Holbech & Wehkamp, J., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3746-3751Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fragmentation of Human Neutrophil α-Defensin 4 to Combat Multidrug Resistant Bacteria
Ehmann, D., Koeninger, L., Wendler, J., Malek, N. P., Stange, E. F., Wehkamp, J. & Jensen, Benjamin Anderschou Holbech, 2020, In: Frontiers in Microbiology. 11, 10 p., 1147.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
Ehret, G. B., Ferreira, T., Chasman, D. I., Jackson, A. U., Schmidt, E. M., Johnson, T., Thorleifsson, G., Luan, J., Donnelly, L. A., Kanoni, S., Petersen, A-K., Pihur, V., Strawbridge, R. J., Shungin, D., Hughes, M. F., Meirelles, O., Kaakinen, M., Bouatia-Naji, N., Kristiansson, K., Shah, S. & 31 others, , 12 Sep 2016, In: Nature Genetics. 48, 10, p. 1171-1184 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sympathoadrenal regulation of adrenocortical steroidogenesis
Ehrhart-Bornstein, M., Bornstein, S. R., Gonzalez-Hernandez, J., Holst, Jens Juul, Watermann, M. R. & Scherbaum, W. A., 1995, In: Endocrine Research. 21, p. 13-24Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sympathoadrenal regulation of adrenal androstenedione release
Ehrhart-Bornstein, M., Bornstein, S. R., Behling, H. G., Holst, Jens Juul, Strohmayer, H. G., Rasmussen, T. N., Scherbaum, W. A. & Adler, G., 1994, In: Neuroendocrinology. 59, p. 406-412Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Vasoactive intestinal peptide in the porcine adrenal gland
Ehrhart-Bornstein, M., Bornstein, S. R. & Holst, Jens Juul, 1991, In: Neuroendocrinology. 54, p. 623-628Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bilio-enteric flow and plasma concentrations of bile acids after gastric bypass and sleeve gastrectomy
Eiken, A., Fuglsang, S., Eiken, M., Svane, M. S., Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Hansen, S. H., Trammell, Sam, Svenningsen, J. S., Rehfeld, Jens Frederik, Bojsen-Møller, K. N., Jørgensen, N. B., Holst, Jens Juul, Madsbad, Sten, Madsen, J. L. & Dirkse, C., 2020, In: International Journal of Obesity. 44, p. 1872-1883Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A novel -192c/g Mutation in the Proximal P2 Promoter of the Hepatocyte Nuclear Factor-4α Gene (HNF4A) Associates With Late-onset Diabetes
Ek, J., Hansen, S. P., Lajer, M., Nicot, C., Boesgaard, T. W., Pruhova, S., Johansen, A., Albrechtsen, Anders, Yderstraede, K., Lauenborg, J., Parrizas, M., Boj, S. F., Jørgensen, T., Borch-Johnsen, K., Damm, Peter, Ferrer, J., Lebl, J., Pedersen, Oluf Borbye & Hansen, Torben, 2006, In: Diabetes. 55, 6, p. 1869-73 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The functional Thr130Ile and Val255Met polymorphisms of the hepatocyte nuclear factor-4alpha (HNF4A): gene associations with type 2 diabetes or altered beta-cell function among Danes
Ek, J., Rose, C. S., Jensen, D. P., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Pedersen, Oluf Borbye & Hansen, Torben, 2005, In: Journal of Clinical Endocrinology and Metabolism. 90, 5, p. 3054-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPR119 - a major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Co-acting in Synergy with FFA1 (GPR40)
Ekberg, J. H., Pedersen, M. H., Kristensen, L. V., Madsen, A. N., Engelstoft, M. S., Husted, Anna Sofie, Sichlau, R., Egerod, Kristoffer Lihme, Timshel, P., Kowalski, T. J., Gribble, F. M., Reiman, F., Hansen, Harald S., Howard, A. D., Holst, Birgitte & Schwartz, Thue W., 25 Oct 2016, In: Endocrinology. 157, 12, p. 4561-4569 9 p., en20161334.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of beta cell and incretin function in patients with MODY1 (HNF4A MODY) and MODY3 (HNF1A MODY) in a Swedish patient collection
Ekholm, E., Shaat, N. & Holst, Jens Juul, Oct 2012, In: Acta Diabetologica. 49, 5, p. 349-54 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transient activation of mTOR following forced treadmill exercise in rats
Elfving, B., Christensen, T., Ratner, C., Wienecke, Jacob & Klein, A. B., 2013, In: Synapse. 67, 9, p. 620-625 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide study of early and severe childhood asthma identifies interaction between CDHR3 and GSDMB
Eliasen, A. U., Pedersen, C. E. T., Rasmussen, M. A., Wang, N., Soverini, M., Fritz, A., Stokholm, J., Chawes, B. L., Morin, A., Bork-Jensen, J., Grarup, N., Pedersen, O., Hansen, T., Linneberg, A., Mortensen, P. B., Hougaard, D. M., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Mors, O., Nordentoft, M. & 14 others, , 2022, In: Journal of Allergy and Clinical Immunology. 150, 3, p. 622-630Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Circulating Metabolomic and Lipidomic Signatures Identify a Type 2 Diabetes Risk Profile in Low-Birth-Weight Men with Non-Alcoholic Fatty Liver Disease
Elingaard-Larsen, L. O., Villumsen, S. O., Justesen, L., Thuesen, Anne Cathrine Baun, Kim, M., Ali, M., Danielsen, E. R., Legido-Quigley, C., van Hall, Gerrit, Hansen, Torben, Ahluwalia, T. S., Vaag, Allan & Brøns, C., 2023, In: Nutrients. 15, 7, 16 p., 1590.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MYC mRNA expression throughout the intestine is not associated with body mass index or type 2 diabetes
Ellegaard, A. & Knop, Filip Krag, 2022, In: Endocrinology, Diabetes and Metabolism. 5, 2, 4 p., 00327.Research output: Contribution to journal › Comment/debate › Research
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Natural selection affects multiple aspects of genetic variation at putatively peutral sites across the human genome
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Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets
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The isoenzyme pattern of LDH does not play a physiological role; except perhaps during fast transitions in energy metabolism
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