Novo Nordisk Foundation Center for Basic Metabolic Research

  1. 2009
  2. Published

    Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

    Schafer, Z. T., Grassian, A. R., Song, L., Jiang, Z., Gerhart-Hines, Zach, Irie, H. Y., Gao, S., Puigserver, P. & Brugge, J. S., 3 Sep 2009, In: Nature. 461, 7260, p. 109-113 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Peroxisome proliferator-activated receptor gamma regulates expression of the anti-lipolytic G-protein-coupled receptor 81 (GPR81/Gpr81)

    Jeninga, E. H., Bugge, A. S., Nielsen, R., Kersten, S., Hamers, N., Dani, C., Wabitsch, M., Berger, R., Stunnenberg, H. G., Mandrup, S. & Kalkhoven, E., 25 Sep 2009, In: The Journal of Biological Chemistry. 284, 39, p. 26385-93 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion

    Jonsson, Anna Elisabet, Isomaa, B., Tuomi, T., Taneera, J., Salehi, A., Nilsson, P., Groop, L. & Lyssenko, V., Oct 2009, In: Diabetes. 58, 10, p. 2409-13 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Genetic and clinical profile of Indian patients of idiopathic restrictive cardiomyopathy with and without hypertrophy

    Rai, T. S., Ahmad, S., Ahluwalia, Tarun Veer Singh, Ahuja, M., Bahl, A., Saikia, U. N., Singh, B., Talwar, K. K. & Khullar, M., Nov 2009, In: Developments in Molecular and Cellular Biochemistry. 331, 1-2, p. 187-92 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Transcriptome complexity in a genome-reduced bacterium.

    Güell, M., van Noort, V., Yus, E., Chen, W., Leigh-Bell, J., Michalodimitrakis, K., Yamada, T., Arumugam, Mani, Doerks, T., Kühner, S., Rode, M., Suyama, M., Schmidt, S., Gavin, A., Bork, P. & Serrano, L., Nov 2009, In: Science. 326, 5957, p. 1268-1271 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Role of the AMPKgamma3 isoform in hypoxia-stimulated glucose transport in glycolytic skeletal muscle

    Deshmukh, Atul Shahaji, Glund, S., Tom, R. Z. & Zierath, Juleen R, Dec 2009, In: American Journal of Physiology: Endocrinology and Metabolism. 297, 6, p. E1388-94

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth

    Markljung, E., Jiang, L., Jaffe, J. D., Mikkelsen, T. S., Wallerman, O., Larhammar, M., Zhang, X., Wang, L., Saenz-Vash, V., Gnirke, A., Lindroth, A. M., Barres, R., Yan, J., Strömberg, S., De, S., Pontén, F., Lander, E. S., Carr, S. A., Zierath, J. R., Kullander, K. & 5 others, Wadelius, C., Lindblad-Toh, K., Andersson, G., Hjälm, G. & Andersson, L., Dec 2009, In: P L o S Biology (Online). 7, 12, p. e1000256

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. 2010
  10. Published

    TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet

    Grau, K., Cauchi, S., Holst, C., Astrup, A., Martinez, J. A., Saris, W. H. M., Blaak, E. E., Oppert, J., Arner, P., Rössner, S., Macdonald, I. A., Klimcakova, E., Langin, D., Pedersen, Oluf Borbye, Froguel, P. & Sørensen, Thorkild I.A., 2010, In: American Journal of Clinical Nutrition. 91, 2, p. 472-479 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors

    Holst, Birgitte, Nygaard, R., Hansen, L. V., Bach, Anders, Engelstoft, M. S., Petersen, P. S., Frimurer, T. M. & Schwartz, Thue W., 2010, In: Journal of Biological Chemistry. 285, 6, p. 3973-85 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    A human gut microbial gene catalogue established by metagenomic sequencing

    MetaHIT Consortium, M. C., 2010, In: Nature. 464, 7285, p. 59-65 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Bed Rest-Induced Changes in TBC1D4 Phosphorylation and Glycogen Synthase Activity. Effects of Acute Exercise

    Bienso, R. S., Ringholm, S., Lundby, C., Achman-Andersen, N. J., Plomgaard, Peter Stendahl, Krogh-Madsen, Rikke, Kiilerich, K., Guerra, B., Treebak, Jonas Thue, Calbet, J. A., Pilegaard, Henriette & Wojtaszewski, J. J. F., 2010, In: Diabetes.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Brain nonoxidative carbohydrate consumption is not explained by export of an unknown carbon source: evaluation of the arterial and jugular venous metabolome

    Rasmussen, P., Nyberg, N., Jaroszewski, J. W., Krogh-Madsen, Rikke, Secher, Niels H. & Quistorff, B., 2010, In: Journal of Cerebral Blood Flow and Metabolism. 30, 6, p. 1240-1246

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Combined Analyses of 20 Common Obesity Susceptibility Variants

    Sandholt, C. H., Sparsø, T., Grarup, Niels, Albrechtsen, Anders, Almind, K., Hansen, L., Toft, U., Jørgensen, T., Hansen, Torben & Pedersen, Oluf Borbye, 2010, In: Diabetes. 59, 7, p. 1667-1673 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Combined effects of weight loss and physical activity on all-cause mortality of overweight men and women

    ÿstergaard, J. N., Grønbaek, M., Schnohr, P., Sørensen, Thorkild I.A. & Heitmann, Berit, 2010, In: International Journal of Obesity. 34, 4, p. 760-9 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure

    Kring, S. I. I., Holst, C., Toubro, S., Astrup, A., Hansen, T., Pedersen, Oluf Borbye & Sørensen, Thorkild I.A., 2010, In: International Journal of Obesity. 34, 1, p. 182-189 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure

    Kring, S. I. I., Holst, C., Toubro, S., Astrup, A., Hansen, T., Pedersen, Oluf Borbye & Sørensen, Thorkild I.A., 2010, In: International Journal of Obesity. 34, 1, p. 182-9 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation

    Nygaard, R., Hansen, L. V., Mokrosinski, J., Frimurer, T. M. & Schwartz, Thue W., 2010, In: Journal of Biological Chemistry. 285, 25, p. 19625-36 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Design of association studies with pooled or un-pooled next-generation sequencing data

    Kim, S. Y., Li, Y., Guo, Y., Li, R., Holmkvist, J., Hansen, Torben, Pedersen, Oluf Borbye, Wang, J. & Nielsen, Rasmus, 2010, In: Genetic Epidemiology. 34, 5, p. 479-491 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Differential aetiology and impact of phosphoinositide 3-kinase (PI3K) and Akt signalling in skeletal muscle on in vivo insulin action

    Friedrichsen, M., Poulsen, P., Richter, Erik A., Hansen, B. F., Birk, Jesper Bratz, Ribel-Madsen, R., Stender-Petersen, K., Nilsson, E., Beck-Nielsen, H., Vaag, Allan & Wojtaszewski, Jørgen F P, 2010, In: Diabetologia. 53, 9, p. 1998-2007 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Do things talk?

    Söderqvist, Thomas & Bencard, Adam, 2010, In: Max Planck Institute for History of Science, Preprint Series. 399, p. 92-102 11 p.

    Research output: Contribution to journalConference articleResearchpeer-review

  23. Published

    Effects of Exercise on Lipid-Induced Insulin Resistance in Human Skeletal Muscle-Signaling at the Level of TBC1D4

    Pehmoller, C., Brandt, N., Birk, Jesper Bratz, Treebak, Jonas Thue, Hoeg, L. D., Sjoberg, K. A., Kiens, Bente, Richter, Erik A. & Wojtaszewski, Jørgen F P, 2010, In: Diabetes.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Effects of category-specific costs on neural systems for perceptual decision-making

    Fleming, S. M., Whiteley, Louise, Hulme, O. J., Sahani, M. & Dolan, R. J., 2010, In: Journal of Neurology & Neurophysiology. 103, 6, p. 3238-47 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity

    Gjesing, A. P., Larsen, L. H., Torekov, S. S., Hainerová, I. A., Kapur, R., Johansen, A., Albrechtsen, A., Boj, S., Holst, B., Harper, A., Urhammer, S. A., Borch-Johnsen, K., Pisinger, C. H., Echwald, S. M., Eiberg, H. R. L., Astrup, A., Lebl, J., Ferrer, J., Schwartz, T. W., Hansen, T. & 1 others, Pedersen, Oluf Borbye, 2010, In: P L o S One. 5, 4, 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation

    Nebbioso, A., Dell'Aversana, C., Bugge, A. S., Sarno, R., Valente, S., Rotili, D., Manzo, F., Teti, D., Mandrup, S., Ciana, P., Maggi, A., Mai, A., Gronemeyer, H. & Altucci, L., 2010, In: Journal of Molecular Endocrinology. 45, 4, p. 219-28 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus

    Okamoto, K., Iwasaki, N., Nishimura, C., Doi, K., Noiri, E., Nakamura, S., Takizawa, M., Ogata, M., Fujimaki, R., Grarup, N., Pisinger, C., Borch-Johnsen, K., Lauritzen, T., Sandbaek, A., Hansen, T., Yasuda, K., Osawa, H., Nanjo, K., Kadowaki, T., Kasuga, M. & 5 others, Pedersen, Oluf Borbye, Fujita, T., Kamatani, N., Iwamoto, Y. & Tokunaga, K., 2010, In: American Journal of Human Genetics. 86, 1, p. 54-64 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Impact of rs361072 in the phosphoinositide 3-kinase p110beta gene on whole-body glucose metabolism and subunit protein expression in skeletal muscle

    Ribel-Madsen, R., Poulsen, P., Holmkvist, J., Mortensen, B., Grarup, Niels, Friedrichsen, M., Jørgensen, T., Lauritzen, T., Wojtaszewski, Jørgen F P, Pedersen, Oluf Borbye, Hansen, Torben & Vaag, Allan, 2010, In: Diabetes. 59, 4, p. 1108-1112 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Impact of size at birth and prematurity on adult anthropometry in 4744 middle-aged Danes - The Inter99 Study

    Pilgaard, K., Færch, K., Poulsen, P., Larsen, C., Andersson, E. A., Pisinger, C. H., Toft, U., Aadahl, M., Pedersen, Oluf Borbye, Hansen, Torben, Jørgensen, T., Borch-Johnsen, K. & Vaag, Allan, 2010, In: Journal of Developmental Origins of Health and Disease. 1, 5, p. 319-328 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans

    Andersson, E. A., Holst, Birgitte, Sparsø, T., Grarup, Niels, Banasik, Karina, Holmkvist, J., Jørgensen, T., Borch-Johnsen, K., Egerod, Kristoffer Lihme, Lauritzen, T., Sørensen, Thorkild I.A., Bonnefond, A., Meyre, D., Froguel, P., Schwartz, Thue W., Pedersen, Oluf Borbye & Hansen, Torben, 2010, In: Diabetes. 59, 6, p. 1539-48 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation

    Bugge, A. S. & Mandrup, S., 2010, In: PPAR Research. 2010

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Neuroscience evidence should be incorporated into our ethical practices

    Felsen, G., Whiteley, Louise, Nadler, R. & Reiner, P. B., 2010, In: A J O B Neuroscience. 1, 4, p. 36-38

    Research output: Contribution to journalComment/debateCommunication

  33. Published

    Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese europeans: The NUGENOB Study

    Corpeleijn, E., Petersen, L., Holst, C., Saris, W. H., Astrup, A., Langin, D., Macdonald, I., Martinez, J. A., Oppert, J., Polak, J., Pedersen, Oluf Borbye, Froguel, P., Arner, P., Sørensen, Thorkild I.A. & Blaak, E. E., 2010, In: Obesity. 18, 7, p. 1369-1377 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants

    Li, Y., Vinckenbosch, N., Tian, G., Huerta-Sanchez, E., Jiang, T., Jiang, H., Albrechtsen, A., Andersen, G., Cao, H., Korneliussen, T. S., Grarup, N., Guo, Y., Hellman, I., Jin, X., Li, Q., Liu, J., Liu, X., Sparsø, T., Tang, M., Wu, H. & 18 others, Wu, R., Yu, C., Zheng, H., Astrup, A., Bolund, L., Holmkvist, J., Jørgensen, T., Kristiansen, Karsten, Schmitz, O., Schwartz, Thue W., Zhang, X., Li, R., Yang, H., Wang, J., Hansen, Torben, Pedersen, Oluf Borbye, Nielsen, Rasmus & Wang, J., 2010, In: Nature Genetics. 42, 11, p. 969-72 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Spatially distributed encoding of covert attentional shifts in human thalamus

    Hulme, O. J., Whiteley, Louise & Shipp, S., 2010, In: Journal of Neurology & Neurophysiology. 104, 6, p. 3644-56 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest

    Alibegovic, A. C., Sonne, M. P., Højbjerre, L., Hansen, T., Pedersen, Oluf Borbye, van Hall, Gerrit, Holst, Jens Juul, Stallknecht, Bente Merete, Dela, Flemming & Vaag, A., 2010, In: Diabetes. 59, 4, p. 836-43 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    The chemistry of life: Four chapters in the history of metabolic research

    Bencard, Adam, 2010

    Research output: Non-textual form2D/3D (psysical products)Communication

  38. Published

    A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes

    Maeda, S., Kobayashi, M., Araki, S., Babazono, T., Freedman, B. I., Bostrom, M. A., Cooke, J. N., Toyoda, M., Umezono, T., Tarnow, L., Hansen, T., Gaede, P., Jorsal, A., Ng, D. P. K., Ikeda, M., Yanagimoto, T., Tsunoda, T., Unoki, H., Kawai, K., Imanishi, M. & 11 others, Suzuki, D., Shin, H. D., Park, K. S., Kashiwagi, A., Iwamoto, Y., Kaku, K., Kawamori, R., Parving, H., Bowden, D. W., Pedersen, Oluf Borbye & Nakamura, Y., 1 Jan 2010, In: P L o S Genetics. 6, 2, p. e1000842

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Advancing the future of physical activity guidelines in Canada: an independent expert panel interpretation of the evidence

    Kesäniemi, A., Riddoch, C. J., Reeder, B., Blair, S. N. & Sørensen, Thorkild I.A., 1 Jan 2010, In: International Journal of Behavioral Nutrition and Physical Activity. 7, p. 41

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Birth weight, childhood body mass index and risk of coronary heart disease in adults: combined historical cohort studies

    Andersen, L. G., Ängquist, Lars, Eriksson, J. G., Forsen, T., Gamborg, Michael Orland, Osmond, C., Baker, J. L. & Sørensen, Thorkild I.A., 1 Jan 2010, In: P L o S One. 5, 11, p. e14126

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Changes in waist circumference and mortality in middle-aged men and women

    Berentzen, T. L., Jakobsen, M. U., Halkjaer, J., Tjønneland, A., Overvad, K. & Sørensen, Thorkild I.A., 1 Jan 2010, In: P L o S One. 5, 9

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Dietary determinants of changes in waist circumference adjusted for body mass index - a proxy measure of visceral adiposity

    Romaguera, D., Ängquist, Lars, Du, H., Jakobsen, M. U., Forouhi, N. G., Halkjaer, J., Feskens, E. J. M., van der A, D. L., Masala, G., Steffen, A., Palli, D., Wareham, N. J., Overvad, K., Tjønneland, A., Boeing, H., Riboli, E. & Sørensen, Thorkild I.A., 1 Jan 2010, In: P L o S One. 5, 7, p. e11588

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Do gene variants influencing adult adiposity affect birth weight? A population-based study of 24 loci in 4,744 Danish individuals

    Andersson, E. A., Pilgaard, K., Pisinger, C., Harder, M. N., Grarup, Niels, Færch, K., Sandholt, C., Poulsen, P., Witte, D. R., Jørgensen, T., Vaag, Allan, Pedersen, Oluf Borbye & Hansen, T., 1 Jan 2010, In: P L o S One. 5, 12, p. e14190

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY)

    Boesgaard, T. W., Pruhova, S., Andersson, E. A., Cinek, O., Obermannova, B., Lauenborg, J., Damm, Peter, Bergholdt, R., Pociot, Flemming, Pisinger, C., Barbetti, F., Lebl, J., Pedersen, Oluf Borbye & Hansen, Torben, 1 Jan 2010, In: B M C Medical Genetics. 11, p. 42

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians

    Linneberg, Allan René, Gonzalez-Quintela, A., Vidal, C., Jørgensen, T., Fenger, M., Hansen, Torben, Pedersen, Oluf Borbye & Husemoen, L. L. N., 1 Jan 2010, In: Clinical and Experimental Allergy. 40, 1, p. 123-30 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Genetic influences on incidence and case-fatality of infectious disease

    Petersen, L., Andersen, Per Kragh & Sørensen, Thorkild I.A., 1 Jan 2010, In: P L o S One. 5, 5, p. e10603

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Gestational protein restriction in mice has pronounced effects on gene expression in newborn offspring's liver and skeletal muscle; protective effect of taurine

    Mortensen, Ole Hartvig, Olsen, H. L., Frandsen, L., Nielsen, Peter E., Nielsen, Finn Cilius, Grunnet, N., Quistorff, B., Mortensen, O. H., Olsen, H. L., Frandsen, L., Nielsen, P. E., Nielsen, Finn Cilius, Grunnet, N. & Quistorff, B., 1 Jan 2010, In: Pediatric Research. 67, 1, p. 47-53 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Maternal postpartum distress and childhood overweight

    Adeltoft, T. A., Andersen, C. S., Ingstrup, K. G., Nohr, E. A., Sørensen, Thorkild I.A. & Sørensen, Thorkild I.A., 1 Jan 2010, In: P L o S One. 5, 6, p. e11136

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Prenatal stress exposure related to maternal bereavement and risk of childhood overweight

    Li, J., Olsen, J., Vestergaard, M., Obel, C., Baker, J. L. & Sørensen, Thorkild I.A., 1 Jan 2010, In: P L o S One. 5, 7, p. e11896

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population

    Husemoen, L. L. N., Jørgensen, T., Borch-Johnsen, K., Hansen, Torben, Pedersen, Oluf Borbye & Linneberg, Allan René, 1 Jan 2010, In: P L o S One. 5, 8, p. e11735

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    The genetic and environmental influences on childhood obesity: a systematic review of twin and adoption studies

    Silventoinen, K., Rokholm, B., Kaprio, J. & Sørensen, Thorkild I.A., 1 Jan 2010, In: International Journal of Obesity. 34, 1, p. 29-40 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Dietary fiber and subsequent changes in body weight and waist circumference in European men and women

    Du, H., van der A, D. L., Boshuizen, H. C., Forouhi, N. G., Wareham, N. J., Halkjaer, J., Tjønneland, A., Overvad, K., Jakobsen, M. U., Boeing, H., Buijsse, B., Masala, G., Palli, D., Sørensen, Thorkild I.A., Saris, W. H. M. & Feskens, E. J. M., 1 Feb 2010, In: American Journal of Clinical Nutrition. 91, 2, p. 329-36 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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