- 2014
- Published
Whole-genome bisulfite sequencing of multiple individuals reveals complementary roles of promoter and gene body methylation in transcriptional regulation
Lou, S., Lee, H., Qin, H., Li, J., Gao, Z., Liu, X., Chan, L. L., Lam, V. K. L., So, W., Wang, Y., Lok, S., Wang, J., Ma, R. C. W., Tsui, S. K., Chan, J. C. N., Chan, T. & Yip, K. Y., 2014, In: Genome Biology (Online Edition). 15, 7, 21 p., 408.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Whole-genome sequence variation, population structure and demographic history of the Dutch population
Francioli, L. C., Menelaou, A., Pulit, S. L., Van Dijk, F., Palamara, P. F., Elbers, C. C., Neerincx, P. B. T., Ye, K., Guryev, V., Kloosterman, W. P., Deelen, P., Abdellaoui, A., Van Leeuwen, E. M., Van Oven, M., Vermaat, M., Li, M., Laros, J. F. J., Karssen, L. C., Kanterakis, A., Amin, N. & 64 others, , 2014, In: Nature Genetics. 46, 8, p. 818-825 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Distal gastrectomy in pancreaticoduodenectomy is associated with accelerated gastric emptying, enhanced postprandial release of GLP-1, and improved insulin sensitivity
Harmuth, S., Wewalka, M., Holst, Jens Juul, Nemecek, R., Thalhammer, S., Schmid, R., Sahora, K., Gnant, M. & Miholić, J., Jan 2014, In: Journal of Gastrointestinal Surgery. 18, 1, p. 52-9 8 p.Research output: Contribution to journal › Conference article › Research › peer-review
- Published
Effects of concentrated arabinoxylan and β-glucan compared with refined wheat and whole grain rye on glucose and appetite in subjects with the metabolic syndrome: a randomized study
Hartvigsen, M. L., Gregersen, S., Lærke, H. N., Holst, Jens Juul, Bach Knudsen, K. E. & Hermansen, K., Jan 2014, In: European Journal of Clinical Nutrition. 68, 1, p. 84-90 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLP-1 responses are heritable and blunted in acquired obesity with high liver fat and insulin resistance
Matikainen, N., Bogl, L. H., Hakkarainen, A., Lundbom, J., Lundbom, N., Kaprio, J., Rissanen, A., Holst, Jens Juul & Pietiläinen, K. H., Jan 2014, In: Diabetes Care. 37, 1, p. 242-51 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of aspirin and statins on long-term survival in patients hospitalized with acute myocardial infarction complicated by heart failure: an analysis of 1706 patients
Lewinter, C., Bland, J. M., Crouch, S., Cleland, J. G. F., Doherty, P., LeWinter, M. M., Køber, Lars Valeur, Hall, A. S. & Gale, C. P., Jan 2014, In: European Journal of Heart Failure. 16, 1, p. 95-102 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Postprandial responses of incretin and pancreatic hormones in non-diabetic patients with end-stage renal disease
Idorn, T., Knop, Filip Krag, Jørgensen, M., Holst, Jens Juul, Hornum, Mads & Feldt-Rasmussen, Bo, Jan 2014, In: Nephrology, Dialysis, Transplantation. 29, 1, p. 119-27 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Systemic immunogenicity of para-Phenylenediamine and Diphenylcyclopropenone: two potent contact allergy-inducing haptens
Svalgaard, J. D., Særmark, C., Dall, M., Buschard, K., Johansen, Jeanne Duus & Engkilde, K., Jan 2014, In: Immunologic Research. 58, 1, p. 40-50 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The authors reply
Idorn, T., Knop, Filip Krag, Jørgensen, M., Holst, Jens Juul, Hornum, Mads & Feldt-Rasmussen, Bo, Jan 2014, In: Kidney International. 85, 1, p. 212-3 2 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Age-related and depot-specific changes in white adipose tissue of growth hormone receptor-null mice
Sackmann-Sala, L., Berryman, D. E., Lubbers, E. R., Zhang, H., Vesel, C. B., Troike, K. M., Gosney, E. S., List, E. O. & Kopchick, J. J., 1 Jan 2014, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 69, 1, p. 34-43 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Childhood Height and Body Mass Index Were Associated with Risk of Adult Thyroid Cancer in a Large Cohort Study
Kitahara, C. M., Gamborg, Michael Orland, Berrington de González, A., Sørensen, Thorkild I.A. & Baker, J. L., 1 Jan 2014, In: Cancer Research. 74, 1, p. 235-242 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty
The ReproGen Consortium, T. R. C., The Early Growth Genetics (EGG) Consortium, T. E. G. G. (. C., The Early Growth Genetics (EGG) Consortium, T. E. G. G. (. C., The ReproGen Consortium, T. R. C. & The GIANT Consortium, T. G. C., 1 Jan 2014, In: Human Molecular Genetics. 23, 16, p. 4452-4464 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting the intestinal L-cell for obesity and type 2 diabetes treatment
Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Deacon, Carolyn F. & Holst, Jens Juul, 1 Jan 2014, In: Expert Review of Endocrinology & Metabolism. 9, 1, p. 61-72 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Type 2 diabetes susceptibility gene variants predispose to adult-onset autoimmune diabetes
Lepola, Mette Andersen, Sterner, M., Forsén, T., Käräjämäki, A., Rolandsson, O., Forsblom, C., Groop, P. H., Lahti, K., Nilsson, P. M., Groop, L. & Tuomi, T., 1 Jan 2014, In: Diabetologia. 57, 9, p. 1859-1868 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection
Christensen, D. P., Gysemans, C., Lundh, M., Dahllöf, M. S., Noesgaard, D., Schmidt, S. F., Mandrup, S., Birkbak, N., Workman, C., Piemonti, L., Blaabjerg, L., Monzani, V., Fossati, G., Mascagni, P., Paraskevas, S., Aikin, R. A., Billestrup, N., Grunnet, L. G., Dinarello, C. A., Mathieu, C. & 1 others, , 6 Jan 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 3, p. 1055-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of chronic glucagon-like peptide-2 therapy during weaning in neonatal pigs
Sigalet, D. L., de Heuvel, E., Wallace, L., Bulloch, E., Turner, J., Wales, P. W., Nation, P., Wizzard, P. R., Hartmann, Bolette, Assad, M. & Holst, Jens Juul, 10 Jan 2014, In: Regulatory Peptides. 188, p. 70-80 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Muscle specific miRNAs are induced by testosterone and independently upregulated by age
Nielsen, S., Hvid, T., Kelly, M., Lindegaard, B., Dethlefsen, C., Winding, K., Mathur, N., Schéele, Camilla Charlotte Nielsen, Pedersen, Bente Klarlund & Laye, M. J., 23 Jan 2014, In: Frontiers in Physiology. 4, p. 1-11 11 p., 394.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MTHFR C677T genotype and cardiovascular risk in a general population without mandatory folic acid fortification
Husemoen, L. L. N., Skaaby, T., Jørgensen, T., Thuesen, B. H., Fenger, M., Grarup, N., Sandholt, C. H., Hansen, Torben, Pedersen, Oluf Borbye & Linneberg, Allan René, 24 Jan 2014, In: European Journal of Nutrition. 53, 7, p. 1549-59 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes
Steinthorsdottir, V., Thorleifsson, G., Sulem, P., Helgason, H., Grarup, N., Sigurdsson, A., Helgadottir, H. T., Johannsdottir, H., Magnusson, O. T., Gudjonsson, S. A., Justesen, J. M., Harder, M. N., Jørgensen, M. E., Christensen, C., Brandslund, I., Sandbæk, A., Lauritzen, T., Vestergaard, H., Linneberg, A., Jørgensen, T. & 14 others, , 26 Jan 2014, In: Nature Genetics. 46, 3, p. 294-300 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Altered promoter methylation of PDK4, IL1 B, IL6, and TNF after Roux-en Y gastric bypass
Kirchner, H., Nylen, C., Laber, S., Barrès, Romain, Yan, J., Krook, A., Zierath, Juleen R & Näslund, E., 28 Jan 2014, In: Surgery for Obesity and Related Diseases. 10, 4, p. 671-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLP-1 Amidation Efficiency Along the Length of the Intestine in Mice, Rats and Pigs and in GLP-1 Secreting Cell Lines
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Windeløv, Johanne Agerlin, Svendsen, B., Hartmann, Bolette & Holst, Jens Juul, 31 Jan 2014, In: Peptides. 55, p. 52-57 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Body mass index in childhood and adult risk of primary liver cancer
Berentzen, T. L., Gamborg, Michael Orland, Holst, C., Sørensen, Thorkild I.A. & Baker, J. L., Feb 2014, In: Journal of Hepatology. 60, 2, p. 325-30 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of sitagliptin and metformin treatment on incretin hormone and insulin secretory responses to oral and "isoglycemic" intravenous glucose
Vardarli, I., Arndt, E., Deacon, Carolyn F., Holst, Jens Juul & Nauck, M. A., Feb 2014, In: Diabetes. 63, 2, p. 663-74 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Generation of L cells in mouse and human small intestine organoids
Petersen, N., Reimann, F., Bartfeld, S., Farin, H. F., Ringnalda, F. C., Vries, R. G. J., van den Brink, S., Clevers, H., Gribble, F. M. & de Koning, E. J. P., Feb 2014, In: Diabetes. 63, 2, p. 410-20 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic and familial environmental effects on suicide attempts: A study of Danish adoptees and their biological and adoptive siblings
Petersen, L., Sørensen, Thorkild I.A., Andersen, Per Kragh, Mortensen, P. B. & Hawton, K., Feb 2014, In: Journal of Affective Disorders. 155, p. 273-277 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
How do pregnancy-related weight changes and breastfeeding relate to maternal weight and BMI-adjusted waist circumference 7 y after delivery? Results from a path analysis
Kirkegaard, H., Stovring, H., Rasmussen, K. M., Abrams, B., Sørensen, Thorkild I.A. & Nohr, E. A., Feb 2014, In: The American Journal of Clinical Nutrition. 99, 2, p. 312-319 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of the reconstruction method on delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy: a prospective randomized study
Tamandl, D., Sahora, K., Prucker, J., Schmid, R., Holst, J., Miholic, J., Goetzinger, P., Gnant, M. & Holst, Jens Juul, Feb 2014, In: World Journal of Surgery. 38, 2, p. 465-75 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanisms of changes in glucose metabolism and bodyweight after bariatric surgery
Madsbad, Sten, Dirksen, C. & Holst, Jens Juul, Feb 2014, In: The Lancet Diabetes & Endocrinology. 2, 2, p. 152-64 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of referral for cardiac rehabilitation on survival following acute myocardial infarction: a comparison survival in two cohorts collected in 1995 and 2003
Lewinter, C., Bland, J. M., Crouch, S., Doherty, P., Lewin, R. J., Køber, Lars Valeur, Hall, A. S. & Gale, C. P., Feb 2014, In: European Journal of Preventive Cardiology. 21, 2, p. 163-171 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interplay between FGF21 and insulin action in the liver regulates metabolism
Emanuelli, Brice, Vienberg, S. G., Smyth, G., Cheng, C., Stanford, K. I., Arumugam, Mani, Michael, M. D., Adams, A. C., Kharitonenkov, A. & Kahn, C. R., 3 Feb 2014, In: The Journal of Clinical Investigation. 124, 2, p. 515-27 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Young men with low birthweight exhibit decreased plasticity of genome-wide muscle DNA methylation by high-fat overfeeding
Jacobsen, S. C., Gillberg, L., Bork-Jensen, J., Ribel-Madsen, R., Lara, E., Calvanese, V., Ling, C., Fernandez, A. F., Fraga, M. F., Poulsen, P., Brøns, C. & Vaag, Allan, 26 Feb 2014, In: Diabetologia. 57, 6, p. 1154-1158 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Adipose triglyceride lipase and g0/g1 switch gene 2: approaching proof of concept
Nielsen, Thomas Svava & Møller, N., Mar 2014, In: Diabetes. 63, 3, p. 847-9 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Birth weight, childhood BMI and height in relation to mammographic density and breast cancer: Register based cohort study
Andersen, Zorana Jovanovic, Baker, J. L., Bihrmann, K., Vejborg, I., Sørensen, Thorkild I.A. & Lynge, Elsebeth, Mar 2014, In: European Journal of Cancer. 50, Suppl S2, p. S75-S75 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Defining the role of GLP-1 in the enteroinsulinar axis in type 2 diabetes using DPP-4 inhibition and GLP-1 receptor blockade
Aulinger, B. A., Bedorf, A., Kutscherauer, G., de Heer, J., Holst, Jens Juul, Göke, B. & Schirra, J., Mar 2014, In: Diabetes. 63, 3, p. 1079-92 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gating function of isoleucine-116 in TM-3 (position III:16/3.40) for the activity state of the CC-chemokine receptor 5 (CCR5)
Steen, A., wbf943, wbf943, Thiele, S., Guo, D., Frimurer, Thomas Michael & Rosenkilde, Mette, Mar 2014, In: British Journal of Pharmacology. 171, 6, p. 1566-79 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
Mahajan, A., Go, M. J., Zhang, W., Below, J. E., Gaulton, K. J., Ferreira, T., Horikoshi, M., Johnson, A. D., Ng, M. C. Y., Prokopenko, I., Saleheen, D., Wang, X., Zeggini, E., Abecasis, G. R., Adair, L. S., Almgren, P., Atalay, M., Aung, T., Baldassarre, D., Balkau, B. & 31 others, , Mar 2014, In: Nature Genetics. 46, 3, p. 234-44 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucose-dependent Insulinotropic Polypeptide: Blood Glucose Stabilizing Effects in Patients With Type 2 Diabetes
Christensen, Mikkel Bring, Calanna, S., Holst, Jens Juul, Vilsbøll, T. & Knop, Filip Krag, Mar 2014, In: The Journal of clinical endocrinology and metabolism. 99, 3, p. E418-26 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insulin resistance alters islet morphology in nondiabetic humans
Mezza, T., Muscogiuri, G., Sorice, G. P., Clemente, G., Hu, J., Pontecorvi, A., Holst, Jens Juul, Giaccari, A. & Kulkarni, R. N., Mar 2014, In: Diabetes. 63, 3, p. 994-1007 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The incretin effect does not differ in trained and untrained, young, healthy men
Lund, M. T., Dalby, S., Hartmann, Bolette, Helge, Jørn Wulff, Holst, Jens Juul & Dela, Flemming, Mar 2014, In: Acta Physiologica. 210, 3, p. 565-72 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Variation in genes related to hepatic lipid metabolism and changes in waist circumference and body weight
Meidtner, K., Fisher, E., Ängquist, Lars, Holst, C., Vimaleswaran, K. S., Boer, J. M. A., Halkjær, J., Masala, G., Ostergaard, J. N., Mortensen, L. M., van der A, D. L., Tjønneland, A., Palli, D., Overvad, K., Wareham, N. J., Loos, R. J. F., Sørensen, Thorkild I.A. & Boeing, H., Mar 2014, In: Genes & Nutrition. 9, p. 1-11 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Similar weight-adjusted insulin secretion and insulin sensitivity in short-duration late autoimmune diabetes of adulthood (LADA) and Type 2 diabetes: Action LADA 8
Juhl, C. B., Bradley, U., Holst, Jens Juul, Leslie, R. D., Yderstraede, K. B., Hunter, S. & Action LADA Consortium, A. L. C., 15 Mar 2014, In: Diabetic Medicine. 31, 8, p. 941-945Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased metabolic flexibility and complexity in a long-lived growth hormone insensitive mouse model
Lee Hong, S., Longo, K. A., Gosney, E. & Kopchick, J. J., 17 Mar 2014, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 69 A, 3, p. 274-281 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Incretin Effect and Glucagon Responses to Oral and Intravenous Glucose in Patients with Maturity Onset Diabetes of the Young - Type 2 and Type 3
Ostoft, S. H., Bagger, J. I., Hansen, Torben, Pedersen, Oluf Borbye, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, T., 27 Mar 2014, In: Diabetes. 63, 8, p. 2838-44 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Probabilistic Genome-Wide Gene Reading Frame Sequence Model
Have, C. T. & Mørk, S., Apr 2014. 12 p.Research output: Contribution to conference › Paper › Research › peer-review
- Published
A functional amino acid substitution in the glucose-dependent insulinotropic polypeptide receptor (GIPR) gene is associated with lower bone mineral density and increased fracture risk
Torekov, Signe Sørensen, Harsløf, T., Rejnmark, L., Eiken, P., Jensen, Jens-Erik Beck, Herman, A. P., Hansen, Torben, Pedersen, Oluf Borbye, Holst, Jens Juul & Langdahl, B. L., Apr 2014, In: The Journal of clinical endocrinology and metabolism. 99, 4, p. E729-33 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLP-1/glucagon coagonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet
Clemmensen, Christoffer, Chabenne, J., Finan, B., Sullivan, L., Fischer, K., Küchler, D., Sehrer, L., Ograjsek, T., Hofmann, S. M., Schriever, S. C., Pfluger, P. T., Pinkstaff, J., Tschöp, M. H., Dimarchi, R. & Müller, T. D., Apr 2014, In: Diabetes. 63, 4, p. 1422-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity
Vrieze, A., Out, C., Fuentes, S., Jonker, L., Reuling, I., Kootte, R. S., van Nood, E., Holleman, F., Knaapen, M., Romijn, J. A., Soeters, M. R., Blaak, E. E., Dallinga-Thie, G. M., Reijnders, D., Ackermans, M. T., Serlie, M. J., Knop, F. K., Holst, J. J., van der Ley, C., Kema, I. P. & 6 others, , Apr 2014, In: Journal of Hepatology. 60, 4, p. 824-31 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interaction between genetic predisposition to obesity and dietary calcium in relation to subsequent change in body weight and waist circumference
Larsen, S. C., Ängquist, Lars, Ahluwalia, Tarun Veer Singh, Skaaby, T., Roswall, N., Tjønneland, A., Halkjær, J., Overvad, K., Pedersen, Oluf Borbye, Hansen, Torben, Linneberg, Allan René, Husemoen, L. L. N., Toft, Ulla Marie Nørgaard, Heitmann, Berit & Sørensen, Thorkild I.A., Apr 2014, In: The American Journal of Clinical Nutrition. 99, 4Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KCNQ1 Long QT syndrome patients have hyperinsulinemia and symptomatic hypoglycemia
Torekov, Signe Sørensen, Iepsen, E., Christiansen, M., Linneberg, Allan René, Pedersen, Oluf Borbye, Holst, Jens Juul, Kanters, Jørgen K. & Hansen, Torben, Apr 2014, In: Diabetes. 63, 4, p. 1315-1325 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Loss of melanocortin-4 receptor function attenuates HPA responses to psychological stress
Ryan, K. K., Mul, J. D., Clemmensen, Christoffer, Egan, A. E., Begg, D. P., Halcomb, K., Seeley, R. J., Herman, J. P. & Ulrich-Lai, Y. M., Apr 2014, In: Psychoneuroendocrinology. 42, p. 98-105 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Loss-of-function mutations in SLC30A8 protect against type 2 diabetes
Flannick, J., Thorleifsson, G., Beer, N. L., Jacobs, S. B. R., Grarup, N., Burtt, N. P., Mahajan, A., Fuchsberger, C., Atzmon, G., Benediktsson, R., Blangero, J., Bowden, D. W., Brandslund, I., Brosnan, J., Burslem, F., Chambers, J., Cho, Y. S., Christensen, C., Douglas, D. A., Duggirala, R. & 31 others, , Apr 2014, In: Nature Genetics. 46, 4, p. 357-63 7 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Pleiotropic effects of HNF1A rs1183910 in a population-based study of 60,283 individuals
Allin, K. H. & Nordestgaard, Børge, Apr 2014, In: Diabetologia. 57, 4, p. 729-737 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of IL-6 on the insulin sensitivity in patients with type 2 diabetes
Harder-Lauridsen, N. M., Krogh-Madsen, Rikke, Holst, Jens Juul, Plomgaard, P., Leick, L., Pedersen, Bente Klarlund & Fischer, C. P., 1 Apr 2014, In: American Journal of Physiology: Endocrinology and Metabolism. 306, 7, p. E769-78 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans
Kuhre, Rune Ehrenreich, Gribble, F. M., Hartmann, Bolette, Reimann, F., Windeløv, Johanne Agerlin, Rehfeld, Jens Frederik & Holst, Jens Juul, 1 Apr 2014, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 306, 7, p. G622-30 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evaluation of growth hormone (GH) action in mice: Discovery of GH receptor antagonists and clinical indications
Kopchick, J. J., List, E. O., Kelder, B., Gosney, E. S. & Berryman, D. E., 5 Apr 2014, In: Molecular and Cellular Endocrinology. 386, 1-2, p. 34-45 12 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Elimination and degradation of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with end-stage renal disease
Idorn, T., Knop, Filip Krag, Jørgensen, M. B., Christensen, Mikkel Bring, Holst, Jens Juul, Hornum, Mads & Feldt-Rasmussen, Bo, 8 Apr 2014, In: The Journal of clinical endocrinology and metabolism. 99, 7, p. 2457-66 10 p., jc20133809.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dose response of continuous subcutaneous infusion of recombinant glucagon-like peptide-1 in combination with metformin and sulphonylurea over 12 weeks in patients with type 2 diabetes mellitus
Torekov, Signe Sørensen, Holst, Jens Juul & Ehlers, M. R., May 2014, In: Diabetes, Obesity and Metabolism. 16, 5, p. 451-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of AMPK activation on insulin sensitivity and metabolism in leptin-deficient ob/ob mice
Zachariah Tom, R., Garcia-Roves, P. M., Sjögren, R. J. O., Jiang, L. Q., Holmström, M. H., Deshmukh, Atul Shahaji, Vieira, E., Chibalin, A. V., Björnholm, M. & Zierath, Juleen R, May 2014, In: Diabetes. 63, 5, p. 1560-71 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glutamate prevents intestinal atrophy via luminal nutrient sensing in a mouse model of total parenteral nutrition
Xiao, W., Feng, Y., Holst, Jens Juul, Hartmann, Bolette, Yang, H. & Teitelbaum, D. H., May 2014, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 28, 5, p. 2073-87 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Is it acceptable to use animals to model obese humans? a critical discussion of two arguments against the use of animals in obesity research
Lund, Thomas Bøker, Sørensen, Thorkild I.A., Olsson, I. A. S., Hansen, Axel Kornerup & Sandøe, Peter, May 2014, In: Journal of Medical Ethics. 40, 5, p. 320-324 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Postprandial effects of test meals including concentrated arabinoxylan and whole grain rye in subjects with the metabolic syndrome: a randomised study
Hartvigsen, M. L., Lærke, H. N., Overgaard, A., Holst, Jens Juul, Bach Knudsen, K. E. & Hermansen, K., May 2014, In: European Journal of Clinical Nutrition. 68, 5, p. 567-74 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Quality control and conduct of genome-wide association meta-analyses
Winkler, T. W., Day, F. R., Croteau-Chonka, D. C., Wood, A. R., Locke, A. E., Mägi, R., Ferreira, T., Fall, T., Graff, M., Justice, A. E., Luan, J., Gustafsson, S., Randall, J. C., Vedantam, S., Workalemahu, T., Kilpeläinen, T., Scherag, A., Esko, T., Kutalik, Z., Heid, I. M. & 2 others, , May 2014, In: Nature Protocols (Online). 9, 5, p. 1192-1212 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FXR is a molecular target for the effects of vertical sleeve gastrectomy
Ryan, K. K., Tremaroli, V., Clemmensen, Christoffer, Kovatcheva-Datchary, P., Myronovych, A., Karns, R., Wilson-Pérez, H. E., Sandoval, D. A., Kohli, R., Bäckhed, F. & Seeley, R. J., 8 May 2014, In: Nature. 509, 7499, p. 183-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acute effects of monounsaturated fat on postprandial lipemia and gene expression in first-degree relatives of subjects with type 2 diabetes
Pietraszek, A., Gregersen, S., Pedersen, S. B., Holst, Jens Juul & Hermansen, K., 14 May 2014, In: European Journal of Clinical Nutrition. 68, p. 1022-28 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon responses to increasing oral loads of glucose and corresponding isoglycaemic intravenous glucose infusions in patients with type 2 diabetes and healthy individuals
Bagger, J. I., Knop, Filip Krag, Lund, Asger Bach, Holst, Jens Juul & Vilsbøll, T., 31 May 2014, In: Diabetologia. 57, 8, p. 1270-25 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chronic glucocorticoid treatment increases de novo lipogenesis in visceral adipose tissue
Vienberg, S. G. & Björnholm, M., Jun 2014, In: Acta Physiologica (Print). 211, 2, p. 257-9 3 p.Research output: Contribution to journal › Editorial › Research › peer-review
- Published
Deficiency of cardiac Acyl-CoA synthetase-1 induces diastolic dysfunction, but pathologic hypertrophy is reversed by rapamycin
Paul, D. S., Grevengoed, Trisha Jean, Pascual, F., Ellis, J. M., Willis, M. S. & Coleman, R. A., Jun 2014, In: B B A - Reviews on Cancer. 1841, 6, p. 880-7 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease
Nielsen, Thomas Svava, Jessen, N., Jørgensen, J. O. L., Møller, N. & Lund, S., Jun 2014, In: Journal of Molecular Endocrinology. 52, 3, p. R199-R222 24 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Glucose Stimulates GLP-1 Secretion from Isolated Perfused Rat Small Intestine by SGLT1 and GLUT2 Mediated Uptake, Causing V-gated Calcium Channel Activation
Kuhre, Rune Ehrenreich, Frost, C. R., Svendsen, B. & Holst, Jens Juul, Jun 2014, In: Diabetes. 63, suppl 1, p. A491 1 p., Abstract no 1915-P.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
High heritability and genetic correlation of intravenous glucose- and tolbutamide-induced insulin secretion among non-diabetic family members of type 2 diabetic patients
Gjesing, A. M. P., Hornbak, M., Allin, K. H., Ekstrøm, Claus Thorn, Urhammer, Søren Asger, Eiberg, Hans Rudolf Lytchoff, Pedersen, Oluf Borbye & Hansen, Torben, Jun 2014, In: Diabetologia. 57, 6, p. 1173-1181 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lessons from whole-exome sequencing in MODYX families
Dusatkova, P., Fang, M., Pruhova, S., Gjesing, A. P., Cinek, O., Hansen, Torben, Pedersen, Oluf Borbye, Xu, X. & Lebl, J., Jun 2014, In: Diabetes Research and Clinical Practice. 104, 3, p. e72-4 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MuRF1 activity is present in cardiac mitochondria and regulates reactive oxygen species production in vivo
Mattox, T. A., Young, M. E., Rubel, C. E., Spaniel, C., Rodríguez, J. E., Grevengoed, Trisha Jean, Gautel, M., Xu, Z., Anderson, E. J. & Willis, M. S., Jun 2014, In: Journal of Bioenergetics and Biomembranes. 46, 3, p. 173-87 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hyperglucagonaemia analysed by glucagon sandwich ELISA: nonspecific interference or truly elevated levels?
Albrechtsen, Nicolai Jacob Wewer, Hartmann, Bolette, Veedfald, Simon, Windeløv, Johanne Agerlin, Plamboeck, A., Bojsen-Møller, K. N., Idorn, T., Feldt-Rasmussen, Bo, Knop, Filip Krag, Vilsbøll, T., Madsbad, Sten, Deacon, Carolyn F. & Holst, Jens Juul, 3 Jun 2014, In: Diabetologia. 57, 9, p. 1919-1926 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
Perry, R. J., Samuel, V. T., Petersen, K. M. F. & Shulmann, G. I., 5 Jun 2014, In: Nature. 510, p. 84-91 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Incretin secretion: direct mechanisms
Balk-Møller, E., Holst, Jens Juul & Kuhre, Rune Ehrenreich, 12 Jun 2014, Diapedia: The living textbook of diabetes. European Association for the Study of Diabetes (EASD), p. 1-3 3 p.Research output: Chapter in Book/Report/Conference proceeding › Encyclopedia chapter › Communication
- Published
Glucose-Lowering Effects and Low Risk of Hypoglycemia in Patients With Maturity-Onset Diabetes of the Young When Treated With a GLP-1 Receptor Agonist: A Double-Blind, Randomized, Crossover Trial
Ostoft, S. H., Bagger, J. I., Hansen, Torben, Pedersen, Oluf Borbye, Faber, Jens, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, T., 14 Jun 2014, In: Diabetes Care. 37, 7, p. 1797-1805 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The impact of dipeptidyl peptidase 4 inhibition on incretin effect, glucose tolerance, and gastrointestinal-mediated glucose disposal in healthy subjects
Rhee, N. A., Østoft, S. H., Holst, Jens Juul, Deacon, Carolyn F., Vilsbøll, T. & Knop, Filip Krag, 16 Jun 2014, In: European Journal of Endocrinology. 171, 3, p. 353-362 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stimulation of intestinal growth and function with DPP-IV inhibition in a mouse short bowel syndrome model
Sueyoshi, R., Ignatoski, K. M. W., Okawada, M., Hartmann, Bolette, Holst, Jens Juul & Teitelbaum, D. H., 26 Jun 2014, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 307, 4, p. G410-19 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mapping Substance P Binding Sites on the Neurokinin-1 Receptor Using Genetic Incorporation of a Photoreactive Amino Acid
Valentin-Hansen, L., Park, M., Huber, T., Grunbeck, A., Naganathan, S., Schwartz, Thue W. & Sakmar, T. P., 27 Jun 2014, In: The Journal of Biological Chemistry. 289, 26, p. 18045-54 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification and characterization of human brown adipose tissue (BAT) content and metabolism in adults using [18F]-FDG PET/MR – a pilot study
Johannesen, H. H., Löfgren, J., Donkin, I., Hansen, A. E., Loft, A., Højgaard, Liselotte & Kjær, Andreas, Jul 2014, In: E J N M M I Physics. 1, Suppl 1, 3 p., A68.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
META-Life: Biotechnologies, Synthetic Biology, Alife and the Arts
Bureaud, A. (ed.), Malina, R. (ed.) & Whiteley, Louise (ed.), Jul 2014, (Leonardo).Research output: Book/Report › Book › peer-review
- Published
Dynamic epigenetic responses to muscle contraction
Rasmussen, M., Zierath, Juleen R & Barrès, Romain, 19 Jul 2014, In: Drug Discovery Today. 19, 7, p. 1010-4 5 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Environmental factors affecting the expression of type IV pilus genes as well as piliation of Thermus thermophilus
Salzer, R., Kern, T., Joos, F. & Averhoff, B., Aug 2014, In: FEMS Microbiology Letters. 357, 1, p. 56-62 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional body composition and related aspects in research on obesity and cachexia: report on the 12th Stock Conference held on 6 and 7 September 2013 in Hamburg, Germany
Müller, M. J., Baracos, V., Bosy-Westphal, A., Dulloo, A. G., Eckel, J., Fearon, K. C. H., Hall, K. D., Pietrobelli, A., Sørensen, Thorkild I.A., Speakman, J., Trayhurn, P., Visser, M. & Heymsfield, S. B., Aug 2014, In: Obesity Reviews. 15, 8, p. 640-656 17 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond
Grarup, N., Sandholt, C. H., Hansen, Torben & Pedersen, Oluf Borbye, Aug 2014, In: Diabetologia. 57, 8, p. 1528-41 14 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
High saturated fatty acid intake induces insulin secretion by elevating gastric inhibitory polypeptide levels in healthy individuals
Itoh, K., Moriguchi, R., Yamada, Y., Fujita, M., Yamato, T., Oumi, M., Holst, Jens Juul & Seino, Y., Aug 2014, In: Nutrition Research. 34, 8, p. 653-60 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and Type 2 diabetes susceptibility
Guigas, B., de Leeuw van Weenen, J. E., van Leeuwen, N., Simonis-Bik, A. M., van Haeften, T. W., Nijpels, G., Houwing-Duistermaat, J. J., Beekman, M., Deelen, J., Havekes, L. M., Penninx, B. W. J. H., Vogelzangs, N., van 't Riet, E., Dehghan, A., Hofman, A., Witteman, J. C., Uitterlinden, A. G., Grarup, N., Jørgensen, T., Witte, D. R. & 15 others, , Aug 2014, In: Diabetic Medicine. 31, 8, p. 1001-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Timing of motor milestones achievement and development of overweight in childhood: a study within the Danish National Birth Cohort
Morgen, C. S., Nybo Andersen, Anne-Marie, Due, P., Neelon, S. B., Gamborg, Michael Orland & Sørensen, Thorkild I.A., Aug 2014, In: Pediatric Obesity. 9, 4, p. 239-48 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glycerol-3-phosphate acyltransferase-4-deficient mice are protected from diet-induced insulin resistance by the enhanced association of mTOR and rictor
Zhang, C., Cooper, D. E., Grevengoed, Trisha Jean, Li, L. O., Klett, E. L., Eaton, J. M., Harris, T. E. & Coleman, R. A., 1 Aug 2014, In: American Journal of Physiology: Endocrinology and Metabolism. 307, 3, p. E305-15Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals
Qi, Q., Oskari Kilpeläinen, T., Downer, M. K., Tanaka, T., Smith, C. E., Sluijs, I., Sonestedt, E., Chu, A. Y., Renström, F., Lin, X., Angquist, L. H., Huang, J., Liu, Z., Li, Y., Asif Ali, M., Xu, M., Ahluwalia, T. V. S., Boer, J. M. A., Chen, P., Daimon, M. & 89 others, , 7 Aug 2014, In: Human Molecular Genetics. 23, 25, p. 6961-6972 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age
Deelen, J., Beekman, M., Uh, H-W., Broer, L., Ayers, K. L., Tan, Q., Kamatani, Y., Bennet, A. M., Tamm, R., Trompet, S., Guðbjartsson, D. F., Flachsbart, F., Rose, G., Viktorin, A., Fischer, K., Nygaard, M., Cordell, H. J., Crocco, P., van den Akker, E. B., Böhringer, S. & 67 others, , 15 Aug 2014, In: Human Molecular Genetics. 23, 16, p. 4420-4432 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tarmbakterier kan have betydning for overvægt i barnealderen
Fonvig, C. E., Pihl, A. F., Hansen, Torben, Pedersen, Oluf Borbye & Holm, Jens-Christian, 18 Aug 2014, In: Ugeskrift for Laeger. 176, p. 2-6 5 p., V03140171.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of high-fat diet on rat myometrium during pregnancy-isolated myometrial mitochondria are not affected
Gam, C. M. B. F., Mortensen, Ole Hartvig, Qvortrup, Klaus, Damm, Peter & Quistorff, B., 21 Aug 2014, In: Pflügers Archiv - European Journal of Physiology. 467, 7, p. 1539-1549 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Altered DNA Methylation and Differential Expression of Genes Influencing Metabolism and Inflammation in Adipose Tissue From Subjects With Type 2 Diabetes
Nilsson, E., Jansson, P. A., Perfilyev, A., Volkov, P., Pedersen, M., Svensson, M. K., Poulsen, P., Ribel-Madsen, R., Pedersen, N. L., Almgren, P., Fadista, J., Rönn, T., Pedersen, Bente Klarlund, Schéele, Camilla Charlotte Nielsen, Vaag, Allan & Ling, C., Sep 2014, In: Diabetes. 63, 9, p. 2962-2976 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study
Vimaleswaran, K. S., Cavadino, A., Berry, D. J., Jorde, R., Dieffenbach, A. K., Lu, C., Alves, A. C., Heerspink, H. J. L., Tikkanen, E., Eriksson, J., Wong, A., Mangino, M., Jablonski, K. A., Nolte, I. M., Houston, D. K., Ahluwalia, T. V. S., van der Most, P. J., Pasko, D., Zgaga, L., Thiering, E. & 31 others, , Sep 2014, In: The Lancet Diabetes & Endocrinology. 2, 9, p. 719-729 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DNA methylation is altered in B and NK lymphocytes in obese and type 2 diabetic human
Simar, D., Versteyhe, S., Donkin, I., Liu, J., Hesson, L., Nylander, V. C., Fossum, A. & Barrès, Romain, Sep 2014, In: Metabolism. 63, 9Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide association analyses identify variants in developmental genes associated with hypospadias
Geller, F., Feenstra, B., Carstensen, L., Pers, Tune H, van Rooij, I. A. L. M., Korberg, I. B., Choudhry, S., Karjalainen, J. M., Schnack, T. H., Hollegaard, M. V., Feitz, W. F. J., Roeleveld, N., Hougaard, D. M., Hirschhorn, J. N., Franke, L., Baskin, L. S., Nordenskjold, A., van der Zanden, L. F. M. & Melbye, M., Sep 2014, In: Nature Genetics. 46, 9, p. 957-+Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucometabolic hormones and cardiovascular risk markers in antipsychotic-treated patients
Ebdrup, Bjørn, Knop, Filip Krag, Madsen, A., Mortensen, H. B., Søgaard, B., Holst, Jens Juul, Szecsi, P. B. & Lublin, H., Sep 2014, In: Journal of Clinical Psychiatry. 75, 9, p. e899-905 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Obesity: Global trends in the prevalence of overweight and obesity
Morgen, C. S. & Sørensen, Thorkild I.A., Sep 2014, In: Nature Reviews Endocrinology. 10, 9, p. 513-514 2 p.Research output: Contribution to journal › Comment/debate › Research
- Published
Safety and efficacy of liraglutide in patients with type 2 diabetes and end-stage renal disease: an investigator-initiated, randomised, placebo-controlled trial
Idorn, T., Knop, Filip Krag, Jorgensen, M. B., Jensen, T., Resuli, M., Hansen, P. M., Christensen, Karl Bang, Holst, Jens Juul, Hornum, M. & Feldt-Rasmussen, B., Sep 2014, In: Diabetologia. 57, 1 supplement, p. S370-S371 909.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Most downloads
-
5500
downloads
Natural selection affects multiple aspects of genetic variation at putatively peutral sites across the human genome
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
5253
downloads
Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
4540
downloads
The isoenzyme pattern of LDH does not play a physiological role; except perhaps during fast transitions in energy metabolism
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Latest publications
Determinants of plasma levels of proglucagon and the metabolic impact of glucagon receptor signalling: a UK Biobank study
Research output: Contribution to journal › Journal article › Research › peer-review
The interplay between birth weight and obesity in determining childhood and adolescent cardiometabolic risk
Research output: Contribution to journal › Journal article › Research › peer-review
Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment
Research output: Contribution to journal › Journal article › Research › peer-review