Novo Nordisk Foundation Center for Basic Metabolic Research

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  1. 2011
  2. Published

    Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1

    Torekov, S. S., Ma, L., Grarup, N., Hartmann, B., Hainerová, I. A., Kielgast, U., Kissow, H., Rosenkilde, M., Lebl, J., Witte, D. R., Jørgensen, T., Sandbaek, A., Lauritzen, T., Madsen, O. D., Wang, J., Linneberg, A., Madsbad, S., Holst, J. J., Hansen, T., Pedersen, O. & 1 others, GIANT Consortium, G. C., 2011, In: Diabetologia. 54, 11, p. 2820-31 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Human papillomavirus 16 E5 modulates the expression of host microRNAs

    Greco, D., Kivi, N., Qian, K., Leivonen, S., Auvinen, P. & Auvinen, E., 2011, In: PloS one. 6, 7, p. e21646

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Impaired regulation of the incretin effect in patients with type 2 diabetes

    Bagger, J. I., Knop, Filip Krag, Lund, Asger Bach, drb459, drb459, Holst, Jens Juul & Vilsbøll, Tina, 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 3, p. 737-45 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Improved glycemic control induced by both metformin and repaglinide is associated with a reduction in blood levels of 3-deoxyglucosone in nonobese patients with type 2 diabetes

    Engelen, L., Lund, S. S., Ferreira, I., Tarnow, L., Parving, H., Gram, J., Winther, Kaj, Pedersen, Oluf Borbye, Teerlink, T., Barto, R., Stehouwer, C. D. A., Vaag, Allan & Schalkwijk, C. G., 2011, In: European Journal of Endocrinology. 164, 3, p. 371-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Increased Postprandial GIP and Glucagon Responses, But Unaltered GLP-1 Response after Intervention with Steroid Hormone, Relative Physical Inactivity, And High-Calorie Diet in Healthy Subjects

    Hansen, K. B., Vilsbøll, Tina, Bagger, J. I., Holst, Jens Juul & Knop, Filip Krag, 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 2, p. 447-53 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Increased lipolysis and energy expenditure in a mouse model with severely impaired glucagon secretion

    Lou, P., Gustavsson, N., Wang, Y., Radda, G. K. & Han, W., 2011, In: PloS one. 6, 10, p. e26671

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Increased postprandial glycaemia, insulinemia, and lipidemia after 10 weeks’ sucrose-rich diet compared to an artificially sweetened diet: a randomised controlled trial

    Raben, Anne, Møller, B. K., Flint, A., Vasilaris, T. H., Møller, A. C., Holst, Jens Juul & Astrup, A., 2011, In: Food & Nutrition Research. 55, 5961, 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Increasing genetic variance of body mass index during the Swedish obesity epidemic

    Rokholm, B., Silventoinen, K., Tynelius, P., Gamborg, M., Sørensen, Thorkild I.A. & Rasmussen, F., 2011, In: P L o S One. 6, 11, p. e27135

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Influences of the common FTO rs9939609 variant on inflammatory markers throughout a broad range of body mass index

    Zimmermann, E., Skogstrand, K., Hougaard, D. M., Astrup, A., Hansen, T., Pedersen, O., Sørensen, Thorkild I.A. & Jess, T., 2011, In: P L o S One. 6, 1, p. e15958 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Inhibition of DPP-4 with vildagliptin improved insulin secretion in response to oral as well as "isoglycemic" intravenous glucose without numerically changing the incretin effect in patients with type 2 diabetes

    Vardarli, I., Nauck, M. A., Köthe, L. D., Deacon, Carolyn F., Holst, Jens Juul, Schweizer, A. & Foley, J. E., 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 4, p. 945-954 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Inkretiner

    Vilsbøll, Tina & Holst, Jens Juul, 2011, Diabetes - sygdom, behandling og organisation. Hilsted, J., Borch-Johnsen, K. & Christiansen, J. S. (eds.). 2 ed. København: Munksgaard , p. 67-74 8 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

  13. Published

    Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile

    Amlacher, S., Sarges, P., Flemming, D., van Noort, V., Kunze, R., Devos, D. P., Arumugam, Mani, Bork, P. & Hurt, E., 2011, In: Cell. 146, 2, p. 277-89 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Intake of total, animal and plant protein and subsequent changes in weight or waist circumference in European men and women: the Diogenes project

    Halkjær, J., Olsen, A., Overvad, K., Jakobsen, M. U., Boeing, H., Buijsse, B., Palli, D., Tognon, G., Du, H., van der, D. L., Forouhi, N. G., Wareham, N. J., Feskens, E. J. M., Sørensen, Thorkild I.A. & Tjønneland, A., 2011, In: International Journal of Obesity. 35, 8, p. 1104-13 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Intrafamilial Variability of Early-Onset Diabetes due to an INS Mutation

    Fredheim, S., Svensson, Jannet, Pørksen, S., Hansen, L., Hansen, Torben, Pedersen, Oluf Borbye, Mortensen, H. B., Barbetti, F. & Nielsen, L. B., 2011, In: Case Reports in Genetics. 2011, p. 258978

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Involvement of endogenous glucagon-like peptide-1 in regulation of gastric motility and pancreatic endocrine secretion

    Witte, A., Grybäck, P., Jacobsson, H., Näslund, E., Hellström, P. M., Holst, Jens Juul, Hilsted, Linda & Schmidt, P. T., 2011, In: Scandinavian Journal of Gastroenterology. Supplement. 46, 4, p. 428-35 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Is socioeconomic status of the rearing environment causally related to obesity in the offspring?

    Fontaine, K. R., Robertson, H. T., Holst, C., Desmond, R., Stunkard, A. J., Sørensen, Thorkild I.A. & Allison, D. B., 2011, In: P L o S One. 6, 11, p. e27692

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    LIF is a contraction-induced myokine stimulating human myocyte proliferation

    Broholm, C., Laye, M. J., Brandt, C., Vadalasetty, R., Pilegaard, Henriette, Pedersen, Bente Klarlund & Schéele, Camilla Charlotte Nielsen, 2011, In: Journal of Applied Physiology. 111, 1, p. 251-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Lifelong doubling of mortality in men entering adult life as obese

    Zimmermann, E., Holst, C. & Sørensen, Thorkild I.A., 2011, In: International Journal of Obesity. 35, 9, p. 1193-9 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Liraglutide Treatment Is Associated with a Low Frequency and Magnitude of Antibody Formation with No Apparent Impact on Glycemic Response or Increased Frequency of Adverse Events: Results from the Liraglutide Effect and Action in Diabetes (LEAD) trials

    Buse, J. B., Garber, A., Rosenstock, J., Schmidt, W. E., Brett, J. H., Videbæk, N., Holst, Jens Juul & Nauck, M., 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 6, p. 1695-702 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Lixisenatide for type 2 diabetes mellitus

    Christensen, M., Knop, Filip Krag, Vilsbøll, Tina & Holst, Jens Juul, 2011, In: Expert Opinion on Investigational Drugs. 20, 4, p. 549-57 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Macronutrient composition in the diets.

    Sonne, Si Brask, Treebak, Jonas Thue, Pilegaard, Henriette, Fjare, E., Froyland, L., Kristiansen, Karsten, Hao, Q., Madsen, L., Petersen, R. K., Ngo, H. T., Lillefosse, H. H., Liaset, B., Ringholm, S. & Ma, Tao, 2011

    Research output: Other contribution › Research

  23. Published

    Mechanism-based population modelling for assessment of L-cell function based on total GLP-1 response following an oral glucose tolerance test

    Møller, J. B., Jusko, W. J., Gao, W., Hansen, Torben, Pedersen, Oluf Borbye, Holst, Jens Juul, Overgaard, R. V., Madsen, H. & Ingwersen, S. H., 2011, In: Journal of Pharmacokinetics and Pharmacodynamics. 38, 6, p. 713-25 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Medical instruments in museums: Immediate impressions and historical meanings

    Söderqvist, Thomas & Arnold, Ken, 2011, In: Isis. 102, 4, p. 718-729 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Minimum information about a marker gene sequence (MIMARKS) and minimum information about any (x) sequence (MIxS) specifications

    Yilmaz, P., Kottmann, R., Field, D., Knight, R., Cole, J. R., Amaral-Zettler, L., Gilbert, J. A., Karsch-Mizrachi, I., Johnston, A., Cochrane, G., Vaughan, R., Hunter, C., Park, J., Morrison, N., Rocca-Serra, P., Sterk, P., Arumugam, M., Bailey, M., Baumgartner, L., Birren, B. W. & 78 others, Blaser, M. J., Bonazzi, V., Booth, T., Bork, P., Bushman, F. D., Buttigieg, P. L., Chain, P. S. G., Charlson, E., Costello, E. K., Huot-Creasy, H., Dawyndt, P., DeSantis, T., Fierer, N., Fuhrman, J. A., Gallery, R. E., Gevers, D., Gibbs, R. A., San Gil, I., Gonzalez, A., Gordon, J. I., Guralnick, R., Hankeln, W., Highlander, S., Hugenholtz, P., Jansson, J., Kau, A. L., Kelley, S. T., Kennedy, J., Knights, D., Koren, O., Kuczynski, J., Kyrpides, N., Larsen, R., Lauber, C. L., Legg, T., Ley, R. E., Lozupone, C. A., Ludwig, W., Lyons, D., Maguire, E., Methé, B. A., Meyer, F., Muegge, B., Nakielny, S., Nelson, K. E., Nemergut, D., Neufeld, J. D., Newbold, L. K., Oliver, A. E., Pace, N. R., Palanisamy, G., Peplies, J., Petrosino, J., Proctor, L., Pruesse, E., Quast, C., Raes, J., Ratnasingham, S., Ravel, J., Relman, D. A., Assunta-Sansone, S., Schloss, P. D., Schriml, L., Sinha, R., Smith, M. I., Sodergren, E., Spo, A., Stombaugh, J., Tiedje, J. M., Ward, D. V., Weinstock, G. M., Wendel, D., White, O., Whiteley, A., Wilke, A., Wortman, J. R., Yatsunenko, T. & Glöckner, F. O., 2011, In: Nature Biotechnology. 29, 5, p. 415-20 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Modelling cue integration in cluttered environments

    Sahani, M. & Whiteley, Louise, 2011, Sensory Cue Integration. Trommershäuser, J., Körding, K. & Landy, M. S. (eds.). Oxford University Press, p. 82-100 (Computational Neuroscience).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  27. Published

    Morbidity, including fatal morbidity, throughout life in men entering adult life as obese

    Zimmermann, E., Holst, C. & Sørensen, Thorkild I.A., 2011, In: P L o S One. 6, 4, p. e18546

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Natural selection affects multiple aspects of genetic variation at putatively peutral sites across the human genome

    Lohmueller, K. E., Albrechtsen, Anders, Li, Y., Kim, S. Y., Korneliussen, Thorfinn Sand, Vinckenbosch, N., Tian, G., Huerta-Sanchez, E., Feder, A. F., Grarup, Niels, Jørgensen, T., Jiang, T., Witte, D. R., Sandbæk, A., Hellmann, I., Lauritzen, T., Hansen, Torben, Pedersen, Oluf Borbye, Wang, J. & Nielsen, Rasmus, 2011, In: P L o S Genetics. 7, 10, 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Neuroprotective properties of GLP-1: theoretical and practical applications

    Holst, Jens Juul, Burcelin, R. & Nathanson, E., 2011, In: Current Medical Research and Opinion. 27, 3, p. 547-58 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Nutrient-dependent acetylation controls basic regulatory metabolic switches and cellular reprogramming

    Dominy, J. E., Gerhart-Hines, Zach & Puigserver, P., 2011, In: Cold Spring Harbor Symposia on Quantitative Biology. 76, p. 203-209 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Obesity - an indication for GLP-1 treatment? Obesity pathophysiology and GLP-1 treatment potential

    Torekov, Signe Sørensen, Madsbad, Sten & Holst, Jens Juul, 2011, In: Obesity Reviews. 12, 8, p. 593-601 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Obesity research based on the Copenhagen School Health Records Register

    Baker, J. L. & Sørensen, Thorkild I.A., 2011, In: Scandinavian Journal of Public Health. Supplement. 39, 7 Suppl, p. 196-200 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Opportunities for European obesity research in the coming decade - a perspective from the European association for the study of obesity (EASO)

    Oppert, J., Sørensen, Thorkild I.A., Hebebrand, J., Woodward, E. & Blundell, J. E., 2011, In: Obesity Facts. 4, 6, p. 425-6 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change

    Jakobsen, M. U., Dethlefsen, C., Due, K. M., Slimani, N., Chajès, V., May, A. M., Sørensen, T. I. A., Halkjær, J., Tjønneland, A., Clavel-Chapelon, F., Boutron-Ruault, M-C., Fagherazzi, G., Teucher, B., Kaaks, R., Boeing, H., Schütze, M., Trichopoulou, A., Zylis, D., Makrygiannis, G., Palli, D. & 21 others, Mattiello, A., Tagliabue, G., van der, D. L., Bueno-de-Mesquita, H. B., Rodríguez, L., Travier, N., Molina-Montes, E., Huerta, J. M., Barricarte, A., Amiano, P., Manjer, J., Wirfält, E., Johansson, I., Hallmans, G., Khaw, K., Wareham, N. J., Crowe, F., Romieu, I., Riboli, E., Peeters, P. H. M. & Overvad, K., 2011, In: Obesity Facts. 4, 4, p. 312-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Protein dose-response effect on glp-1, pyy and appetite in male subjects

    Sparre, A. B., Sørensen, M. Q., Holst, Jens Juul, Rehfeld, Jens Frederik & Astrup, A., 2011, In: Obesity Reviews. 12, suppl. 1, p. 59 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  36. Published

    Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans

    Nauck, M. A., Kemmeries, G., Holst, Jens Juul & Meier, J. J., 2011, In: Diabetes. 60, 5, p. 1561-5 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Reversed binding of a small molecule ligand in homologous chemokine receptors – differential role of extracellular loop 2.

    Rummel, P. C., Thiele, S., Steen, A. M. F., Elder, A., Kolbech, R., Ghosh, S., Frimurer, Thomas Michael & Rosenkilde, Mette, 2011, In: British Journal of Pharmacology. 166

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down?

    Nauck, M. A., Vardarli, I., Deacon, Carolyn F., Holst, Jens Juul & Meier, J., 2011, In: Diabetologia. 54, 1, p. 10-18 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Short sleep duration as a possible cause of obesity: critical analysis of the epidemiological evidence

    Nielsen, L. S., Danielsen, K. & Sørensen, Thorkild I.A., 2011, In: Obesity Reviews. 12, 2, p. 78-92 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Smallpox vaccination and all-cause infectious disease hospitalization: a Danish register-based cohort study

    Sørup, S., Villumsen, M., Ravn, H., Benn, C. S., Sørensen, Thorkild I.A., Aaby, P., Jess, T. & Roth, A. A. E., 2011, In: International Journal of Epidemiology. 40, 4, p. 955-63 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Studies based on the Danish Adoption Register: schizophrenia, BMI, smoking, and mortality in perspective

    Petersen, L. & Sørensen, Thorkild I.A., 2011, In: Scandinavian Journal of Public Health. 39, 7 Suppl, p. 191-5 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Studies of the Association of Arg72Pro of Tumor Suppressor Protein p53 with Type 2 Diabetes in a Combined Analysis of 55,521 Europeans

    Burgdorf, K. S., Grarup, Niels, Justesen, Johanne Marie, Harder, M. N., Witte, D. R., Jørgensen, T., Sandbæk, A., Lauritzen, T., Madsbad, Sten, Hansen, Torben, DIAGRAM Consortium, D. C. & Pedersen, Oluf Borbye, 2011, In: P L o S One. 6, 1, p. e15813 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    The Danish Adoption Register

    Petersen, L. & Sørensen, Thorkild I.A., 2011, In: Scandinavian Journal of Public Health. 39, 7 Suppl, p. 83-6 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals

    Grarup, Niels, Overvad, M., Sparsø, T., Witte, D. R., Pisinger, C., Jørgensen, T., Yamauchi, T., Hara, K., Maeda, S., Kadowaki, T., Hansen, T. & Pedersen, Oluf Borbye, 2011, In: Diabetologica. 54, 4, p. 789-94 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    The effect of Glucagon-Like Peptide-2 on mesenteric blood flow and cardiac parameters in end-jejunostomy short bowel patients

    Bremholm, L., Hornum, Mads, Andersen, U. B., Hartmann, Bolette, Holst, Jens Juul & Jeppesen, Palle Bekker, 2011, In: Regulatory Peptides. 168, 1-3, p. 32-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    The effect of dietary fish oil in addition to lifestyle counselling on lipid oxidation and body composition in slightly overweight teenage boys

    Pedersen, M. H., Mølgaard, Christian, Hellgren, L., Matthiessen, J., Holst, Jens Juul & Lauritzen, Lotte, 2011, In: Journal of Nutrition and Metabolism. 2011, 348368, 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    The effects of L-arabinose on intestinal sucrase activity: dose-response studies in vitro and in humans

    Krog-Mikkelsen, I., Hels, O., Tetens, Inge , Holst, Jens Juul, Andersen, Jens Rikardt & Bukhave, K., 2011, In: American Journal of Clinical Nutrition. 94, 2, p. 472-478 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    The effects of adding group-based lifestyle counselling to individual counselling on changes in plasma glucose levels in a randomized controlled trial: the Inter99 study

    Lau, C., Vistisen, D., Toft, U., Tetens, Inge , Glümer, C., Pedersen, Oluf Borbye, Jørgensen, T. & Borch-Johnsen, K., 2011, In: Diabetes & Metabolism. 37, 6, p. 546-52 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    The isoenzyme pattern of LDH does not play a physiological role; except perhaps during fast transitions in energy metabolism

    Quistorff, B. & Grunnet, N., 2011, In: Aging. 3, 5, p. 457-460

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    The separate and combined impact of the intestinal hormones, GIP, GLP-1, and GLP-2, on glucagon secretion in type 2 diabetes

    Lund, Asger Bach, Vilsbøll, Tina, Bagger, J. I., Holst, Jens Juul & Knop, Filip Krag, 2011, In: American Journal of Physiology: Endocrinology and Metabolism. 300, 6, p. E1038-E1046 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Three-dimensional reconstructions of intrahepatic bile duct tubulogenesis in human liver

    Vestentoft, P. S., Jelnes, P., Hopkinson, B. M., Vainer, B., Møllgård, Kjeld, Quistorff, B. & Bisgaard, Hanne Cathrine, 2011, In: B M C Developmental Biology. 11, p. 56

    Research output: Contribution to journal › Journal article › Research › peer-review

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