Novo Nordisk Foundation Center for Basic Metabolic Research

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  1. 2012
  2. Published

    Bereavement in early life and later childhood overweight

    Li, J., Olsen, J., Vestergaard, M., Obel, C., Baker, J. L. & Sørensen, Thorkild I.A., 2012, In: Obesity Facts. 5, 6, p. 881-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Beta-Cell Specific DMT1 KO Protects Islets from Cytokine Induced ROS and Apoptosis

    Hansen, J. B., Heller, S., Madsen, A. N., Holst, Birgitte, Tonnesen, M. F. & Mandrup-Poulsen, Thomas, 2012.

    Research output: Contribution to conference › Poster › Research › peer-review

  4. Published

    Calcium sensing in exocytosis

    Gustavsson, N., Wu, B. & Han, W., 2012, In: Advances in Experimental Medicine and Biology. 740, p. 731-57 27 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Changes in Gastrointestinal Hormone Responses, Insulin Sensitivity, and Beta-Cell Function Within 2 Weeks After Gastric Bypass in Non-diabetic Subjects

    Jacobsen, S. H., Olesen, S. C., Dirksen, C., Jørgensen, N. B., Bojsen-Møller, K. N., Kielgast, U., Worm, Dorte, Almdal, Thomas Peter, Naver, L. S., Hvolris, L. E., Rehfeld, Jens Frederik, Wulff, B. S., Clausen, T. R., Hansen, D. L., Holst, Jens Juul & Madsbad, Sten, 2012, In: Obesity Surgery. 22, 7, p. 1084-96 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Clinical correlates of weight loss and attrition during a 10-week dietary intervention study: Results from the NUGENOB project

    Handjieva-Darlenska, T., Holst, C., Grau, K., Blaak, E., Martinez, J. A., Oppert, J., Taylor, M. A., Sørensen, Thorkild I.A. & Astrup, A., 2012, In: Obesity Facts. 5, 6, p. 928-936 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Common variation in oxidative phosphorylation genes is not a major cause of insulin resistance or type 2 diabetes

    Snogdal, L. S., Wod, M., Grarup, N., Vestmar, M., Sparsø, T. H., Jørgensen, T., Lauritzen, T., Beck-Nielsen, H., Henriksen, J. E., Pedersen, Oluf Borbye, Hansen, Torben & Højlund, K., 2012, In: Diabetologia. 55, 2, p. 340-8 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Contributions of incidence and persistence to the prevalence of childhood obesity during the emerging epidemic in Denmark

    Andersen, L. G., Baker, J. L. & Sørensen, Thorkild I.A., 2012, In: P L o S One. 7, 8, p. e42521

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Development of obesity and polycystic ovary syndrome in adolescents

    Vilmann, L. S., Thisted, E., Baker, J. L. & Holm, Jens-Christian, 2012, In: Hormone Research in Paediatrics. 78, 5-6, p. 269-78 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic ß cell fate in response to cytokines

    Hansen, J. B., Tonnesen, M. F., Madsen, A. N., Hagedorn, P., Friberg, J., Grunnet, L. G., Heller, R. S., Nielsen, A. Ø., Størling, J., Baeyens, L., Anker-Kitai, L., Qvortrup, K., Bouwens, L., Efrat, S., Aalund, M., Andrews, N. C., Billestrup, N., Karlsen, A. E., Holst, B., Pociot, F. & 1 others, Mandrup-Poulsen, Thomas, 2012, In: Cell Metabolism. 16, 4, p. 449-61 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Effects of 2weeks lower limb immobilization and two separate rehabilitation regimens on gastrocnemius muscle protein turnover signaling and normalization genes

    Nedergaard, A., Jespersen, J. G., Pingel, Jessica, Christensen, B., Sroczynski, N., Langberg, Henning, Kjaer, M. & Schjerling, Peter, 2012, In: BMC Research Notes.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes

    Mortensen, L. S., Holmer-Jensen, J., Hartvigsen, M., Jensen, V. K., Astrup, A., Vrese, M. D., Holst, Jens Juul, Thomsen, C. H. P. & Hermansen, K., 2012, In: European Journal of Clinical Nutrition. 66, 7, p. 799-805 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Effects of everyday life events on glucose, insulin, and glucagon dynamics in continuous subcutaneous insulin infusion-treated type 1 diabetes: collection of clinical data for glucose modeling

    Schmidt, S. D., Finan, D. A., Duun-Henriksen, A. K., Jørgensen, J. B., Madsen, H., Bengtsson, H., Holst, Jens Juul, Madsbad, S. & Nørgaard, K., 2012, In: Diabetes Technology & Therapeutics. 14, 3, p. 210-217 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Effects of high-fat overfeeding on mitochondrial function, glucose and fat metabolism, and adipokine levels in low birth weight subjects.

    Brøns, C., Jacobsen, S., Hiscock, N., White, A., Nilsson, E., Dunger, D., Astrup, A., Quistorff, B. & Vaag, A., 2012, In: American Journal of Physiology: Endocrinology and Metabolism. 302, 1, p. E43-E51 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Effects of pre-meal drinks with protein and amino acids on glycemic and metabolic responses at a subsequent composite meal

    Gunnerud, U. J., Heinzle, C., Holst, Jens Juul, Östman, E. M. & Björck, I. M. E., 2012, In: P L o S One. 7, 9, p. e44731

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men

    Jacobsen, S. C., Brøns, C., Bork-Jensen, J., Ribel-Madsen, R., Yang, B., Lara, E., Hall, E., Calvanese, V., Nilsson, E., Jørgensen, S. W., Mandrup, S., Ling, C., Fernandez, A. F., Fraga, M. F., Poulsen, P. & Vaag, Allan, 2012, In: Diabetologia. 55, 12, p. 3341-3349 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Enteral bile acid treatment improves parenteral nutrition-related liver disease and intestinal mucosal atrophy in neonatal pigs

    Jain, A. K., Stoll, B., Burrin, D. G., Holst, Jens Juul & Moore, D. D., 2012, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 302, 2, p. G218-24

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Exogenous glucagon-like peptide-2 (GLP-2) prevents chemotherapy-induced mucositis in rat small intestine

    Kissow, Hannelouise, Viby, N., Hartmann, Bolette, Holst, Jens Juul, Timm, M., Thim, L. & Poulsen, Steen Seier, 2012, In: Cancer Chemotherapy and Pharmacology. Supplement. 70, 1, p. 39-48 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Fasting and oral glucose-stimulated levels of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are highly familial traits

    Gjesing, A. M. P., Ekstrøm, Claus Thorn, Eiberg, Hans Rudolf Lytchoff, Urhammer, S. A., Holst, Jens Juul, Pedersen, Oluf Borbye & Hansen, Teis Schjals, 2012, In: Diabetologia. 55, 5, p. 1338-1345 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Fish consumption does not prevent increase in waist circumference in European women and men

    Jakobsen, M. U., Due, K. M., Dethlefsen, C., Halkjaer, J., Holst, C., Forouhi, N. G., Tjønneland, A., Boeing, H., Buijsse, B., Palli, D., Masala, G., Du, H., van der A, D. L., Wareham, N. J., Feskens, E. J. M., Sørensen, Thorkild I.A. & Overvad, K., 2012, In: British Journal of Nutrition. 108, 5, p. 924-31 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma

    Guo, G., Gui, Y., Gao, S., Tang, A., Hu, X., Huang, Y., Jia, W., Li, Z., He, M., Sun, L., Song, P., Sun, X., Zhao, X., Yang, S., Liang, C., Wan, S., Zhou, F., Chen, C., Zhu, J., Li, X. & 35 others, Jian, M., Zhou, L., Ye, R., Huang, P., Chen, J., Jiang, T., Liu, X., Wang, Y., Zou, J., Jiang, Z., Wu, R., Wu, S., Fan, F., Zhang, Z., Liu, L., Yang, R., Liu, X., Wu, H., Yin, W., Zhao, X., Liu, Y., Peng, H., Jiang, B., Feng, Q., Li, C., Xie, J., Lu, J., Kristiansen, Karsten, Li, Y., Zhang, X., Li, S., Wang, J., Yang, H., Cai, Z. & Wang, J., 2012, In: Nature Genetics. 44, 1, p. 17-19 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance

    Biensø, R. S., Jørgensen, Stine Ringholm, Kiilerich, K., Aachmann-Andersen, N. J., Krogh-Madsen, Rikke, Guerra, B., Plomgaard, Peter Stendahl, van Hall, Gerrit, Treebak, Jonas Thue, Saltin, B., Lundby, C., Calbet, J. A. L., Pilegaard, Henriette & Wojtaszewski, Jørgen F P, 2012, In: Diabetes. 61, 5, p. 1090-1099 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Genetic Variant SLC2A2 Is Associated with Risk of Cardiovascular Disease - Assessing the Individual and Cumulative Effect of 46 Type 2 Diabetes Related Genetic Variants

    Borglykke, A., Grarup, N., Sparsø, T., Linneberg, Allan René, Fenger, M., Jeppesen, J., Hansen, Torben, Pedersen, Oluf Borbye & Jørgensen, T., 2012, In: P L o S One. 7, 11, p. e50418

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight

    Tyrrell, J., Huikari, V., Christie, J. T., Cavadino, A., Bakker, R., Brion, M-J. A., Geller, F., Paternoster, L., Myhre, R., Potter, C., Johnson, P. C. D., Ebrahim, S., Feenstra, B., Hartikainen, A-L., Hattersley, A. T., Hofman, A., Kaakinen, M., Lowe, L. P., Magnus, P., McConnachie, A. & 24 others, Melbye, M., Ng, J. W. Y., Nohr, E. A., Power, C., Ring, S. M., Sebert, S. P., Sengpiel, V., Taal, H. R., Watt, G. C. M., Sattar, N., Relton, C. L., Jacobsson, B., Frayling, T. M., Sørensen, Thorkild I.A., Murray, J. C., Lawlor, D. A., Pennell, C. E., Jaddoe, V. W. V., Hypponen, E., Lowe, W. L., Jarvelin, M., Davey Smith, G., Freathy, R. M. & Early Growth Genetics (EGG) Consortium, E. G. G. (. C., 2012, In: Human Molecular Genetics. 21, 24, p. 5344-58 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes

    Ribel-Madsen, R., Fraga, M. F., Jacobsen, S., Bork-Jensen, J., Lara, E., Calvanese, V., Fernandez, A. F., Friedrichsen, M., Vind, B. F., Højlund, K., Beck-Nielsen, H., Esteller, M., Vaag, Allan & Poulsen, P., 2012, In: P L o S One. 7, 12, p. e51302

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Genome-wide and caste-specific DNA methylomes of the ants Camponotus floridanus and Harpegnathos saltator

    Bonasio, R., Li, Q., Lian, J., Mutti, N. S., Jin, L., Zhao, H., Zhang, P., Wen, P., Xiang, H., Ding, Y., Jin, Z., Shen, S. S., Wang, Z., Wang, W., Wang, J., Berger, S. L., Liebig, J., KU, thw266 & Reinberg, D., 2012, In: Current Biology. 22, 19, p. 1755-1764 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Growth in height in childhood and risk of coronary heart disease in adult men and women

    Silventoinen, K., Baker, J. L. & Sørensen, Thorkild I.A., 2012, In: P L o S One. 7, 1, p. e30476

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Impact of postprandial glycaemia on health and prevention of disease

    Blaak, E. E., Antoine, J., Benton, D., Björck, I., Bozzetto, L., Brouns, F., Diamant, M., Dye, L., Hulshof, T., Holst, Jens Juul, Lamport, D. J., Laville, M., Lawton, C. L., Meheust, A., Nilson, A., Normand, S., Rivellese, A. A., Theis, S., Torekov, Signe Sørensen & Vinoy, S., 2012, In: Obesity Reviews. 13, 10, p. 923-984

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Impaired crosstalk between pulsatile insulin and glucagon secretion in prediabetic individuals

    Rohrer, S., Menge, B. A., Grüber, L., Deacon, Carolyn F., Schmidt, W. E., Veldhuis, J. D., Holst, Jens Juul & Meier, J. J., 2012, In: Journal of Clinical Endocrinology and Metabolism. 97, 5, p. E791-E795

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Impaired incretin effect and fasting hyperglucagonaemia characterizing type 2 diabetic subjects are early signs of dysmetabolism in obesity

    Knop, Filip Krag, Aaboe, K., Vilsbøll, Tina, Vølund, A., Holst, Jens Juul, Krarup, T. & Madsbad, Sten, 2012, In: Diabetes, Obesity and Metabolism. 14, 6, p. 500-510 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects

    Hansen, K. B., Vilsbøll, Tina, Bagger, J. I., Holst, Jens Juul & Knop, Filip Krag, 2012, In: Journal of Clinical Endocrinology and Metabolism. 97, 4, p. 1363-70 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helix variants of PYY3-36

    Pedersen, S. L., Bhatia, V. K., Jurt, S., Paulsson, J. F., Pedersen, M. H., Jørgensen, R., Holst, Birgitte, Stamou, Dimitrios, Vrang, N., Zerbe, O. & Jensen, Knud Jørgen, 2012, In: Journal of Peptide Science. 18, 9, p. 579-587 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele

    Faerch, K., Pilgaard, K., Knop, Filip Krag, Hansen, Torben, Pedersen, Oluf Borbye, Jørgensen, T. & Holst, Jens Juul, 2012, In: Diabetes, Obesity and Metabolism Online. 15, 1, p. 91-95 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Incretin based therapies: do they hold their promise?

    Holst, Jens Juul, 2012, In: Journal of Diabetes. 4, 1, p. 4-7 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscle

    Vendelbo, M., Clasen, B. F. F., Treebak, Jonas Thue, Møller, L., Krusenstjerna-Hafstrøm, T., Madsen, M., Nielsen, Thomas Svava, Stødkilde-Jørgensen, H., Pedersen, S. B., Jørgensen, J. O. L., Goodyear, L. J., Wojtaszewski, Jørgen F P, Møller, N. & Jessen, N., 2012, In: American Journal of Physiology: Endocrinology and Metabolism. 302, 2, p. E190-E200 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Intake of ruminant trans fatty acids and changes in body weight and waist circumference

    Hansen, C. P., Berentzen, T. L., Halkjær, J., Tjønneland, A., Sørensen, Thorkild I.A., Overvad, K. & Jakobsen, M. U., 2012, In: European Journal of Clinical Nutrition. 66, 10, p. 1104-9 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Leg length, sitting height and postmenopausal breast cancer risk

    Mellemkjær, L., Christensen, J., Frederiksen, K., Baker, J. L., Olsen, A., Sørensen, Thorkild I.A. & Tjønneland, A., 2012, In: B J C. 107, 1, p. 165-8 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Leptin og dens betydning for vægtvedligeholdelse

    Iepsen, E. P. W., Torekov, Signe Sørensen & Holst, Jens Juul, 2012, In: Klinisk biokemi i Norden. 24, 4, p. 8-15 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Linagliptin, a selective DPP-4 inhibitor, inhibits DPP-4, increases incretin levels, lowers glucagon, and improves glycaemic control in patients with Type 2 diabetes.

    Rauch, T., Graefe-Mody, U., Deacon, Carolyn F., Ring, A., Holst, Jens Juul, Woerle, H., Dugi, K. & Heise, T., 2012, In: Diabetes Therapy. 3, 1, p. 10

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Longitudinal changes in blood pressure during weight loss and regain of weight in obese boys and girls

    Holm, J., Gamborg, M., Neland, M., Ward, L., Gammeltoft, S., Heitmann, B. L., Sørensen, Thorkild I.A. & Ibsen, K. K., 2012, In: Journal of Hypertension. 30, 2, p. 368-74 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Low-grade inflammation in young adults exposed to intrauterine hyperglycemia

    Kelstrup, L., Clausen, Tine Dalsgaard, Mathiesen, Elisabeth, Hansen, Torben & Damm, Peter, 2012, In: Diabetes Research and Clinical Practice. 97, 2, p. 322-330 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Læsningen af vignetter

    Grünfeld, Martin & Monrad, M., 2012, Vignetmetoden. Ejrnæs, M. & Monrad, M. (eds.). Akademisk Forlag

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  43. Published

    MR spectroscopy of liver in overweight children and adolescents: investigation of ¹H T2 relaxation times at 3T

    Chabanova, E., Bille, D. S., Thisted, E., Holm, Jens-Christian & Thomsen, Henrik S., 2012, In: European Journal of Radiology Extra. 81, 5, p. 811-4 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Maternal Distress during Pregnancy and Offspring Childhood Overweight

    Ingstrup, K. G., Schou Andersen, C., Adeltoft, T. A., Pedersen, P., Sørensen, Thorkild I.A. & Nohr, E. A., 2012, In: Journal of Obesity. 2012, p. 462845

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Maternal Recreational Exercise during Pregnancy in relation to Children's BMI at 7 Years of Age

    Schou Andersen, C., Juhl, M., Gamborg, M., Sørensen, Thorkild I.A. & Nohr, E. A., 2012, In: International Journal of Pediatrics. 2012, p. 920583

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Maternal dietary glycaemic load during pregnancy and gestational weight gain, birth weight and postpartum weight retention: a study within the Danish National Birth Cohort

    Knudsen, V. K., Heitmann, B. L., Halldorsson, T. I., Sørensen, Thorkild I.A. & Olsen, S. F., 2012, In: British Journal of Nutrition. p. 1-8 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Maternal inflammatory bowel disease and offspring body size: a prospective cohort study

    Ajslev, T. A., Sørensen, Thorkild I.A. & Jess, T., 2012, In: Inflammatory Bowel Diseases. 18, 4, p. 709-17 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Mechanisms of improved glycaemic control after Roux-en-Y gastric bypass

    Dirksen, C., Jørgensen, N. B., Bojsen-Møller, K. N., Jacobsen, S. H., Hansen, D. L., Worm, Dorte, Holst, Jens Juul & Madsbad, Sten, 2012, In: Diabetologia. 55, 7, p. 1890-901 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Metabolic effects of short-term GLP-1 treatment in insulin resistant heart failure patients

    Nielsen, R., Wiggers, H., Halbirk, M., Bøtker, H., Holst, Jens Juul, Schmitz, O., Frandsen, E. R., Nielsen, S., Møller, N. & Nørrelund, H., 2012, In: Experimental and Clinical Endocrinology and Diabetes. 120, 5, p. 266-72 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Metformin stimulates FGF21 expression in primary hepatocytes

    Nygaard, E. B., Vienberg, S. G., Ørskov, Cathrine, Hansen, Harald S. & Andersen, B., 2012, In: Experimental Diabetes Research. 2012, p. 465282 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    MicroRNA expression profiling of carcinoma in situ cells of the testis

    Novotny, G. W., Belling, K. C., Bramsen, J. B., Nielsen, J. E., Bork-Jensen, J., Almstrup, Kristian, Sonne, Si Brask, Kjems, J., Rajpert-De Meyts, E. & Leffers, H., 2012, In: Endocrine - Related Cancer. 19, p. 365-379 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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