Novo Nordisk Foundation Center for Basic Metabolic Research

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  1. 2012
  2. Published

    No body is as it seems

    Whiteley, Louise, 29 Jun 2012, In: Science (New York, N.Y.). 336, 6089, p. 1641 1 p.

    Research output: Contribution to journal › Literature review › Research

  3. Published

    GPR119 as a fat sensor

    Hansen, Harald S., Rosenkilde, Mette, Holst, Jens Juul & Schwartz, Thue W., Jul 2012, In: Trends in Pharmacological Sciences. 33, 7, p. 374-81 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Intrinsic differences in adipocyte precursor cells from different white fat depots

    Macotela, Y., Emanuelli, Brice, Mori, M. A., Gesta, S., Schulz, T. J., Tseng, Y. & Kahn, C. R., Jul 2012, In: Diabetes. 61, 7, p. 1691-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes

    Rosengren, A. H., Braun, M., Mahdi, T., Andersson, S. A., Travers, M. E., Shigeto, M., Zhang, E., Almgren, P., Ladenvall, C., Axelsson, A. S., Edlund, A., Pedersen, M. G., Jonsson, A. E., Ramracheya, R., Tang, Y., Walker, J. N., Barrett, A., Johnson, P. R. V., Lyssenko, V., McCarthy, M. I. & 6 others, Groop, L., Salehi, A., Gloyn, A. L., Renström, E., Rorsman, P. & Eliasson, L., Jul 2012, In: Diabetes. 61, 7, p. 1726-33 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Association of variants in HLA-DQA1-DQB1, PTPN22, INS, and CTLA4 with GAD autoantibodies and insulin secretion in nondiabetic adults of the Botnia Prospective Study

    Lepola, Mette Andersen, Lundgren, V., Isomaa, B., Groop, L. & Tuomi, T., 1 Jul 2012, In: European Journal of Endocrinology. 167, 1, p. 27-33 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets

    Taneera, J., Lang, S., Sharma, A., Fadista, J., Zhou, Y., Ahlqvist, E., Jonsson, A. E., Lyssenko, V., Vikman, P., Hansson, O., Parikh, H., Korsgren, O., Soni, A., Krus, U., Zhang, E., Jing, X-J., Esguerra, J. L. S., Wollheim, C. B., Salehi, A., Rosengren, A. & 2 others, Renström, E. & Groop, L., 3 Jul 2012, In: Cell Metabolism. 16, 1, p. 122-34 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Mechanisms for the antihyperglycemic effect of sitagliptin in patients with type 2 diabetes

    Muscelli, E., Casolaro, A., Gastaldelli, A., Mari, A., Seghieri, G., Astiarraga, B., Chen, Y., Alba, M., Holst, Jens Juul & Ferrannini, E., Aug 2012, In: Journal of Clinical Endocrinology and Metabolism. 97, 8, p. 2818-26 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Effects of intravenous infusions of PYY3-36 and GLP-1, as monoinfusion and in combination, on ad libitum energy intake in healthy obese subjects

    Schmidt, J. B., Gregersen, N. T., Pedersen, S. D., Holst, Jens Juul, Schwartz, Thue W., Astrup, A. & Sjödin, Anders Mikael, 10 Aug 2012, In: Regulatory Peptides. 177, Supplement, p. S32 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  10. Published

    Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside

    Midtkandal, R. R., Redpath, P., Trammell, Sam, MacDonald, S. J. F., Brenner, C. & Migaud, M. E., 15 Aug 2012, In: Bioorganic and Medicinal Chemistry Letters. 22, 16, p. 5204-5207 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism

    Szekeres, F., Chadt, A., Tom, R. Z., Deshmukh, Atul Shahaji, Chibalin, A. V., Björnholm, M., Al-Hasani, H. & Zierath, Juleen R, 15 Aug 2012, In: American Journal of Physiology: Endocrinology and Metabolism. 303, 4, p. E524-33

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Råd. Sundhedsstyrelsen svigter overvægtige

    Astrup, A., Bitz, C. & Sørensen, Thorkild I.A., 27 Aug 2012, In: Politiken. p. 8 1 p.

    Research output: Contribution to journal › Contribution to newspaper - Comment/debate › Communication

  13. Published

    Continuous parenteral and enteral nutrition induces metabolic dysfunction in neonatal pigs

    Stoll, B., Puiman, P. J., Cui, L., Chang, X., Benight, N. M., Bauchart-Thevret, C., Hartmann, Bolette, Holst, Jens Juul & Burrin, D. G., Sep 2012, In: Journal of Parenteral and Enteral Nutrition. 36, 5, p. 538-50 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Intestinal adaptation is stimulated by partial enteral nutrition supplemented with the prebiotic short-chain fructooligosaccharide in a neonatal intestinal failure piglet model

    Barnes, J. L., Hartmann, Bolette, Holst, Jens Juul & Tappenden, K. A., Sep 2012, In: Journal of Parenteral and Enteral Nutrition. 36, 5, p. 524-37 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

    Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, D. G. R. A. M. (. C., Sep 2012, In: Nature Genetics. 44, 9, p. 991-1005 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

    Morris, A. P., Voight, B. F., Teslovich, T. M., Ferreira, T., Segrè, A. V., Steinthorsdottir, V., Strawbridge, R. J., Khan, A. H., Grallert, H., Mahajan, A., Prokopenko, I., Kang, H. M., Dina, C., Esko, T., Fraser, R. M., Kanoni, S., Kumar, A., Lagou, V., Langenberg, C., Luan, J. & 31 others, Lindgren, C. M., Müller-Nurasyid, M., Pechlivanis, S., Rayner, N. W., Scott, L. J., Wiltshire, S., Yengo, L., Kinnunen, L., Rossin, E. J., Raychaudhuri, S., Johnson, A. D., Dimas, A. S., Loos, R. J. F., Vedantam, S., Chen, H., Florez, J. C., Fox, C., Liu, C., Rybin, D., Couper, D. J., Kao, W. H. L., Li, M., Cornelis, M. C., Kraft, P., Sun, Q., van Dam, R. M., Stringham, H. M., Jonsson, Anna Elisabet, Lind, L., Njølstad, I. & Wellcome Trust Case Control Consortium, W. T. C. C. C., Sep 2012, In: Nature Genetics. 44, 9, p. 981-90 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop

    Mokrosinski, J., Frimurer, Thomas Michael, Sivertsen, B., Schwartz, Thue W. & Holst, Birgitte, Sep 2012, In: Journal of Biological Chemistry. 287, p. 33488-33502 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    RNase L controls terminal adipocyte differentiation, lipids storage and insulin sensitivity via CHOP10 mRNA regulation

    Fabre, O. M. J., Salehzada, T., Lambert, K., Boo Seok, Y., Zhou, A., Mercier, J. & Bisbal, C., Sep 2012, In: Cell Death and Differentiation. 19, 9, p. 1470-81 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    The effect of a very low calorie diet on insulin sensitivity, beta cell function, insulin clearance, incretin hormone secretion, androgen levels and body composition in obese young women

    Svendsen, P. F., Jensen, F. K., Holst, Jens Juul, Haugaard, Steen Bendix, Nilas, L. & Madsbad, Sten, Sep 2012, In: Scandinavian Journal of Clinical & Laboratory Investigation. 72, 5, p. 410-9 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Enteral nutrients potentiate glucagon-like peptide-2 action and reduce dependence on parenteral nutrition in a rat model of human intestinal failure

    Brinkman, A. S., Murali, S. G., Hitt, S., Solverson, P. M., Holst, Jens Juul & Ney, D. M., 1 Sep 2012, In: A J P: Gastrointestinal and Liver Physiology (Online). 303, 5, p. G610-22

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    A metabolic prosurvival role for PML in breast cancer

    Carracedo, A., Weiss, D., Leliaert, A. K., Bhasin, M., De Boer, V. C. J., Laurent, G., Adams, A. C., Sundvall, M., Song, S. J., Ito, K., Finley, L. S., Egia, A., Libermann, T., Gerhart-Hines, Zach, Puigserver, P., Haigis, M. C., Maratos-Flier, E., Richardson, A. L., Schafer, Z. T. & Pandolfi, P. P., 4 Sep 2012, In: Journal of Clinical Investigation. 122, 9, p. 3088-3100 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor

    Els, S., Schild, E., Petersen, P. S., Kilian, T., Mokrosinski, J., Frimurer, Thomas Michael, Chollet, C., Schwartz, Thue W., Holst, Birgitte & Beck-Sickinger, A. G., 13 Sep 2012, In: Journal of Medicinal Chemistry. 55, 17, p. 7437-49 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    The arginine of the DRY motif in transmembrane segment III functions as a balancing micro-switch in the activation of the β2-adrenergic receptor

    Hansen, L. V., Groenen, M., Nygaard, R., Frimurer, Thomas Michael, Holliday, N. D. & Schwartz, Thue W., 14 Sep 2012, In: Journal of Biological Chemistry. 287, 38, p. 31973-82 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses

    Procaccini, C., De Rosa, V., Galgani, M., Carbone, F., Cassano, S., Greco, D., Qian, K., Auvinen, P., Calì, G., Stallone, G., Formisano, L., La Cava, A. & Matarese, G., 15 Sep 2012, In: Journal of Immunology. 189, 6, p. 2941-53 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Modulation in selectivity and allosteric properties of small-molecule ligands for CC-chemokine receptors

    Thiele, S., Malmgaard-Clausen, M., Engel-Andreasen, J., Steen, A., Rummel, P. C., Nielsen, M. C., Gloriam, David E., Frimurer, Thomas Michael, Ulven, Trond & Rosenkilde, Mette, 27 Sep 2012, In: Journal of Medicinal Chemistry. 55, 18, p. 8164-77 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Characterization of beta cell and incretin function in patients with MODY1 (HNF4A MODY) and MODY3 (HNF1A MODY) in a Swedish patient collection

    Ekholm, E., Shaat, N. & Holst, Jens Juul, Oct 2012, In: Acta Diabetologica. 49, 5, p. 349-54 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Incretin hormones in patients with type 2 diabetes are increased by diet-oil, a pro-drug for the GPR 119 receptor agonist, 2-oleoyl-glycerol

    Mandoe, M. J., Hansen, K. B., Knop, Filip Krag, Holst, Jens Juul & Hansen, Harald S., Oct 2012, In: Diabetologia. 55, p. S340-S340

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  28. Published

    miRSeqNovel: an R based workflow for analyzing miRNA sequencing data

    Qian, K., Auvinen, E., Greco, D. & Auvinen, P., Oct 2012, In: Molecular and Cellular Probes. 26, 5, p. 208-11 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Association of an Osteopontin gene promoter polymorphism with susceptibility to diabetic nephropathy in Asian Indians

    Cheema, B. S., Iyengar, S., Ahluwalia, Tarun Veer Singh, Kohli, H. S., Sharma, R., Shah, V. N., Bhansali, A., Sakhuja, V. & Khullar, M., 9 Oct 2012, In: Clinica chimica acta; international journal of clinical chemistry. 413, 19-20, p. 1600-4 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Rational design of conformationally constrained cyclopentapeptide antagonists for C-x-C chemokine receptor 4 (CXCR4)

    Mungalpara, J., Thiele, S., Eriksen, Ø., Eksteen, J., Rosenkilde, Mette & Våbenø, J., 9 Oct 2012, In: Journal of Medicinal Chemistry. 55, 22, p. 10287-10291 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183)

    Benned-Jensen, T., Norn, C., Laurent, S., Madsen, C. M., Larsen, H. M., Arfelt, K. N., Wolf, R. M., Frimurer, Thomas Michael, Sailer, A. W. & Rosenkilde, Mette, 12 Oct 2012, In: The Journal of Biological Chemistry. 287, 42, p. 35470-83 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Molecular mechanisms of lipoapoptosis and metformin protection in GLP-1 secreting cells

    Kappe, C., Holst, Jens Juul, Zhang, Q. & Sjöholm, A., 12 Oct 2012, In: Biochemical and Biophysical Research Communications. 427, 1, p. 91-5 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Relationships among tonic and episodic aspects of motivation to eat, gut peptides, and weight before and after bariatric surgery

    Bryant, E. J., King, N. A., Falkén, Y., Hellström, P. M., Holst, Jens Juul, Blundell, J. E. & Näslund, E., 12 Oct 2012, In: Surgery for Obesity and Related Diseases.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Glucagon-like peptide-1 as a treatment for chemotherapy-induced mucositis

    Kissow, Hannelouise, Hartmann, Bolette, Holst, Jens Juul & Poulsen, Steen Seier, 20 Oct 2012, In: Gut.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Linagliptin increases incretin levels, lowers glucagon, and improves glycemic control in type 2 diabetes mellitus

    Rauch, T., Graefe-Mody, U., Deacon, Carolyn F., Ring, A., Holst, Jens Juul, Woerle, H., Dugi, K. A. & Heise, T., Nov 2012, In: Diabetes Therapy. 3, 1, p. 10

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase

    Shehata, S. N., Hunter, R. W., Ohta, E., Peggie, M. W., Lou, H. J., Sicheri, F., Zeqiraj, E., Turk, B. E. & Sakamoto, Kei, 1 Nov 2012, In: Cellular Signalling. 24, 11, p. 2085-2094 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Glucagon-like peptide-1 (GLP-1) receptor agonism or DPP-4 inhibition does not accelerate neoplasia in carcinogen treated mice

    Kissow, Hannelouise, Hartmann, Bolette, Holst, Jens Juul, Viby, N., Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Hare, K. J. & Poulsen, Steen Seier, 10 Nov 2012, In: Regulatory Peptides. 179, 1-3, p. 91-100 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Adult glucose metabolism in extremely birthweight-discordant monozygotic twins

    Frost, M., Petersen, I., Brixen, K., Beck-Nielsen, H., Holst, Jens Juul, Christiansen, L., Højlund, K. & Christensen, K., Dec 2012, In: Diabetologia. 55, 12, p. 3204-12 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Chenodeoxycholic acid reduces intestinal permeability in newly weaned piglets

    van der Meer, Y., Gerrits, W. J. J., van den Bosch, M., Holst, Jens Juul, Moreto, M., Buurman, W. A., Kulik, W. & van Kempen, T. A. T. G., Dec 2012, In: Journal of Animal Science. 90 Suppl 4, p. 302-4 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Dissecting signaling and functions of adhesion G protein-coupled receptors

    Araç, D., Aust, G., Calebiro, D., Engel, F. B., Formstone, C., Goffinet, A., Hamann, J., Kittel, R. J., Liebscher, I., Lin, H-H., Monk, K. R., Petrenko, A., Piao, X., Prömel, S., Schiöth, H. B., Schwartz, T. W., Stacey, M., Ushkaryov, Y. A., Wobus, M., Wolfrum, U. & 2 others, Xu, L. & Langenhan, T., Dec 2012, In: Annals of the New York Academy of Sciences. 1276, p. 1-25 25 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Effect of a common variant of the PCSK2 gene on reduced insulin secretion

    Jonsson, Anna Elisabet, Isomaa, B., Tuomi, T., Eriksson, J. G., Groop, L. & Lyssenko, V., Dec 2012, In: Diabetologia. 55, 12, p. 3245-51 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Examining the effects of hyperglycemia on pancreatic endocrine function in humans: evidence for in vivo glucotoxicity

    Solomon, T. P. J., Knudsen, S. H., Karstoft, K., Winding, K., Holst, Jens Juul & Pedersen, Bente Klarlund, Dec 2012, In: Journal of Clinical Endocrinology and Metabolism. 97, 12, p. 4682-91 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Glucagon-like peptide-1 decreases intracerebral glucose content by activating hexokinase and changing glucose clearance during hyperglycemia

    Gejl, M., Egefjord, L., Lerche, S., Vang, K., Bibby, B. M., Holst, Jens Juul, Mengel, A., Møller, N., Rungby, J., Brock, B. & Gjedde, Albert, Dec 2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, 12, p. 2146-2152 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Glucagon-like peptide-2 (GLP-2) increases net amino acid utilization by the portal-drained viscera of ruminating calves

    Taylor-Edwards, C. C., Burrin, D. G., Kristensen, N. B., Holst, Jens Juul, McLeod, K. R. & Harmon, D. L., Dec 2012, In: Animal. 6, 12, p. 1985-97 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Propionate absorbed from the colon acts as gluconeogenic substrate in a strict carnivore, the domestic cat (Felis catus)

    Verbrugghe, A., Hesta, M., Daminet, S., Polis, I., Holst, Jens Juul, Buyse, J., Wuyts, B. & Janssens, G. P. J., Dec 2012, In: Journal of Animal Physiology and Animal Nutrition (Online). 96, 6, p. 1054-64 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    A Major Lineage of Enteroendocrine Cells Coexpress CCK, Secretin, GIP, GLP-1, PYY, and Neurotensin but Not Somatostatin

    Egerod, Kristoffer Lihme, Engelstoft, M. S., Grunddal, Kaare Villum, Nøhr, M. K., Secher, A., Sakata, I., Pedersen, Jens, Windeløv, Johanne Agerlin, Füchtbauer, E., Olsen, Jørgen, Sundler, F., Christensen, Jan Pravsgaard, Wierup, N., Olsen, Jesper Velgaard, Holst, Jens Juul, Zigman, J. M., Poulsen, Steen Seier & Schwartz, Thue W., 1 Dec 2012, In: Endocrinology. 153, 12, p. 5782-95 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance

    Vernochet, C., Mourier, A., Bezy, O., Macotela, Y., Boucher, J., Rardin, M. J., An, D., Lee, K. Y., Ilkayeva, O. R., Zingaretti, C. M., Emanuelli, Brice, Smyth, G., Cinti, S., Newgard, C. B., Gibson, B. W., Larsson, N. & Kahn, C. R., 5 Dec 2012, In: Cell Metabolism. 16, 6, p. 765-76 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    PheVI:09 (Phe6.44) as a sliding microswitch in seven-transmembrane (7TM) G protein-coupled receptor activation

    Valentin-Hansen, L., Holst, Birgitte, Frimurer, Thomas Michael, Schwartz, Thue W. & Hansen, L. V., 21 Dec 2012, In: Journal of Biological Chemistry. 287, 52, p. 43516-43526 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. 2013
  50. Published

    24h urinary sodium excretion and subsequent change in weight, waist circumference and body composition

    Larsen, S. C., Ängquist, Lars, Sørensen, Thorkild I.A. & Heitmann, Berit, 2013, In: P L o S One. 8, 7, 6 p., e69689.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    A Novel Domain Cassette Identifies Plasmodium falciparum PfEMP1 Proteins Binding ICAM-1 and Is a Target of Cross-Reactive, Adhesion-Inhibitory Antibodies

    Bengtsson, A., Joergensen, L., Rask, T. S., Olsen, R. W., Andersen, M. A., Turner, Louise, Theander, Thor Grundtvig, Hviid, Lars, Higgins, M. K., Craig, A., Brown, A. & Jensen, Anja Ramstedt, 2013, In: Journal of Immunology. 190, 1, p. 240-9 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    A method for noninvasive detection of fetal large deletions/duplications by low coverage massively parallel sequencing

    Chen, S., Lau, T. K., Zhang, C., Xu, C., Xu, Z., Hu, P., Xu, J., Huang, H., Pan, L., Jiang, F., Chen, F., Pan, X., Xie, W., Liu, P., Li, X., Zhang, L., Li, S., Li, Y., Xu, X., Wang, W. & 3 others, Wang, J., Jiang, H. & Zhang, X., 2013, In: Prenatal Diagnosis. 33, 6, p. 584-590 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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