Novo Nordisk Foundation Center for Basic Metabolic Research

The immunoproteasome is induced by cytokines and regulates apoptosis in human islets

Lundh, M., Bugliani, M., Dahlby, T., Chou, D. H., Wagner , B., Ghiasi, S. M., De Tata, V., Chen, Z., Lund, Marianne N., Davies, Michael J., Marchetti, P. & Mandrup-Poulsen, Thomas, 2017, In: Journal of Endocrinology. 233, 3, p. 369-379 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The impact of EndoBarrier gastrointestinal liner in obese patients with normal glucose tolerance and in patients with type 2 diabetes

Rohde, U., Federspiel, C. A., Vilmann, Peter, Langholz, Ebbe, Friis, S. U., Krakauer, M., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Feb 2017, In: Diabetes, Obesity and Metabolism. 19, 2, p. 189-199 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The impact of acute fluctuations in plasma glucose on echocardiographic derived measures of systolic function in patients with type 1 diabetes

Andreasen, C. R., Andersen, A., Haqelqvist, P. G., Abelin, K., Lauritsen, J. V., Jorgensen, P. G., Engberg, S., Faber, Jens, Holst, Jens Juul, Pedersen-Bjergaard, Ulrik, Knop, Filip Krag & Vilsbøll, Tina, 2021, In: Diabetologia. 64, SUPPL 1, p. 135-136 2 p.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

The impact of acute glycaemic fluctuations on left ventricular systolic function in insulin-treated type 2 diabetes

Andersen, A., Jorgensen, P. G., Bagger, J. I., Baldassarre, M. P. A., Christensen, M., Abelin, K. U., Faber, Jens, Pedersen-Bjergaard, Ulrik, Holst, Jens Juul, Lindhardt, T., Gislason, Gunnar Hilmar, Knop, Filip Krag & Vilsbøll, Tina, 2020, In: Diabetologia. 63, SUPPL 1, p. S429-S429 897.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

The impact of anorexia nervosa and BMI polygenic risk on childhood growth: A 20-year longitudinal population-based study

Abdulkadir, M., Hübel, C., Herle, M., Loos, Ruth, Breen, G., Bulik, C. M. & Micali, N., 2022, In: American Journal of Human Genetics. 109, 7, p. 1242-1254 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The impact of dipeptidyl peptidase 4 inhibition on incretin effect, glucose tolerance, and gastrointestinal-mediated glucose disposal in healthy subjects

Rhee, N. A., Østoft, S. H., Holst, Jens Juul, Deacon, Carolyn F., Vilsbøll, T. & Knop, Filip Krag, 16 Jun 2014, In: European Journal of Endocrinology. 171, 3, p. 353-362 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The impact of short chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon

Christiansen, Charlotte Bayer, Gabe, M. B. N., Svendsen, B., Dragsted, Lars Ove, Rosenkilde, Mette & Holst, Jens Juul, 2018, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 315, 1, p. G53-G65 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The impact of surgery and oncological treatment on risk of type 2 diabetes onset in patients with colorectal cancer: nationwide cohort study in Denmark

Krag, C., Svane, M. S., Madsbad, Sten, Graversen, S. B., Christensen, J. F., Sørensen, Thorkild I.A., Lehrskov, L. L. & Laurberg, T., 2024, In: eLife. 12, 13 p., RP89354.

Research output: Contribution to journal › Journal article › Research › peer-review

The importance of endogenously secreted GLP-1 and GIP for postprandial glucose tolerance and β-cell function after Roux-en-Y gastric bypass and sleeve gastrectomy surgery

Hindsø, M., Hedbäck, N., Svane, M. S., Møller, A., Martinussen, C., Jørgensen, N. B., Dirksen, C., Gasbjerg, Lærke Smidt, Kristiansen, V. B., Hartmann, Bolette, Rosenkilde, Mette, Holst, Jens Juul, Madsbad, Sten & Bojsen-Møller, K. N., 2023, In: Diabetes. 72, 3, p. 336–347

Research output: Contribution to journal › Journal article › Research › peer-review

The importance of glucose-dependent insulinotropic polypeptide receptor activation for the effects of tirzepatide

Gasbjerg, Lærke Smidt, Rosenkilde, Mette, Meier, J. J., Holst, Jens Juul & Knop, Filip Krag, 2023, In: Diabetes, Obesity and Metabolism. 25, 11, p. 3079-3092

Research output: Contribution to journal › Review › Research › peer-review

The incretin effect does not differ in trained and untrained, young, healthy men

Lund, M. T., Dalby, S., Hartmann, Bolette, Helge, Jørn Wulff, Holst, Jens Juul & Dela, Flemming, Mar 2014, In: Acta Physiologica. 210, 3, p. 565-72 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The incretin effect in patients with maturity onset diabetes of the young

Ostoft, S. H., Bagger, J. I., Hansen, T., Pedersen, O., Holst, Jens Juul, Knop, Filip Krag & Vilsboll, T., 2012, In: Diabetologia. 55, p. S144-S144

Research output: Contribution to journal › Journal article › Research › peer-review

The incretin system in healthy humans: The role of GIP and GLP-1

Holst, Jens Juul, 2019, In: Metabolism. 96, p. 46-55

Research output: Contribution to journal › Journal article › Research › peer-review

The incretin/glucagon system as a target for pharmacotherapy of obesity

Del Prato, S., Gallwitz, B., Holst, Jens Juul & Meier, J. J., 2022, In: Obesity Reviews. 23, 2, 13 p., e13372.

Research output: Contribution to journal › Journal article › Research › peer-review

The independent effect of type 2 diabetes mellitus on ischemic heart disease, stroke, and death: a population-based study of 13,000 men and women with 20 years of follow-up

Almdal, Thomas Peter, Scharling, H., Jensen, J. S. & drb459, drb459, 12 Jul 2004, In: J A M A Internal Medicine. 164, 13, p. 1422-6 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The influence of glucagon on postprandial hyperglycaemia in children 5 years after onset of type 1 diabetes

Fredheim, S., Andersen, M. M., Pörksen, S., Nielsen, L. B., Pipper, C., Hansen, L., Holst, Jens Juul, Thomsen, J., Johannesen, Jesper, Mortensen, H. B. & Svensson, Jannet, 2015, In: Diabetologia. 58, 4, p. 828-34 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The influence of insulin-related genetic variants on fetal growth, fetal blood flow, and placental weight in a prospective pregnancy cohort

Reim, Pauline Kromann, pjx571, pjx571, Gybel-Brask, D., Schnurr, T. M., Kelstrup, Louise, Høgdall, Estrid Vilma Solyom & Hansen, Torben, 2023, In: Scientific Reports. 13, 10 p., 19638.

Research output: Contribution to journal › Journal article › Research › peer-review

The influence of parental history of diabetes and offspring birthweight on offspring glucose metabolism in adulthood

Lauenborg, J., Jørgensen, M. K., Damm, Peter, Major-Pedersen, A., Eiberg, Hans Rudolf Lytchoff, Urhammer, S., Pedersen, Oluf Borbye & Hansen, Torben, Dec 2011, In: Acta Obstetricia et Gynecologica Scandinavica. 90, 12, p. 1357-1363 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The influence of persistent organic pollutants in the traditional Inuit diet on markers of inflammation

Schæbel, L. K., Bonefeld-Jørgensen, E. C., drb459, drb459 & Andersen, S., 2017, In: PLOS ONE. 12, 5, 16 p., e0177781.

Research output: Contribution to journal › Journal article › Research › peer-review

The influence of transmitted and non-transmitted parental BMI-associated alleles on the risk of overweight in childhood

Schnurr, T. M., Morgen, C. S., Borisevich, D., Beaumont, R. N., pjx571, pjx571, Ängquist, Lars, Have, C. T., Freathy, R. M., Smith, G. D., Nohr, E. A., Hansen, Torben & Sørensen, Thorkild I.A., 2020, In: Scientific Reports. 10, 1, 10 p., 4806.

Research output: Contribution to journal › Journal article › Research › peer-review

The insulinogenic effect of whey protein is partially mediated by a direct effect of amino acids and GIP on β-cells

Salehi, A., Gunnerud, U., Muhammed, S. J., Ostman, E., Holst, Jens Juul, Björck, I. & Rorsman, P., 2012, In: Nutrition & Metabolism. 9, 1, p. 48

Research output: Contribution to journal › Journal article › Research › peer-review

The insulinotropic effect of exogenous GLP-1 is not affected by acute vagotomy in anaesthetized pigs

Veedfald, Simon, Hansen, M., Christensen, L. W., Larsen, S. A. H., Hjøllund, K. R., Plamboeck, A., Hartmann, Bolette, Deacon, Carolyn F. & Holst, Jens Juul, 30 Mar 2016, In: Experimental Physiology. 101, 7, p. 895-912 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The interaction between the adaptor protein APS and Enigma is involved in actin organisation

Barrès, Romain, Gonzalez, T., Le Marchand-Brustel, Y. & Tanti, J., 15 Aug 2005, In: Experimental Cell Research. 308, 2, p. 334-44 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The interleukin-1 receptor antagonist anakinra improves first-phase insulin secretion and insulinogenic index in subjects with impaired glucose tolerance

van Poppel, P. C. M., van Asseldonk, E. J. P., Holst, Jens Juul, Vilsbøll, Tina, Netea, M. G. & Tack, C. J., Dec 2014, In: Diabetes, Obesity and Metabolism. 16, 12, p. 1269-73 5 p.

Research output: Contribution to journal › Letter › Research › peer-review

The intestinal distribution pattern of appetite- and glucose regulatory peptides in mice, rats and pigs

Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Toräng, S. & Holst, Jens Juul, 2 Feb 2016, In: BMC Research Notes. 9, 1, p. 1-6 6 p., 60.

Research output: Contribution to journal › Journal article › Research › peer-review

The intestinal microbiome is a co-determinant of the postprandial plasma glucose response

Søndertoft, N. B., Vogt, J. K., Arumugam, Mani, Kristensen, M., Gøbel, R. J., Fan, Yong, Lyu, Liwei, Bahl, M. I., Eriksen, C., Ängquist, Lars, Frøkiær, Hanne, Hansen, T. H., Brix, Susanne, Nielsen, H. B., Hansen, Torben, Vestergaard, H., Gupta, R., Licht, T. R., Lauritzen, Lotte & Pedersen, Oluf Borbye, 2020, In: P L o S One. 15, 9, 23 p., e0238648.

Research output: Contribution to journal › Journal article › Research › peer-review

The intestinotrophic peptide, GLP-2, counteracts the gastrointestinal atrophy in mice induced by the epidermal growth factor receptor inhibitor, erlotinib, and cisplatin

Rasmussen, A. R., Viby, N., Hare, K. J., Hartmann, Bolette, Thim, L., Holst, Jens Juul & Poulsen, Steen Seier, 1 Oct 2010, In: Digestive Diseases and Sciences. 55, 10, p. 2785-96 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The intracellular to extracellular proton gradient following maximal whole body exercise and its implication for anaerobic energy production

Voiantis, S., Secher, Niels H. & Quistorff, B., Aug 2010, In: European Journal of Applied Physiology. 109, 6, p. 1171-1177 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The isoenzyme pattern of LDH does not play a physiological role; except perhaps during fast transitions in energy metabolism

Quistorff, B. & Grunnet, N., 2011, In: Aging. 3, 5, p. 457-460

Research output: Contribution to journal › Journal article › Research › peer-review

The lack of natural processes of delivery and neonatal intensive care treatment lead to impaired cytokine responses later in life

Martikainen, M. V., Keski-Nisula, L., Jakupovic, Hermina, Karvonen, A. M., Pekkanen, J., Hirvonen, M. R. & Roponen, M., 1 Mar 2017, In: American Journal of Reproductive Immunology. 77, 3, e12621.

Research output: Contribution to journal › Journal article › Research › peer-review

The legacy of our ancestors' lifestyle

Barrès, Romain, 2016, In: Biochemist. 38, 2, p. 1-4 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The levelling off of the obesity epidemic since the year 1999--a review of evidence and perspectives

Rokholm, B., Baker, J. L. & Sørensen, Thorkild I.A., 1 Dec 2010, In: Obesity Reviews. 11, 12, p. 835-46 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The liver-alpha cell axis and type 2 diabetes

Albrechtsen, Nicolai Jacob Wewer, Pedersen, Jens, Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Suppli, M. P., Janah, L., Gromada, J., Vilstrup, H., Knop, Filip Krag & Holst, Jens Juul, 2019, In: Endocrine Reviews. 40, 5, p. 1353-1366

Research output: Contribution to journal › Review › Research › peer-review

The liver-alpha-cell axis after a mixed meal and during weight loss in type 2 diabetes

Otten, J., Stomby, A., Waling, M., Chorell, E., Ryberg, M., Svensson, M., Holst, Jens Juul & Olsson, T., 2021, In: Endocrine Connections. 10, 9, p. 1101-1110

Research output: Contribution to journal › Journal article › Research › peer-review

The liver–alpha cell axis associates with liver fat and insulin resistance: a validation study in women with non-steatotic liver fat levels

Gar, C., Haschka, S. J., Kern-Matschilles, S., Rauch, B., Sacco, V., Prehn, C., Adamski, J., Seissler, J., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul & Lechner, A., 2021, In: Diabetologia. 64, 3, p. 512-520

Research output: Contribution to journal › Journal article › Research › peer-review

The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo

Panaro, B. L., Tough, I. R., Engelstoft, M. S., Matthews, R. T., Digby, G. J., Møller, C. L., Svendsen, B., Gribble, F., Reimann, F., Holst, Jens Juul, Holst, Birgitte, Schwartz, Thue W., Cox, H. M. & Cone, R. D., 2 Dec 2014, In: Cell Metabolism. 20, 6, p. 1018-29 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The metabolic actions of neurotensin secreted from the gut

Ratner, C., Johnsen, Cecilie Hundahl & Holst, Birgitte, Sep 2016, In: Cardiovascular Endocrinology. 5, 3, p. 102-111

Research output: Contribution to journal › Review › Research › peer-review

The microbiome of captive hamadryas baboons

Li, Xuan Ji, Trivedi, Urvish, Brejnrod, A. D., Vestergaard, G. A., Mortensen, M. S., Bertelsen, Mads Frost & Sørensen, Søren Johannes, 2020, In: BMC Animal Microbiome. 2, 10 p., 25.

Research output: Contribution to journal › Journal article › Research › peer-review

The microbiome of tunnels in hidradenitis suppurativa patients

Ring, H. C., Sigsgaard, V., Thorsen, Jonathan Jan Ilve, Fuursted, K., Fabricius, S., Saunte, Ditte Marie & Jemec, Gregor, 2019, In: Journal of the European Academy of Dermatology and Venereology : JEADV. 33, 9, p. 1775-1780 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load

Hornbak, M., Banasik, Karina, Justesen, Johanne Marie, Krarup, N. T., Sandholt, C. H., Andersson, Åsa, Sandbaek, A., Lauritzen, T., Pisinger, C., Witte, D. R., Sørensen, Thorkild I.A., Pedersen, Oluf Borbye & Hansen, Torben, 6 Jan 2011, In: BMC Medical Genetics. 12, 1, p. 4 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The morphogenetic MreBCD proteins of Escherichia coli form an essential membrane-bound complex

Kruse, Thomas, Bork-Jensen, J. & Gerdes, K., Jan 2005, In: Molecular Microbiology. 55, 1, p. 78-89 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The multifactorial and multistage character of protective immunity to Plasmodium falciparum, naturally acquired by an indigenous population in Burkina Faso

Boudin, C., Sheick, I., Chumpitazi, B., Pazart, L., Høgh, Birthe, Peyron, F., Deloron, P., Picot, S. & Ambroise-Thomas, P., Apr 1994, In: Scandinavian Journal of Immunology. 39, 4, p. 409-17 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The national child odontology registry (SCOR): a valuable resource for odontological and public health research

Nygaard, Nikoline, Ängquist, Lars, Midjord-Belstrøm, Daniel, Stankevic, Evelina, Hansen, Torben, Olsen, A., Rosing, Kasper & Markvart, Merete, 2023, In: BMC Oral Health. 23, 13 p., 608.

Research output: Contribution to journal › Journal article › Research › peer-review

The naturally occurring GIP(1-30)NH₂ is a GIP receptor agonist in humans

Krogh, L. S. L., Henriksen, K., Stensen, S., Skov-Jeppesen, Kirsa, Bergmann, N. C., Størling, Joachim, Rosenkilde, Mette, Hartmann, Bolette, Holst, Jens Juul, Gasbjerg, Lærke Smidt & Knop, Filip Krag, 2023, In: European Journal of Endocrinology. 188, 1, lvac015.

Research output: Contribution to journal › Journal article › Research › peer-review

The new donor vigilance system in Denmark reveals regional differences in adverse reactions supposedly caused by variation in the registration

Mikkelsen, Christina, Paarup, H. M., Bruun, M. T., Pedersen, L. Ø., Hasslund, S., Larsen, R., Aagaard, B. & Sørensen, B. S., 2022, In: Vox Sanguinis. 117, 3, p. 321-327

Research output: Contribution to journal › Journal article › Research › peer-review

The next decade of metabolism

Backhed, F., Bugianesi, E., Christofk, H., Dikic, I., Gupta, R., Mair, W. B., O'Neill, L. A. J., Ralser, M., Sabatini, D. M. & Tschop, M., 2019, In: Nature Metabolism. 1, p. 2-4

Research output: Contribution to journal › Comment/debate › Research

The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids

Desjardins, E. M., Smith, B. K., Day, E. A., Ducommun, S., Sanders, M. J., Nederveen, J. P., Ford, R. J., Pinkosky, S. L., Townsend, L. K., Gutgesell, R. M., Lu, R., Sakamoto, Kei & Steinberg, G. R., 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 48, 8 p., e2119824119.

Research output: Contribution to journal › Journal article › Research › peer-review

The physiology of experimental overfeeding in animals

Ranea-Robles, Pablo, Lund, Jens & Clemmensen, Christoffer, 2022, In: Molecular Metabolism. 64, 15 p., 101573.

Research output: Contribution to journal › Review › Research › peer-review

The physiology of obesity: from mechanisms to medicine (M2M). Part one

Lewis, J. E. & Aldiss, Peter Stuart Jacob, 2022, In: Journal of Physiology. 600, 4, p. 697-698 2 p.

Research output: Contribution to journal › Editorial › Research

The physiology of obesity; from mechanisms to medicine. Part two

Aldiss, Peter Stuart Jacob & Lewis, J. E., 2022, In: Journal of Physiology. 600, 5, p. 999-1000 2 p.

Research output: Contribution to journal › Editorial › Research

The plasticity of NBS resistance genes in sorghum is driven by multiple evolutionary processes

Mace, E., Tai, S., Innes, D., Godwin, I., Hu, W., Campbell, B., Gilding, E., Cruickshank, A., Prentis, P., Wang, J. & Jordan, D., 2014, In: B M C Plant Biology. 14, 14 p., 253.

Research output: Contribution to journal › Journal article › Research › peer-review

The potential of tailoring the gut microbiome to prevent and treat cardiometabolic disease

Chakaroun, R. M., Olsson, L. M. & Bäckhed, F., 2023, In: Nature Reviews Cardiology. 20, p. 217-235

Research output: Contribution to journal › Review › Research › peer-review

The potential role of SOCS-3 in the interleukin-1beta-induced desensitization of insulin signaling in pancreatic beta-cells

Emanuelli, Brice, Glondu, M., Filloux, C., Peraldi, P. & Van Obberghen, E., Dec 2004, In: Diabetes. 53 Suppl 3, p. S97-S103

Research output: Contribution to journal › Journal article › Research › peer-review

The potential role of inhibitor of differentiation-3 in human adipose tissue remodeling and metabolic health

Svendstrup, M. & drb459, drb459, Nov 2014, In: Molecular Genetics and Metabolism. 113, 3, p. 149-154 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes

Huerta-Chagoya, A., Schroeder, P., Mandla, R., Deutsch, A. J., Zhu, W., Petty, L., Yi, X., Cole, J. B., Udler, M. S., Dornbos, P., Porneala, B., DiCorpo, D., Liu, C. T., Li, J. H., Szczerbiński, L., Kaur, V., Kim, J., Lu, Y., Martin, A., Eizirik, D. L. & 31 others, Marchetti, P., Marselli, L., Chen, L., Srinivasan, S., Todd, J., Flannick, J., Gubitosi-Klug, R., Levitsky, L., Shah, R., Kelsey, M., Burke, B., Dabelea, D. M., Divers, J., Marcovina, S., Stalbow, L., Loos, Ruth, Darst, B. F., Kooperberg, C., Raffield, L. M., Haiman, C., Sun, Q., McCormick, J. B., Fisher-Hoch, S. P., Ordoñez, M. L., Meigs, J., Baier, L. J., González-Villalpando, C., González-Villalpando, M. E., Orozco, L., García-García, L. & Mexican Biobank, M. B., 2023, In: Diabetologia. 66, p. 1273-1288 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The power of genetic diversity in genome-wide association studies of lipids

Graham, S. E., Clarke, S. L., Wu, K-H. H., Kanoni, S., Zajac, G. J. M., Ramdas, S., Surakka, I., Ntalla, I., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Hwang, M. Y., Han, S., Narita, A., Choudhury, A., Bentley, A. R., Ekoru, K., Verma, A., Trivedi, B. & 504 others, Martin, H. C., Hunt, K. A., Hui, Q., Klarin, D., Zhu, X., Thorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Akiyama, M., Sakaue, S., Terao, C., Kanai, M., Zhou, W., Brumpton, B. M., Rasheed, H., Ruotsalainen, S. E., Havulinna, A. S., Veturi, Y., Feng, Q., Rosenthal, E. A., Lingren, T., Pacheco, J. A., Pendergrass, S. A., Haessler, J., Giulianini, F., Bradford, Y., Miller, J. E., Campbell, A., Lin, K., Millwood, I. Y., Hindy, G., Rasheed, A., Faul, J. D., Zhao, W., Weir, D. R., Turman, C., Huang, H., Graff, M., Mahajan, A., Brown, M. R., Zhang, W., Yu, K., Schmidt, E. M., Pandit, A., Gustafsson, S., Yin, X., Luan, J., Zhao, J., Matsuda, F., Jang, H., Yoon, K., Medina-Gomez, C., Pitsillides, A., Hottenga, J. J., Willemsen, G., Wood, A. R., Ji, Y., Gao, Z., Haworth, S., Mitchell, R. E., Chai, J. F., Aadahl, Mette, Yao, J., Manichaikul, A., Warren, H. R., Ramirez, J., Bork-Jensen, J., Karhus, L. L., Goel, A., Sabater-Lleal, M., Noordam, R., Sidore, C., Fiorillo, E., McDaid, A. F., Marques-Vidal, P., Wielscher, M., Trompet, S., Sattar, N., Møllehave, Line Tang, Thuesen, B. H., Munz, M., Zeng, L., Huang, J., Yang, B., Poveda, A., Kurbasic, A., Lamina, C., Forer, L., Scholz, M., Galesloot, T. E., Bradfield, J. P., Daw, E. W., Zmuda, J. M., Mitchell, J. S., Fuchsberger, C., Christensen, H., Brody, J. A., Feitosa, M. F., Wojczynski, M. K., Preuss, M., Mangino, M., Christofidou, P., Verweij, N., Benjamins, J. W., Engmann, J., Kember, R. L., Slieker, R. C., Lo, K. S., Zilhao, N. R., Phuong Le, Kleber, M. E., Delgado, G. E., Huo, S., Ikeda, D. D., Iha, H., Yang, J., Liu, J., Leonard, H. L., Marten, J., Schmidt, B., Arendt, M., Smyth, L. J., Canadas-Garre, M., Wang, C., Nakatochi, M., Wong, A., Hutri-Kahonen, N., Sim, X., Xia, R., Huerta-Chagoya, A., Fernandez-Lopez, J. C., Lyssenko, V., Ahmed, M., Jackson, A. U., Irvin, M. R., Oldmeadow, C., Kim, H., Ryu, S., Timmers, P. R. H. J., Arbeeva, L., Dorajoo, R., Lange, L. A., Chai, X., Prasad, G., Lores-Motta, L., Pauper, M., Long, J., Li, X., Theusch, E., Takeuchi, F., Spracklen, C. N., Loukola, A., Bollepalli, S., Warner, S. C., Wang, Y. X., Wei, W. B., Nutile, T., Ruggiero, D., Sung, Y. J., Hung, Y., Chen, S., Liu, F., Yang, J., Kentistou, K. A., Gorski, M., Brumat, M., Meidtner, K., Bielak, L. F., Smith, J. A., Hebbar, P., Farmaki, A., Hofer, E., Lin, M., Xue, C., Zhang, J., Concas, M. P., Vaccargiu, S., van der Most, P. J., Pitkanen, N., Cade, B. E., Lee, J., van Der Laan, S. W., Chitrala, K. N., Weiss, S., Zimmermann, M. E., Lee, J. Y., Choi, H. 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Research output: Contribution to journal › Journal article › Research › peer-review

The prebiotic inulin improves substrate metabolism and promotes short-chain fatty acid production in overweight to obese men

van der Beek, C. M., Canfora, E. E., Kip, A. M., Gorissen, S. H. M., Damink, S. W. M. O., van Eijk, H. M., Holst, Jens Juul, Blaak, E. E., Dejong, C. H. C. & Lenaerts, K., Oct 2018, In: Metabolism. 87, p. 25-35

Research output: Contribution to journal › Journal article › Research › peer-review

The presence of resuscitation equipment and influencing factors at General Practitioners' offices in Denmark: A cross-sectional study

Niegsch, M. L., Krarup, N. T. & Clausen, N. E., 17 Sep 2013, In: Resuscitation. 85, 1, p. 65-69 5 p.

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The prevalence of the metabolic syndrome in a danish population of women with previous gestational diabetes mellitus is three-fold higher than in the general population

Lauenborg, J., Mathiesen, Elisabeth, Hansen, Torben, Glümer, C., Jørgensen, T., Borch-Johnsen, K., Hornnes, P., Pedersen, Oluf Borbye & Damm, Peter, 2005, In: Journal of Clinical Endocrinology and Metabolism. 90, 7, p. 4004-10 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The proteomic profile of the human myotendinous junction

Karlsen, Anders, Gonzalez-Franquesa, A., Jakobsen, J. R., Krogsgaard, Michael R., Koch, M., Kjær, Michael, Schiaffino, S., Mackey, Abigail & Deshmukh, Atul Shahaji, 2022, In: iScience. 25, 2, 19 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The regulation of function, growth and survival of GLP-1-producing L-cells.

Kuhre, Rune Ehrenreich, Holst, Jens Juul & Kappe, C., 1 Jan 2016, In: Clinical Science. 130, 2, p. 79-91 13 p.

Research output: Contribution to journal › Review › Research › peer-review

The renal protective effect of angiotensin receptor blockers depends on intra-individual response variation in multiple risk markers

Schievink, B., de Zeeuw, D., Parving, H., Rossing, Peter & Lambers Heerspink, H. J., Oct 2015, In: British Journal of Clinical Pharmacology. 80, 4, p. 678-86 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The role of GH in adipose tissue: Lessons from adipose-specific GH receptor gene-disrupted mice

List, E. O., Berryman, D. E., Funk, K., Gosney, E. S., Jara, A., Kelder, B., Wang, X., Kutz, L., Troike, K., Lozier, N., Mikula, V., Lubbers, E. R., Zhang, H., Vesel, C., Junnila, R. K., Frank, S. J., Masternak, M. M., Bartke, A. & Kopchick, J. J., 7 Mar 2013, In: Molecular Endocrinology. 27, 3, p. 524-535 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The role of GLP-1 in postprandial glucose metabolism after bariatric surgery: a narrative review of human GLP-1 receptor antagonist studies

Hindsø, M., Svane, M. S., Hedbäck, N., Holst, Jens Juul, Madsbad, Sten & Bojsen-Møller, K. N., 2021, In: Surgery for Obesity and Related Diseases. 17, 7, p. 1383-1391

Research output: Contribution to journal › Review › Research › peer-review

The role of GLP-1 in the postprandial effects of acarbose in type 2 diabetes

Dalsgaard, N. B., Gasbjerg, Lærke Smidt, Hansen, L. S., Hansen, N. L., Stensen, S., Hartmann, Bolette, Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2021, In: European Journal of Endocrinology. 184, 3, p. 387-398 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The role of Xist-mediated Polycomb recruitment in the initiation of X-chromosome inactivation

Bousard, A., Raposo, A. C., Żylicz, J. J., Picard, C., Pires, V. B., Qi, Y., Gil, Cláudia, Syx, L., Chang, H. Y., Heard, E. & da Rocha, S. T., 4 Oct 2019, In: EMBO Reports. 20, 10, e48019.

Research output: Contribution to journal › Journal article › Research › peer-review

The role of a traditional and western diet on glucose homeostasis in Greenlandic Inuit carriers and non-carriers of type 2 diabetes variant in the TBC1D4 gene: A protocol for a randomized clinical trial

Møller, G., Lind, M. V., Hauptmann, A. L., Senftleber, N., Hansen, C. B., Hansen, Torben, Jørgensen, M. E. & Lauritzen, Lotte, 2021, In: Contemporary Clinical Trials Communications. 21, 6 p., 100734.

Research output: Contribution to journal › Journal article › Research › peer-review

The role of diet and exercise in the transgenerational epigenetic landscape of T2DM

Barrès, Romain & Zierath, Juleen R, Aug 2016, In: Nature Reviews Endocrinology. 12, 8, p. 441-51 11 p.

Research output: Contribution to journal › Review › Research › peer-review

The role of efferent cholinergic transmission for the insulinotropic and glucagonostatic effects of GLP-1

Plamboeck, A., Veedfald, Simon, Deacon, Carolyn F., Hartmann, Bolette, Vilsbøll, T., Knop, Filip Krag & Holst, Jens Juul, Sep 2015, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 309, 5, p. R544-51 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The role of endogenous GIP and GLP-1 in postprandial bone homeostasis

Helsted, M. M., Gasbjerg, Lærke Smidt, Lanng, A. R., Bergmann, N. C., Stensen, S., Hartmann, Bolette, Christensen, Mikkel Bring, Holst, Jens Juul, Vilsbøll, Tina, Rosenkilde, Mette & Knop, Filip Krag, 2020, In: Bone. 140, 7 p., 115553.

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The role of glucagon in the acute therapeutic effects of SGLT2 inhibition

Hædersdal, S., Lund, A., Nielsen-Hannerup, E., Maagensen, H., van Hall, Gerrit, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2020, In: Diabetes. 69, 12, p. 2619-2629 11 p.

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The role of glucagon in the maintenance of euglycemia in the fed and the fasted state. Monoclonal antibody treatment as a tool in glucagon physiology in rats.

Brand, C. L., Jørgensen, P. N., Svendsen, I., Kristensen, J. S., Knigge, U., Warberg, J. & Holst, Jens Juul, 1995, In: Am. J. Physiol.. 269, p. E469-E477

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The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

Perry, R. J., Samuel, V. T., Petersen, K. M. F. & Shulmann, G. I., 5 Jun 2014, In: Nature. 510, p. 84-91 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The role of incretins on insulin function and glucose homeostasis

Holst, Jens Juul, Gasbjerg, Lærke Smidt & Rosenkilde, Mette, 2021, In: Endocrinology. 162, 7, 10 p., bqab065.

Research output: Contribution to journal › Review › Research › peer-review

The role of kisspeptin and RFRP in the circadian control of female reproduction

Beymer, M., Henningsen, J., Bahougne, T. & Simonneaux, V., 15 Dec 2016, In: Molecular and Cellular Endocrinology. 438, p. 89-99 11 p.

Research output: Contribution to journal › Review › Research › peer-review

The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study

Koivula, R. W., Atabaki-Pasdar, N., Giordano, G. N., White, T., Adamski, J., Bell, J. D., Beulens, J., Brage, S., Brunak, S., De Masi, F., Dermitzakis, E. T., Forgie, I. M., Frost, G., Hansen, T., Hansen, T. H., Hattersley, A., Kokkola, T., Kurbasic, A., Laakso, M., Mari, A. & 15 others, McDonald, T. J., Pedersen, Oluf Borbye, Rutters, F., Schwenk, J. M., Teare, H. J. A., Thomas, E. L., Vinuela, A., Mahajan, A., McCarthy, M. I., Ruetten, H., Walker, M., Pearson, E., Pavo, I., Franks, P. W. & IMI-DIRECT consortium, I. C., 2020, In: Diabetologia. 63, 4, p. 744-756 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The role of somatostatin in GLP-1-induced inhibition of glucagon secretion in mice

Ørgaard, A. & Holst, Jens Juul, Sep 2017, In: Diabetologia. 60, 9, p. 1731-1739 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The role of the incretins in the postprandial bone remodelling

Helsted, M. M., Gasbjerg, Lærke Smidt, Lanng, A. R., Stensen, S., Hartmann, Bolette, Christensen, Mikkel Bring, Holst, Jens Juul, Vilsbøll, Tina, Rosenkilde, M. M. & Knop, Filip Krag, 2018, In: Diabetologia. 61, S1, p. S221-S221 449.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

The role of the molecular circadian clock in human energy homeostasis

Dollet, L., Pendergrast, L. A. & Zierath, Juleen R, 2021, In: Current Opinion in Lipidology. 32, 1, p. 16-23 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm

Helgadottir, A., Thorleifsson, G., Magnusson, K. P., Grétarsdottir, S., Steinthorsdottir, V., Manolescu, A., Jones, G. T., Rinkel, G. J. E., Blankensteijn, J. D., Ronkainen, A., Jääskeläinen, J. E., Kyo, Y., Lenk, G. M., Sakalihasan, N., Kostulas, K., Gottsäter, A., Flex, A., Stefansson, H., Hansen, T., Andersen, G. & 48 others, Weinsheimer, S., Borch-Johnsen, K., Jørgensen, T., Shah, S. H., Quyyumi, A. A., Granger, C. B., Reilly, M. P., Austin, H., Levey, A. I., Vaccarino, V., Palsdottir, E., Walters, G. B., Jonsdottir, T., Snorradottir, S., Magnusdottir, D., Gudmundsson, G., Ferrell, R. E., Sveinbjornsdottir, S., Hernesniemi, J., Niemelä, M., Limet, R., Andersen, K., Sigurdsson, G., Benediktsson, R., Verhoeven, E. L. G., Teijink, J. A. W., Grobbee, D. E., Rader, D. J., Collier, D. A., Pedersen, Oluf Borbye, Pola, R., Hillert, J., Lindblad, B., Valdimarsson, E. M., Magnadottir, H. B., Wijmenga, C., Tromp, G., Baas, A. F., Ruigrok, Y. M., van Rij, A. M., Kuivaniemi, H., Powell, J. T., Matthiasson, S. E., Gulcher, J. R., Thorgeirsson, G., Kong, A., Thorsteinsdottir, U. & Stefansson, K., 2008, In: Nature Genetics. 40, 2, p. 217-24 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation

Fischer, K., Fenzl, A., Liu, D., Dyar, K. A., Kleinert, M., Brielmeier, M., Clemmensen, C., Fedl, A., Finan, B., Gessner, A., Jastroch, M., Huang, J., Keipert, S., Klingenspor, M., Brüning, J. C., Kneilling, M., Maier, F. C., Othman, A. E., Pichler, B. J., Pramme-Steinwachs, I. & 13 others, Sachs, S., Scheideler, A., Thaiss, W. M., Uhlenhaut, H., Ussar, S., Woods, S. C., Zorn, J., Stemmer, K., Collins, S., Diaz-Meco, M., Moscat, J., Tschöp, M. H. & Müller, T. D., 2020, In: Nature Communications. 11, 1, 13 p., 2306.

Research output: Contribution to journal › Journal article › Research › peer-review

The search for putative unifying genetic factors for components of the metabolic syndrome

Sjögren, M., Lyssenko, V., Jonsson, Anna Elisabet, Berglund, G., Nilsson, P., Groop, L. & Orho-Melander, M., Dec 2008, In: Diabetologia. 51, 12, p. 2242-51 10 p.

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The separate and combined impact of the intestinal hormones, GIP, GLP-1, and GLP-2, on glucagon secretion in type 2 diabetes

Lund, Asger Bach, Vilsbøll, Tina, Bagger, J. I., Holst, Jens Juul & Knop, Filip Krag, 2011, In: American Journal of Physiology: Endocrinology and Metabolism. 300, 6, p. E1038-E1046 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The social origins of obesity within and across generations

Hemmingsson, E., Nowicka, P., Ulijaszek, S. & Sørensen, Thorkild I.A., 2023, In: Obesity Reviews. 24, 1, 11 p., e13514.

Research output: Contribution to journal › Review › Research › peer-review

The structure of wheat bread influences the postprandial metabolic response in healthy men

Eelderink, C., Noort, M. W. J., Sozer, N., Koehorst, M., Holst, Jens Juul, Deacon, Carolyn F., Rehfeld, Jens Frederik, Poutanen, K., Vonk, R. J., Oudhuis, L. & Priebe, M. G., Oct 2015, In: Food & Function. 6, 10, p. 3236-48 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The trans-ancestral genomic architecture of glycemic traits

Chen, J., Spracklen, C. N., Marenne, G., Varshney, A., Corbin, L. J., Luan, J., Willems, S. M., Wu, Y., Zhang, X., Horikoshi, M., Boutin, T. S., Magi, R., Waage, J., Li-Gao, R., Chan, K. H. K., Yao, J., Anasanti, M. D., Chu, A. Y., Claringbould, A., Heikkinen, J. & 31 others, Hong, J., Hottenga, J., Huo, S., Kaakinen, M. A., Louie, T., Maerz, W., Moreno-Macias, H., Ndungu, A., Nelson, S. C., Nolte, I. M., North, K. E., Appel, E. V. R., Liu, J., Sparso, T., Zhao, J., Astrup, A., Jørgensen, M. E., Linneberg, Allan René, Vestergaard, H., Bisgaard, H., Bønnelykke, Klaus, Grarup, Niels, Hansen, Torben, Kovacs, P., Lind, L., Loos, R. J. F., Njølstad, I., Pedersen, Oluf Borbye, Schwarz, Peter, Sørensen, Thorkild I.A. & Meta-Analysis of Glucose and Insulin-Related Trait Consortium (MAGIC), M. O. G. A. I. T. C. (., 2021, In: Nature Genetics. 53, 6, p. 840-860 41 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load

Holmkvist, J., Banasik, K., Andersen, G., Unoki, H., Jensen, T. S., Pisinger, C., Borch-Johnsen, K., Sandbaek, A., Lauritzen, T., Brunak, Søren, Maeda, S., Hansen, T. & Pedersen, Oluf Borbye, 2009, In: PLoS ONE. 4, 6, p. e5872

Research output: Contribution to journal › Journal article › Research › peer-review

The unidentified hormonal defense against weight gain

Lund, Jens, Lund, Camilla, Morville, T. H. & Clemmensen, Christoffer, 2020, In: PLOS Biology. 18, 2, 14 p., e3000629.

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The use of a systems approach to increase NAD⁺ in human participants

Henderson, John David, Quigley, S. N. Z., Chachra, S. S., Conlon, N. & Ford, D., 2024, In: npj Aging. 10, 12 p., 7.

Research output: Contribution to journal › Journal article › Research › peer-review

The use of double-balloon enteroscopy in retrieving mucosal biopsies from the entire human gastrointestinal tract

Rhee, N. A., Vilmann, Peter, Hassan, H., Hendel, J. W., Holst, Jens Juul, Vilsbøll, T. & Knop, Filip Krag, Sep 2014, In: Scandinavian Journal of Gastroenterology. 49, 9, p. 1143-1149 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The use of proteomics to study infectious diseases

List, E. O., Berryman, D. E., Bower, B., Sackmann-Sala, L., Gosney, E., Ding, J., Okada, S. & Kopchick, J. J., 1 Mar 2008, In: Infectious Disorders - Drug Targets. 8, 1, p. 31-45 15 p.

Research output: Contribution to journal › Review › Research › peer-review

The “mesh” as evidence – model comparison and alternative interpretations of feedback

Hulme, Oliver James & Whiteley, Louise, 2007, In: Behavioral and Brain Sciences. 30

Research output: Contribution to journal › Comment/debate › Communication

Therapeutic Potential of Butyrate for Treatment of Type 2 Diabetes

Arora, Tulika & Tremaroli, V., 2021, In: Frontiers in Endocrinology. 12, 10 p., 761834.

Research output: Contribution to journal › Review › Research › peer-review

Therapies for inter-relating diabetes and obesity - GLP-1 and obesity

Iepsen, E. P. W., Torekov, Signe Sørensen & Holst, Jens Juul, Dec 2014, In: Expert Opinion on Pharmacotherapy. 15, 17, p. 2487-500 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling

Segref, A., Vakkayil, K. L., Padvitski, T., Li, Q., Kroef, V., Lormann, J., Körner, L., Finger, Fabian Michael & Hoppe, T., 2022, In: Nature Communications. 13, 1, 17 p., 5874.

Research output: Contribution to journal › Journal article › Research › peer-review

Thirty days of resveratrol supplementation does not affect postprandial incretin hormone responses, but suppresses postprandial glucagon in obese subjects

Knop, Filip Krag, Konings, E., Timmers, S., Schrauwen, P., Holst, Jens Juul & Blaak, E. E., 11 May 2013, In: Diabetic Medicine. 30, 10, p. 1214-1218 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review