Novo Nordisk Foundation Center for Basic Metabolic Research

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  1. 2009
  2. Published

    ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth

    Markljung, E., Jiang, L., Jaffe, J. D., Mikkelsen, T. S., Wallerman, O., Larhammar, M., Zhang, X., Wang, L., Saenz-Vash, V., Gnirke, A., Lindroth, A. M., Barres, R., Yan, J., Strömberg, S., De, S., Pontén, F., Lander, E. S., Carr, S. A., Zierath, J. R., Kullander, K. & 5 others, Wadelius, C., Lindblad-Toh, K., Andersson, G., Hjälm, G. & Andersson, L., Dec 2009, In: P L o S Biology (Online). 7, 12, p. e1000256

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention

    Meur, G., Simon, A., Harun, N., Virally, M., Dechaume, A., Bonnefond, A., Fetita, S., Tarasov, A. I., Guillausseau, P., Boesgaard, T. W., Pedersen, Oluf Borbye, Hansen, T., Polak, M., Gautier, J., Froguel, P., Rutter, G. A. & Vaxillaire, M., 2009, In: Diabetes. 59, 3, p. 653-61 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Predictive performance for population models using stochastic differential equations applied on data from an oral glucose tolerance test

    Møller, J. B., Overgaard, R. V., Madsen, H., Hansen, T., Pedersen, Oluf Borbye & Ingwersen, S. H., 2009, In: Journal of Pharmacokinetics and Pharmacodynamics. 37, 1, p. 85-98 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Past and current body size affect validity of reported energy intake among middle-aged Danish men

    Nielsen, B. M., Nielsen, M. M., Toubro, S., Pedersen, Oluf Borbye, Astrup, A., Sørensen, Thorkild I.A., Jess, T. & Heitmann, B. L., 2009, In: Journal of Nutrition. 139, 12, p. 2337-2343 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Unique splicing pattern of the TCF7L2 gene in human pancreatic islets

    Osmark, P., Hansson, O., Jonsson, Anna Elisabet, Rönn, T., Groop, L. & Renström, E., May 2009, In: Diabetologia. 52, 5, p. 850-4 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Intensified multifactorial treatment of patients with Type 2 diabetes: what can be achieved and does it pay off?

    Pedersen, Oluf Borbye, 2009, In: Journal of Diabetes. 1, 2, p. 83-9 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes

    Perry, J. R. B., Weedon, M. N., Langenberg, C., Jackson, A. U., Lyssenko, V., Sparsø, T., Thorleifsson, G., Grallert, H., Ferrucci, L., Maggio, M., Paolisso, G., Walker, M., Palmer, C. N. A., Payne, F., Young, E., Herder, C., Narisu, N., Morken, M. A., Bonnycastle, L. L., Owen, K. R. & 38 others, Shields, B., Knight, B., Bennett, A., Groves, C. J., Ruokonen, A., Jarvelin, M. R., Pearson, E., Pascoe, L., Ferrannini, E., Bornstein, S. R., Stringham, H. M., Scott, L. J., Kuusisto, J., Nilsson, Carl Martin Peter, Neptin, M., Gjesing, A. P., Pisinger, C., Lauritzen, T., Sandbaek, A., Sampson, M., Zeggini, M. E., Lindgren, C. M., Steinthorsdottir, V., Thorsteinsdottir, U., Hansen, T., Schwarz, Peter, Illig, T., Laakso, M., Stefansson, K., Morris, A. D., Groop, L., Pedersen, Oluf Borbye, Boehnke, M., Barroso, I., Wareham, N. J., Hattersley, A. T., McCarthy, M. I. & Frayling, T. M., 2009, In: Human Molecular Genetics. 19, 3, p. 535-44 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men

    Pilgaard, K., Jensen, C., Schou, J., Lyssenko, V., Wegner, L., Brøns, C., Vilsbøll, T., Hansen, T., Madsbad, S., Holst, J., Vølund, A., Poulsen, P., Groop, L., Pedersen, O., Vaag, A., Pilgaard, K., Jensen, C. B., Schou, J. H., Lyssenko, V., Wegner, L. & 10 others, Brøns, C., Vilsbøll, T., Hansen, T., Madsbad, Sten, Holst, J. M., Vølund, A., Poulsen, P., Groop, L., Pedersen, O. & Vaag, A., 1 Jul 2009, In: Diabetologia. 52, 7, p. 1298-307 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes

    Pulizzi, N., Lyssenko, V., Jonsson, Anna Elisabet, Osmond, C., Laakso, M., Kajantie, E., Barker, D. J., Groop, L. C. & Eriksson, J. G., May 2009, In: Diabetologia. 52, 5, p. 825-9 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    IDENTIFICATION OF NOVEL VARIANTS IN THE HEPATOCYTE NUCLEAR FACTOR 1 ALPHA GENE IN SOUTH INDIAN PATIENTS WITH MATURITY ONSET DIABETES OF YOUNG

    Radha, V., Ek, J., Anuradha, S., Hansen, T., Pedersen, Oluf Borbye & Mohan, V., 2009, In: Journal of Clinical Endocrinology and Metabolism. 6, p. 1959-65

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Identification of novel variants in the hepatocyte nuclear factor-1alpha gene in South Indian patients with maturity onset diabetes of young

    Radha, V., Ek, J., Anuradha, S., Hansen, T., Pedersen, Oluf Borbye & Mohan, V., 2009, In: Journal of Clinical Endocrinology and Metabolism. 94, 6, p. 1959-1965 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Genetic and clinical profile of Indian patients of idiopathic restrictive cardiomyopathy with and without hypertrophy

    Rai, T. S., Ahmad, S., Ahluwalia, Tarun Veer Singh, Ahuja, M., Bahl, A., Saikia, U. N., Singh, B., Talwar, K. K. & Khullar, M., Nov 2009, In: Developments in Molecular and Cellular Biochemistry. 331, 1-2, p. 187-92 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Genotype phenotype correlations of cardiac beta-myosin heavy chain mutations in Indian patients with hypertrophic and dilated cardiomyopathy

    Rai, T. S., Ahmad, S., Bahl, A., Ahuja, M., Ahluwalia, Tarun Veer Singh, Singh, B., Talwar, K. K. & Khullar, M., Jan 2009, In: Molecular and Celluar Biochemistry. 321, 1-2, p. 189-96 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Association of polymorphisms of the CHI3L1 gene with asthma and atopy: a populations-based study of 6514 Danish adults

    Rathcke, C. N., Holmkvist, J., Husmoen, L. L. N., Hansen, T., Pedersen, Oluf Borbye, drb459, drb459 & Linneberg, Allan René, 2009, In: PLoS ONE. 4, 7, p. e6106

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Variation in CHI3LI in relation to type 2 diabetes and related quantitative traits

    Rathcke, C. N., Holmkvist, J., Jørgensen, T., Borch-Johnsen, K., Hansen, T., Pedersen, Oluf Borbye & drb459, drb459, 2009, In: PLoS ONE. 4, 5, p. e5469

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: The DAMAGE study

    Reiling, E., van Vliet-Ostaptchouk, J. V., van 't Riet, E., van Haeften, T. W., Arp, P. A., Hansen, Torben, Kremer, D., Groenewoud, M. J., van Hove, E. C., Romijn, J. A., Smit, J. W. A., Nijpels, G., Heine, R. J., Uitterlinden, A. G., Pedersen, Oluf Borbye, Slagboom, P. E., Maassen, J. A., Hofker, M. H., 't Hart, L. M. & Dekker, J. M., 2009, In: European Journal of Human Genetics. 17, 8, p. 1056-1062 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads

    Rose, C. S., Grarup, N., Krarup, N. T., Poulsen, P., Wegner, L., Nielsen, T., Banasik, Karina, Faerch, K., Andersen, G., Albrechtsen, Anders, Borch-Johnsen, K., Clausen, J. O., Jørgensen, T., Vaag, Allan, Pedersen, Oluf Borbye & Hansen, Torben, 2009, In: Diabetologia. 52, 10, p. 2122-2129 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

    Rung, J., Cauchi, S., Albrechtsen, A., Shen, L., Rocheleau, G., Cavalcanti-Proença, C., Bacot, F., Balkau, B., Belisle, A., Borch-Johnsen, K., Charpentier, G., Dina, C., Durand, E., Elliott, P., Hadjadj, S., Järvelin, M-R., Laitinen, J., Lauritzen, T., Marre, M., Mazur, A. & 20 others, Meyre, D., Montpetit, A., Pisinger, C., Posner, B., Poulsen, P., Pouta, A., Prentki, M., Ribel-Madsen, R., Ruokonen, A., Sandbaek, A., Serre, D., Tichet, J., Vaxillaire, M., Wojtaszewski, Jørgen F P, Vaag, Allan, Hansen, T., Polychronakos, C., Pedersen, Oluf Borbye, Froguel, P. & Sladek, R., 2009, In: Nature Genetics. 41, 10, p. 1110-1115 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

    Schafer, Z. T., Grassian, A. R., Song, L., Jiang, Z., Gerhart-Hines, Zach, Irie, H. Y., Gao, S., Puigserver, P. & Brugge, J. S., 3 Sep 2009, In: Nature. 461, 7260, p. 109-113 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Long-term exendin-4 treatment delays natural deterioration of glycaemic control in diabetic Goto-Kakizaki rats

    Simonsen, L., Pilgaard, S., Orskov, C., Hartmann, Bolette, Holst, Jens Juul & Deacon, Carolyn F., 2009, In: Diabetes, Obesity and Metabolism. 11, 9, p. 884-90 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene-gene interaction

    Sparsø, T., Grarup, N., Andreasen, C., Albrechtsen, A., Holmkvist, J., Andersen, G., Jørgensen, T., Borch-Johnsen, K., Sandbaek, A., Lauritzen, T., Madsbad, S., Hansen, T., Pedersen, O., Sparsø, T., Grarup, N., Andreasen, C., Albrechtsen, A., Holmkvist, J., Andersen, G., Jørgensen, T. & 6 others, Borch-Johnsen, K., Sandbaek, A., Lauritzen, T., Madsbad, Sten, Hansen, T. & Pedersen, O., 2009, In: Diabetologia. 52, 7, p. 1308-14 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans

    Sparsø, T., Bonnefond, A., Andersson, E., Bouatia-Naji, N., Holmkvist, J., Wegner, L., Grarup, N., Gjesing, A. P., Banasik, K., Cavalcanti-Proença, C., Marchand, M., Vaxillaire, M., Charpentier, G., Jarvelin, M-R., Tichet, J., Balkau, B., Marre, M., Lévy-Marchal, C., Faerch, K., Borch-Johnsen, K. & 36 others, Jørgensen, T., Madsbad, Sten, Poulsen, P., Vaag, Allan, Dina, C., Hansen, T., Pedersen, Oluf Borbye, Froguel, P., Sparsø, T., Bonnefond, A., Andersson, E., Bouatia-Naji, N., Holmkvist, J., Wegner, L., Grarup, N., Gjesing, A. P., Banasik, K., Cavalcanti-Proença, C., Marchand, M., Vaxillaire, M., Charpentier, G., Jarvelin, M., Tichet, J., Balkau, B., Marre, M., Lévy-Marchal, C., Faerch, K., Borch-Johnsen, K., Jørgensen, T., Madsbad, Sten, Poulsen, P., Vaag, A., Dina, C., Hansen, T., Pedersen, O. & Froguel, P., 2009, In: Diabetes. 58, 6, p. 1450-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells

    Suchankova, G., Nelson, L. E., Gerhart-Hines, Zach, Kelly, M., Gauthier, M. S., Saha, A. K., Ido, Y., Puigserver, P. & Ruderman, N. B., 23 Jan 2009, In: Biochemical and Biophysical Research Communications. 378, 4, p. 836-841 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

    Thorleifsson, G., Walters, G. B., Gudbjartsson, D. F., Steinthorsdottir, V., Sulem, P., Helgadottir, A., Styrkarsdottir, U., Gretarsdottir, S., Thorlacius, S., Jonsdottir, I., Jonsdottir, T., Olafsdottir, E. J., Olafsdottir, G. H., Jonsson, T., Jonsson, F., Borch-Johnsen, K., Hansen, T., Andersen, G., Jørgensen, T., Lauritzen, T. & 15 others, Aben, K. K., Verbeek, A. L. M., Roeleveld, N., Kampman, E., Yanek, L. R., Becker, L. C., Tryggvadottir, L., Rafnar, T., Becker, D. M., Gulcher, J., Kiemeney, L. A., Pedersen, Oluf Borbye, Kong, A., Thorsteinsdottir, U. & Stefansson, K., 2009, In: Nature Genetics. 41, 1, p. 18-24 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Mutations in the VNTR of the carboxyl-ester lipase gene (CEL) are a rare cause of monogenic diabetes

    Torsvik, J., Johansson, S., Johansen, A., Ek, J., Minton, J., Raeder, H., Ellard, S., Hattersley, A., Pedersen, Oluf Borbye, Hansen, T., Molven, A. & Njølstad, P. R., 2009, In: Human Genetics. 127, 1, p. 55-64 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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