Novo Nordisk Foundation Center for Basic Metabolic Research

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  1. 2011
  2. Published

    Gastric emptying, glucose metabolism and gut hormones: evaluation of a common preoperative carbohydrate beverage

    Vermeulen, M. A. R., Richir, M. C., Garretsen, M. K., van Schie, A., Ghatei, M. A., Holst, Jens Juul, Heijboer, A. C., Uitdehaag, B. M. J., Diamant, M., Eekhoff, E. M. W., van Leeuwen, P. A. M. & Ligthart-Melis, G. C., Sep 2011, In: Nutrition. 27, 9, p. 897-903 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Pleiotropic effects of GIP on islet function involve osteopontin

    Lyssenko, V., Eliasson, L., Kotova, O., Pilgaard, K., Wierup, N., Salehi, A., Wendt, A., Jonsson, A. E., De Marinis, Y. Z., Berglund, L. M., Taneera, J., Balhuizen, A., Hansson, O., Osmark, P., Dunér, P., Brøns, C., Stancáková, A., Kuusisto, J., Bugliani, M., Saxena, R. & 19 others, Ahlqvist, E., Kieffer, T. J., Tuomi, T., Isomaa, B., Melander, O., Sonestedt, E., Orho-Melander, M., Nilsson, P., Bonetti, S., Bonadonna, R., Miccoli, R., Delprato, S., Marchetti, P., Madsbad, Sten, Poulsen, P., Vaag, Allan, Laakso, M., Gomez, M. F. & Groop, L., Sep 2011, In: Diabetes. 60, 9, p. 2424-33 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Postprandial insulin secretion after gastric bypass surgery: the role of glucagon-like peptide 1

    Holst, Jens Juul, Sep 2011, In: Diabetes. 60, 9, p. 2203-2205 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Structural biology: snapshot of a signalling complex.

    Schwartz, Thue W. & Sakmar, T., Sep 2011, In: Nature.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

    Jing, E., Emanuelli, Brice, Hirschey, M. D., Boucher, J., Lee, K. Y., Lombard, D., Verdin, E. M. & Kahn, C. R., 30 Aug 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 35, p. 14608-13 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Administration of a dipeptidyl peptidase IV inhibitor enhances the intestinal adaptation in a mouse model of short bowel syndrome

    Okawada, M., Holst, Jens Juul & Teitelbaum, D. H., Aug 2011, In: Surgery. 150, 2, p. 217-223 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies

    Vassy, J. L., Shrader, P., Jonsson, Anna Elisabet, Fox, C. S., Lyssenko, V., Isomaa, B., Groop, L., Meigs, J. B. & Franks, P. W., Aug 2011, In: Diabetes Research and Clinical Practice. 93, 2, p. e76-9

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Child overweight - mothers' competence to take action

    Brødsgaard, A., Wagner, L., Peitersen, B., Poulsen, I. & Sørensen, Thorkild I.A., Aug 2011, In: Obesity Facts. 4, 4, p. 305-11 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Chronic care treatment of obese children and adolescents

    Holm, Jens-Christian, Gamborg, M., Bille, D. S., Gr Nb K, H. N., Ward, L. C. & Faerk, J., Aug 2011, In: International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity. 6, 3-4, p. 188-96 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Incretin hormone and insulin responses to oral versus intravenous lipid administration in humans

    Lindgren, O., Carr, R. D., Deacon, Carolyn F., Holst, Jens Juul, Pacini, G., Mari, A. & Ahrén, B., Aug 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 8, p. 2519-2524 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Loss of inverse relationship between pulsatile insulin and glucagon secretion in patients with type 2 diabetes

    Menge, B. A., Grüber, L., Jørgensen, S. M., Deacon, Carolyn F., Schmidt, W. E., Veldhuis, J. D., Holst, Jens Juul & Meier, J. J., Aug 2011, In: Diabetes. 60, 8, p. 2160-2168 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Physiological and pharmacological mechanisms through which the DPP-4 inhibitor sitagliptin regulates glycemia in mice

    Waget, A., Cabou, C., Masseboeuf, M., Cattan, P., Armanet, M., Karaca, M., Castel, J., Garret, C., Payros, G., Maida, A., Sulpice, T., Holst, Jens Juul, Drucker, D. J., Magnan, C. & Burcelin, R., Aug 2011, In: Endocrinology. 152, 8, p. 3018-3029 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Phosphorylation and Acetylation of Acyl-CoA Synthetase- I

    Frahm, J. L., Li, L. O., Grevengoed, Trisha Jean & Coleman, R. A., 22 Jul 2011, In: Journal of Proteomics & Bioinformatics. 4, 7, p. 129-137 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Comparison of Accuracy of Diabetes Risk Score and Components of the Metabolic Syndrome in Assessing Risk of Incident Type 2 Diabetes in Inter99 Cohort

    Shafizadeh, T. B., Moler, E. J., Kolberg, J. A., Nguyen, U. T., Hansen, Torben, Jørgensen, T., Pedersen, Oluf Borbye & Borch-Johnsen, K., 1 Jul 2011, In: P L o S One. 6, 7, p. e22863 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Dissociated incretin hormone response to protein versus fat ingestion in obese subjects

    Lindgren, O., Carr, R., Holst, Jens Juul, Deacon, Carolyn F. & Ahren, B., Jul 2011, In: Diabetes, Obesity and Metabolism Online. 13, 9, p. 863-865 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Four weeks of treatment with liraglutide reduces insulin dose without loss of glycemic control in type 1 diabetic patients with and without residual beta-cell function

    Kielgast, U., Krarup, T., Holst, Jens Juul, Madsbad, Sten & Krarup, T., Jul 2011, In: Diabetes Care. 34, 7, p. 1463-1468 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Glutamine reduces postprandial glycemia and augments the glucagon-like peptide-1 response in type 2 diabetes patients

    Samocha-Bonet, D., Wong, O., Synnott, E., Piyaratna, N., Douglas, A., Gribble, F. M., Holst, Jens Juul, Chisholm, D. J. & Greenfield, J. R., Jul 2011, In: Journal of Nutrition. 141, 7, p. 1233-1238 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Synaptotagmin-7 as a positive regulator of glucose-induced glucagon-like peptide-1 secretion in mice

    Gustavsson, N., Wang, Y., Kang, Y., Seah, T., Chua, S., Radda, G. K. & Han, W., Jul 2011, In: Diabetologia. 54, 7, p. 1824-30 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    KU bestemmer selv over sin forskning

    Wewer, Ulla M., Holst, Jens Juul, Schwartz, Thue W. & Quistorff, B., 2 Jun 2011, In: Universitetsavisen.

    Research output: Contribution to journal › Contribution to newspaper - Comment/debate › Communication

  21. Published

    Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse

    List, E. O., Sackmann-Sala, L., Berryman, D. E., Funk, K., Kelder, B., Gosney, E. S., Okada, S., Ding, J., Cruz-Topete, D. & Kopchick, J. J., 1 Jun 2011, In: Endocrine Reviews. 32, 3, p. 356-386 31 p.

    Research output: Contribution to journal › Review › Research › peer-review

  22. Published

    Implications of central obesity-related variants in LYPLAL1, NRXN3, MSRA, and TFAP2B on quantitative metabolic traits in adult Danes

    Bille, D. S., Banasik, Karina, Justesen, Johanne Marie, Sandholt, C. H., Sandbæk, A., Lauritzen, T., Jørgensen, T., Witte, D. R., Holm, Jens-Christian, Hansen, Torben & Pedersen, Oluf Borbye, 1 Jun 2011, In: P L o S One. 6, 6, p. e20640 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Retinol-Binding Protein 4 in Young Men With Low Versus Normal Birth Weight: Physiological Response to Short-Term Overfeeding

    Ribel-Madsen, R., Brøns, C., Friedrichsen, M., Poulsen, P. & Vaag, Allan, 1 Jun 2011, In: Obesity. 19, 6, p. 1304-1306 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Inhibition of glucagon secretion by GLP-1 agonists and DPP4 inhibitors

    Hansen, M., Juul Hare, K., Holst, Jens Juul & Knop, Filip Krag, Jun 2011, In: Journal of Clinical Metabolism & Diabetes. 2, 2, p. 7-13 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Nutritional status affects the epigenomic profile of peripheral blood cells

    Zierath, Juleen R & Barrès, Romain, Jun 2011, In: Epigenomics. 3, 3, p. 259-60 2 p.

    Research output: Contribution to journal › Journal article › Communication

  26. Published

    PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans

    Bezy, O., Tran, T. T., Pihlajamäki, J., Suzuki, R., Emanuelli, Brice, Winnay, J., Mori, M. A., Haas, J., Biddinger, S. B., Leitges, M., Goldfine, A. B., Patti, M. E., King, G. L. & Kahn, C. R., Jun 2011, In: The Journal of Clinical Investigation. 121, 6, p. 2504-17 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Common variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes.

    Ahluwalia, Tarun Veer Singh, Lindholm, E. & Groop, L., 15 May 2011, In: Diabetologia.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Familial mild hyperglycemia associated with a novel ABCC8-V84I mutation within three generations

    Gonsorcikova, L., Vaxillaire, M., Pruhova, S., Dechaume, A., Dusatkova, P., Cinek, O., Pedersen, Oluf Borbye, Froguel, P., Hansen, Torben & Lebl, J., 1 May 2011, In: Pediatric Diabetes. 12, 3pt2, p. 266-9 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release

    Nielsen, T., Sparsø, T., Grarup, N., Jørgensen, T., Pisinger, C. H., Witte, D. R., Hansen, T., Pedersen, Oluf Borbye & Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, D. G. R. A. M. (. C., 1 May 2011, In: Diabetologica. 54, 5, p. 1052-6 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    An overview of once-weekly glucagon-like peptide-1 receptor agonists--available efficacy and safety data and perspectives for the future

    Madsbad, Sten, Kielgast, U., Asmar, M., Deacon, Carolyn F., Torekov, Signe Sørensen & Holst, Jens Juul, May 2011, In: Diabetes, Obesity and Metabolism. 13, 5, p. 394-407 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Antidiabetic actions of endogenous and exogenous GLP-1 in type 1 diabetic patients with and without residual ß-cell function

    Kielgast, U., Holst, Jens Juul & Madsbad, Sten, May 2011, In: Diabetes. 60, 5, p. 1599-1607 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    In cirrhotic patients reduced muscle strength is unrelated to muscle capacity for ATP turnover suggesting a central limitation

    Gam, C. M. B., Nielsen, H. B., Secher, Niels H., Larsen, F. S., Ott, P. & Quistorff, B., May 2011, In: Clinical Physiology and Functional Imaging. 31, 3, p. 169-74 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Loss of Incretin Effect Is a Specific, Important, and Early Characteristic of Type 2 Diabetes

    Holst, Jens Juul, Knop, Filip Krag, Vilsbøll, Tina, Krarup, T. & Madsbad, Sten, May 2011, In: Diabetes Care. 34, Supplement 2, p. S251-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Neuroethics and fMRI: Mapping a fledgling relationship

    Garnett, A., Whiteley, Louise, Piwowar, H., Rasmussen, E. & Illes, J., 22 Apr 2011, In: P L o S One. 6, 4, p. e18537

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Meta-analysis of heterogeneous data sources for genome-scale identification of risk genes in complex phenotypes

    Pers, T. H., Hansen, N. T., Hansen, K. L., Koefoed, P., Dworzynski, P., Miller, M. L., Flint, T. J., Mellerup, E., Dam, H., Andreassen, O. A., Djurovic, S., Melle, I., Børglum, A. D., Werge, T., Purcell, S., Ferreira, M. A., Kouskoumvekaki, I., Workman, C., Hansen, T., Mors, O. & 1 others, Brunak, Søren, 11 Apr 2011, In: Genetic Epidemiology. 35, 5, p. 318-332 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Childhood overweight after establishment of the gut microbiota: the role of delivery mode, pre-pregnancy weight and early administration of antibiotics

    Adeltoft, T. A., Andersen, C. S., Gamborg, Michael Orland, Sørensen, Thorkild I.A. & Riis, J. T., 1 Apr 2011, In: International Journal of Obesity. 35, 4, p. 522-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    DNA methylation in metabolic disorders

    Barrès, Romain & Zierath, Juleen R, 1 Apr 2011, In: American Journal of Clinical Nutrition. 93, 4, p. 897S-900

    Research output: Contribution to journal › Review › Research › peer-review

  38. Published

    IL-6 has no acute effect on the regulation of urea synthesis in vivo in rats

    Thomsen, K., Aagaard, N. K., Grønbæk, H., Holst, Jens Juul, Jessen, N., Frystyk, J. & Vilstrup, H., Apr 2011, In: Scandinavian Journal of Clinical & Laboratory Investigation. 71, 2, p. 150-156 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Inhibition de la sécrétion du glucagon par les antagonistes du GLP-1 et les inhibiteurs de la DPP-4

    Hansen, M., Knop, Filip Krag & Holst, Jens Juul, Apr 2011, In: Medecine des Maladies Metaboliques. 5, 2

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism

    Feng, D., Liu, T., Sun, Z., Bugge, A. S., Mullican, S. E., Alenghat, T., Liu, X. S. & Lazar, M. A., 11 Mar 2011, In: Science (New York, N.Y.). 331, 6022, p. 1315-9 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Heritability of optic disc diameters: a twin study

    Drobnjak, D., Taarnhøj, N. C., Mitchell, P., Wang, J. J., Tan, A., Kessel, Line, Hougaard, J., Sørensen, Thorkild I.A. & Larsen, Michael, 1 Mar 2011, In: Acta Ophthamologica (Online). 89, 2, p. e193-8

    Research output: Contribution to journal › Journal article › Research

  42. Published

    Influence of psychosocial factors on postpartum weight retention

    Pedersen, P., Baker, J. L., Henriksen, T. B., Lissner, L., Heitmann, B. L., Sørensen, Thorkild I.A., Nohr, E. A. & Pedersen, P., 1 Mar 2011, In: Obesity. 19, 3, p. 639-46 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity

    Mashili, F. L., Austin, R. L., Deshmukh, Atul Shahaji, Fritz, T., Caidahl, K., Bergdahl, K., Zierath, Juleen R, Chibalin, A. V., Moller, D. E., Kharitonenkov, A. & Krook, A., Mar 2011, In: Diabetes - Metabolism: Research and Reviews (Print Edition). 27, 3, p. 286-97 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Plasma levels of glucagon like peptide-1 associate with diastolic function in elderly men

    Nathanson, D., Zethelius, B., Berne, C., Lind, L., Andrén, B., Ingelsson, E., Holst, Jens Juul & Nyström, T., Mar 2011, In: Diabetic Medicine. 28, 3, p. 301-305 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Structure and stability of the spinach aquaporin SoPIP2;1 in detergent micelles and lipid membranes

    Plasencia, I., Survery, S., Ibragimova, S., Hansen, J. S., Kjellbom, P., Helix-Nielsen, C., Johanson, U. & Mouritsen, Ole G., 28 Feb 2011, In: PLoS ONE. 6, 2, e14674.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Birthweight and mortality in adulthood: a systematic review and meta-analysis

    Risnes, K. R., Vatten, L. J., Baker, J. L., Jameson, K., Sovio, U., Kajantie, E., Osler, Merete, Morley, R., Jokela, M., Painter, R. C., Sundh, V., Jacobsen, G. W., Eriksson, J. G., Sørensen, Thorkild I.A., Bracken, M. B. & Jacobsen, G. W., 15 Feb 2011, In: International Journal of Epidemiology. 40, 3, p. 647-661

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Body composition and body fat distribution in relation to later risk of acute myocardial infarction: a Danish follow-up study

    Stegger, J., Schmidt, E. B., Obel, T., Berentzen, T. L., Tjønneland, A., Sørensen, Thorkild I.A. & Overvad, K., 1 Feb 2011, In: International Journal of Obesity.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Delayed onset of hyperglycaemia in a mouse model with impaired glucagon secretion demonstrates that dysregulated glucagon secretion promotes hyperglycaemia and type 2 diabetes

    Gustavsson, N., Seah, T., Lao, Y., Radda, G. K., Südhof, T. C. & Han, W., Feb 2011, In: Diabetologia. 54, 2, p. 415-22 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load

    Hornbak, M., Banasik, Karina, Justesen, Johanne Marie, Krarup, N. T., Sandholt, C. H., Andersson, Åsa, Sandbaek, A., Lauritzen, T., Pisinger, C., Witte, D. R., Sørensen, Thorkild I.A., Pedersen, Oluf Borbye & Hansen, Torben, 6 Jan 2011, In: BMC Medical Genetics. 12, 1, p. 4 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    A germline variant in the TP53 polyadenylation signal confers cancer susceptibility

    Stacey, S. N., Sulem, P., Jonasdottir, A., Masson, G., Gudmundsson, J., Gudbjartsson, D. F., Magnusson, O. T., Gudjonsson, S. A., Sigurgeirsson, B., Thorisdottir, K., Ragnarsson, R., Benediktsdottir, K. R., Nexø, B. A., Tjønneland, A., Overvad, K., Rudnai, P., Gurzau, E., Koppova, K., Hemminki, K., Corredera, C. & 31 others, Fuentelsaz, V., Grasa, P., Navarrete, S., Fuertes, F., García-Prats, M. D., Sanambrosio, E., Panadero, A., De Juan, A., Garcia, A., Rivera, F., Planelles, D., Soriano, V., Requena, C., Aben, K. K., van Rossum, M. M., Cremers, R. G. H. M., van Oort, I. M., van Spronsen, D., Schalken, J. A., Peters, W. H. M., Helfand, B. T., Donovan, J. L., Hamdy, F. C., Badescu, D., Codreanu, O., Banasik, Karina, Jørgensen, T., Witte, D. R., Hansen, Torben, Pedersen, Oluf Borbye & Swedish Low-risk Colorectal Cancer Study Group, S. L. C. C. S. G., 1 Jan 2011, In: Nature Genetics. 43, 11, p. 1098-1103 6 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  51. Published

    A possible association between a dysfunctional skin barrier (filaggrin null-mutation status) and diabetes: a cross-sectional study

    Thyssen, Jacob Pontoppidan, Linneberg, Allan René, Carlsen, B. C., Johansen, Jeanne Duus, Engkilde, K., Hansen, Torben, Pociot, Flemming, Pedersen, Oluf Borbye, Meldgaard, M., Szecsi, P. B., Stender, Steen & Menné, T., 1 Jan 2011, In: BMJ Open. 1, 1, p. e000062 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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