Novo Nordisk Foundation Center for Basic Metabolic Research

  1. Published

    Structure-based discovery of novel US28 small molecule ligands with different modes of action

    Lückmann, Michael, Amarandi, R., Papargyri, N., Jakobsen, M. H., Ulven, Elisabeth Rexen, Jensen, Lars Juhl, Pui, A., Schwartz, Thue W., Rosenkilde, Mette & Frimurer, Thomas Michael, 2017, In: Chemical Biology & Drug Design. 89, 3, p. 289–296

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Structure-Activity Studies of 3,9-Diazaspiro[5.5]undecane-Based ?-Aminobutyric Acid Type A Receptor Antagonists with Immunomodulatory Effect

    Bavo, Francesco, De-Jong, H., Petersen, Jonas Odgaard, Falk-Petersen, C. B., Löffler, R., Sparrow, E., Rostrup, F., Eliasen, Jannik Nicklas, Wilhelmsen, K. S., Barslund, K., Bundgaard, C., Nielsen, Birgitte, Kristiansen, Uffe, Wellendorph, Petrine, Bogdanov, Y. & Frølund, Bente, 2021, In: Journal of Medicinal Chemistry. 64, 24, p. 17795-17812

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Structure-Activity Relationships and Identification of Optmized CC-Chemokine Receptor CCR1, 5, and 8 Metal-Ion Chelators

    Chalikiopoulos, A., Thiele, S., Malmgaard-Clausen, M., Rydberg, P., Isberg, V., Ulven, Trond, Frimurer, Thomas Michael, Rosenkilde, Mette & Gloriam, David E., 25 Nov 2013, In: Journal of Chemical Information and Modeling. 53, 11, p. 2863-73 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1

    Ulven, Elisabeth Rexen, Trauelsen, Mette, Brvar, M., Lückmann, Michael, Bielefeldt, L. Ø., Jensen, L. K. I., Schwartz, Thue W. & Frimurer, Thomas Michael, 2018, In: Scientific Reports. 8, 1, p. 1-18 10010.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Structure and stability of the spinach aquaporin SoPIP2;1 in detergent micelles and lipid membranes

    Plasencia, I., Survery, S., Ibragimova, S., Hansen, J. S., Kjellbom, P., Helix-Nielsen, C., Johanson, U. & Mouritsen, Ole G., 28 Feb 2011, In: PLoS ONE. 6, 2, e14674.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published
  7. Published

    Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production

    Venskutonytė, R., Koh, A., Stenström, O., Khan, M. T., Lundqvist, A., Akke, M., Bäckhed, F. & Lindkvist-Petersson, K., 2021, In: Nature Communications. 12, 1, 1 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Structural changes at the myrtenol backbone reverse its positive allosteric potential into inhibitory GABAA receptor modulation

    Milanos, S., Kuenzel, K., Gilbert, D. F., Janzen, D., Sasi, M., Buettner, A., Frimurer, Thomas Michael & Villmann, C., 2018, In: Biological Chemistry. 399, 6, p. 549-563 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Structural biology: snapshot of a signalling complex.

    Schwartz, Thue W. & Sakmar, T., Sep 2011, In: Nature.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Structural biology: Full monty of family B GPCRs

    Schwartz, Thue W. & Frimurer, Thomas Michael, 2017, In: Nature Chemical Biology. 13, 8, p. 819-821

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Structural basis for constitutive activity and agonist-induced activation of the enteroendocrine fat sensor GPR119

    Engelstoft, M. S., Norn, C., Pedersen, M. H., Holliday, N. D., Elster, L., Lehmann, J., Jones, R. M., Frimurer, Thomas Michael & Schwartz, Thue W., Dec 2014, In: British Journal of Pharmacology. 171, 24, p. 5774-89 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Structural basis for GPCR signaling by small polar versus large lipid metabolites-discovery of non-metabolite ligands

    Lückmann, Michael, Trauelsen, Mette, Frimurer, Thomas Michael & Schwartz, Thue W., 2020, In: Current Opinion in Cell Biology. 63, p. 38-48

    Research output: Contribution to journalReviewResearchpeer-review

  13. Published

    Structural and functional development of small intestine in intrauterine growth retarded porcine offspring born to gilts fed diets with differing protein ratios throughout pregnancy

    Mickiewicz, M., Zabielski, R., Grenier, B., Le Normand, L., Savary, G., Holst, Jens Juul, Oswald, I. P., Metges, C. C. & Guilloteau, P., 2012, In: Journal of Physiology and Pharmacology. 63, 3, p. 225-39 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease

    Gupta, Y., Friedman, D. J., McNulty, M. T., Khan, A., Lane, B., Wang, C., Ke, J., Jin, G., Wooden, B., Knob, A. L., Lim, T. Y., Appel, G. B., Huggins, K., Liu, L., Mitrotti, A., Stangl, M. C., Bomback, A., Westland, R., Bodria, M., Marasa, M. & 60 others, Shang, N., Cohen, D. J., Crew, R. J., Morello, W., Canetta, P., Radhakrishnan, J., Martino, J., Liu, Q., Chung, W. K., Espinoza, A., Luo, Y., Wei, W., Feng, Q., Weng, C., Fang, Y., Kullo, I. J., Naderian, M., Limdi, N., Irvin, M. R., Tiwari, H., Mohan, S., Rao, M., Dube, G. K., Chaudhary, N. S., Gutiérrez, O. M., Judd, S. E., Cushman, M., Lange, L. A., Lange, E. M., Bivona, D. L., Verbitsky, M., Winkler, C. A., Kopp, J. B., Santoriello, D., Batal, I., Pinheiro, S. V. B., Oliveira, E. A., Simoes e Silva, A. C., Pisani, I., Fiaccadori, E., Lin, F., Gesualdo, L., Amoroso, A., Ghiggeri, G. M., D’Agati, V. D., Magistroni, R., Kenny, E. E., Loos, Ruth, Montini, G., Hildebrandt, F., Paul, D. S., Petrovski, S., Goldstein, D. B., Kretzler, M., Gbadegesin, R., Gharavi, A. G., Kiryluk, K., Sampson, M. G., Pollak, M. R. & Sanna-Cherchi, S., 2023, In: Nature Communications. 14, 8 p., 7836.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Stress hormone release is a key component of the metabolic response to lipopolysaccharide (LPS): studies in hypopituitary and healthy subjects

    Bach, E., Møller, A. B., Jorgensen, J. O. L., Vendelbo, M. H., Jessen, N., Pedersen, S. B., Nielsen, Thomas Svava & Møller, N., 25 Aug 2016, In: European Journal of Endocrinology. 175, 5, p. 455-465 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Strenuous physical exercise adversely affects monocyte chemotaxis

    Czepluch, F. S., Barrès, Romain, Caidahl, K., Olieslagers, S., Krook, A., Rickenlund, A., Zierath, Juleen R & Waltenberger, J., Jan 2011, In: Thrombosis and Haemostasis. 105, 1, p. 122-30 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers

    Taylor, A. E., Morris, R. W., Fluharty, M. E., Bjorngaard, J. H., Åsvold, B. O., Gabrielsen, M. E., Campbell, A., Marioni, R., Kumari, M., Hällfors, J., Männistö, S., Marques-Vidal, P., Kaakinen, M., Cavadino, A., Postmus, I., Husemoen, L. L. N., Skaaby, T., Ahluwalia, T. V. S., Treur, J. L., Willemsen, G. & 44 others, Dale, C., Wannamethee, S. G., Lahti, J., Palotie, A., Räikkönen, K., Kisialiou, A., McConnachie, A., Padmanabhan, S., Wong, A., Dalgård, C., Paternoster, L., Ben-Shlomo, Y., Tyrrell, J., Horwood, J., Fergusson, D. M., Kennedy, M. A., Frayling, T., Nohr, E. A., Christiansen, L., Ohm Kyvik, K., Kuh, D., Watt, G., Eriksson, J., Whincup, P. H., Vink, J. M., Boomsma, D. I., Davey Smith, G., Lawlor, D., Linneberg, Allan René, Ford, I., Jukema, J. W., Power, C., Hyppönen, E., Jarvelin, M., Preisig, M., Borodulin, K., Kaprio, J., Kivimaki, M., Smith, B. H., Hayward, C., Romundstad, P. R., Sørensen, Thorkild I.A., Munafò, M. R. & Sattar, N., Dec 2014, In: P L o S Genetics. 10, 12, p. 1-6 6 p., e1004799.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Strategies for conditional two-locus nonparametric linkage analysis

    Ängquist, Lars, Hössjer, O. & Groop, L., 1 Jul 2008, In: Human Heredity. 66, 3, p. 138-156 19 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Stool energy density is positively correlated to intestinal transit time and related to microbial enterotypes

    Boekhorst, J., Venlet, N., Procházková, Nicola, Hansen, M. L., Lieberoth, C. B., Bahl, M. I., Lauritzen, Lotte, Pedersen, Oluf Borbye, Licht, T. R., Kleerebezem, M. & Roager, Henrik Munch, 2022, In: Microbiome. 10, 10 p., 223.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published
  21. Published

    Stimulation of the Bile Acid Receptor Tgr5 Promotes Intestinal Growth

    Dal, Jenna Elizabeth Hunt, Hartmann, Bolette, Ullmer, C., Holst, Jens Juul & Kissow, Hannelouise, 1 May 2018, In: Gastroenterology. 154, 6 (S1), 1 p., S-333.

    Research output: Contribution to journalConference abstract in journalResearch

  22. Published

    Stimulation of intestinal growth and function with DPP-IV inhibition in a mouse short bowel syndrome model

    Sueyoshi, R., Ignatoski, K. M. W., Okawada, M., Hartmann, Bolette, Holst, Jens Juul & Teitelbaum, D. H., 26 Jun 2014, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 307, 4, p. G410-19 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Steroid-induced insulin resistance and impaired glucose tolerance are both associated with a progressive decline of incretin effect in first-degree relatives of patients with type 2 diabetes

    Jensen, D. H., Aaboe, K., Henriksen, J. E., Vølund, A., Holst, Jens Juul, Madsbad, Sten & Krarup, T., 2012, In: Diabetologia. 55, 5, p. 1406-16 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Steno-2-studiet: intensiv multifaktoriel behandling reducerer forekomsten af kardiovaskulaer sygdom hos patienter med type 2-diabetes

    Gaede, P. H., Jepsen, P. V., Larsen, J. N. B., Jensen, G. V., Parving, H. & Pedersen, Oluf Borbye, 2003, In: Ugeskrift for Laeger. 165, 26, p. 2658-61 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Stella modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition

    Huang, Yun, Kim, J. K., Do, D. V., Lee, C., Penfold, C. A., Zylicz, Jan Jakub, Marioni, J. C., Hackett, J. A. & Surani, M. A., 21 Mar 2017, In: eLife. 6, e22345.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Staying strong during hibernation

    Sommer, F. & Bäckhed, F., 2022, In: Science. 375, 6579, p. 376-377 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Statins for cirrhosis: almost ready for clinical application

    Kimer, N., Kronborg, T. M., Bendtsen, Flemming & Møller, Søren, 2020, In: Digestive Medicine Research. 3, 4 p., 111.

    Research output: Contribution to journalEditorialResearch

  28. Published

    Statins are independently associated with increased HbA1c in type 1 diabetes: The Thousand & 1 Study

    Jensen, M. T., Andersen, H. U., Rossing, Peter & Jensen, J. S., Jan 2016, In: Diabetes Research and Clinical Practice. 111, p. 51–57

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Statin therapy is associated with lower prevalence of gut microbiota dysbiosis

    Vieira-Silva, S., Falony, G., Belda, E., Nielsen, T., Aron-Wisnewsky, J., Chakaroun, R., Forslund, S. K., Assmann, K., Valles-Colomer, M., Nguyen, T. T. D., Proost, S., Prifti, E., Tremaroli, V., Pons, N., Le Chatelier, E., Andreelli, F., Bastard, J-P., Coelho, L. P., Galleron, N., Hansen, T. H. & 28 others, Hulot, J., Lewinter, C., Pedersen, H. K., Quinquis, B., Rouault, C., Roume, H., Salem, J., Søndertoft, N. B., Touch, S., Dumas, M., Ehrlich, S. D., Galan, P., Gøtze, J. P., Hansen, Torben, Holst, Jens Juul, Køber, Lars Valeur, Letunic, I., Nielsen, J., Oppert, J., Stumvoll, M., Vestergaard, H., Zucker, J., Bork, P., Pedersen, Oluf Borbye, Bäckhed, F., Clément, K., Raes, J. & MetaCardis Consortium, M. C., 2020, In: Nature. 581, 7808, p. 310-315

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Stata tip 92: Manual implementation of permutations and bootstraps

    Ängquist, Lars, 1 Dec 2010, In: Stata Journal. 10, 4, p. 686-688 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Stata tip 117: graph combine-Combining graphs

    Ängquist, Lars, 2014, In: Stata Journal. 14, 1, p. 221-225

    Research output: Contribution to journalEditorialResearchpeer-review

  32. Published

    Standard procedures for blood withdrawal in conscious male rats induce stress and profoundly affect glucose tolerance and secretion of glucoregulatory hormones

    Pedersen, K., Andersen, H., Fledelius, C., Holst, Jens Juul, Hjuler, S. T. & Kuhre, Rune Ehrenreich, 2023, In: Molecular Metabolism. 69, 101689.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Stable intergenerational associations of childhood overweight during the development of the obesity epidemic

    Ajslev, T. A., Ängquist, Lars, Silventoinen, K., Baker, J. L. & Sørensen, Thorkild I.A., Jun 2015, In: Obesity. 23, 6, p. 1279-87 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Stability of the Associations between Early Life Risk Indicators and Adolescent Overweight over the Evolving Obesity Epidemic

    Graversen, L., Sørensen, Thorkild I.A., Petersen, L., Sovio, U., Kaakinen, M., Sandbæk, A., Laitinen, J., Taanila, A., Pouta, A., Järvelin, M. & Obel, C., 2014, In: PLOS ONE. 9, 4, p. 1-9 9 p., e95314.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Stability of glucagon-like peptide-1 and glucagon in human plasma

    Albrechtsen, Nicolai Jacob Wewer, Bak, M. J., Hartmann, Bolette, Christensen, L. W., Kuhre, Rune Ehrenreich, Deacon, Carolyn F. & Holst, Jens Juul, 16 Jan 2015, In: Endocrine Connections. 4, 1, p. 50-57 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Squeezing Flux Out of Fat

    Gonzalez-Franquesa, A. & Patti, M., 2018, In: Trends in Endocrinology and Metabolism. 29, 4, p. 201-202

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Spinal astroglial cannabinoid receptors control pathological tremor

    Carlsen, Eva Maria Meier, Falk, S., Skupio, U., Robin, L., Zottola, A. C. P., Marsicano, G. & Perrier, Jean-Francois Marie, 2021, In: Nature Neuroscience. 24, p. 658–666 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Sphingolipids Are Depleted in Alcohol-Related Liver Fibrosis

    Thiele, M., Suvitaival, T., Trošt, K., Kim, M., de Zawadzki, A., Kjaergaard, M., Rasmussen, D. N., Lindvig, K. P., Israelsen, M., Detlefsen, S., Andersen, P., Juel, H. B., Nielsen, T., Georgiou, S., Filippa, V., Kuhn, M., Nishijima, S., Moitinho-Silva, L., Rossing, P., Trebicka, J. & 14 others, Anastasiadou, E., Bork, P., Hansen, T., Legido-Quigley, C., Krag, A., Mann, M., Matthijnssens, J., Arumugam, Mani, Henrar, R., Israelsen, H., Karsdal, M., Melberg, H. O., MicrobLiver Consortium, M. C. & GALAXY Consortium, G. C., 2023, In: Gastroenterology. 164, 7, p. 1248-1260

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Sperm epigenetics and influence of environmental factors

    Donkin, I. & Barrès, Romain, 2018, In: Molecular Metabolism. 14, p. 1-11 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  40. Published

    Sperm count is increased by diet-induced weight loss and maintained by exercise or GLP-1 analogue treatment: a randomized controlled trial

    Andersen, E., Juhl, C. R., Kjøller, E. T., Lundgren, J. R., Janus, C., Dehestani, Y., Saupstad, M., Ingerslev, L. R., Duun, O. M., Jensen, Simon Birk Kjær, Holst, Jens Juul, Stallknecht, Bente Merete, Madsbad, Sten, Torekov, Signe Sørensen & Barrès, Romain, May 2022, In: Human Reproduction. 37, 7, p. 1414–1422 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Specificity and sensitivity of commercially available assays for glucagon-like peptide-1 (GLP-1): Implications for GLP-1 measurements in clinical studies

    Bak, M. J., Albrechtsen, Nicolai Jacob Wewer, Pedersen, Jens, Knop, Filip Krag, Vilsbøll, Tina, Jørgensen, N. B., Hartmann, Bolette, Deacon, Carolyn F., Dragsted, Lars Ove & Holst, Jens Juul, 2014, In: Diabetes, Obesity and Metabolism. 16, 11, p. 1155-1164 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Specificity and sensitivity of commercially available assays for glucagon and oxyntomodulin measurement in humans

    Bak, M. J., Albrechtsen, Nicolai Jacob Wewer, Pedersen, Jens, Hartmann, Bolette, Christensen, M., Vilsbøll, T., Knop, F. K., Deacon, Carolyn F., Dragsted, Lars Ove & Holst, Jens Juul, 2014, In: European Journal of Endocrinology. 170, 4, p. 529-538 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Specific synbiotics in early life protect against diet-induced obesity in adult mice

    Mischke, M., Arora, Tulika, Tims, S., Engels, E., Sommer, N., van Limpt, K., Baars, A., Oozeer, R., Oosting, A., Bäckhed, F. & Knol, J., 2018, In: Diabetes, Obesity and Metabolism. 20, 6, p. 1408-1418 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Specific inhibition of bile acid transport alters plasma lipids and GLP-1

    Rudling, M., Camilleri, M., Graffner, H., Holst, Jens Juul & Rikner, L., 2015, In: B M C Cardiovascular Disorders. 15, p. 1-8 8 p., 75.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Specific gut microbiota features and metabolic markers in postmenopausal women with obesity

    Brahe, L. K., Le Chatelier, E., Prifti, E., Pons, N., Kennedy, S., Hansen, Torben, Pedersen, Oluf Borbye, Astrup, A., Ehrlich, S. D. & Larsen, L. H., 15 May 2015, In: Nutrition and Diabetes. 5, 7 p., e159.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Specific and nonspecific responses to Plasmodium falciparum blood-stage parasites and observations on the gametocytemia in schoolchildren living in a malaria-endemic area of Mozambique

    Høgh, Birthe, Thompson, R., Hetzel, C., Fleck, S. L., Kruse, N. A., Jones, I., Dgedge, M., Barreto, J. & Sinden, R. E., Jan 1995, In: American Journal of Tropical Medicine and Hygiene. 52, 1, p. 50-9 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Species-specific action of (Pro3)GIP - an efficacious agonist on human GIP receptor, but partial agonist and competitive antagonist on rat and mouse GIP receptors

    wbf943, wbf943, Gasbjerg, Lærke Smidt, Svendsen, B., Christensen, M., Knop, Filip Krag, Hartmann, Bolette, Holst, Jens Juul & Rosenkilde, Mette, Jan 2016, In: British Journal of Pharmacology. 173, 1, p. 27-38 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Spatially distributed encoding of covert attentional shifts in human thalamus

    Hulme, O. J., Whiteley, Louise & Shipp, S., 2010, In: Journal of Neurology & Neurophysiology. 104, 6, p. 3644-56 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Spatial consequences of bridging the saccadic gap

    Yarrow, K., Whiteley, Louise, Rothwell, J. C. & Haggard, P., 2006, In: Vision Research. 46, 4, p. 545-55 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Spatial QRS-T angle variants for prediction of all-cause mortality

    Kück, K., Isaksen, Jonas L., Graff, C., Skaaby, T., Linneberg, Allan René, Hansen, Torben & Kanters, Jørgen K., 2018, In: Journal of Electrocardiology. 51, 5, p. 768-775 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review