Novo Nordisk Foundation Center for Basic Metabolic Research

  1. Published

    Roux-en-Y gastric bypass surgery does not preserve energy expenditure in humans

    Schmidt, J. B., Gunvald, L. E., Gregersen, N. T., Pedersen, S. D., Holst, Jens Juul, Hansen, D. L., Worm, Dorte, Madsbad, Sten, Astrup, A. & Sjödin, Anders Mikael, 2012, In: Regulatory Peptides. 177, suppl.1, p. S32 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  2. Published

    Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation

    Tremaroli, V., Karlsson, F., Werling, M., Ståhlman, M., Kovatcheva-Datchary, P., Olbers, T., Fändriks, L., le Roux, C. W., Nielsen, J. & Bäckhed, G. F., 4 Aug 2015, In: Cell Metabolism. 22, 2, p. 228-38 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Roux-en-Y Gastric Bypass Surgery Induces Early Plasma Metabolomic and Lipidomic Alterations in Humans Associated with Diabetes Remission

    Arora, T., Velagapudi, V., Pournaras, D. J., Welbourn, R., le Roux, C. W., Orešič, M. & Bäckhed, G. F., 2015, In: PLOS ONE. 10, 5, p. 1-10 10 p., e0126401.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Rosiglitazone treatment of patients with extreme insulin resistance and diabetes mellitus due to insulin receptor mutations has no effects on glucose and lipid metabolism

    drb459, drb459, Lund, S., Pedersen, Oluf Borbye & drb459, drb459, Nov 2001, In: Journal of Internal Medicine. 250, 5, p. 406-14 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Rosiglitazone monotherapy for type 2 diabetes mellitus-too soon to ADOPT?

    Gaede, P. & Pedersen, Oluf Borbye, 2007, In: Nature clinical practice. Endocrinology & metabolism. 3, 6, p. 456-7 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Roles of the Gut in Glucose Homeostasis

    Holst, Jens Juul, Gribble, F., Horowitz, M. & Rayner, C. K., Jun 2016, In: Diabetes Care. 39, 6, p. 884-92 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Roles of increased glycemic variability, GLP-1 and glucagon in hypoglycaemia after Roux-en-Y gastric bypass

    Tharakan, G., Behary, P., Albrechtsen, Nicolai Jacob Wewer, Chahal, H., Kenkre, J., Miras, A. D., Ahmed, A. R., Holst, Jens Juul, Bloom, S. R. & Tan, T. M. M., 1 Dec 2017, In: European Journal of Endocrinology. 177, p. 455-464 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Roles of RFRP-3 in the Daily and Seasonal Regulation of Reproductive Activity in Female Syrian Hamsters

    Henningsen, J. B., Ancel, C., Mikkelsen, Jens D., Gauer, F. & Simonneaux, V., 1 Mar 2017, In: Endocrinology. 158, 3, p. 652-663 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function

    Neve, B., Fernandez-Zapico, M. E., Ashkenazi-Katalan, V., Dina, C., Hamid, Y. H., Joly, E., Vaillant, E., Benmezroua, Y., Durand, E., Bakaher, N., Delannoy, V., Vaxillaire, M., Cook, T., Dallinga-Thie, G. M., Jansen, H., Charles, M-A., Clément, K., Galan, P., Hercberg, S., Helbecque, N. & 7 others, Charpentier, G., Prentki, M., Hansen, Torben, Pedersen, Oluf Borbye, Urrutia, R., Melloul, D. & Froguel, P., 2005, In: Proceedings of the National Academy of Sciences of the United States of America. 102, 13, p. 4807-12 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Role of the AMPKgamma3 isoform in hypoxia-stimulated glucose transport in glycolytic skeletal muscle

    Deshmukh, Atul Shahaji, Glund, S., Tom, R. Z. & Zierath, Juleen R, Dec 2009, In: American Journal of Physiology: Endocrinology and Metabolism. 297, 6, p. E1388-94

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Role of sociodemographic, clinical, behavioral, and molecular factors in precision prevention of type 2 diabetes: a systematic review

    Bodhini, D., Morton, R. W., Santhakumar, V., Nakabuye, Mariam, Pomares-Millan, H., Clemmensen, Christoffer, Fitzpatrick, S. L., Guasch Ferre, Marta, Pankow, J. S., Ried-Larsen, M., Franks, P. W., Tobias, D. K., Merino, Jordi, Mohan, V., Loos, Ruth & ADA/EASD Precision Medicine in Diabetes Initiative, A. P. M. I. D. I., 2023, medRxiv.

    Research output: Working paperPreprintResearch

  12. Published

    Role of hypothalamic MAPK/ERK signaling and central action of FGF1 in diabetes remission

    Brown, Jenny, Bentsen, M. A., Belmont-Rausch, Dylan Matthew, Phan, B. A., Wieck, D., Wasanwala, H., Matsen, M. E., Acharya, N., Richardson, N. E., Zhao, X., Zhai, P., Secher, A., Morton, G. J., Pers, Tune H, Schwartz, M. W. & Scarlett, J. M., 2021, In: iScience. 24, 9, 19 p., 102944.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Role of gut microbiota in atherosclerosis

    Jonsson, A. L. & Bäckhed, G. F., Feb 2017, In: Nature Reviews. Cardiology. 14, 2, p. 79-87 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Role of fasting duration and weekday in incretin and glucose regulation

    Clemmensen, K. K. B., Quist, J. S., Vistisen, D., Witte, D. R., Jonsson, Anna Elisabet, Pedersen, Oluf Borbye, Hansen, Torben, Holst, Jens Juul, Lauritzen, T., Jørgensen, M. E., Torekov, Signe Sørensen & Færch, K., 2020, In: Endocrine Connections. 9, 4, p. 279-288

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Role of endogenous incretins in the regulation of postprandial lipoprotein metabolism

    Taskinen, M., Matikainen, N., Björnson, E., Söderlund, S., Ainola, M., Hakkarainen, A., Lundbom, N., Sihlbom, C., Thorsell, A., Andersson, L., Adiels, M., Hartmann, Bolette, Deacon, Carolyn F., Holst, Jens Juul, Packard, C. J. & Borén, J., 2022, In: European Journal of Endocrinology. 187, 1, p. 75-84 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Role of classical and peptidergic neurotransmitters in insulin secretion

    Holst, Jens Juul, 1991, Nutrient Regulation of Insulin Secretion. Portland Press

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  17. Published

    Role of PKCδ in Insulin Sensitivity and Skeletal Muscle Metabolism

    Li, M., Vienberg, S. G., Bezy, O., O'Neill, B. T. & Kahn, C. R., Dec 2015, In: Diabetes. 64, 12, p. 4023-32 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Role of Glucagon in Catabolism and Muscle Wasting of Critical Illness and Modulation by Nutrition

    Thiessen, S. E., Derde, S., Derese, I., Dufour, T., Vega, C. A., Langouche, L., Goossens, C., Peersman, N., Vermeersch, P., Vander Perre, S., Holst, Jens Juul, Wouters, P. J., Vanhorebeek, I. & Van den Berghe, G., 1 Nov 2017, In: American Journal of Respiratory and Critical Care Medicine. 196, 9, p. 1131-1143 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Role of Gastrin‐Releasing Peptide in Vagal Control of Gastrin Secretion

    Holst, Jens Juul, KNUHTSEN, S., Ørskov, Cathrine, SKAK‐NIELSEN, T., Poulsen, Steen Seier & NIELSEN, O. V., 1 Jan 1988, In: Annals of the New York Academy of Sciences. 547, 1, p. 514-515 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Role of Energy Excretion in Human Body Weight Regulation

    Lund, Jens, Gerhart-Hines, Zach & Clemmensen, Christoffer, 2020, In: Trends in Endocrinology and Metabolism. 31, 10, p. 705-708 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Role of Diacylglycerol Kinases in Glucose and Energy Homeostasis

    Massart, J. & Zierath, Juleen R, 2019, In: Trends in Endocrinology and Metabolism. 30, 9, p. 603-617

    Research output: Contribution to journalReviewResearchpeer-review

  22. Published

    Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding

    Barington, L., Rummel, P. C., Lückmann, Michael, Pihl, H., Larsen, Olav, Daugvilaite, V., Johnsen, A. H., Frimurer, Thomas Michael, Karlshøj, S. & Rosenkilde, Mette, 19 May 2016, In: The Journal of Biological Chemistry. 291, 31, p. 16208-16220

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Role of AMPK in IL-6 release from isolated mouse skeletal muscle

    Glund, S., Treebak, Jonas Thue, Long, Y. C., Barrès, Romain, Viollet, B., Wojtaszewski, Jørgen F P & Zierath, Juleen R, 2008, In: Diabetologia.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Role of AMP-activated protein kinase for regulating post-exercise insulin sensitivity

    Kjøbsted, Rasmus, Wojtaszewski, Jørgen F P & Treebak, Jonas Thue, 2016, AMP-activated Protein Kinase. Cordero, M. D. & Viollet, B. (eds.). Springer, p. 81-126 46 p. (E X S, Vol. 107).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  25. Published

    Robust GLP-1 secretion by basic L-amino acids does not require the GPRC6A receptor

    Clemmensen, Christoffer, Jørgensen, C. V., Smajilovic, S. & Bräuner, Hans, 2017, In: Diabetes, Obesity and Metabolism. 19, 4, p. 599-603

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Road Traffic and Railway Noise Exposures and Adiposity in Adults: A Cross-Sectional Analysis of the Danish Diet, Cancer, and Health Cohort

    Christensen, J. S., Raaschou-Nielsen, O., Tjønneland, A., Overvad, K., Nordsborg, R. B., Ketzel, M., Sørensen, Thorkild I.A. & Sørensen, M., Mar 2016, In: Environmental Health Perspectives. 124, 3, p. 329-35 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Risk stratification by endocrinologists of patients with type 2 diabetes in a Danish specialised outpatient clinic: a cross-sectional study

    Munch, L., Arreskov, Anne Beiter, Sperling, M., Overgaard, D., Knop, Filip Krag, Vilsbøll, Tina & Røder, M. E., 2016, In: BMC Health Services Research. 16, 10 p., 124.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Risk of venous thromboembolism and myocardial infarction associated with factor V Leiden and prothrombin mutations and blood type

    Sode, B. F., Allin, K. H., Dahl, Morten, Gyntelberg, F. & Nordestgaard, Børge, 2013, In: C M A J. 185, 5, p. E229-E237

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Risk of pancreatitis in patients with inflammatory bowel disease - a meta-analysis

    Pedersen, J. E., Ängquist, Lars, Jensen, C. B., Kjærgaard, J. S., Jess, T. & Allin, K. H., 2020, In: Danish Medical Journal. 67, 3, 6 p., A08190427.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Risk of Urolithiasis in Patients With Inflammatory Bowel Disease: A Nationwide Danish Cohort Study 1977–2018

    Dimke, H., Winther-Jensen, M., Allin, K. H., Lund, L. & Jess, T., 2021, In: Clinical Gastroenterology and Hepatology. 19, 12, p. 2532-2540.e2

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Risk of Breast Cancer in Relation to Combined Effects of Hormone Therapy, Body Mass Index, and Alcohol Use, by Hormone-receptor Status

    Hvidtfeldt, U. A., Tjønneland, Anne, Keiding, N., Lange, Theis, Andersen, Ingelise, Sørensen, Thorkild I.A., Prescott, Eva, Hansen, Åse Marie, Gronbaek, M., Bojesen, Stig Egil, Diderichsen, Finn & Rod, Naja Hulvej, May 2015, In: Epidemiology. 26, 3, p. 353-361

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Rising rural body-mass index is the main driver of the global obesity epidemic in adults

    Ängquist, Lars, Baker, J. L., Damsgaard, Camilla Trab, Eliasen, M., Linneberg, Allan René, Michaelsen, Kim F., Molbo, Drude, Mortensen, Erik Lykke, Sørensen, Thorkild I.A., Jørgensen, T., Tang Møllehave, L., Thuesen, B. H., Osler, Merete & NCD Risk Factor Collaboration (NCD-RisC), N. R. F. C., 2019, In: Nature. 569, 7755, p. 260-264 5 p.

    Research output: Contribution to journalLetterResearchpeer-review

  33. Published

    Rifaximin-α for liver fibrosis in patients with alcohol-related liver disease (GALA-RIF): a randomised, double-blind, placebo-controlled, phase 2 trial

    Israelsen, M., Madsen, B. S., Torp, N., Johansen, S., Hansen, C. D., Detlefsen, S., Andersen, P., Hansen, J. K., Lindvig, K. P., Rasmussen, D. N., Thorhauge, K. H., Kjærgaard, M., Karsdal, M., Hansen, Torben, Arumugam, Mani, Trebicka, J., Thiele, M., Krag, A. & GALAXY, G., 2023, In: The Lancet Gastroenterology and Hepatology. 8, 6, p. 523-532 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Richness of human gut microbiome correlates with metabolic markers

    Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J-M., Kennedy, S., Leonard, P., Li, J., Burgdorf, K. S., Grarup, N., Jørgensen, T., Brandslund, I., Nielsen, H. B., Juncker, A., dos Santos, M. B. Q., Levenez, F. & 62 others, Pons, N., Rasmussen, Simon, Sunagawa, S., Tap, J., Tims, S., Zoetendal, E. G., Brunak, S., Clément, K., Doré, J., Kleerebezem, M., Kristiansen, Karsten, Renault, P., Sicheritz-Ponten, T., de Vos, W. M., Zucker, J., Raes, J., Hansen, Torben, Bork, P., Wang, J., Ehrlich, S. D., Pedersen, Oluf Borbye, Guedon, E., Delorme, C., Layec, S., Khaci, G., van de Guchte, M., Vandemeulebrouck, G., Jamet, A., Dervyn, R., Sanchez, N., Maguin, E., Haimet, F., Winogradski, Y., Cultrone, A., Leclerc, M., Juste, C., Blottière, H., Pelletier, E., LePaslier, D., Artiguenave, F., Bruls, T., Weissenbach, J., Turner, K., Parkhill, J., Antolin, M., Manichanh, C., Casellas, F., Boruel, N., Varela, E., Torrejon, A., Guarner, F., Denariaz, G., Derrien, M., van Hylckama Vlieg, J. E. T., Veiga, P., Oozeer, R., Knol, J., Rescigno, M., Brechot, C., Mérieux, A., M'Rini, C. & Yamada, T., 2013, In: Nature. 500, 7464, p. 541-546 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response

    Snieckute, Goda, Genzor Garbayo, Aitana Victoria, Vind, Anna Constance, Jordan, Laura Ryder, Stoneley, M., Chamois, S., Dreos, R., Nordgaard, C., Sass, Frederike, Blasius, Melanie, López, A. R., Brynjólfsdóttir, S. H., Andersen, Kasper Langebjerg, Willis, A. E., Frankel, Lisa, Poulsen, Steen Seier, Gatfield, D., Gerhart-Hines, Zach, Clemmensen, Christoffer & Bekker-Jensen, Simon Holst, 2022, In: Cell Metabolism. 34, 12, p. 2036-2046.e8 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Rhythmic history: Towards a new research agenda for the history of health and medicine

    Hussey, Kristin D., 2022, In: Endeavour. 46, 4, 10 p., 100846.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    RhoA in tyrosine hydroxylase neurons regulates food intake and body weight via altered sensitivity to peripheral hormones

    Skov, Louise Julie, Ratner, C., Hansen, Nikolaj Winther, Thompson, J. J., Egerod, Kristoffer Lihme, Burm, Hayley Beth, Dalbøge, L. S., Hedegaard, M. A., Brakebusch, Cord Herbert, Pers, Tune H, Perrier, Jean-Francois Marie & Holst, Birgitte, 2019, In: Journal of Neuroendocrinology. 31, 7, 13 p., UNSP e12761.

    Research output: Contribution to journalConference articleResearchpeer-review

  38. Published

    Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production

    Piccand, J., Vagne, C., Blot, F., Meunier, A., Beucher, A., Strasser, P., Lund, M. L., Ghimire, S., Nivlet, L., Lapp, C., Petersen, N., Engelstoft, M. S., Thibault-Carpentier, C., Keime, C., Correa, S. J., Schreiber, V., Molina, N., Schwartz, Thue W., De Arcangelis, A. & Gradwohl, G., 2019, In: Molecular Metabolism. 29, p. 24-39

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Revisiting How the Brain Senses Glucose-And Why

    Bentsen, M. A., Mirzadeh, Z. & Schwartz, M. W., 2019, In: Cell Metabolism. 29, 1, p. 11-17

    Research output: Contribution to journalReviewResearchpeer-review

  40. Published

    Revision rates of trapeziometacarpal total joint arthroplasty in relation to occupational hand force requirements

    Kirkeby, L., Frost, Poul, Svendsen, S. W. & Hansen, Torben, 2021, In: Journal of Hand Surgery: European Volume. 46, 9, p. 968-974 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension

    de Franchis, R., Baveno V Faculty, B. V. F. & Sørensen, Thorkild I.A., 1 Oct 2010, In: Journal of Hepatology. 53, 4, p. 762-8 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published
  43. Published

    Review of 'Medical Imaging and Philosophy: Challenges, Reflections, Actions. Edited by Heiner Fangerau, Rethy Chhem, Irmgard Müller and Shih-Chang Wang.'

    Whiteley, Louise, 2013, In: Isis. 104, 4, p. 820-821 2 p.

    Research output: Contribution to journalLiterature reviewResearch

  44. Published

    Reversed binding of a small molecule ligand in homologous chemokine receptors – differential role of extracellular loop 2.

    Rummel, P. C., Thiele, S., Steen, A. M. F., Elder, A., Kolbech, R., Ghosh, S., Frimurer, Thomas Michael & Rosenkilde, Mette, 2011, In: British Journal of Pharmacology. 166

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Reversal of Hypertriglyceridemia, Fatty Liver Disease, and Insulin Resistance by a Liver-Targeted Mitochondrial Uncoupler

    Perry, R. J., Kim, T., Zhang, X., Lee, H., Pesta, D., Popov, V. B., Zhang, D., Rahimi, Y., Jurczak, M. J., Cline, G. W., Spiegel, D. A. & Shulman, G. I., 2013, In: Cell Metabolism. 18, 5, p. 740-748

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Rev-erbα and the circadian transcriptional regulation of metabolism.

    Gerhart-Hines, Zach & Lazar, M. A., 2015, In: Diabetes, Obesity and Metabolism Online. 17, S1, p. 12-16 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function

    Bugge, A. S., Feng, D., Everett, L. J., Briggs, E. R., Mullican, S. E., Wang, F., Jager, J. & Lazar, M. A., 1 Apr 2012, In: Genes & Development. 26, 7, p. 657-67 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Reuniting philosophy and science to advance cancer research

    Pradeu, T., Daignan-Fornier, B., Ewald, A., Germain, P. L., Okasha, S., Plutynski, A., Benzekry, S., Bertolaso, M., Bissell, M., Brown, J. S., Chin-Yee, B., Chin-Yee, I., Clevers, H., Cognet, L., Darrason, M., Farge, E., Feunteun, J., Galon, J., Giroux, E., Green, S. & 18 others, Gross, F., Jaulin, F., Knight, R., Laconi, E., Larmonier, N., Maley, C., Mantovani, A., Moreau, V., Nassoy, P., Rondeau, E., Santamaria, D., Sawai, C. M., Seluanov, A., Sepich-Poore, G. D., Sisirak, V., Solary, E., Yvonnet, Sarah & Laplane, L., 2023, In: Biological Reviews. 98, p. 1668-1686 19 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Retinopathy is associated with impaired myocardial function assessed by advanced echocardiography in type 1 diabetes patients – The Thousand & 1 Study

    Nouhravesh, N., Andersen, H. U., Jensen, J. S., Rossing, Peter & Jensen, M. T., Jun 2016, In: Diabetes Research and Clinical Practice. 116, p. 263-9 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Retinol-Binding Protein 4 in Young Men With Low Versus Normal Birth Weight: Physiological Response to Short-Term Overfeeding

    Ribel-Madsen, R., Brøns, C., Friedrichsen, M., Poulsen, P. & Vaag, Allan, 1 Jun 2011, In: Obesity. 19, 6, p. 1304-1306 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review