Novo Nordisk Foundation Center for Basic Metabolic Research

  1. Published

    The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders

    Andersen, M. K., Jørsboe, E., Skotte, L., Hanghøj, K., Sandholt, C. H., Moltke, I., Grarup, N., Kern, T., Mahendran, Y., Søborg, B., Bjerregaard, P., Larsen, C. V. L., Dahl-Petersen, I. K., Tiwari, H. K., Feenstra, B., Koch, A., Wiener, H. W., Hopkins, S. E., Pedersen, O., Melbye, M. & 4 others, Boyer, B. B., Jørgensen, M. E., Albrechtsen, Anders & Hansen, Torben, 2020, In: PLOS Genetics. 16, 1, 17 p., e1008544.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations

    Stalbow, L. A., Preuss, M. H., Smit, Roelof Adriaan Johan, Chami, N., Bjørkhaug, L., Aukrust, I., Gloyn, A. L. & Loos, Ruth, 2023, In: Diabetologia. 66, p. 116-126 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    The complement system is differently regulated in white and brown adipocytes

    Justesen, L., Bayarri-Olmos, R., Schéele, Camilla Charlotte Nielsen & Garred, Peter, 2018, In: Molecular Immunology. 102, p. 170 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  4. Published

    The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study

    Boesgaard, T. W., Zilinskaite, J., Vänttinen, M., Laakso, M., Jansson, P., Hammarstedt, A., Smith, U., Stefan, N., Fritsche, A., Häring, H., Hribal, M., Sesti, G., Zobel, D. P., Pedersen, Oluf Borbye, Hansen, Torben & EUGENE 2 Consortium, E. 2. C., 2008, In: Diabetologia. 51, 5, p. 816-20 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    The combination of colesevelam with sitagliptin enhances glycemic control in diabetic ZDF rat model

    Shang, Q., Liu, M. K., Saumoy, M., Holst, Jens Juul, Salen, G. & Xu, G., 2012, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 302, 8, p. G815-23

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

    Lynes, M. D., Leiria, L. O., Lundh, M., Bartelt, A., Shamsi, F., Huang, T. L., Takahashi, H., Hirshman, M. F., Schlein, C., Lee, A., Baer, L. A., May, F. J., Narain, N. R., Chen, E. Y., Kiebish, M. A., Cypess, A. M., Blüher, M., Goodyear, L. J., Hotamisligil, G. S., Stanford, K. I. & 1 others, Tseng, Y., May 2017, In: Nature Medicine. 23, 5, p. 631-637 7 p.

    Research output: Contribution to journalLetterResearchpeer-review

  7. Published

    The clinical effects of a carbohydrate-reduced high-protein diet on glycaemic variability in metformin-treated patients with type 2 diabetes mellitus: A randomised controlled study

    Thomsen, M. N., fbg982, fbg982, Astrup, A., Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten, Krarup, T., Haugaard, Steen Bendix & Samkani, A., 2020, In: Clinical Nutrition ESPEN. 39, p. 46-52 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    The chemistry of the vitamin B3 metabolome

    Makarov, M. V., Trammell, Sam & Migaud, M. E., 2019, In: Biochemical Society Transactions. 47, 1, p. 131-147

    Research output: Contribution to journalReviewResearchpeer-review

  9. Published

    The chemistry of life: Four chapters in the history of metabolic research

    Bencard, Adam, 2010

    Research output: Non-textual form2D/3D (psysical products)Communication

  10. Published

    The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD +

    Gerhart-Hines, Zach, Dominy, J. E., Blättler, S. M., Jedrychowski, M. P., Banks, A. S., Lim, J. H., Chim, H., Gygi, S. P. & Puigserver, P., 23 Dec 2011, In: Molecular Cell. 44, 6, p. 851-863 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The brominated flame retardant PBDE 99 promotes adipogenesis via regulating mitotic clonal expansion and PPARγ expression

    Wen, Q., Xie, X., Zhao, C., Ren, Q., Zhang, X., Wei, D., Emanuelli, Brice & Du, Y., 2019, In: The Science of the Total Environment. 670, p. 67-77 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    The blunted effect of glucose-dependent insulinotropic polypeptide in subcutaneous abdominal adipose tissue in obese subjects is partly reversed by weight loss

    Asmar, M., Arngrim, N., Simonsen, L., Asmar, A., Nordby, P., Holst, Jens Juul & Bülow, J., 2016, In: Nutrition and Diabetes. 6, 7 p., e208.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    The biology of glucagon and the consequences of hyperglucagonemia

    Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Pedersen, Jens, Knop, Filip Krag & Holst, Jens Juul, 9 Sep 2016, In: Biomarkers in Medicine. 10, 11, p. 1141-1151 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    The biochemistry and physiology of long-chain dicarboxylic acid metabolism

    Ranea-Robles, Pablo & Houten, S. M., 2023, In: Biochemical Journal. 480, 9, p. 607-627 21 p.

    Research output: Contribution to journalReviewResearchpeer-review

  15. Published

    The bile acid-sequestering resin sevelamer eliminates the acute GLP-1 stimulatory effect of endogenously released bile acids in patients with type 2 diabetes

    Brønden, A., Albér, A., Rohde, U., Gasbjerg, Lærke Smidt, Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 1 Feb 2018, In: Diabetes, Obesity and Metabolism. 20, 2, p. 362-369

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    The authors reply

    Idorn, T., Knop, Filip Krag, Jørgensen, M., Holst, Jens Juul, Hornum, Mads & Feldt-Rasmussen, Bo, Jan 2014, In: Kidney International. 85, 1, p. 212-3 2 p.

    Research output: Contribution to journalLetterResearchpeer-review

  17. E-pub ahead of print

    The association of cardiometabolic, diet and lifestyle parameters with plasma glucagon-like peptide-1: An IMI DIRECT study

    Eriksen, R., White, M. C., Dawed, A. Y., Perez, I. G., Posma, J. M., Haid, M., Sharma, S., Prehn, C., Thomas, L. E., Koivula, R. W., Bizzotto, R., Mari, A., Giordano, G. N., Pavo, I., Schwenk, J. M., De Masi, F., Tsirigos, K. D., Brunak, S., Viñuela, A., Mahajan, A. & 26 others, McDonald, T. J., Kokkola, T., Rutters, F., Beulens, J., Muilwijk, M., Blom, M., Elders, P., Hansen, T. H., Fernandez-Tajes, J., Jones, A., Jennison, C., Walker, M., McCarthy, M. I., Pedersen, Oluf Borbye, Ruetten, H., Forgie, I., Holst, Jens Juul, Thomsen, Henrik S., Ridderstråle, M., Bell, J. D., Adamski, J., Franks, P. W., Hansen, Torben, Holmes, E., Frost, G. & Pearson, E. R., 2024, (E-pub ahead of print) In: Journal of Clinical Endocrinology and Metabolism.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population

    Husemoen, L. L. N., Jørgensen, T., Borch-Johnsen, K., Hansen, Torben, Pedersen, Oluf Borbye & Linneberg, Allan René, 1 Jan 2010, In: P L o S One. 5, 8, p. e11735

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    The association of IgA deficiency on infection rate, self-perceived health, and levels of C-reactive protein in healthy blood donors

    Hauge, S. C., Jensen, C. K., Nielsen, L. K., Pedersen, Oluf Borbye, Sørensen, E., Thørner, L. W., Hjalgrim, H., Erikstrup, C., Nielsen, K. R., Kaspersen, K. A., Didriksen, Maria, Dziegiel, Morten Hanefeld & Ullum, H., 1 Mar 2018, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 126, 3, p. 248-256 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    The association between the val/ala-55 polymorphism of the uncoupling protein 2 gene and exercise efficiency

    Buemann, B., Schierning, B., Toubro, S., Bibby, B. M., Sørensen, Thorkild I.A., Dalgaard, L., Pedersen, Oluf Borbye & Astrup, A., 2001, In: International Journal of Obesity. 25, p. 467-471 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    The association between candidate migraine susceptibility loci and severe migraine phenotype in a clinical sample

    Esserlind, A., Christensen, A. F., Steinberg, S., Grarup, N., Pedersen, Oluf Borbye, Hansen, Torben, Werge, Thomas, Hansen, T. F., Husemoen, L. L. N., Linneberg, Allan René, Budtz-Joergensen, Esben, Westergaard, M. L., Stefansson, H. & Olesen, Jes, 2016, In: Cephalalgia : an international journal of headache. 36, 7, p. 1-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones

    Rudenko, Olga, Shang, J., Munk, A., Ekberg, J. P., Petersen, N., Engelstoft, M. S., Egerod, Kristoffer Lihme, Hjorth, Siv Annegrethe, Wu, M., Feng, Y., Zhou, Y., Mokrosinski, J., Thams, P., Reimann, F., Gribble, F., Rehfeld, Jens Frederik, Holst, Jens Juul, Treebak, Jonas Thue, Howard, A. D. & Schwartz, Thue W., 2019, In: Molecular Metabolism. 19, p. 49-64 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    The arginine of the DRY motif in transmembrane segment III functions as a balancing micro-switch in the activation of the β2-adrenergic receptor

    Hansen, L. V., Groenen, M., Nygaard, R., Frimurer, Thomas Michael, Holliday, N. D. & Schwartz, Thue W., 14 Sep 2012, In: Journal of Biological Chemistry. 287, 38, p. 31973-82 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    The antiresorptive effect of GIP, but not GLP-2, is preserved in patients with hypoparathyroidism - a randomized crossover study

    Skov-Jeppesen, Kirsa, Hepp, N., Oeke, J., Hansen, M. S., Jafari Kermani, Abbas, Svane, M. S., Balenga, N., Olson, J. A., Frost, M., Kassem, Moustapha Saad El-Deen, Madsbad, Sten, Jensen, Jens-Erik Beck, Holst, Jens Juul, Rosenkilde, Mette & Hartmann, Bolette, 2021, In: Journal of Bone and Mineral Research. 36, 8, p. 1448-1458 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    The antidepressant-like effect of probiotics and their faecal abundance may be modulated by the cohabiting gut microbiota in rats

    Abildgaard, A., Kern, T., Pedersen, Oluf Borbye, Hansen, Torben, Wegener, G. & Lund, S., 2019, In: European Neuropsychopharmacology. 29, 1, p. 98-110

    Research output: Contribution to journalJournal articleResearchpeer-review