Novo Nordisk Foundation Center for Basic Metabolic Research

  1. Published

    Dietary Protein Restriction Improves Metabolic Dysfunction in Patients with Metabolic Syndrome in a Randomized, Controlled Trial

    Ferraz-Bannitz, R., Beraldo, R. A., Peluso, A., Dall, M., Babaei, P., Foglietti, R. C., Martins, L. M., Gomes, P. M., Marchini, J. S., Miguel Suen, V. M., Conti de Freitas, L. C., Navegantes, L. C., Pretti, M. A. M., Boroni, M., Treebak, Jonas Thue, Mori, M. A., Foss, M. C. & Foss-Freitas, M. C., 2022, In: Nutrients. 14, 13, 18 p., 2670.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella

    Kovatcheva-Datchary, P., Nilsson, A., Akrami, R., Lee, Y. S., De Vadder, F., Arora, T., Hallen, A., Martens, E., Björck, I. & Bäckhed, G. F., 1 Dec 2015, In: Cell Metabolism. 22, 6, p. 971-82 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Dietary Fiber is Essential to Maintain L Cell Secretion and Intestinal Weight

    Dal, Jenna Elizabeth Hunt, Hartmann, Bolette, Holst, Jens Juul & Kissow, Hannelouise, 1 May 2019, In: Gastroenterology. 156, 6 (S1), p. S-477

    Research output: Contribution to journalConference abstract in journalResearch

  4. Published

    Dietary Fiber Is Essential to Maintain Intestinal Size, L-Cell Secretion, and Intestinal Integrity in Mice

    Dal, Jenna Elizabeth Hunt, Hartmann, Bolette, Schoonjans, K., Holst, Jens Juul & Kissow, Hannelouise, 2021, In: Frontiers in Endocrinology. 12, 10 p., 640602.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Dietary Fat and the Genetic Risk of Type 2 Diabetes

    Carrasquilla, Germán D., Jakupovic, Hermina & Kilpeläinen, Tuomas O., 2019, In: Current Diabetes Reports. 19, 6 p., 109.

    Research output: Contribution to journalReviewResearchpeer-review

  6. Published

    Dietary Assessment in the MetaCardis Study: Development and Relative Validity of an Online Food Frequency Questionnaire

    Verger, E. O., Armstrong, P., Nielsen, T., Chakaroun, R., Aron-Wisnewsky, J., Gøbel, R. J., Schütz, T., Delaere, F., Gausseres, N., Clément, K., Holmes, B. A. & MetaCardis Consortium, M. C., Jun 2017, In: Journal of the Academy of Nutrition and Dietetics. 117, 6, p. 878-888 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Dietary n-6 PUFA, carbohydrate: protein ratio and change in body weight and waist circumference: a follow-up study

    Jakobsen, M. U., Madsen, L., Dethlefsen, C., Due, K. M., Halkjaer, J., Sørensen, Thorkild I.A., Kristiansen, Karsten & Overvad, K., 2015, In: Public Health Nutrition. 18, 07, p. 1317-1323 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Diet-microbiota interactions as moderators of human metabolism

    Sonnenburg, J. L. & Bäckhed, G. F., 7 Jul 2016, In: Nature. 535, 7610, p. 56-64 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  9. Published

    Diagnostik og behandling af maturity onset diabetes of the young type 3

    Rose, K., Christensen, A. S., Storgaard, H., Hædersdal, S., Hansen, Torben, Knop, Filip Krag & Vilsbøll, Tina, 2018, In: Ugeskrift for Laeger. 180, 6 p., V06170502.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Diabetologia at 50: celebrating half a century of progress in diabetes research and care

    Zierath, Juleen R, Aug 2015, In: Diabetologia. 58, 8, p. 1685-7 3 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  11. Published

    Diabetic intestinal growth adaptation and glucagon-like peptide 2 in the rat: effects of dietary fibre

    Thulesen, J., Hartmann, Bolette, Nielsen, C., Holst, Jens Juul & Poulsen, Steen Seier, Nov 1999, In: Gut. 45, 5, p. 672-8 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Diabetic cats have decreased gut microbial diversity and a lack of butyrate producing bacteria

    Kieler, Ida Nordang, Osto, M., Hugentobler, L., Puetz, Lara Christine, Gilbert, M Thomas P, Hansen, Torben, Pedersen, Oluf Borbye, Reusch, C. E., Zini, E., Lutz, T. A. & Bjørnvad, Charlotte Reinhard, 2019, In: Scientific Reports. 9, p. 1-13 13 p., 4822.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Diabetic and nondiabetic patients with nonalcoholic fatty liver disease have an impaired incretin effect and fasting hyperglucagonaemia

    Junker, A. E., Gluud, Lise Lotte, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, May 2016, In: Journal of Internal Medicine. 279, 5, p. 485–493 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Diabetes-associated microbiota in fa/fa rats is modified by Roux-en-Y gastric bypass

    Arora, Tulika, Seyfried, F., Docherty, N. G., Tremaroli, V., le Roux, C. W., Perkins, R. & Bäckhed, F., Sep 2017, In: I S M E Journal. 11, 9, p. 2035-2046 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Diabetes mellitus and metabolic syndrome

    Ortega, E., Martín-Cordero, L., Garcia-Roves, P. M., Chicco, A. J., Gonzalez-Franquesa, A. & Marado, D., 1 Jan 2015, Biomarkers of Cardiometabolic Risk, Inflammation and Disease. Springer, p. 55-79 25 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  16. Published

    Diabetes in population isolates: lessons from Greenland

    Grarup, N., Moltke, Ida, Albrechtsen, Anders & Hansen, Torben, 2015, In: The Review of Diabetic Studies. 12, 3-4, p. 320-329 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  17. Published

    Diabetes in infants may be treated with sulfonylurea as a replacement for insulin

    Lauridsen, M. H., Boesgaard, T. W., Pedersen, Oluf Borbye, Hansen, T. & Hertz, B., 2009, In: Ugeskrift for læger. 171, 23, p. 1923-1924 1 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Diabetes and obesity treatment based on dual incretin receptor activation: ‘twincretins’

    Skow, M. A., Bergmann, N. C. & Knop, Filip Krag, Sep 2016, In: Diabetes, Obesity and Metabolism. 18, 9, p. 847-54 8 p.

    Research output: Contribution to journalReviewResearchpeer-review

  19. Published

    Developmental trajectory of the healthy human gut microbiota during the first 5 years of life

    Roswall, J., Olsson, L. M., Kovatcheva-Datchary, P., Nilsson, S., Tremaroli, V., Simon, M., Kiilerich, P., Akrami, R., Kramer, M., Uhlen, M., Gummesson, A., Kristiansen, Karsten, Dahlgren, J. & Bäckhed, F., 2021, In: Cell Host & Microbe. 29, 5, p. 765-776.e3 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Developmental language disorder – a comprehensive study of more than 46,000 individuals

    Nudel, R., Christensen, Rikke Vang, Kalnak, N., Schwinn, M., Banasik, Karina, Dinh, K. M., Erikstrup, C., Pedersen, Ole Birger Vesterager, Burgdorf, Kristoffer Sølvsten, Ullum, H., Ostrowski, Sisse Rye, Hansen, Thomas Folkmann, Werge, Thomas & DBDS Genomic Consortium, D. G. C., 2023, In: Psychiatry Research. 323, 9 p., 115171.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Development, tracking, distribution and time trends in body weight during childhood

    Bjerregaard, L. G., Baker, J. L. & Sørensen, Thorkild I.A., 2018, Eating Disorders and Obesity in Children and Adolescents. Hebebrand, J. & Herpertz-Dahlmann, B. (eds.). 1 ed. St. Louis, Missouri: Elsevier, p. 63-66 4 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  22. Published

    Development of obesity and polycystic ovary syndrome in adolescents

    Vilmann, L. S., Thisted, E., Baker, J. L. & Holm, Jens-Christian, 2012, In: Hormone Research in Paediatrics. 78, 5-6, p. 269-78 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Development of immunity against Plasmodium falciparum malaria: clinical and parasitologic immunity cannot be separated

    Petersen, E., Høgh, Birthe, Marbiah, N. T., David, K. & Hanson, A. P., Nov 1991, In: The Journal of Infectious Diseases. 164, 5, p. 949-53 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Development of an automated, high-throughput assay to detect angiotensin AT2-receptor agonistic compounds by nitric oxide measurements in vitro

    Souza-Silva, I. M., Peluso, A. A., Mortensen, C., Nazarova, A. L., Stage, T. B., Sumners, C., Katritch, V. & Steckelings, U. M., 2024, In: Peptides. 172, 7 p., 171137.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Development of a type 2 diabetes risk model from a panel of serum biomarkers from the Inter99 cohort

    Kolberg, J. A., Jørgensen, T., Gerwien, R. W., Hamren, S., McKenna, M. P., Moler, E., Rowe, M. W., Urdea, M. S., Xu, X. M., Hansen, T., Pedersen, Oluf Borbye & Borch-Johnsen, K., 2009, In: Diabetes Care. 32, 7, p. 1207-12 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Development of a glucagon sensitivity test in humans: Pilot data and the GLUSENTIC study protocol

    Kjeldsen, S. A. S., Richter, M. M., Jensen, N. J., Nilsson, M. S. D., Heinz, N., Nybing, J. D., Linden, F. H., Høgh-Schmidt, E., Boesen, M. P., Madsbad, S., Vilstrup, H., Schiødt, F. V., Møller, A., Nørgaard, K., Schmidt, S., Rashu, E. B., Gluud, L. L., Haugaard, S. B., Holst, J. J., Rungby, J. & 1 others, Albrechtsen, Nicolai Jacob Wewer, 2023, In: Peptides. 161, 10 p., 170938.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Development and Validation of a Risk Score Predicting Substantial Weight Gain over 5 Years in Middle-Aged European Men and Women

    Steffen, A., Sørensen, T. I. A., Knüppel, S., Travier, N., Sánchez, M-J., Huerta, J. M., Quirós, J. R., Ardanaz, E., Dorronsoro, M., Teucher, B., Li, K., Bueno-de-Mesquita, H. B., van der A, D., Mattiello, A., Palli, D., Tumino, R., Krogh, V., Vineis, P., Trichopoulou, A., Orfanos, P. & 15 others, Trichopoulos, D., Hedblad, B., Wallström, P., Overvad, K., Halkjær, J., Tjønneland, Anne, Fagherazzi, G., Dartois, L., Crowe, F., Khaw, K., Wareham, N., Middleton, L., May, A. M., Peeters, P. H. M. & Boeing, H., 2013, In: P L o S One. 8, 7, p. 1-11 11 p., e67429.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. E-pub ahead of print
  29. Published

    Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

    Goodrich, J. K., Singer-Berk, M., Son, R., Sveden, A., Wood, J., England, E., Cole, J. B., Weisburd, B., Watts, N., Caulkins, L., Dornbos, P., Koesterer, R., Zappala, Z., Zhang, H., Maloney, K. A., Dahl, A., Aguilar-Salinas, C. A., Atzmon, G., Barajas-Olmos, F., Barzilai, N. & 31 others, Blangero, J., Boerwinkle, E., Bonnycastle, L. L., Bottinger, E., Bowden, D. W., Centeno-Cruz, F., Chambers, J. C., Chami, N., Chan, E., Chan, J., Cheng, C. Y., Cho, Y. S., Contreras-Cubas, C., Córdova, E., Correa, A., DeFronzo, R. A., Duggirala, R., Dupuis, J., Garay-Sevilla, M. E., García-Ortiz, H., Gieger, C., Glaser, B., González-Villalpando, C., Gonzalez, M. E., Grarup, N., Groop, L., Gross, M., Hansen, Torben, Linneberg, Allan René, Pedersen, Oluf Borbye & AMP-T2D-GENES Consortia, A. C., 2021, In: Nature Communications. 12, 15 p., 3505.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Determinants of Fasting Hyperglucagonemia in Patients with Type 2 Diabetes and Nondiabetic Control Subjects

    Demant, M., Bagger, J. I., Suppli, M. P., Lund, A., Gyldenløve, M., Hansen, K. B., Hare, Kristine Juul, Christensen, Mikkel Bring, Sonne, D. P., Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Dec 2018, In: Metabolic Syndrome and Related Disorders. 16, 10, p. 530-536 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing

    Jiang, Y., Yuen, R. K. C., Wang, M., Jin, X., Chen, N., Wu, X., Ju, J., Mei, J., Shi, Y., He, M., Wang, G., Liang, J., Wang, Z., Cao, D., Carter, M. T., Chrysler, C., Drmic, I. E., Howe, J. L., Lau, L., Marshall, C. R. & 19 others, Merico, D., Nalpathamkalam, T., Thiruvahindrapuram, B., Thompson, A., Uddin, M., Walker, S., Luo, J., Anagnostou, E., Zwaigenbaum, L., Ring, R. H., Wang, J., Lajonchere, C., Wang, J., Shih, A., Szatmari, P., Yang, H., Dawson, G., Li, Y. & Scherer, S. W., 2013, In: American Journal of Human Genetics. 93, 2, p. 249-263 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Designing Poly-agonists for Treatment of Metabolic Diseases: Challenges and Opportunities

    Petersen, Jonas Odgaard, Strømgaard, Kristian, Frølund, Bente & Clemmensen, Christoffer, 2019, In: Drugs. 79, 11, p. 1187-1197 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Design of association studies with pooled or un-pooled next-generation sequencing data

    Kim, S. Y., Li, Y., Guo, Y., Li, R., Holmkvist, J., Hansen, Torben, Pedersen, Oluf Borbye, Wang, J. & Nielsen, Rasmus, 2010, In: Genetic Epidemiology. 34, 5, p. 479-491 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Describing the fecal metabolome in cryogenically collected samples from healthy participants

    Trošt, K., Ahonen, L., Suvitaival, T., Christiansen, N., Nielsen, T., Thiele, M., Jacobsen, S., Krag, A., Rossing, Peter, Hansen, Torben, Dragsted, Lars Ove & Legido-Quigley, C., 2020, In: Scientific Reports. 10, 1, 8 p., 885.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Depressive symptoms in women's midlife in relation to their body weight before, during and after childbearing years

    Bliddal, M., Pottegård, A., Kirkegaard, H., Olsen, J., Sørensen, Thorkild I.A. & Nohr, E. A., Dec 2016, In: Obesity Science & Practice. 2, 4, p. 415-425 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography

    Deschasaux, M., Bouter, K. E., Prodan, A., Levin, E., Groen, A. K., Herrema, H., Tremaroli, V., Bakker, G. J., Attaye, I., Pinto-Sietsma, S., van Raalte, D. H., Snijder, M. B., Nicolaou, M., Peters, R., Zwinderman, A. H., Backhed, F. & Nieuwdorp, M., 2018, In: Nature Medicine. 24, 10, p. 1526-1531

    Research output: Contribution to journalLetterResearchpeer-review

  37. Published

    Denmark's big tent includes postdocs

    Dall, M. & Pedersen, M. H., 2023, In: Science. 380, 6641, p. 143 1 p.

    Research output: Contribution to journalLetterResearchpeer-review

  38. Published

    Delayed ß-cell response and glucose intolerance in young women with Turner syndrome

    Hjerrild, B. E., Holst, Jens Juul, Juhl, C., Christiansen, J. S., Schmitz, O. & Gravholt, C. H., 2011, In: B M C Endocrine Disorders. 11, p. 11-6 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Delayed onset of hyperglycaemia in a mouse model with impaired glucagon secretion demonstrates that dysregulated glucagon secretion promotes hyperglycaemia and type 2 diabetes

    Gustavsson, N., Seah, T., Lao, Y., Radda, G. K., Südhof, T. C. & Han, W., Feb 2011, In: Diabetologia. 54, 2, p. 415-22 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Delayed age at transfer of adoptees to adoptive parents is associated with increased mortality irrespective of social class of the adoptive parents: a cohort study

    Petersen, L., Andersen, Per Kragh, Sørensen, Thorkild I.A. & Mortensen, Erik Lykke, 2018, In: BMC Public Health. 18, 1, 7 p., 435.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Degradation of glucagon-like peptide-1 in vitro yields an N-terminally truncated peptide which is a major endogenous metabolite in vivo.

    Deacon, Carolyn F., Johnsen, A. H. & Holst, Jens Juul, 1995, In: Journal of Clinical Endocrinology and Metabolism. 80, p. 952-957

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Defining the role of GLP-1 in the enteroinsulinar axis in type 2 diabetes using DPP-4 inhibition and GLP-1 receptor blockade

    Aulinger, B. A., Bedorf, A., Kutscherauer, G., de Heer, J., Holst, Jens Juul, Göke, B. & Schirra, J., Mar 2014, In: Diabetes. 63, 3, p. 1079-92 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Deficiency of the intestinal growth factor, glucagon-like peptide 2, in the colon of SCID mice with inflammatory bowel disease induced by transplantation of CD4+ T cells

    Schmidt, P. T., Hartmann, Bolette, Bregenholt, S., Holst, Jens Juul & Claesson, Mogens Helweg, 1 May 2000, In: Scandinavian Journal of Gastroenterology. 35, 5, p. 522-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Deficiency of cardiac Acyl-CoA synthetase-1 induces diastolic dysfunction, but pathologic hypertrophy is reversed by rapamycin

    Paul, D. S., Grevengoed, Trisha Jean, Pascual, F., Ellis, J. M., Willis, M. S. & Coleman, R. A., Jun 2014, In: B B A - Reviews on Cancer. 1841, 6, p. 880-7 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Defects in α-Cell Function in Patients With Diabetes Due to Chronic Pancreatitis Compared With Patients With Type 2 Diabetes and Healthy Individuals

    Mumme, L., Breuer, T. G. K., Rohrer, S., Schenker, N., Menge, B. A., Holst, Jens Juul, Nauck, M. A. & Meier, J. J., Oct 2017, In: Diabetes Care. 40, 10, p. 1314-1322 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Defects in TLR3 expression and RNase L activation lead to decreased MnSOD expression and insulin resistance in muscle cells of obese people

    Fabre, O. M. J., Breuker, C., Amouzou, C., Salehzada, T., Kitzmann, M., Mercier, J. & Bisbal, C., 2014, In: Cell Death & Disease. 5, p. 1-11 11 p., e1136.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    DeepFake electrocardiograms using generative adversarial networks are the beginning of the end for privacy issues in medicine

    Thambawita, Vajira Lasantha Bandara, Isaksen, Jonas L., Hicks, S. A., Ghouse, Jonas, Ahlberg, G., Linneberg, Allan René, Grarup, N., Ellervik, Christina, Olesen, Morten Steen Salling, Hansen, Torben, Graff, C., Holstein-Rathlou, N., Strümke, I., Hammer, H. L., Maleckar, M. M., Halvorsen, P., Riegler, M. A. & Kanters, Jørgen K., 2021, In: Scientific Reports. 11, 1, 8 p., 21896.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    DeepFake electrocardiograms: the key for open science for artificial intelligence in medicine

    Thambawita, V., Isaksen, Jonas L., Hicks, S. A., Ghouse, Jonas, Ahlberg, Gustav, Linneberg, Allan René, Grarup, N., Ellervik, Christina, Olesen, Morten Steen Salling, Hansen, Torben, Graff, C., Holstein-Rathlou, N., Strümke, I., Hammer, H. L., Maleckar, M., Halvorsen, P., Riegler, M. A. & Kanters, Jørgen K., 2022, 17 p. (medRxiv).

    Research output: Working paperPreprintResearch

  49. Published

    Deep proteomics of mouse skeletal muscle enables quantitation of protein isoforms, metabolic pathways and transcription factors

    Deshmukh, Atul Shahaji, Murgia, M., Nagaraja, N., Treebak, Jonas Thue, Cox, J. & Mann, Matthias, Apr 2015, In: Molecular and Cellular Proteomics. 14, 4, p. 841-853

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published