- 2019
- Published
Effects of glucagon-like peptide 1 analogs on alcohol intake in alcohol-preferring vervet monkeys
Thomsen, M., Holst, Jens Juul, Molander, A., Linnet, Kristian, Ptito, M. & Fink-Jensen, Anders, Feb 2019, In: Psychopharmacology. 236, 2, p. 603–611Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of liraglutide on body weight and microvascular function in non-diabetic overweight women with coronary microvascular dysfunction
Suhrs, H. E., Raft, K. F., Bové, K., Madsbad, Sten, Holst, Jens Juul, Zander, M. & Prescott, Eva, 2 Jan 2019, In: International Journal of Cardiology. 283, p. 28-34Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial
Roager, H. M., Vogt, J. K., Kristensen, M. B., Hansen, L. B. S., Ibrügger, S., Mærkedahl, R. B., Bahl, M. I., Lind, M. V., Nielsen, R. L., Frøkiær, H., Gøbel, R. J., Landberg, R., Ross, A. B., Brix, S., Holck, J., Meyer, A. S., Sparholt, M. H., Christensen, A. F., Carvalho, V., Hartmann, B. & 18 others, , Jan 2019, In: Gut. 68, 1, p. 83-93 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FADS and PPARG2 single nucleotide polymorphisms are associated with plasma lipids in 9-mo-old infants
Lauritzen, Lotte, Amundsen, I. D., Damsgaard, Camilla Trab, Lind, M. V., Schnurr, T. M., Hansen, Torben, Michaelsen, Kim F. & Vogel, U., 2019, In: Journal of Nutrition. 149, 5, p. 708-715 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training
Blond, Martin Bæk, Schnurr, T. M., Rasenkilde, M., Quist, Jonas Salling, Gram, A. S., Reichkendler, M. H., Auerbach, P. L., Nordby, P., Skovgaard, Lene Theil, Ribel-Madsen, R., Justesen, Johanne Marie, Kilpeläinen, Tuomas O., Ploug, Thorkil, Stallknecht, Bente Merete & Hansen, Torben, 2019, In: Physiological Genomics. 51, 6, p. 254-260Research output: Contribution to journal › Journal article › Research › peer-review
- Published
N-acyl taurines are endogenous lipid messengers that improve glucose homeostasis
Grevengoed, Trisha Jean, Trammell, Sam, McKinney, M. K., Petersen, N., Cardone, R. L., Svenningsen, J. S., Ogasawara, D., Nexøe-Larsen, C. C., Knop, Filip Krag, Schwartz, Thue W., Kibbey, R. G., Cravatt, B. F. & Gillum, M. P., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 49, p. 24770-24778Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Pilot Study Showing Acute Inhibitory Effect of GLP-1 on the Bone Resorption Marker CTX in Humans
Nissen, A., Marstrand, S., Skov-Jeppesen, Kirsa, Bremholm, L., Hornum, Mads, Andersen, U. B., Holst, Jens Juul, Rosenkilde, M. M. & Hartmann, Bolette, 2019, In: JBMR Plus. 3, 10, 6 p., e10209.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A carbohydrate-reduced high-protein diet improves HbA1c and liver fat content in weight stable participants with type 2 diabetes: a randomised controlled trial
fbg982, fbg982, Samkani, A., Petersen, A. D., Thomsen, M. N., Astrup, A., Chabanova, E., Frystyk, J., Holst, Jens Juul, Thomsen, Henrik S., Madsbad, Sten, Larsen, T. M., Haugaard, Steen Bendix & Krarup, T., 2019, In: Diabetologia. 62, 11, p. 2066-2078 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A cost analysis of intensified vs conventional multifactorial therapy in individuals with type 2 diabetes: a post hoc analysis of the Steno-2 study
Gæde, J., Oellgaard, J., Ibsen, R., Gæde, P., Nortoft, E., Parving, H., Kjellberg, J. & Pedersen, Oluf Borbye, 2019, In: Diabetologia. 62, 1, p. 147-155Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A house of collaboration: investigating the intersections of art and biomedicine
Arnold, Ken, Bencard, Adam, Pedersen, B. V., Söderqvist, Thomas, Tybjerg, Karin & Whiteley, Louise, 2019, Art and Science in Museums. Rossi-Linnemann, C. & di Martini, G. (eds.). 1 ed. Routledge, (Routledge Research in Museum Studies).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
A meta-analysis of genome-wide association studies identifies multiple longevity genes
Deelen, J., Evans, D. S., Arking, D. E., Tesi, N., Nygaard, M., Liu, X., Wojczynski, M. K., Biggs, M. L., van Der Spek, A., Atzmon, G., Ware, E. B., Sarnowski, C., Smith, A. V., Seppala, I., Cordell, H. J., Dose, J., Amin, N., Arnold, A. M., Ayers, K. L., Barzilai, N. & 64 others, , 2019, In: Nature Communications. 10, 14 p., 3669.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity
van der Lee, S. J., Conway, O. J., Jansen, I., Carrasquillo, M. M., Kleineidam, L., van den Akker, E., Hernandez, I., van Eijk, K. R., Stringa, N., Chen, J. A., Zettergren, A., Andlauer, T. F. M., Diez-Fairen, M., Simon-Sanchez, J., Lleo, A., Zetterberg, H., Nygaard, M., Blauwendraat, C., Savage, J. E., Mengel-From, J. & 81 others, , 2019, In: Acta Neuropathologica. 138, 2, p. 237-250 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria
Ahluwalia, T. S., Schulz, C-A., Waage, J., Skaaby, T., Sandholm, N., van Zuydam, N., Charmet, R., Bork-Jensen, J., Almgren, P., Thuesen, B. H., Bedin, M., Brandslund, I., Christensen, C. K., Linneberg, A., Ahlqvist, E., Groop, P-H., Hadjadj, S., Tregouet, D-A., Jorgensen, M. E., Grarup, N. & 9 others, , 2019, In: Diabetologia. 62, 2, p. 292-305Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A pre-meal of whey proteins induces differential effects on glucose and lipid metabolism in subjects with the metabolic syndrome: a randomised cross-over trial
Bjørnshave, A., Holst, Jens Juul & Hermansen, K., 2019, In: European Journal of Nutrition. 58, 2, p. 755-764Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A role for exogenous GLP-1 in the management of postprandial hypoglycaemia after Roux-en-Y gastric bypass?
Øhrstrøm, C. C. & Knop, Filip Krag, 2019, In: European Journal of Endocrinology. 181, 3, p. C5-C8Research output: Contribution to journal › Comment/debate › Research
- Published
A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity
Bradfield, J. P., Vogelezang, S., Felix, J. F., Chesi, A., Helgeland, O., Horikoshi, M., Karhunen, V., Lowry, E., Cousminer, D. L., Ahluwalia, T. S., Thiering, E., Boh, E. T-H., Zafarmand, M. H., Vilor-Tejedor, N., Wang, C. A., Joro, R., Chen, Z., Gauderman, W. J., Pitkanen, N., Parra, E. J. & 79 others, , 2019, In: Human Molecular Genetics. 28, 19, p. 3327-3338Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ADAMTS9 regulates skeletal muscle insulin sensitivity through extracellular matrix alterations
Graae, A-S., Grarup, N., Ribel-Madsen, R., Lystbæk, S. H., Boesgaard, T., Staiger, H., Fritsche, A., Wellner, N., Sulek, K., Kjølby, M. F., Backe, M. B., Chubanava, S., Prats, C., Serup, A. K. L., Birk, J. B., Dubail, J., Gillberg, L., Vienberg, S. G., Nykjær, A., Kiens, B. & 10 others, , 2019, In: Diabetes. 68, 3, p. 502-514Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Abdominal adiposity and cardiometabolic risk factors in children and adolescents: A Mendelian randomization analysis
Viitasalo, A., Schnurr, T. M., Pitkänen, N., Hollensted, M., Nielsen, T. R. H., Pahkala, K., Atalay, M., Lind, M. V., Heikkinen, S., Frithioff-Bøjsøe, C., Fonvig, C. E., Grarup, N., Kähönen, M., Carrasquilla, G. D., Larnkjær, A., Pedersen, O., Michaelsen, K. F., Lakka, T. A., Holm, J-C., Lehtimäki, T. & 3 others, , 2019, In: American Journal of Clinical Nutrition. 110, 5, p. 1079-1087 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Abscisic acid stimulates the release of insulin and of GLP-1 in the rat perfused pancreas and intestine
Booz, V., Christiansen, Charlotte Bayer, Kuhre, Rune Ehrenreich, Saltiel, M. Y., Sociali, G., Schaltenberg, N., Fischer, A. W., Heeren, J., Zocchi, E., Holst, Jens Juul & Bruzzone, S., 2019, In: Diabetes - Metabolism: Research and Reviews (Print Edition). 35, 8 p., e3102.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Abundance of gut Prevotella at baseline and metabolic response to barley prebiotics
Sandberg, J., Kovatcheva-datchary, P., Björck, I., Bäckhed, F. & Nilsson, A., 2019, In: European Journal of Nutrition. 58, 6, p. 2365-2376Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients
Vestergaard, E. T., Hjelholt, A. J., Kuhre, Rune Ehrenreich, Møller, N., Larraufie, P., Gribble, F. M., Reimann, F., Jessen, N., Holst, Jens Juul & Jørgensen, J. O. L., 2019, In: The Journal of clinical endocrinology and metabolism. 104, 7, p. 2581-2592Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Aerobic Exercise Performance and Muscle Strength in Statin Users-The LIFESTAT Study
Morville, T., Dohlmann, T. L., Kuhlman, A. B., Sahl, Ronni Eg, Kriegbaum, Margit, Larsen, Steen, Dela, Flemming & Helge, Jørn Wulff, 2019, In: Medicine and Science in Sports and Exercise. 51, 7, p. 1429-1437 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Aerobic and resistance exercise training reverses age-dependent decline in NAD(+) salvage capacity in human skeletal muscle
de Guia, R. M., Agerholm, M., Nielsen, Thomas Svava, Consitt, L. A., Sogaard, D., Helge, Jørn Wulff, Larsen, Steen, Brandauer, J., Houmard, J. A. & Treebak, Jonas Thue, 2019, In: Physiological Reports. 7, 12, 15 p., e14139.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Afadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue
Lundh, M., Petersen, P. S., Isidor, Marie Sophie, Kazoka-Sørensen, D. N., Plucinska, Kaja, Shamsi, F., Ørskov, Cathrine, Tozzi, M., Brown, E. L., Andersen, E., Ma, Tao, Müller, U. A., Barrès, Romain, Kristiansen, V. B., Gerhart-Hines, Zach, Tseng, Y. & Emanuelli, Brice, 2019, In: EMBO Reports. 20, 8, e48216.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Affective disorders and high familial risk of affective disorders associate with aberrant intestinal microbiota
Vinberg, Maj, Ottesen, N., Meluken, I., Sørensen, N., Pedersen, Oluf Borbye, Kessing, Lars Vedel & Miskowiak, Kamilla, 2019, In: European Neuropsychopharmacology. 29, Suppl. 1, p. S51 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial
Savikj, M., Gabriel, B. M., Alm, P. S., Smith, J., Caidahl, K., Bjoernholm, M., Fritz, T., Krook, A., Zierath, Juleen R & Wallberg-Henriksson, H., 2019, In: Diabetologia. 62, p. 233-237Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Allostery in Coagulation Factor VIIa Revealed by Ensemble Refinement of Crystallographic Structures
Sørensen, A. B., Madsen, J. J., Frimurer, Thomas Michael, Overgaard, M. T., Gandhi, P. S., Persson, E. & Olsen, O. H., 2019, In: Biophysical Journal. 116, 10, p. 1823-1835Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise
Ziegler, A. K., Damgaard, A., Mackey, Abigail, Schjerling, Peter, Magnusson, Stig Peter, Olesen, A. T., Kjær, Michael & Schéele, Camilla Charlotte Nielsen, 2019, In: Scientific Reports. 9, 11 p., 12069.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Animal models of mucositis: critical tools for advancing pathobiological understanding and identifying therapeutic targets
Wardill, H. R., Tissing, W. J. E., Kissow, Hannelouise & Stringer, A. M., 2019, In: Current Opinion in Supportive and Palliative Care. 13, 2, p. 119-133Research output: Contribution to journal › Review › Research › peer-review
- Published
Antibiotic use during pregnancy and childhood overweight: A population-based nationwide cohort study
Jess, T., Morgen, C. S., Harpsoe, M. C., Sørensen, Thorkild I.A., Ajslev, T. A., Antvorskov, J. C. & Allin, K. H., 2019, In: Scientific Reports. 9, 9 p., 11528 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Application of unsupervised learning in weight-loss categorisation for weight management programs
Babajide, O., Hissam, T., Palczewska, A., Astrup, A., Martinez, J. A., Oppert, J. M. & Sørensen, Thorkild I.A., 2019, The 10th IEEE International Conference on Dependable Systems, Services and Technologies. DESSERT'2019: Conference proceedings. IEEE, p. 94-101 8 p. 8770032Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
- Published
Assessment of Islet Alphaand beta-cell function
Madsbad, Sten & Holst, Jens Juul, 2019, Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease: A Focus on Early Phase Clinical Drug Development. Springer, p. 37-74 38 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Assessment of mouse liver [1-13C]pyruvate metabolism by dynamic hyperpolarized MRS
Faarkrog Høyer, K., Laustsen, C., Ringgaard, S., Qi, H., Mariager, C. Ø., Nielsen, Thomas Svava, Sundekilde, U. K., Treebak, Jonas Thue, Jessen, N. & Stødkilde-Jørgensen, H., 2019, In: Journal of Endocrinology. 242, 3, p. 251-260 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association between fat mass, adipose tissue, fat fraction per adipose tissue, and metabolic risks: a cross-sectional study in normal, overweight, and obese adults
Huebers, M., Geisler, C., Bosy-Westphal, A., Braun, W., Pourhassan, M., Sørensen, Thorkild I.A. & Mueller, M. J., 2019, In: European Journal of Clinical Nutrition. 73, 1, p. 62-71 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association between topical corticosteroid use and type 2 diabetes in two European population-based adult cohorts
Andersen, Y. M. F., Egeberg, A., Ban, L., Gran, S., Williams, H. C., Francis, N. A., Knop, Filip Krag, Gislason, Gunnar Hilmar, Skov, Lone & Thyssen, Jacob Pontoppidan, 2019, In: Diabetes Care. 42, 6, p. 1095-1103Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study
Huang, T., Wang, T., Zheng, Y., Ellervik, C., Li, X., Gao, M., Fang, Z., Chai, J-F., Ahluwalia, T. V. S., Wang, Y., Voortman, T., Noordam, R., Frazier-Wood, A., Scholz, M., Sonestedt, E., Akiyama, M., Dorajoo, R., Zhou, A., Kilpeläinen, T. O., Kleber, M. E. & 31 others, , 2019, In: JAMA Network Open. 2, 9, 18 p., e1910915.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes
Voerman, E., Santos, S., Inskip, H., Amiano, P., Barros, H., Charles, M-A., Chatzi, L., Chrousos, G. P., Corpeleijn, E., Crozier, S., Doyon, M., Eggesbo, M., Fantini, M. P., Farchi, S., Forastiere, F., Georgiu, V., Gori, D., Hanke, W., Hertz-Picciotto, I., Heude, B. & 46 others, , 2019, In: J A M A: The Journal of the American Medical Association. 321, 17, p. 1702-1715 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis
Skaaby, T., Kilpeläinen, T. O., Taylor, A. E., Mahendran, Y., Wong, A., Ahluwalia, T. S., Paternoster, L., Trompet, S., Stott, D. J., Flexeder, C., Zhou, A., Brusselle, G., Sajjad, A., Lahousse, L., Tiemeier, H., Have, C. T., Thuesen, B. H., Kårhus, L. L., Møllehave, L. T., Leth-Møller, K. B. & 27 others, , 2019, In: Addiction. 114, 2, p. 216-225 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association of genetic variants previously implicated in coronary artery disease with age at onset of coronary artery disease requiring revascularizations
Andersson, C., Krogager, M. L., Skals, R. K., Appel, E. V. R., Have, C. T., Grarup, N., Pedersen, O., Jeppesen, J. L., Pedersen, O. D., Dominguez, H., Dixen, U., Engstrøm, T., Tønder, N., Roden, D. M., Stender, S., Gislason, G. H., Enghusen-Poulsen, H., Hansen, T., Køber, L., Torp-Pedersen, C. & 1 others, , 2019, In: P L o S One. 14, 2, 12 p., e0211690.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Associations between adult height and type 2 diabetes mellitus: a systematic review and meta-analysis of observational studies
Shrestha, S., Rasmussen, S. H., Pottegård, A., Ängquist, Lars, Jess, T., Allin, K. H., Bjerregaard, L. G. & Baker, J. L., 2019, In: Journal of Epidemiology & Community Health. 73, 7, p. 681-688Research output: Contribution to journal › Review › Research › peer-review
- Published
Associations between birth weight and glucose intolerance in adulthood among Greenlandic Inuit
Rønn, P. F., Jørgensen, M. E., Smith, L. S., Bjerregaard, P., Dahl-Petersen, I. K., Larsen, C. V. L., Grarup, Niels & Andersen, G. S., 2019, In: Diabetes Research and Clinical Practice. 150, p. 129-137 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Associations between olfactory pathway gene methylation marks, obesity features and dietary intakes
Ramos-Lopez, O., Riezu-Boj, J. I., Milagro, F. I., Zulet, M. A., Santos, J. L., Martinez, J. A., Astrup, A., Larsen, T. M. & MENA Project, M. P., 2019, In: Genes & Nutrition. 14, 10 p., 11.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Associations between thyroid-stimulating hormone, blood pressure and adiponectin are attenuated in children and adolescents with overweight or obesity
Drivsholm, A., Lund, Morten Asp Vonsild, Hedley, P. L., Jespersen, Thomas, Christiansen, M., Hansen, Torben & Holm, Jens-Christian, 2019, In: Journal of Pediatric Endocrinology and Metabolism. 32, 12, p. 1351-1358Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits
Kraja, A. T., Liu, C., Fetterman, J. L., Graff, M., Have, C. T., Gu, C., Yanek, L. R., Feitosa, M. F., Arking, D. E., Chasman, D. I., Young, K., Ligthart, S., Hill, W. D., Weiss, S., Luan, J., Giulianini, F., Li-Gao, R., Hartwig, F. P., Lin, S. J., Wang, L. & 132 others, , 2019, In: American Journal of Human Genetics. 104, 1, p. 112-138 27 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Attitudes to and experiences with body weight control and changes in body weight in relation to all-cause mortality in the general population
Morgen, C. S., Ängquist, Lars, Appleyard, M., Schnohr, P., Jensen, G. B. & Sørensen, Thorkild I.A., 2019, In: PLoS ONE. 14, 8, 13 p., e0220838.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bariatric surgery in patients with non-alcoholic fatty liver disease from pathophysiology to clinical effects
Laursen, T. L., Hagemann, C. A., Wei, C., Kazankov, K., Thomsen, K. L., Knop, Filip Krag & Gronbaek, H., 2019, In: World Journal of Hepatology. 11, 2, p. 138-149Research output: Contribution to journal › Review › Research › peer-review
- Published
Bariatric surgery-which procedure is the optimal choice?
Madsbad, Sten & Holst, Jens Juul, 2019, In: Lancet. 393, 10178, p. 1263-1264Research output: Contribution to journal › Comment/debate › Research
- Published
Benchmarker: An Unbiased, Association-Data-Driven Strategy to Evaluate Gene Prioritization Algorithms
Fine, R. S., Pers, Tune H, Amariuta, T., Raychaudhuri, S. & Hirschhorn, J. N., 2019, In: American Journal of Human Genetics. 104, 6, p. 1025-1039Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Beneficial impact of intensified multifactorial intervention on risk of stroke: outcome of 21 years of follow-up in the randomised Steno-2 Study
Gæde, P., Oellgaard, J., Kruuse, Christina Rostrup, Rossing, Peter, Parving, H. & Pedersen, Oluf Borbye, 2019, In: Diabetologia. 62, 9, p. 1575-1580Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Benefit-Risk Assessment of Obesity Drugs: Focus on Glucagon-like Peptide-1 Receptor Agonists
Christensen, R. M., Juhl, C. R. & Torekov, Signe Sørensen, 2019, In: Drug Safety. 42, 8, p. 957-971 15 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7
Jørgensen, Astrid Sissel, Larsen, Olav, Uetz-von Allmen, E., Lückmann, Michael, Legler, D. F., Frimurer, Thomas Michael, Veldkamp, C. T., Hjortø, Gertrud Malene & Rosenkilde, Mette, 2019, In: Frontiers in Immunology. 10, 14 p., 2156.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bile Modulates Secretion of Incretins and Insulin: A Study of Human Extrahepatic Cholestasis
Mezza, T., Moffa, S., Ferraro, P. M., Quero, G., Capece, U., Carfi, A., Cefalo, C. M. A., Cinti, F., Sorice, G. P., Impronta, F., Mari, A., Pontecorvi, A., Alfieri, S., Holst, Jens Juul & Giaccari, A., 2019, In: Journal of Clinical Endocrinology & Metabolism. 104, 7, p. 2685-2694Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents
Christiansen, Charlotte Bayer, Trammell, Sam, Albrechtsen, Nicolai Jacob Wewer, Schoonjans, K., Albrechtsen, Reidar, Gillum, M. P., Kuhre, Rune Ehrenreich & Holst, Jens Juul, 2019, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 316, 5, p. G574-G584 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biliopancreatic diversion with duodenal switch (BPD-DS) and single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) result in distinct post-prandial hormone profiles
Pereira, S. S., Guimarães, M., Almeida, R., Pereira, A. M., Lobato, C. B., Hartmann, Bolette, Hilsted, Linda, Holst, Jens Juul, Nora, M. & Monteiro, M. P., 2019, In: International Journal of Obesity. 43, p. 2518-2527Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biomarkører for kardiovaskulær sygdom ved type 2-diabetes
Krogh, S. K., Andersen, A., Knop, Filip Krag & Vilsbøll, Tina, 2019, In: Ugeskrift for Laeger. 181, 6 p., V10180711.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Birth weight and the risk of histological subtypes of ovarian and endometrial cancers: Results from the Copenhagen School Health Records Register
Trabert, B., Aarestrup, J., Ulrich, L. G., Wentzensen, N., Sørensen, Thorkild I.A. & Baker, J. L., 2019, In: Gynecologic Oncology. 148, 3, p. 547-552 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Birthweight and risk of thyroid cancer and its histological types: A large cohort study
Aarestrup, J., Kitahara, C. M. & Baker, J. L., 2019, In: Cancer Epidemiology. 62, 101564.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Body mass index in young men and risk of inflammatory bowel disease through adult life: A population-based Danish cohort study
Mendell, M. A., Jensen, C. B., Sørensen, Thorkild I.A., Ängquist, Lars & Jess, T., 2019, In: Scientific Reports. 9, 9 p., 6360.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bone Status in Obese, Non-diabetic, Antipsychotic-Treated Patients, and Effects of the Glucagon-Like Peptide-1 Receptor Agonist Exenatide on Bone Turnover Markers and Bone Mineral Density
Eriksson, R., Broberg, B. V., Ishoy, P. L., Bak, N., Andersen, U. B., Jorgensen, N. R., Knop, Filip Krag & Ebdrup, Bjørn, 2019, In: Frontiers in Psychiatry. 9, 7 p., 781.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Breastfeeding duration in infancy and adult risks of type 2 diabetes in a high-income country
Bjerregaard, L. G., Pedersen, D. C., Mortensen, Erik Lykke, Sørensen, Thorkild I.A. & Baker, J. L., 2019, In: Maternal and Child Nutrition. 15, 4, 9 p., e12869.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Calorie restriction prevents diet-induced insulin resistance independently of PGC-1-driven mitochondrial biogenesis in white adipose tissue
Pardo, R., Vila, M., Cervela, L., de Marco, M., Gama-Perez, P., Gonzalez-Franquesa, A., Statuto, L., Vilallonga, R., Simo, R., Garcia-Roves, P. M. & Villena, J. A., 2019, In: FASEB Journal. 33, 2, p. 2343-2358Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cardiovascular Risk Profile Among Patients With Inflammatory Bowel Disease: A Population-based Study of More Than 100 000 Individuals
Aarestrup, J., Jess, T., Kobylecki, C. J., Nordestgaard, Børge & Allin, K. H., 2019, In: Journal of Crohn's and Colitis. 13, 3, p. 319-323 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Changes in Childhood Body-Mass Index and Risk of Venous Thromboembolism in Adulthood
Sundbøll, J., Ängquist, Lars, Adelborg, K., Gjærde, L. K., Ording, A., Sørensen, Thorkild I.A., Baker, J. L. & Sørensen, H. T., 2019, In: Journal of the American Heart Association. 8, 6, 20 p., e011407.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Changes in Vitamin D Status in Overweight Middle-Aged Adults with or without Impaired Glucose Metabolism in Two Consecutive Nordic Summers
Lundstrom, P., Caidahl, K., Eriksson, M. J., Fritz, T., Krook, A., Zierath, Juleen R & Rickenlund, A., 2019, In: Journal of Nutrition and Metabolism. 2019, p. 1-8 1840374.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Childhood Overweight, Tallness, and Growth Increase Risks of Ovarian Cancer
Aarestrup, J., Trabert, B., Ulrich, L. G., Wentzensen, N., Sørensen, Thorkild I.A. & Baker, J. L., 2019, In: Cancer Epidemiology, Biomarkers & Prevention. 28, 1, p. 183-188Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Childhood growth and risk of inflammatory bowel disease: a population-based study of 317,030 children
Mendall, M., Jensen, C. B., Ängquist, Lars, Baker, J. L. & Jess, T., 2019, In: Scandinavian Journal of Gastroenterology. 54, 7, p. 863-868Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Childhood height and risk of testicular germ cell tumors in adulthood
McGlynn, K. A., Petrick, J. L., Gamborg, Michael Orland, Aarestrup, J. & Baker, J. L., 2019, In: International Journal of Cancer. 143, 4, p. 767-772 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Circadian rhythms and exercise - re-setting the clock in metabolic disease
Gabriel, B. M. & Zierath, Juleen R, 2019, In: Nature Reviews Endocrinology. 15, 4, p. 197-206Research output: Contribution to journal › Review › Research › peer-review
- Published
Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans
Muller, M., Hernandez, M. A. G., Goossens, G. H., Reijnders, D., Holst, Jens Juul, Jocken, J. W. E., van Eijk, H., Canfora, E. E. & Blaak, E. E., 2019, In: Scientific Reports. 9, 9 p., 12515.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Circulating microbiome in blood of different circulatory compartments
Schierwagen, R., Alvarez Silva, Maria Camila, Madsen, M. S. A., Kolbe, C. C., Meyer, C., Thomas, D., Uschner, F. E., Magdaleno, F., Jansen, C., Pohlmann, A., Praktiknjo, M., Hischebeth, G. T., Molitor, E., Latz, E., Lelouvier, B., Trebicka, J. & Arumugam, Mani, 2019, In: Gut. 68, 3, p. 578-580Research output: Contribution to journal › Letter › Research › peer-review
- Published
Clinical characteristics and glucose-lowering drug utilization among patients initiating liraglutide in Denmark: a routine clinical care prescription study
Knudsen, J. S., Thomsen, R. W., Pottegard, A., Knop, Filip Krag & Sørensen, H. T., 2019, In: Journal of Diabetes. 11, 8, p. 690-694Research output: Contribution to journal › Letter › Research › peer-review
- Published
Cohort Profile: The DynaHEALTH consortium - a European consortium for a life-course bio-psychosocial model of healthy ageing of glucose homeostasis
Sebert, S., Lowry, E., Aumuller, N., Bermudez, M. G., Bjerregaard, L. G., de Rooij, S. R., De Silva, M., El Marroun, H., Hummel, N., Juola, T., Mason, G., Much, D., Oliveros, E., Poupakis, S., Rautio, N., Schwarzfischer, P., Tzala, E., Uhl, O., van de Beek, C., Vehmeijer, F. & 23 others, , 2019, In: International Journal of Epidemiology. 48, 4, p. 1051-1051k 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Combined GLP-1, Oxyntomodulin, and Peptide YY Improves Body Weight and Glycemia in Obesity and Prediabetes/Type 2 Diabetes: A Randomized Single-Blinded Placebo Controlled Study
Behary, P., Tharakan, G., Alexiadou, K., Johnson, N., Albrechtsen, N. J. W., Kenkre, J., Cuenco, J., Hope, D., Anyiam, O., Choudhury, S., Alessimii, H., Poddar, A., Minnion, J., Doyle, C., Frost, G., Le Roux, C., Purkayastha, S., Moorthy, K., Dhillo, W., Holst, J. J. & 4 others, , 2019, In: Diabetes Care. 42, 7, 8 p., dc190449.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparative genome sequencing and analyses of Mycobacterium cosmeticum reveal potential for biodesulfization of gasoline
Wee, W. Y., Dutta, A., Jayaraj, J. & Choo, S. W., 2019, In: PLOS ONE. 14, 4, 18 p., e0214663.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis
Alvarez Silva, Maria Camila, Schierwagen, R., Pohlmann, A., Magdaleno, F., Uschner, F. E., Ryan, P., Vehreschild, M. J. G. T., Claria, J., Latz, E., Lelouvier, B., Arumugam, Mani & Trebicka, J., 2019, In: Frontiers in Immunology. 10, 11 p., 69.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology
Tanigawa, Y., Li, J., Justesen, Johanne Marie, Horn, H., Aguirre, M., DeBoever, C., Chang, C., Narasimhan, B., Lage, K., Hastie, T., Park, C. Y., Bejerano, G., Ingelsson, E. & Rivas, M. A., 2019, In: Nature Communications. 10, 14 p., 4064.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Copeptin, a surrogate marker for arginine vasopressin secretion, is positively associated with glucagon
Lundegaard Asferg, C., Bjørn Andersen, U., Linneberg, Allan René, Goetze, Jens P. , Holst, Jens Juul & Jeppesen, J. L., 2019, In: Diabetic Medicine. 36, 11, p. 1408-1411 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Curating experimental entanglements
Bencard, Adam, Whiteley, Louise & Thon, C. H., 2019, Curatorial Challenges: Interdisciplinary Perspectives on Contemporary Curating. Hansen, M. V., Henningsen, A. F. & Gregersen, A. (eds.). 1 ed. Routledge, (Routledge research in art museums and exhibitions).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise
Henriquez-Olguín, Carlos, Knudsen, Jonas Roland, Raun, Steffen Henning, Li, Z., Kellezi, Emilie Dalbram, Treebak, Jonas Thue, Sylow, Lykke, Holmdahl, R., Richter, Erik A., Jaimovich, E. & Jensen, Thomas Elbenhardt, 2019, In: Nature Communications. 10, 11 p., 4623.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dairy Intake and Body Composition and Cardiometabolic Traits among Adults: Mendelian Randomization Analysis of 182041 Individuals from 18 Studies
Huang, T., Sun, D., Heianza, Y., Bergholdt, H. K. M., Gao, M., Fang, Z., Ding, M., Frazier-Wood, A. C., North, K. E., Marouli, E., Graff, M., Smith, C. E., Varbo, A., Lemaitre, R. N., Corella, D., Wang, C. A., Tjønneland, A., Overvad, K., Sørensen, T. I. A., Feitosa, M. F. & 36 others, , 2019, In: Clinical Chemistry. 65, 6, p. 751-760 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Designing Poly-agonists for Treatment of Metabolic Diseases: Challenges and Opportunities
Petersen, Jonas Odgaard, Strømgaard, Kristian, Frølund, Bente & Clemmensen, Christoffer, 2019, In: Drugs. 79, 11, p. 1187-1197 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Diabetic cats have decreased gut microbial diversity and a lack of butyrate producing bacteria
Kieler, Ida Nordang, Osto, M., Hugentobler, L., Puetz, Lara Christine, Gilbert, M Thomas P, Hansen, Torben, Pedersen, Oluf Borbye, Reusch, C. E., Zini, E., Lutz, T. A. & Bjørnvad, Charlotte Reinhard, 2019, In: Scientific Reports. 9, p. 1-13 13 p., 4822.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dietary Fat and the Genetic Risk of Type 2 Diabetes
Carrasquilla, Germán D., Jakupovic, Hermina & Kilpeläinen, Tuomas O., 2019, In: Current Diabetes Reports. 19, 6 p., 109.Research output: Contribution to journal › Review › Research › peer-review
- Published
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium
Koivula, R. W., Forgie, I. M., Kurbasic, A., Viñuela, A., Heggie, A., Giordano, G. N., Hansen, T. H., Hudson, M., Koopman, A. D. M., Rutters, F., Siloaho, M., Allin, K. H., Brage, S., Brorsson, C. A., Dawed, A. Y., De Masi, F., Groves, C. J., Kokkola, T., Mahajan, A., Perry, M. H. & 31 others, , 2019, In: Diabetologia. 62, 9, p. 1601-1615Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Disentangling the genetics of lean mass
Karasik, D., Zillikens, M. C., Hsu, Y. H., Aghdassi, A., Akesson, K., Amin, N., Barroso, I., Bennett, D. A., Bertram, L., Bochud, M., Borecki, I. B., Broer, L., Buchman, A. S., Byberg, L., Campbell, H., Campos-Obando, N., Cauley, J. A., Cawthon, P. M., Chambers, J. C., Chen, Z. & 137 others, , 2019, In: American Journal of Clinical Nutrition. 109, 2, p. 276-287Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells
Min, S. Y., Desai, A., Yang, Z., Sharma, A., DeSouza, T., Genga, R. M. J., Kucukural, A., Lifshitz, L. M., Nielsen, S., Schéele, Camilla Charlotte Nielsen, Maehr, R., Garber, M. & Corvera, S., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 36, p. 17970-17979Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Does genetic predisposition to higher fat expandability attenuate the impact of weight gain on cardiometabolic risk?
Carrasquilla, Germán D., Linneberg, Allan René, Jørgensen, T., Grarup, Niels, Pedersen, Oluf Borbye, Hansen, Torben, Sørensen, Thorkild I.A. & Kilpeläinen, Tuomas O., 2019, In: European Journal of Human Genetics. 27, Suppl. 2, p. 1764 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Dysregulated autophagy in muscle precursor cells from humans with type 2 diabetes
Henriksen, T. I., Wigge, L. V., Nielsen, J., Pedersen, Bente Klarlund, Sandri, M. & Schéele, Camilla Charlotte Nielsen, 2019, In: Scientific Reports. 9, 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity
Dallner, O. S., Marinis, J. M., Lu, Y., Birsoy, K., Werner, E., Fayzikhodjaeva, G., Dill, B. D., Molina, H., Moscati, A., Kutalik, Z., Marques-Vidal, P., Kilpeläinen, Tuomas O., Grarup, Niels, Linneberg, Allan René, Zhang, Y., Vaughan, R., Loos, Ruth, Lazar, M. A. & Friedman, J. M., 2019, In: Nature Medicine. 25, 3, p. 507-530 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Early Life Body Size in Relation to First Intracerebral or Subarachnoid Hemorrhage
Gjærde, L. K., Truelsen, Thomas Clement, Sørensen, Thorkild I.A. & Baker, J. L., 2019, In: Journal of Stroke. 21, 1, p. 60-68 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis
Hartwig, F. P., Davies, N. M., Horta, B. L., Ahluwalia, T. S., Bisgaard, H., Bønnelykke, K., Caspi, A., Moffitt, T. E., Poulton, R., Sajjad, A., Tiemeier, H. W., Dalmau-Bueno, A., Guxens, M., Bustamante, M., Santa-Marina, L., Parker, N., Paus, T., Pausova, Z., Lauritzen, L., Schnurr, T. M. & 7 others, , 2019, In: International Journal of Epidemiology. 48, 1, p. 45-57 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of bariatric surgery on plasma GDF15 in humans
Kleinert, Maximilian, Bojsen-Møller, K. N., Jørgensen, N. B., Svane, M. S., Martinussen, C., Kiens, Bente, Wojtaszewski, Jørgen F P, Madsbad, Sten, Richter, Erik A. & Clemmensen, Christoffer, 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 316, 4, p. E615-E621 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of Acute GLP-1 Infusion on Pulmonary and Systemic Hemodynamics in Patients With Heart Failure: A Pilot Study
Clarke, S. J., Pettit, S., Giblett, J. P., Zhao, T., Kydd, A. C., Albrechtsen, Nicolai Jacob Wewer, Deacon, Carolyn F., Parameshwar, J. & Hoole, S. P., 2019, In: Clinical Therapeutics. 41, 1, p. 118-127 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of Exercise Training and IL-6 Receptor Blockade on Gastric Emptying and GLP-1 Secretion in Obese Humans: Secondary Analyses From a Double Blind Randomized Clinical Trial
Lehrskov, L. L., Christensen, R. H., Wedell-Neergaard, A-S., Legaard, G. E., Dorph, E., Larsen, M. K., Henneberg, M., Launbo, N., Fagerlind, S. R., Seide, S. K., Nymand, S., Ball, M., Vinum, N., Dahl, C., Albrechtsen, N. J. W., Holst, J. J., Ried-Larsen, M., Rosenmeier, J. B., Krogh-Madsen, R., Karstoft, K. & 2 others, , 2019, In: Frontiers in Physiology. 10, 11 p., 1249 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of a high-protein/moderate-carbohydrate diet on appetite, gut peptides, and endocannabinoids: A Preview study
Tischmann, L., Drummen, M., Gatta-Cherifi, B., Raben, Anne, Fogelholm, M., Hartmann, Bolette, Holst, Jens Juul, Matias, I., Cota, D., Mensink, R. P., Peters, J., Westerterp-Plantenga, M. S. & Adam, T. C., 2019, In: Nutrients. 11, 16 p., 2269.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of active commuting and leisure-time exercise on appetite in individuals with overweight and obesity
Quist, Jonas Salling, Blond, Martin Bæk, Gram, A. S., Steenholt, C. B., Janus, C., Holst, Jens Juul, Rehfeld, Jens Frederik, Sjödin, Anders Mikael, Stallknecht, Bente Merete & Rosenkilde, M., 2019, In: Journal of Applied Physiology. 126, 4, p. 941-951Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of combined GIP and GLP-1 infusion on energy intake, appetite and energy expenditure in overweight/obese individuals: a randomised, crossover study
Bergmann, N. C., Lund, A., Gasbjerg, Lærke Smidt, Meessen, E. C. E., Andersen, M. M., Bergmann, S., Hartmann, Bolette, Holst, Jens Juul, Jessen, L., Christensen, Mikkel Bring, Vilsbøll, Tina & Knop, Filip Krag, 2019, In: Diabetologia. 62, 4, p. 665-675 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of short-term prednisolone treatment on indices of lipolysis and lipase signaling in abdominal adipose tissue in healthy humans
Ramshanker, N., Jessen, N., Voss, T. S., Pedersen, S. B., Jørgensen, J. O. L., Nielsen, Thomas Svava, Frystyk, J. & Møller, N., 2019, In: Metabolism: Clinical and Experimental. 99, p. 1-10Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Electrical pulse stimulation induces differential responses in insulin action in myotubes from severely obese individuals
Park, S., Turner, K. D., Zheng, D., Brault, J. J., Zou, K., Chaves, A. B., Nielsen, Thomas Svava, Tanner, C. J., Treebak, Jonas Thue & Houmard, J. A., 2019, In: The Journal of Physiology. 597, 2, p. 449-466Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases
Clemmensen, Christoffer, Finan, B., Müller, T. D., DiMarchi, R. D., Tschöp, M. H. & Hofmann, S. M., 2019, In: Nature Reviews Endocrinology. 15, p. 90-104Research output: Contribution to journal › Review › Research › peer-review
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Natural selection affects multiple aspects of genetic variation at putatively peutral sites across the human genome
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Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets
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Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity
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Determinants of plasma levels of proglucagon and the metabolic impact of glucagon receptor signalling: a UK Biobank study
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Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment
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