Novo Nordisk Foundation Center for Basic Metabolic Research

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  1. 2010
  2. Published

    Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people

    Boesgaard, T. W., Grarup, N., Jørgensen, T., Borch-Johnsen, K., Hansen, Torben, Pedersen, Oluf Borbye & Meta-Analysis of Glucose and Insulin-Related Trait Consortium (MAGIC), M. O. G. A. I. T. C. (., 1 Aug 2010, In: Diabetologia. 53, 8, p. 1647-55 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    LMNA rs4641 and the muscle lamin A and C isoforms in twins--metabolic implications and transcriptional regulation

    Wegner, L., Anthonsen, S., Bork-Jensen, J., Dalgaard, L., Hansen, Torben, Pedersen, Oluf Borbye, Poulsen, P. & Vaag, Allan, Aug 2010, In: The Journal of clinical endocrinology and metabolism. 95, 8, p. 3884-92 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Nutrient-dependent regulation of PGC-1α's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5

    Dominy, J. E., Lee, Y., Gerhart-Hines, Zach & Puigserver, P., Aug 2010, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1804, 8, p. 1676-1683 8 p.

    Research output: Contribution to journal › Review › Research › peer-review

  5. Published

    The intracellular to extracellular proton gradient following maximal whole body exercise and its implication for anaerobic energy production

    Voiantis, S., Secher, Niels H. & Quistorff, B., Aug 2010, In: European Journal of Applied Physiology. 109, 6, p. 1171-1177 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes

    Burgdorf, K. S., Sandholt, C. H., Sparsø, T., Andersen, G., Witte, D. R., Jørgensen, T., Sandbaek, A., Lauritzen, T., Sørensen, Thorkild I.A., Madsbad, Sten, Hansen, Torben & Pedersen, Oluf Borbye, 1 Jul 2010, In: European Journal of Endocrinology. 163, 1, p. 81-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

    Voight, B. F., Scott, L. J., Steinthorsdottir, V., Morris, A. P., Dina, C., Welch, R. P., Zeggini, E., Huth, C., Aulchenko, Y. S., Thorleifsson, G., McCulloch, L. J., Ferreira, T., Grallert, H., Amin, N., Wu, G., Willer, C. J., Raychaudhuri, S., McCarroll, S. A., Langenberg, C., Hofmann, O. M. & 31 others, Dupuis, J., Qi, L., Segrè, A. V., van Hoek, M., Navarro, P., Ardlie, K., Balkau, B., Benediktsson, R., Bennett, A. J., Blagieva, R., Boerwinkle, E., Bonnycastle, L. L., Bengtsson Boström, K., Bravenboer, B., Bumpstead, S., Burtt, N. P., Charpentier, G., Chines, P. S., Cornelis, M., Couper, D. J., Crawford, G., Doney, A. S. F., Elliott, K. S., Elliott, A. L., Erdos, M. R., Grarup, N., Jørgensen, T., Sparsø, T., Hansen, Torben, Pedersen, Oluf Borbye & MAGIC investigators, M. I., 1 Jul 2010, In: Nature Genetics. 42, 7, p. 579-89 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    A novel intronic peroxisome proliferator-activated receptor gamma enhancer in the uncoupling protein (UCP) 3 gene as a regulator of both UCP2 and -3 expression in adipocytes

    Bugge, A. S., Siersbaek, M., Madsen, M. S., Göndör, A., Rougier, C. & Mandrup, S., 4 Jun 2010, In: The Journal of Biological Chemistry. 285, 23, p. 17310-7 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls

    Kring, S. I., Brummett, B. H., Barefoot, J., Garrett, M. E., Ashley-Koch, A. E., Boyle, S. H., Siegler, I. C., Sørensen, Thorkild I.A. & Williams, R. B., 1 Jun 2010, In: Psychosomatic Medicine. 72, 5, p. 427-33 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Nitric oxide increases cyclic GMP levels, AMP-activated protein kinase (AMPK)alpha1-specific activity and glucose transport in human skeletal muscle

    Deshmukh, Atul Shahaji, Long, Y. C., de Castro Barbosa, T., Karlsson, H. K. R., Glund, S., Zavadoski, W. J., Gibbs, E. M., Koistinen, H. A., Wallberg-Henriksson, H. & Zierath, Juleen R, Jun 2010, In: Diabetologia. 53, 6, p. 1142-50 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Associations between dietary intake and body fat independent of genetic and familial environmental background

    Hasselbalch, A. L., Heitmann, B. L., Kyvik, K. O. & Sørensen, Thorkild I.A., 1 May 2010, In: International Journal of Obesity. 34, 5, p. 892-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Genetic and environmental influences on risk of death due to infections assessed in Danish twins, 1943-2001

    Obel, Niels, Christensen, K., Petersen, I., Sørensen, Thorkild I.A. & Skytthe, A., 1 May 2010, In: American Journal of Epidemiology. 171, 9, p. 1007-13 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Twin study of heritability of eating bread in Danish and Finnish men and women

    Hasselbalch, A. L., Silventoinen, K., Keskitalo, K., Pietiläinen, K. H., Rissanen, A., Heitmann, B. L., Kyvik, K. O., Sørensen, Thorkild I.A. & Kaprio, J., 1 Apr 2010, In: Twin Research and Human Genetics. 13, 2, p. 163-7 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Down-regulation of HSP27 sensitizes TRAIL-resistant tumor cell to TRAIL-induced apoptosis

    Zhuang, H., Jiang, W., Cheng, W., Qian, K., Dong, W., Cao, L., Huang, Q., Li, S., Dou, F., Chiu, J., Fang, X., Lu, M. & Hua, Z., Apr 2010, In: Lung Cancer. 68, 1, p. 27-38 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

    Cantó, C., Jiang, L. Q., Deshmukh, Atul Shahaji, Mataki, C., Coste, A., Lagouge, M., Zierath, Juleen R & Auwerx, J., 3 Mar 2010, In: Cell Metabolism. 11, 3, p. 213-9 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Obesity as a clinical and public health problem: is there a need for a new definition based on lipotoxicity effects?

    Sørensen, Thorkild I.A., Virtue, S. & Vidal-Puig, A., 1 Mar 2010, In: B B A - Molecular and Cell Biology of Lipids. 1801, 3, p. 400-4 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Dietary fiber and subsequent changes in body weight and waist circumference in European men and women

    Du, H., van der A, D. L., Boshuizen, H. C., Forouhi, N. G., Wareham, N. J., Halkjaer, J., Tjønneland, A., Overvad, K., Jakobsen, M. U., Boeing, H., Buijsse, B., Masala, G., Palli, D., Sørensen, Thorkild I.A., Saris, W. H. M. & Feskens, E. J. M., 1 Feb 2010, In: American Journal of Clinical Nutrition. 91, 2, p. 329-36 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

    Saxena, R., Hivert, M-F., Langenberg, C., Tanaka, T., Pankow, J. S., Vollenweider, P., Lyssenko, V., Bouatia-Naji, N., Dupuis, J., Jackson, A. U., Kao, W. H. L., Li, M., Glazer, N. L., Manning, A. K., Luan, J., Stringham, H. M., Prokopenko, I., Johnson, T., Grarup, N., Boesgaard, T. W. & 31 others, Lecoeur, C., Shrader, P., O'Connell, J., Ingelsson, E., Couper, D. J., Rice, K., Song, K., Andreasen, C. H., Dina, C., Köttgen, A., Le Bacquer, O., Pattou, F., Taneera, J., Steinthorsdottir, V., Rybin, D., Ardlie, K., Sampson, M., Qi, L., van Hoek, M., Weedon, M. N., Aulchenko, Y. S., Voight, B. F., Grallert, H., Balkau, B., Bergman, R. N., Borch-Johnsen, K., Jørgensen, T., Sparsø, T., Hansen, Torben, Pedersen, Oluf Borbye & GIANT Consortium, G. C., 1 Feb 2010, In: Nature Genetics. 42, 2, p. 142-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

    Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A. U., Wheeler, E., Glazer, N. L., Bouatia-Naji, N., Gloyn, A. L., Lindgren, C. M., Mägi, R., Morris, A. P., Randall, J., Johnson, T., Elliott, P., Rybin, D., Thorleifsson, G., Steinthorsdottir, V., Henneman, P. & 31 others, Grallert, H., Dehghan, A., Hottenga, J. J., Franklin, C. S., Navarro, P., Song, K., Goel, A., Perry, J. R. B., Egan, J. M., Lajunen, T., Grarup, N., Sparsø, T., Doney, A., Voight, B. F., Stringham, H. M., Li, M., Kanoni, S., Shrader, P., Cavalcanti-Proença, C., Kumari, M., Qi, L., Timpson, N. J., Gieger, C., Zabena, C., Rocheleau, G., Ingelsson, E., An, P., Jørgensen, T., Hansen, Torben, Pedersen, Oluf Borbye & DIAGRAM Consortium, D. C., 1 Feb 2010, In: Nature Genetics. 42, 2, p. 105-16 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes

    Maeda, S., Kobayashi, M., Araki, S., Babazono, T., Freedman, B. I., Bostrom, M. A., Cooke, J. N., Toyoda, M., Umezono, T., Tarnow, L., Hansen, T., Gaede, P., Jorsal, A., Ng, D. P. K., Ikeda, M., Yanagimoto, T., Tsunoda, T., Unoki, H., Kawai, K., Imanishi, M. & 11 others, Suzuki, D., Shin, H. D., Park, K. S., Kashiwagi, A., Iwamoto, Y., Kaku, K., Kawamori, R., Parving, H., Bowden, D. W., Pedersen, Oluf Borbye & Nakamura, Y., 1 Jan 2010, In: P L o S Genetics. 6, 2, p. e1000842

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Advancing the future of physical activity guidelines in Canada: an independent expert panel interpretation of the evidence

    Kesäniemi, A., Riddoch, C. J., Reeder, B., Blair, S. N. & Sørensen, Thorkild I.A., 1 Jan 2010, In: International Journal of Behavioral Nutrition and Physical Activity. 7, p. 41

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Birth weight, childhood body mass index and risk of coronary heart disease in adults: combined historical cohort studies

    Andersen, L. G., Ängquist, Lars, Eriksson, J. G., Forsen, T., Gamborg, Michael Orland, Osmond, C., Baker, J. L. & Sørensen, Thorkild I.A., 1 Jan 2010, In: P L o S One. 5, 11, p. e14126

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Changes in waist circumference and mortality in middle-aged men and women

    Berentzen, T. L., Jakobsen, M. U., Halkjaer, J., Tjønneland, A., Overvad, K. & Sørensen, Thorkild I.A., 1 Jan 2010, In: P L o S One. 5, 9

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Dietary determinants of changes in waist circumference adjusted for body mass index - a proxy measure of visceral adiposity

    Romaguera, D., Ängquist, Lars, Du, H., Jakobsen, M. U., Forouhi, N. G., Halkjaer, J., Feskens, E. J. M., van der A, D. L., Masala, G., Steffen, A., Palli, D., Wareham, N. J., Overvad, K., Tjønneland, A., Boeing, H., Riboli, E. & Sørensen, Thorkild I.A., 1 Jan 2010, In: P L o S One. 5, 7, p. e11588

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Do gene variants influencing adult adiposity affect birth weight? A population-based study of 24 loci in 4,744 Danish individuals

    Andersson, E. A., Pilgaard, K., Pisinger, C., Harder, M. N., Grarup, N., Færch, K., Sandholt, C., Poulsen, P., Witte, D. R., Jørgensen, T., Vaag, Allan, Pedersen, Oluf Borbye & Hansen, T., 1 Jan 2010, In: P L o S One. 5, 12, p. e14190

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY)

    Boesgaard, T. W., Pruhova, S., Andersson, E. A., Cinek, O., Obermannova, B., Lauenborg, J., Damm, Peter, Bergholdt, R., Pociot, Flemming, Pisinger, C., Barbetti, F., Lebl, J., Pedersen, Oluf Borbye & Hansen, Torben, 1 Jan 2010, In: B M C Medical Genetics. 11, p. 42

    Research output: Contribution to journal › Journal article › Research › peer-review

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