Novo Nordisk Foundation Center for Basic Metabolic Research

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  1. 2009
  2. Published

    Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

    Rung, J., Cauchi, S., Albrechtsen, A., Shen, L., Rocheleau, G., Cavalcanti-Proença, C., Bacot, F., Balkau, B., Belisle, A., Borch-Johnsen, K., Charpentier, G., Dina, C., Durand, E., Elliott, P., Hadjadj, S., Järvelin, M-R., Laitinen, J., Lauritzen, T., Marre, M., Mazur, A. & 20 others, Meyre, D., Montpetit, A., Pisinger, C., Posner, B., Poulsen, P., Pouta, A., Prentki, M., Ribel-Madsen, R., Ruokonen, A., Sandbaek, A., Serre, D., Tichet, J., Vaxillaire, M., Wojtaszewski, Jørgen F P, Vaag, Allan, Hansen, T., Polychronakos, C., Pedersen, Oluf Borbye, Froguel, P. & Sladek, R., 2009, In: Nature Genetics. 41, 10, p. 1110-1115 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

    Thorleifsson, G., Walters, G. B., Gudbjartsson, D. F., Steinthorsdottir, V., Sulem, P., Helgadottir, A., Styrkarsdottir, U., Gretarsdottir, S., Thorlacius, S., Jonsdottir, I., Jonsdottir, T., Olafsdottir, E. J., Olafsdottir, G. H., Jonsson, T., Jonsson, F., Borch-Johnsen, K., Hansen, T., Andersen, G., Jørgensen, T., Lauritzen, T. & 15 others, Aben, K. K., Verbeek, A. L. M., Roeleveld, N., Kampman, E., Yanek, L. R., Becker, L. C., Tryggvadottir, L., Rafnar, T., Becker, D. M., Gulcher, J., Kiemeney, L. A., Pedersen, Oluf Borbye, Kong, A., Thorsteinsdottir, U. & Stefansson, K., 2009, In: Nature Genetics. 41, 1, p. 18-24 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    IDENTIFICATION OF NOVEL VARIANTS IN THE HEPATOCYTE NUCLEAR FACTOR 1 ALPHA GENE IN SOUTH INDIAN PATIENTS WITH MATURITY ONSET DIABETES OF YOUNG

    Radha, V., Ek, J., Anuradha, S., Hansen, T., Pedersen, Oluf Borbye & Mohan, V., 2009, In: Journal of Clinical Endocrinology and Metabolism. 6, p. 1959-65

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Identification of novel variants in the hepatocyte nuclear factor-1alpha gene in South Indian patients with maturity onset diabetes of young

    Radha, V., Ek, J., Anuradha, S., Hansen, T., Pedersen, Oluf Borbye & Mohan, V., 2009, In: Journal of Clinical Endocrinology and Metabolism. 94, 6, p. 1959-1965 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics

    Koutnikova, H., Laakso, M., Lu, L., Combe, R., Paananen, J., Kuulasmaa, T., Kuusisto, J., Häring, H., Hansen, T., Pedersen, Oluf Borbye, Smith, U., Hanefeld, M., Williams, R. W. & Auwerx, J., 2009, In: PLoS Genetics. 5, 8, p. e1000591

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Impaired Insulin-Mediated Phosphorylation of Skeletal Muscle TBC1D4 at Multiple Sites in Type 2 Diabetes. Effect of Endurance Training on TBC1D4 Protein and Phosphorylation

    Vind, B. F., Pehmoller, C., Treebak, Jonas Thue, Birk, Jesper Bratz, Hey-Mogensen, M., Beck-Nielsen, H., Wojtaszewski, Jørgen F P & Hojlund, K., 2009, In: Diabetes.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention

    Meur, G., Simon, A., Harun, N., Virally, M., Dechaume, A., Bonnefond, A., Fetita, S., Tarasov, A. I., Guillausseau, P., Boesgaard, T. W., Pedersen, Oluf Borbye, Hansen, T., Polak, M., Gautier, J., Froguel, P., Rutter, G. A. & Vaxillaire, M., 2009, In: Diabetes. 59, 3, p. 653-61 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Intensified multifactorial treatment of patients with Type 2 diabetes: what can be achieved and does it pay off?

    Pedersen, Oluf Borbye, 2009, In: Journal of Diabetes. 1, 2, p. 83-9 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G >C with circulating glucose levels, interleukin-6 levels, and body mass index.

    Huth, C., Illig, T., Herder, C., Gieger, C., Grallert, H., Vollmert, C., Rathmann, W., Hamid, Y., Pedersen, O., Hansen, T., Thorand, B., Meisinger, C., Doring, A., Klopp, N., Gohlke, H., Lieb, W., Hengstenberg, C., Lyssenko, V., Groop, L., Ireland, H. & 16 others, Stephens, J., Wernstedt Asterholm, I., Jansson, J., Boeing, H., Mohlig, M., Stringham, H., Boehnke, M., Tuomilehto, J., Fernandez-Real, J., Lopez-Bermejo, A., Gallart, L., Vendrell, J., Humphries, S., Kronenberg, F., Wichmann, H. & Heid, I., 2009, In: Annals of Medicine. 41, p. 128-38

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index

    Huth, C., Illig, T., Herder, C., Gieger, C., Grallert, H., Vollmert, C., Rathmann, W., Hamid, Y. H., Pedersen, O., Hansen, T., Thorand, B., Meisinger, C., Doring, A., Klopp, N., Gohlke, H., Lieb, W., Hengstenberg, C., Lyssenko, V., Groop, L., Ireland, H. & 16 others, Stephens, J. W., Asterholm, I. W., Jansson, J. O., Boeing, H., Mohlig, M., Stringham, H. M., Boehnke, M., Tuomilehto, J., Fernandez-Real, J. M., Lopez-Bermejo, A., Gallart, L., Vendrell, J., Humphries, S. E., Kronenberg, F., Wichmann, H. E. & Heid, I. M., 2009, In: Annals of Medicine. 41, 2, p. 128-138 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Long-term exendin-4 treatment delays natural deterioration of glycaemic control in diabetic Goto-Kakizaki rats

    Simonsen, L., Pilgaard, S., Orskov, C., Hartmann, Bolette, Holst, Jens Juul & Deacon, Carolyn F., 2009, In: Diabetes, Obesity and Metabolism. 11, 9, p. 884-90 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Longitudinal Analysis of Leptin Variation during Weight Regain after Weight Loss in Obese Children

    Holm, Jens-Christian, Gamborg, Michael Orland, Leigh, W., Kaas, I. K., Ibsen, G., Sørensen, Thorkild I.A., Lilienthal, H. B., Holm, Jens-Christian, Gamborg, M., Ward, L., Ibsen, K. K., Gammeltoft, S., Sørensen, Thorkild I.A. & Heitmann, B. L., 2009, In: Obesity Facts. 2, 4, p. 243-248 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Mitochondrial function in lamb as a consequence of maternal caloric restriction during pregnancy and high-fat-high-carbohydrate diet post partem

    Jørgensen, W., Nielsen, M. O., Gam, C., Scheibye-Knudsen, M., Grunnet, N. & Quistorff, B., 2009, In: Journal of Diabetes. 1, Suppl. 1, p. A81 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  15. Published

    Mutations in the VNTR of the carboxyl-ester lipase gene (CEL) are a rare cause of monogenic diabetes

    Torsvik, J., Johansson, S., Johansen, A., Ek, J., Minton, J., Raeder, H., Ellard, S., Hattersley, A., Pedersen, Oluf Borbye, Hansen, T., Molven, A. & Njølstad, P. R., 2009, In: Human Genetics. 127, 1, p. 55-64 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    No consistent effect of ADRB2 haplotypes on obesity, hypertension and quantitative traits of body fatness and blood pressure among 6,514 adult Danes

    Gjesing, A. P., Sparsø, T., Borch-Johnsen, K., Jørgensen, T., Pedersen, Oluf Borbye, Hansen, T. & Olsen, N. V., 2009, In: PLoS ONE. 4, 9, p. e7206

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Past and current body size affect validity of reported energy intake among middle-aged Danish men

    Nielsen, B. M., Nielsen, M. M., Toubro, S., Pedersen, Oluf Borbye, Astrup, A., Sørensen, Thorkild I.A., Jess, T. & Heitmann, B. L., 2009, In: Journal of Nutrition. 139, 12, p. 2337-2343 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Polymorphisms of serotonin receptor 2A and 2C genes and COMT in relation to obesity and type 2 diabetes

    Kring, S. I. I., Werge, Thomas, Holst, C., Toubro, S., Astrup, A., Hansen, Torben, Pedersen, Oluf Borbye & Sørensen, Thorkild I.A., 2009, In: PLoS ONE. 4, 8, p. e6696 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Predictive performance for population models using stochastic differential equations applied on data from an oral glucose tolerance test

    Møller, J. B., Overgaard, R. V., Madsen, H., Hansen, T., Pedersen, Oluf Borbye & Ingwersen, S. H., 2009, In: Journal of Pharmacokinetics and Pharmacodynamics. 37, 1, p. 85-98 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Predictors of future fasting and 2-h post-OGTT plasma glucose levels in middle-aged men and women-the Inter99 study

    Faerch, K., Vaag, Allan, Witte, D. R., Jørgensen, T., Pedersen, Oluf Borbye & Borch-Johnsen, K., 2009, In: Diabetic Medicine. 26, 4, p. 377-83 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Progression to impaired glucose regulation and diabetes in the population-based Inter99 study

    Engberg, S., Vistisen, D., Lau, C., Glümer, C., Jørgensen, T., Pedersen, Oluf Borbye & Borch-Johnsen, K., 2009, In: Diabetes Care. 32, p. 606-11

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Spaedbørnsdiabetes kan ofte behandles med sulfonylurinstof i stedet for insulin

    Lauridsen, M. H., Boesgaard, T. W., Pedersen, Oluf Borbye, Hansen, T. & Hertz, B., 2009, In: Ugeskrift for læger. 171, 23, p. 1923-4 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Studies of CTNNBL1 and FDFT1 variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes

    Andreasen, C. H., Mogensen, M. S., Borch-Johnsen, K., Sandbaek, A., Lauritzen, T., Almind, K., Hansen, L., Jørgensen, T., Pedersen, Oluf Borbye & Hansen, Torben, 2009, In: BMC Medical Genetics. 10, 1, p. 17

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load

    Holmkvist, J., Banasik, K., Andersen, G., Unoki, H., Jensen, T. S., Pisinger, C., Borch-Johnsen, K., Sandbaek, A., Lauritzen, T., Brunak, Søren, Maeda, S., Hansen, T. & Pedersen, Oluf Borbye, 2009, In: PLoS ONE. 4, 6, p. e5872

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Validation of a multimarker model for assessing risk of type 2 diabetes from a five-year prospective study of 6784 Danish people (Inter99)

    Urdea, M., Kolberg, J., Wilber, J., Gerwien, R., Moler, E., Rowe, M., Jorgensen, P., Hansen, T., Pedersen, Oluf Borbye, Jørgensen, T. & Borch-Johnsen, K., 2009, In: Journal of Diabetes Science and Technology. 3, 4, p. 748-55 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study

    Boesgaard, T. W., Gjesing, A. P., Grarup, N., Rutanen, J., Jansson, P., Hribal, M. L., Sesti, G., Fritsche, A., Stefan, N., Staiger, H., Häring, H., Smith, U., Laakso, M., Pedersen, Oluf Borbye, Hansen, T. & EUGENE2 Consortium, E. C., 2009, In: PLoS ONE. 4, 9, p. e7236

    Research output: Contribution to journal › Journal article › Research › peer-review

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