Novo Nordisk Foundation Center for Basic Metabolic Research

  1. 2018
  2. Published

    Specific synbiotics in early life protect against diet-induced obesity in adult mice

    Mischke, M., Arora, Tulika, Tims, S., Engels, E., Sommer, N., van Limpt, K., Baars, A., Oozeer, R., Oosting, A., Bäckhed, F. & Knol, J., 2018, In: Diabetes, Obesity and Metabolism. 20, 6, p. 1408-1418 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Sperm epigenetics and influence of environmental factors

    Donkin, I. & Barrès, Romain, 2018, In: Molecular Metabolism. 14, p. 1-11 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  4. Published

    Squeezing Flux Out of Fat

    Gonzalez-Franquesa, A. & Patti, M., 2018, In: Trends in Endocrinology and Metabolism. 29, 4, p. 201-202

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published
  6. Published

    Structural changes at the myrtenol backbone reverse its positive allosteric potential into inhibitory GABAA receptor modulation

    Milanos, S., Kuenzel, K., Gilbert, D. F., Janzen, D., Sasi, M., Buettner, A., Frimurer, Thomas Michael & Villmann, C., 2018, In: Biological Chemistry. 399, 6, p. 549-563 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1

    Ulven, Elisabeth Rexen, Trauelsen, Mette, Brvar, M., Lückmann, Michael, Bielefeldt, L. Ø., Jensen, L. K. I., Schwartz, Thue W. & Frimurer, Thomas Michael, 2018, In: Scientific Reports. 8, 1, p. 1-18 10010.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Succesfuld behandling af KCNJ11-neonatal diabetes uden insulin

    Gade-Rasmussen, B., Madsbad, Sten, Svane, M. S., Martinussen, C. & Hansen, Torben, 2018, In: Ugeskrift for Laeger. 180, 46, 2 p., V08180547.

    Research output: Contribution to journalLetterResearchpeer-review

  9. Published

    Systems signatures reveal unique remission-path of Type 2 diabetes following Roux-en-Y gastric bypass surgery

    Li, Q-R., Wang, Z-M., Albrechtsen, N. J. W., Wang, D-D., Su, Z-D., Gao, X-F., Wu, Q-Q., Zhang, H-P., Zhu, L., Li, R-X., Jacobsen, S., Jørgensen, N. B., Dirksen, C., Bojsen-Møller, K. N., Petersen, J. S., Madsbad, S., Clausen, T. R., Diderichsen, B., Chen, L-N., Holst, J. J. & 2 others, Zeng, R. & Wu, J., 2018, In: EBioMedicine. 28, p. 234-240 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    T cell epigenetic remodeling and accelerated epigenetic aging are linked to long-term immune alterations in childhood cancer survivors

    Daniel, S., Nylander, V., Ingerslev, L. R., Zhong, L., Fabre, O., Clifford, B., Johnston, K., Cohn, R. J., Barrès, Romain & Simar, D., 2018, In: Clinical Epigenetics. 10, p. 1-13 138.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The Combination of Fosfomycin, Metronidazole, and Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor is Stable in vitro and Has Maintained Antibacterial Activity

    Fonnes, S., Holzknecht, Barbara Juliane, Gasbjerg, Lærke Smidt, Weisser, J. J., Hallberg, H. W., Arpi, M. & Rosenberg, Jacob, 2018, In: Drug Research. 68, 6, p. 349-354

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    The Effect of Ethanol on Inflammation Markers and FGF-21 in Healthy Individuals

    Lanng, A. R., Gasbjerg, Lærke Smidt, Bergmann, N. C., Møller, H., Gillum, M., Gronbaek, H., Vilsbøll, Tina & Knop, Filip Krag, 2018, In: Diabetes. 67, Supplement 1, 2415-PUB.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    The HETE Is on FFAR1 and Pancreatic Islet Cells

    Trauelsen, Mette, Lückmann, Michael, Frimurer, Thomas Michael & Schwartz, Thue W., 2018, In: Cell Metabolism. 27, 2, p. 273-275 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease

    Makki, K., Deehan, E. C., Walter, J. & Backhed, F., 2018, In: Cell Host & Microbe. 23, 6, p. 705-715

    Research output: Contribution to journalReviewResearchpeer-review

  15. Published

    The Intestinotrophic Effects of Glucagon-Like Peptide-2 in Relation to Intestinal Neoplasia

    Orhan, Adile, Gögenur, Ismail & Kissow, Hannelouise, 2018, In: The Journal of clinical endocrinology and metabolism. 103, 8, p. 2827-2837

    Research output: Contribution to journalReviewResearchpeer-review

  16. Published

    The Role of Glucagon in the Pathophysiology and Treatment of Type 2 Diabetes

    Hædersdal, S., Lund, A., Knop, Filip Krag & Vilsbøll, Tina, 2018, In: Mayo Clinic Proceedings. 93, 2, p. 217-239

    Research output: Contribution to journalReviewResearchpeer-review

  17. Published

    The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial

    Samkani, A., fbg982, fbg982, Anholm, C., Astrup, A., Deacon, Carolyn F., Holst, Jens Juul, Madsbad, S., Boston, R., Krarup, T. & Haugaard, Steen Bendix, 2018, In: Lipids in Health and Disease. 17, 9 p., 295.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    The complement system is differently regulated in white and brown adipocytes

    Justesen, L., Bayarri-Olmos, R., Schéele, Camilla Charlotte Nielsen & Garred, Peter, 2018, In: Molecular Immunology. 102, p. 170 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  19. Published

    The developmental neurogenic niche of the Entorhinal cortex revealed by single-cell transcriptomics.

    Bergmann, T. B., Liu, Y., Lee, J., Peralvo Vidal, Juan Miguel, Mori, Yuki, Seemann, Ernst Stefan, Pihl, M., Thomsen, Preben Dybdahl, Hyttel, P., witter, M., Gorodkin, Jan, Hall, Vanessa Jane & Pers, Tune H, 2018.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  20. Published

    The effect of DPP-4 protected GLP-1 (7-36) on coronary microcirculation in obese adults

    Nilsson, M., Bove, K., Suhrs, E., Hermann, T., Madsbad, Sten, Holst, Jens Juul, Prescott, Eva & Zander, M., 2018, In: Diabetologia. 61, S1, p. S354-S355 729.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  21. Published

    The effect of casein, hydrolyzed casein, and whey proteins on urinary and postprandial plasma metabolites in overweight and moderately obese human subjects

    Schmedes, M. S., Bendtsen, L. Q., Gomes, S., Liaset, B., Holst, Jens Juul, Ritz, C., Reitelseder, S., Sjödin, Anders Mikael, Astrup, A., Young, J. F., Sundekilde, U. K. & Bertram, H. C., 2018, In: Journal of the Science of Food and Agriculture. 98, 15, p. 5598-5605 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    The effect of diaries written by relatives for intensive care patients on posttraumatic stress (DRIP study): protocol for a randomized controlled trial and mixed methods study

    Nielsen, A. H., Angel, S., Egerod, Ingrid Eugenie & Hansen, Torben, 2018, In: BMC Nursing. 17, p. 1-10 10 p., 37.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    The effect of drinking water pH on the human gut microbiota and glucose regulation: results of a randomized controlled cross-over intervention

    Hansen, T. H., Thomassen, M. T., Madsen, M. L., Kern, T., Bak, Emilie Glad, Kashani, A., Allin, K. H., Hansen, Torben & Pedersen, Oluf Borbye, 2018, In: Scientific Reports. 8, 12 p., 16626.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    The effect of impaired glucose metabolism on weight loss in multidisciplinary childhood obesity treatment

    Kloppenborg, J. T., Gamborg, Michael Orland, Fonvig, Cilius Esmann, Nielsen, T. R. H., Pedersen, Oluf Borbye, Johannesen, Jesper, Hansen, Torben & Holm, Jens-Christian, 2018, In: Pediatric Diabetes. 19, 3, p. 366-374 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    The effect of metformin versus placebo in combination with insulin analogues on bone mineral density and trabecular bone score in patients with type 2 diabetes mellitus: a randomized placebo-controlled trial

    Nordklint, A. K., Almdal, Thomas Peter, Vestergaard, P., Lundby-Christensen, L., Boesgaard, T. W., Breum, Leif, Gade-Rasmussen, B., Sneppen, S. B., Gluud, C., Hemmingsen, B., Jensen, T., Krarup, T., Madsbad, Sten, Mathiesen, Elisabeth, Perrild, Hans, Tarnow, L., Thorsteinsson, B., drb459, drb459, Lund, S. S. & Eiken, P., 2018, In: Osteoporosis International. 29, 11, p. 2517-2526

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    The glucagon like peptide-2 'axis': Capacity for production and response following intestinal resection or repair of gastroschisis in infants

    Sigalet, D. L., Lam, V., Brindle, M., Boctor, D., Wallace, L., de Heuval, E., Hartmann, Bolette & Holst, Jens Juul, 2018, In: Journal of Pediatric Surgery. 53, 5, p. 898-904

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    The impact of short chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon

    Christiansen, Charlotte Bayer, Gabe, M. B. N., Svendsen, B., Dragsted, Lars Ove, Rosenkilde, Mette & Holst, Jens Juul, 2018, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 315, 1, p. G53-G65 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    The role of the incretins in the postprandial bone remodelling

    Helsted, M. M., Gasbjerg, Lærke Smidt, Lanng, A. R., Stensen, S., Hartmann, Bolette, Christensen, Mikkel Bring, Holst, Jens Juul, Vilsbøll, Tina, Rosenkilde, M. M. & Knop, Filip Krag, 2018, In: Diabetologia. 61, S1, p. S221-S221 449.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  29. Published

    Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood–brain barrier in leptin resistant mice

    Kleinert, Maximilian, Kotzbeck, P., Altendorfer-Kroath, T., Birngruber, T., Tschöp, M. H. & Clemmensen, Christoffer, 2018, In: Molecular Metabolism. 13, p. 77-82 6 p.

    Research output: Contribution to journalLetterResearchpeer-review

  30. Published

    Translating biased signaling in the ghrelin receptor system into differential in vivo functions

    Mende, F., Johnsen, Cecilie Hundahl, Plouffe, B., Skov, Louise Julie, Sivertsen, B., Madsen, A. N., Lückmann, Michael, Diep, T. A., Offermanns, S., Frimurer, Thomas Michael, Bouvier, M. & Holst, Birgitte, 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 43, p. E10255-E10264 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Treatment with GLP-1 Receptor Agonists

    Madsbad, Sten & Holst, Jens Juul, 2018, Diabetes: Epidemiology, Genetics, Pathogenesis, Diagnosis, Prevention, and Treatment. Bonora, E. & DeFronzo, R. (eds.). Springer, 45 p. (Endocrinology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  32. Published

    Uncovering the anatomical and molecular landscape of the developing entorhinal cortex.

    Liu, Y., Bergmann, T. B., Peralvo Vidal, Juan Miguel, Lee, J., Mori, Yuki, Seemann, Ernst Stefan, Pihl, M., Thomsen, Preben Dybdahl, Gorodkin, Jan, Hyttel, P., Pers, Tune H, witter, M. & Hall, Vanessa Jane, 2018.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  33. Published

    Universal infant health interventions and young adult outcomes

    Wüst, Miriam, Mortensen, Erik Lykke, Osler, Merete & Sørensen, Thorkild I.A., 2018, In: Health Economics. 27, 8, p. 1319-1324 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Volume of ropivacaine 0.2% and common peroneal nerve block duration: a randomised, double-blind cohort trial in healthy volunteers

    Christiansen, Charlotte Bayer, Madsen, M. H., Rothe, C., Andreasen, A. M., Lundstrøm, L. H. & Lange, Kai, 2018, In: Anaesthesia. 73, 11, p. 1361-1367 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Whole-genome and Transcriptome Sequencing of Prostate Cancer Identify New Genetic Alterations Driving Disease Progression

    Ren, S., Wei, G-H., Liu, D., Wang, L., Hou, Y., Zhu, S., Peng, L., Zhang, Q., Cheng, Y., Su, H., Zhou, X., Zhang, J., Li, F., Zheng, H., Zhao, Z., Yin, C., He, Z., Gao, X., Zhau, H. E., Chu, C-Y. & 42 others, Wu, J. B., Collins, C., Volik, S. V., Bell, R., Huang, J., Wu, K., Xu, D., Ye, D., Yu, Y., Zhu, L., Qiao, M., Lee, H., Yang, Y., Zhu, Y., Shi, X., Chen, R., Wang, Y., Xu, W., Cheng, Y., Xu, C., Gao, X., Zhou, T., Yang, B., Hou, J., Liu, L., Zhang, Z., Zhu, Y., Qin, C., Shao, P., Pang, J., Chung, L. W. K., Xu, J., Wu, C., Zhong, W., Xu, X., Li, Y., Zhang, X., Wang, J., Yang, H., Wang, J., Huang, H. & Sun, Y., 2018, In: European Urology. 73, 3, p. 322-339 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Why looking at things matter: An argument from the aesthethic philosophy of Alexander Gottlieb Baumgarten

    Bencard, Adam, 2018, In: Museums Worlds: Advances in Research. 6, 1, p. 48-59 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. 2017
  38. Published

    Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

    Flannick, J., Fuchsberger, C., Mahajan, A., Teslovich, T. M., Agarwala, V., Gaulton, K. J., Caulkins, L., Koesterer, R., Ma, C., Moutsianas, L., McCarthy, D. J., Rivas, M. A., Perry, J. R. B., Sim, X., Blackwell, T. W., Robertson, N. R., Rayner, N. W., Cingolani, P., Locke, A. E., Tajes, J. F. & 281 others, Highland, H. M., Dupuis, J., Chines, P. S., Lindgren, C. M., Hartl, C., Jackson, A. U., Chen, H., Huyghe, J. R., Van De Bunt, M., Pearson, R. D., Kumar, A., Müller-Nurasyid, M., Grarup, N., Stringham, H. M., Gamazon, E. R., Lee, J., Chen, Y., Scott, R. A., Below, J. E., Chen, P., Huang, J., Go, M. J., Stitzel, M. L., Pasko, D., Parker, S. C. J., V Varga, Tibor, Green, T., Beer, N. L., Day-Williams, A. G., Ferreira, T., Fingerlin, T., Horikoshi, M., Hu, C., Huh, I., Ikram, M. K., Kim, B. J., Kim, Y., Kim, Y. J., Kwon, M. S., Lee, J., Lee, S., Lin, K. H., Maxwell, T. J., Nagai, Y., Wang, X., Welch, R. P., Yoon, J., Zhang, W., Barzilai, N., Voight, B. F., Han, B. G., Jenkinson, C. P., Kuulasmaa, T., Kuusisto, J., Manning, A., Ng, M. C. Y., Palmer, N. D., Balkau, B., Stančáková, A., Abboud, H. E., Boeing, H., Giedraitis, V., Prabhakaran, D., Gottesman, O., Scott, J., Carey, J., Kwan, P., Grant, G., Smith, J. D., Neale, B. M., Purcell, S., Butterworth, A. S., Howson, J. M. M., Lee, H. M., Lu, Y., Kwak, S. H., Zhao, W., Danesh, J., Lam, V. K. L., Park, K. S., Saleheen, D., So, W. Y., Tam, C. H. T., Afzal, U., Aguilar, D., Arya, R., Aung, T., Chan, E., Navarro, C., Cheng, C. Y., Palli, D., Correa, A., Curran, J. E., Rybin, D., Farook, V. S., Fowler, S. P., Freedman, B. I., Griswold, M., Hale, D. E., Hicks, P. J., Khor, C. C., Kumar, S., Lehne, B., Thuillier, D., Lim, W. Y., Liu, J., Loh, M., Musani, S. K., Puppala, S., Scott, W. R., Yengo, L., Tan, S. T., Taylor, H. A., Thameem, F., Wilson, G., Wong, T. Y., Njølstad, P. R., Levy, J. C., Mangino, M., Bonnycastle, L. L., Schwarzmayr, T., Fadista, J., Surdulescu, G. L., Herder, C., Groves, C. J., Wieland, T., Bork-Jensen, J., Brandslund, I., Christensen, C., Koistinen, H. A., Doney, A. S. F., Kinnunen, L., Esko, T., Farmer, A. J., Hakaste, L., Hodgkiss, D., Kravic, J., Lyssenko, V., Hollensted, M., Jørgensen, M. E., Jørgensen, T., Ladenvall, C., Justesen, Johanne Marie, Käräjämäki, A., Kriebel, J., Rathmann, W., Lannfelt, L., Lauritzen, T., Narisu, N., Linneberg, Allan René, Melander, O., Milani, L., Neville, M., Orho-Melander, M., Qi, L., Qi, Q., Roden, M., Rolandsson, O., Swift, A., Rosengren, A. H., Stirrups, K., Wood, A. R., Mihailov, E., Blancher, C., Carneiro, M. O., Maguire, J., Poplin, R., Shakir, K., Fennell, T., DePristo, M., De Angelis, M. H., Deloukas, P., Gjesing, A. P., Jun, G., Nilsson, P. M., Murphy, J., Onofrio, R., Thorand, B., Hansen, Torben, Meisinger, C., Hu, F. B., Isomaa, B., Karpe, F., Liang, L., Peters, A., Huth, C., O'Rahilly, S. P., Palmer, C. N. A., Pedersen, Oluf Borbye, Rauramaa, R., Tuomilehto, J., Salomaa, V., Watanabe, R. M., Syvänen, A. C., Bergman, R. N., Bharadwaj, D., Bottinger, E. P., Cho, Y. S., Chandak, G. R., Chan, J. C. N., Chia, K. S., Daly, M. J., Ebrahim, S. B., Langenberg, C., Elliott, P., Jablonski, K. A., Lehman, D. M., Jia, W., Ma, R. C. W., Pollin, T. I., Sandhu, M., Tandon, N., Froguel, P., Barroso, I., Teo, Y. Y., Zeggini, E., Loos, Ruth, Small, K. S., Ried, J. S., DeFronzo, R. A., Grallert, H., Glaser, B., Metspalu, A., Wareham, N. J., Walker, M., Banks, E., Gieger, C., Ingelsson, E., Im, H. K., Illig, T., Franks, P. W., Buck, G., Trakalo, J., Buck, D., Prokopenko, I., Mägi, R., Lind, L., Farjoun, Y., Owen, K. R., Gloyn, A. L., Strauch, K., Tuomi, T., Kooner, J. S., Lee, J. Y., Park, T., Donnelly, P., Morris, A. D., Hattersley, A. T., Bowden, D. W., Collins, F. S., Atzmon, G., Chambers, J. C., Spector, T. D., Laakso, M., Strom, T. M., Bell, G. I., Blangero, J., Duggirala, R., Tai, E., McVean, G., Hanis, C. L., Wilson, J. G., Seielstad, M., Frayling, T. M., Meigs, J. B., Cox, N. J., Sladek, R., Lander, E. S., Gabriel, S., Mohlke, K. L., Meitinger, T., Groop, L., Abecasis, G., Scott, L. J., Morris, A. P., Kang, H. M., Altshuler, D., Burtt, N. P., Florez, J. C., Boehnke, M. & McCarthy, M. I., 19 Dec 2017, In: Scientific Data. 4, p. 1-20 20 p., 170179.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    On the relationship between glucose absorption and glucose‐stimulated secretion of GLP‐1, neurotensin, and PYY from different intestinal segments in the rat

    Kuhre, Rune Ehrenreich, Christiansen, Charlotte Bayer, Saltiel, M. Y., Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 3 Dec 2017, In: Physiological Reports. 5, 23, 13 p., e13507.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Efficacy and immunogenicity of a Vi-tetanus toxoid conjugate vaccine in the prevention of typhoid fever using a controlled human infection model of Salmonella Typhi: a randomised controlled, phase 2b trial

    Jin, C., Gibani, M. M., Moore, M., Juel, H. B., Jones, E., Meiring, J., Harris, V., Gardner, J., Nebykova, A., Kerridge, S. A., Hill, J., Thomaides-Brears, H., Blohmke, C. J., Yu, L. M., Angus, B. & Pollard, A. J., 2 Dec 2017, In: The Lancet. 390, 10111, p. 2472-2480 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Discovery, characterization, and clinical development of the glucagon-like peptides

    Drucker, D. J., Habener, J. F. & Holst, Jens Juul, 1 Dec 2017, In: The Journal of Clinical Investigation. 127, 12, p. 4217-4227 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  42. Published

    Exome-wide association study of plasma lipids in >300,000 individuals

    Liu, D. J., Peloso, G. M., Yu, H., Butterworth, A. S., Wang, X., Mahajan, A., Saleheen, D., Emdin, C., Alam, D., Alves, A. C., Amouyel, P., Angelantonio, E. DI., Arveiler, D., Assimes, T. L., Auer, P. L., Baber, U., Ballantyne, C. M., Bang, L. E., Benn, M., Bis, J. C. & 208 others, Boehnke, M., Boerwinkle, E., Bork-Jensen, J., Bottinger, E. P., Brandslund, I., Brown, M., Busonero, F., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. E., Chen, Y. D. I., Chowdhury, R., Christensen, C., Chu, A. Y., Connell, J. M., Cucca, F., Cupples, L. A., Damrauer, S. M., Davies, G., Deary, I. J., Dedoussis, G., Denny, J. C., Dominiczak, A., Dubé, M. P., Ebeling, T., Eiriksdottir, G., Esko, T., Farmaki, A. E., Feitosa, M. F., Ferrario, M., Ferrieres, J., Ford, I., Fornage, M., Franks, P. W., Frayling, T. M., Frikke-Schmidt, Ruth, Fritsche, L. G., Frossard, P., Fuster, V., Ganesh, S. K., Gao, W., Garcia, M. E., Gieger, C., Giulianini, F., Goodarzi, M. O., Grallert, H., Grarup, N., Groop, L., Grove, M. L., Gudnason, V., Hansen, Torben, Harris, T. B., Hayward, C., Hirschhorn, J. N., Holmen, O. L., Huffman, J., Huo, Y., Hveem, K., Jabeen, S., Jackson, A. U., Jakobsdottir, J., Jarvelin, M. R., Jensen, G. B., Jørgensen, M. E., Jukema, J. W., Justesen, Johanne Marie, Kamstrup, P. R., Kanoni, S., Karpe, F., Kee, F., Khera, A. V., Klarin, D., Koistinen, H. A., Kooner, J. S., Kooperberg, C., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, T., Langenberg, C., Langsted, A., Launer, L. J., Lauritzen, T., MLiewald, D. C., Lin, L. A., Linneberg, Allan René, Loos, R. J. F., Lu, Y., Lu, X., Mägi, R., Malarstig, A., Manichaikul, A., Manning, A. K., Mäntyselkä, P., Marouli, E., Masca, N. G. D., Maschio, A., Meigs, J. B., Melander, O., Metspalu, A., Morris, A. P., Morrison, A. C., Mulas, A., Müller-Nurasyid, M., Munroe, P. B., Neville, M. J., Nielsen, S. F., Nielsen, J. B., Nordestgaard, Børge, Ordovas, J. M., Mehran, R., O'Donnell, C. J., Orho-Melander, M., Molony, C. M., Muntendam, P., Padmanabhan, S., Palmer, C. N. A., Pasko, D., Patel, A. P., Pedersen, Oluf Borbye, Perola, M., Peters, A., Pisinger, C., Pistis, G., Polasek, O., Poulter, N., Psaty, B. M., Rader, D. J., Rasheed, A., Rauramaa, R., Reilly, D. F., Reiner, A. P., Renström, F., Rich, S. S., Ridker, P. M., Rioux, J. D., Robertson, N. R., Roden, D. M., Rotter, J. I., Rudan, I., Salomaa, V., Samani, N. J., Sanna, S., Sattar, N., Schmidt, E. M., Scott, R. A., Sever, P., Sevilla, R. S., Shaffer, C. M., Sim, X., Sivapalaratnam, S., Small, K. S., Smith, A. V., Smith, B. H., Somayajula, S., Southam, L., Spector, T. D., Speliotes, E. K., Starr, J. M., Stirrups, K. E., Stitziel, N., Strauch, K., Stringham, H. M., Surendran, P., Tada, H., Tall, A. R., Tang, H., Tardif, J. C., Taylor, K. D., Trompet, S., Tsao, P. S., Tuomilehto, J., Tybjærg-Hansen, Anne, Zuydam, N. R. V., Varbo, A., Varga, T. V., Virtamo, J., Waldenberger, M., Wang, N., Wareham, N. J., Warren, H. R., Weeke, P. E., Weinstock, J., Wessel, J., Wilson, J. G., Wilson, P. W. F., Xu, M., Yaghootkar, H., Young, R., Zeggini, E., Zhang, H., Zheng, N. S., Zhang, W., Zhang, Y., Zhou, W., Zhou, Y., Zoledziewska, M., Howson, J. M. M., Danesh, J., McCarthy, M. I., Cowan, C. A., Abecasis, G., Deloukas, P., Musunuru, K., Willer, C. J., Kathiresan, S. & V Varga, Tibor, 1 Dec 2017, In: Nature Genetics. 49, 12, p. 1758-1766 9 p.

    Research output: Contribution to journalLetterResearchpeer-review

  43. Published

    Roles of increased glycemic variability, GLP-1 and glucagon in hypoglycaemia after Roux-en-Y gastric bypass

    Tharakan, G., Behary, P., Albrechtsen, Nicolai Jacob Wewer, Chahal, H., Kenkre, J., Miras, A. D., Ahmed, A. R., Holst, Jens Juul, Bloom, S. R. & Tan, T. M. M., 1 Dec 2017, In: European Journal of Endocrinology. 177, p. 455-464 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

    Manning, A., Highland, H. M., Gasser, J., Sim, X., Tukiainen, T., Fontanillas, P., Grarup, N., Rivas, M. A., Mahajan, A., Locke, A. E., Cingolani, P., Pers, T. H., Viñuela, A., Brown, A. A., Wu, Y., Flannick, J., Fuchsberger, C., Gamazon, E. R., Gaulton, K. J., Im, H. K. & 243 others, Teslovich, T. M., Blackwell, T. W., Bork-Jensen, J., Burtt, N. P., Chen, Y., Green, T., Hartl, C., Kang, H. M., Kumar, A., Ladenvall, C., Ma, C., Moutsianas, L., Pearson, R. D., Perry, J. R. B., Rayner, N. W., Robertson, N. R., Scott, L. J., van de Bunt, M., Eriksson, J. G., Jula, A., Koskinen, S., Lehtimäki, T., Palotie, A., Raitakari, O. T., Jacobs, S. B., Wessel, J., Chu, A. Y., Scott, R. A., Goodarzi, M. O., Blancher, C., Buck, G., Buck, D., Chines, P. S., Gabriel, S., Gjesing, A. M. P., Groves, C. J., Hollensted, M., Huyghe, J. R., Jackson, A. U., Jun, G., Justesen, Johanne Marie, Mangino, M., Murphy, J., Neville, M., Onofrio, R., Small, K. S., Stringham, H. M., Trakalo, J., Banks, E., Carey, J., Carneiro, M. O., DePristo, M., Farjoun, Y., Fennell, T., Goldstein, J. I., Grant, G., Hrabé de Angelis, M., Maguire, J., Neale, B. M., Poplin, R., Purcell, S., Schwarzmayr, T., Shakir, K., Smith, J. D., Strom, T. M., Wieland, T., Lindstrom, J., Brandslund, I., Christensen, C., Surdulescu, G. L., Lakka, T. A., Doney, A. S. F., Nilsson, P., Wareham, N. J., Langenberg, C., V Varga, Tibor, Franks, P. W., Rolandsson, O., Rosengren, A. H., Farook, V. S., Thameem, F., Puppala, S., Kumar, S., Lehman, D. M., Jenkinson, C. P., Curran, J. E., Hale, D. E., Fowler, S. P., Arya, R., DeFronzo, R. A., Abboud, H. E., Syvänen, A., Hicks, P. J., Palmer, N. D., Ng, M. C. Y., Bowden, D. W., Freedman, B. I., Esko, T., Mägi, R., Milani, L., Mihailov, E., Metspalu, A., Narisu, N., Kinnunen, L., Bonnycastle, L. L., Swift, A., Pasko, D., Wood, A. R., Fadista, J., Pollin, T. I., Barzilai, N., Atzmon, G., Glaser, B., Thorand, B., Strauch, K., Peters, A., Roden, M., Müller-Nurasyid, M., Liang, L., Kriebel, J., Illig, T., Grallert, H., Gieger, C., Meisinger, C., Lannfelt, L., Musani, S. K., Griswold, M., Taylor, H. A., Wilson, G., Correa, A., Oksa, H., Scott, W. R., Afzal, U., Tan, S., Loh, M., Chambers, J. C., Sehmi, J., Kooner, J. S., Lehne, B., Cho, Y. S., Lee, J., Han, B., Käräjämäki, A., Qi, Q., Qi, L., Huang, J., Hu, F. B., Melander, O., Orho-Melander, M., Below, J. E., Aguilar, D., Wong, T. Y., Liu, J., Khor, C., Chia, K. S., Lim, W. Y., Cheng, C., Chan, E., Tai, E. S., Aung, T., Linneberg, Allan René, Isomaa, B., Meitinger, T., Tuomi, T., Hakaste, L., Kravic, J., Jørgensen, M. E., Lauritzen, T., Deloukas, P., Stirrups, K. E., Owen, K. R., Farmer, A. J., Frayling, T. M., O'Rahilly, S. P., Walker, M., Levy, J. C., Hodgkiss, D., Hattersley, A. T., Kuulasmaa, T., Stančáková, A., Barroso, I., Bharadwaj, D., Chan, J., Chandak, G. R., Daly, M. J., Donnelly, P. J., Ebrahim, S. B., Elliott, P., Fingerlin, T., Froguel, P., Hu, C., Jia, W., Ma, R. C. W., McVean, G., Park, T., Prabhakaran, D., Sandhu, M., Scott, J., Sladek, R., Tandon, N., Teo, Y. Y., Zeggini, E., Watanabe, R. M., Koistinen, H. A., Kesaniemi, Y. A., Uusitupa, M., Spector, T. D., Salomaa, V., Rauramaa, R., Palmer, C. N. A., Prokopenko, I., Morris, A. D., Bergman, R. N., Collins, F. S., Lind, L., Ingelsson, E., Tuomilehto, J., Karpe, F., Groop, L., Jørgensen, T., Hansen, Torben, Pedersen, Oluf Borbye, Kuusisto, J., Abecasis, G., Bell, G. I., Blangero, J., Cox, N. J., Duggirala, R., Seielstad, M., Wilson, J. G., Dupuis, J., Ripatti, S., Hanis, C. L., Florez, J. C., Mohlke, K. L., Meigs, J. B., Laakso, M., Morris, A. P., Boehnke, M., Altshuler, D., McCarthy, M. I., Gloyn, A. L. & Lindgren, C. M., Dec 2017, In: Diabetes. 66, p. 2019-2032 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Cardiovascular and All-Cause Mortality Risk Associated With Urinary Excretion of 8-oxoGuo, a Biomarker for RNA Oxidation, in Patients With Type 2 Diabetes: A Prospective Cohort Study

    Kjær, L. K., Cejvanovic, V., Henriksen, T., Petersen, K. M., Hansen, Torben, Pedersen, Oluf Borbye, Christensen, C. K., Torp-Pedersen, C., Gerds, Thomas Alexander, Brandslund, I., Mandrup-Poulsen, Thomas & Poulsen, Henrik Enghusen, Dec 2017, In: Diabetes Care. 40, 12, p. 1771-1778 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Childhood body mass index and height in relation to site-specific risks of colorectal cancers in adult life

    Jensen, B. W., Gamborg, M., Gögenur, Ismail, Renehan, A. G., Sørensen, Thorkild I.A. & Baker, J. L., Dec 2017, In: European Journal of Epidemiology. 32, 12, p. 1097-1106

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Glucagon-like peptide-1 acutely affects renal blood flow and urinary flow rate in spontaneously hypertensive rats despite significantly reduced renal expression of GLP-1 receptors

    Ronn, J., Jensen, E. P., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul & Sorensen, Charlotte Mehlin, Dec 2017, In: Physiological Reports. 5, 23, 14 p., e13503.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Impaired beta cell sensitivity to incretins in type 2 diabetes is insufficiently compensated by higher incretin response

    Tura, A., Bagger, J. I., Ferrannini, E., Holst, Jens Juul, Knop, Filip Krag, Vilsbøll, Tina & Mari, A., Dec 2017, In: Nutrition, Metabolism and Cardiovascular Diseases. 27, 12, p. 1123-1129 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice

    Camporez, J. P., Wang, Y., Faarkrog, K., Chukijrungroat, N., Petersen, K. F. & Shulman, G. I., Dec 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 52, p. E11285-E11292 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Nutrient re-routing and altered gut-islet cell crosstalk may explain early relief of severe postprandial hypoglycaemia after reversal of Roux-en-Y gastric bypass

    Svane, M. S., Toft-Nielsen, M. B., Kristiansen, V. B., Hartmann, Bolette, Holst, Jens Juul, Madsbad, Sten & Bojsen-Møller, K. N., Dec 2017, In: Diabetic Medicine Online. 34, 12, p. 1783-1787

    Research output: Contribution to journalLetterResearchpeer-review

  51. Published

    Parent perspectives on biomarkers for OCD: Talking of difficult presents, desired pasts, and imagined futures

    Whiteley, Louise, Borgelt, E. L., Stewart, S. E. & Illes, J., Dec 2017, In: BioSocieties. 12, 4, p. 471–493 22 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91

    Trauelsen, Mette, Ulven, Elisabeth Rexen, Hjorth, Siv Annegrethe, Brvar, M., Monaco, C., Frimurer, Thomas Michael & Schwartz, Thue W., Dec 2017, In: Molecular Metabolism. 6, 12, p. 1585-1596 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Subjective evaluation of psychosocial well-being in children and youths with overweight or obesity: the impact of multidisciplinary obesity treatment

    Fonvig, Cilius Esmann, Hamann, S. A., Nielsen, T. R. H., Johansen, M. Ø., Grønbæk, H. N., Mollerup, P. M. & Holm, Jens-Christian, Dec 2017, In: Quality of Life Research. 26, 12, p. 3279-3288 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Unchanged mitochondrial phenotype, but accumulation of lipids in the myometrium in obese pregnant women

    Gam, C. M. B. F., Larsen, L. H., Mortensen, Ole Hartvig, pjx571, pjx571, Poulsen, Steen Seier, Qvortrup, Klaus, Mathiesen, Elisabeth, Damm, Peter & Quistorff, B., Dec 2017, In: Journal of Physiology. 595, 23, p. 7109-7122 24 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Environmental spread of microbes impacts the development of metabolic phenotypes in mice transplanted with microbial communities from humans

    Zhang, L., Bahl, M. I., Roager, Henrik Munch, Fonvig, C. E., Hellgren, L. I., Frandsen, H. L., Pedersen, Oluf Borbye, Holm, Jens-Christian, Hansen, Torben & Licht, T. R., 18 Nov 2017, In: The ISME Journal. 11, p. 676-690 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    In Situ Fixation Redefines Quiescence and Early Activation of Skeletal Muscle Stem Cells

    Machado, L., Esteves de Lima, J., Fabre, O., Proux, C., Legendre, R., Szegedi, A., Varet, H., Ingerslev, L. R., Barrès, Romain, Relaix, F. & Mourikis, P., 14 Nov 2017, In: Cell Reports. 21, 7, p. 1982-1993 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans

    Laker, R. C., Garde, C., Camera, D. M., Smiles, W. J., Zierath, Juleen R, Hawley, J. A. & Barrès, Romain, 9 Nov 2017, In: Scientific Reports. 7, 1, 12 p., 15134.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Genetic determinants of circulating GIP and GLP-1 concentrations

    Almgren, P., Lindqvist, A., Krus, U., Hakaste, L., Ottosson-Laakso, E., Asplund, O., Sonestedt, E., Prasad, R. B., Laurila, E., Orho-Melander, M., Melander, O., Tuomi, T., Holst, Jens Juul, Nilsson, P. M., Wierup, N., Groop, L. & Ahlqvist, E., 2 Nov 2017, In: JCI insight. 2, 21, 13 p., e93306.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Association of childhood body mass index and change in body mass index with first adult ischemic stroke

    Gjærde, L. K., Gamborg, M., Ängquist, Lars, Truelsen, T. C., Sørensen, Thorkild I.A. & Baker, J. L., 1 Nov 2017, In: JAMA Neurology. 74, 11, p. 1312-1318 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Cross-Validation of a Glucose-Insulin-Glucagon Pharmacodynamics Model for Simulation Using Data From Patients With Type 1 Diabetes

    Wendt, S. L., Ranjan, A., Møller, J. K., Schmidt, S., Knudsen, C. B., Holst, Jens Juul, Madsbad, Sten, Madsen, H., Nørgaard, Kirsten & Jørgensen, J. B., 1 Nov 2017, In: Journal of Diabetes Science and Technology. 11, 6, p. 1101-1111 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Evidence Suggesting Absence of Mitochondrial DNA Methylation

    Mechta, Mie, Ingerslev, L. R., Fabre, O., Picard, M. & Barrès, Romain, 1 Nov 2017, In: Frontiers in Genetics. 8, 9 p., 166.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    Role of Glucagon in Catabolism and Muscle Wasting of Critical Illness and Modulation by Nutrition

    Thiessen, S. E., Derde, S., Derese, I., Dufour, T., Vega, C. A., Langouche, L., Goossens, C., Peersman, N., Vermeersch, P., Vander Perre, S., Holst, Jens Juul, Wouters, P. J., Vanhorebeek, I. & Van den Berghe, G., 1 Nov 2017, In: American Journal of Respiratory and Critical Care Medicine. 196, 9, p. 1131-1143 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    'No cognitive-enhancing effect of GLP-1 receptor agonism in antipsychotic-treated, obese patients with schizophrenia': authors' response

    Ebdrup, Bjørn, Ishøy, P. L., Fagerlund, Birgitte, Broberg, B. V., Bak, N., Knop, Filip Krag & Glenthøj, Birte Yding, Nov 2017, In: Acta Psychiatrica Scandinavica. 136, 5, p. 526-527

    Research output: Contribution to journalComment/debateResearch

  64. Published

    Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project

    Jelenkovic, A., Yokoyama, Y., Sund, R., Pietiläinen, K. H., Hur, Y-M., Willemsen, G., Bartels, M., van Beijsterveldt, T. C., Ooki, S., Saudino, K. J., Stazi, M. A., Fagnani, C., D'Ippolito, C., Nelson, T. L., Whitfield, K. E., Knafo-Noam, A., Mankuta, D., Abramson, L., Heikkilä, K., Cutler, T. L. & 46 others, Hopper, J. L., Wardle, J., Llewellyn, C. H., Fisher, A., Corley, R. P., Huibregtse, B. M., Derom, C. A., Vlietinck, R. F., Loos, R. J., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Tarnoki, A. D., Tarnoki, D. L., Burt, S. A., Klump, K. L., Ordoñana, J. R., Sánchez-Romera, J. F., Colodro-Conde, L., Dubois, L., Boivin, M., Brendgen, M., Dionne, G., Vitaro, F., Harris, J. R., Brandt, I., Nilsen, T. S., Craig, J. M., Saffery, R., Rasmussen, F., Tynelius, P., Bayasgalan, G., Narandalai, D., Haworth, C. M., Plomin, R., Ji, F., Ning, F., Pang, Z., Rebato, E., Krueger, R. F., McGue, M., Pahlen, S., Boomsma, D. I., Sørensen, Thorkild I.A., Kaprio, J. & Silventoinen, K., Nov 2017, In: International Journal of Epidemiology. 46, 5, p. 1488-1498 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production

    Albrechtsen, N. J. W., Kuhre, R. E., Hornburg, D., Jensen, C. Z., Hornum, M., Dirksen, C., Svane, M., Gasbjerg, L. S., Jorgensen, N. B., Gabe, M. N., Balk-Moller, E., Albrechtsen, R., Winther-Sorensen, M., Galsgaard, K. D., Meissner, F., Jorsal, T., Lund, A., Vilsboll, T., Eliasen, R., Bojsen-Moller, K. N. & 9 others, Idorn, T., Deacon, Carolyn F., Knop, Filip Krag, Rosenkilde, Mette, Hartmann, Bolette, Feldt-Rasmussen, Bo, Mann, Matthias, Madsbad, Sten & Holst, Jens Juul, Nov 2017, In: Cell Reports. 21, 6, p. 1452-1460

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. Published

    Elevated Postoperative Endogenous GLP-1 Levels Mediate Effects of Roux-en-Y Gastric Bypass on Neural Responsivity to Food Cues

    Ten Kulve, J. S., Veltman, D. J., Gerdes, V. E. A., van Bloemendaal, L., Barkhof, F., Deacon, Carolyn F., Holst, Jens Juul, Drent, M. L., Diamant, M. & IJzerman, R. G., Nov 2017, In: Diabetes Care. 40, 11, p. 1522-1529 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. Published

    Host-microbiota interaction induces bi-phasic inflammation and glucose intolerance in mice

    Molinaro, A., Caesar, R., Holm, L. M., Tremaroli, V., Cani, P. D. & Bäckhed, F., Nov 2017, In: Molecular Metabolism. 6, 11, p. 1371-1380 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. Published

    Keeping fat on time: Circadian control of adipose tissue

    Ninel Hansen, S., Peics, J. & Gerhart-Hines, Zach, Nov 2017, In: Experimental Cell Research. 360, 1, p. 31-34 4 p.

    Research output: Contribution to journalReviewResearchpeer-review

  69. Published

    Macrophage Area Content and Phenotype in Hepatic and Adipose Tissue in Patients with Obesity Undergoing Roux-en-Y Gastric Bypass

    Kristensen, M. D., Lund, M. T., Hansen, M., Poulsen, Steen Seier, Ploug, Thorkil, Dela, Flemming, Helge, Jørn Wulff & Prats Gavalda, Clara, Nov 2017, In: Obesity. 25, 11, p. 1921-1931 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  70. Published

    Postmenopausal hormone therapy and risk of stroke: A pooled analysis of data from population-based cohort studies

    Carrasquilla, Germán D., Frumento, P., Berglund, A., Borgfeldt, C., Bottai, M., Chiavenna, C., Eliasson, M., Engstrom, G., Hallmans, G., Jansson, J., Magnusson, P. K., Nilsson, P. M., Pedersen, N. L., Wolk, A. & Leander, K., Nov 2017, In: PLoS Medicine. 14, 11

    Research output: Contribution to journalJournal articleResearchpeer-review

  71. Published

    Single-Dose Metformin Enhances Bile Acid-Induced Glucagon-Like Peptide-1 Secretion in Patients With Type 2 Diabetes

    Brønden, A., Albér, A., Rohde, U., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Nov 2017, In: The Journal of clinical endocrinology and metabolism. 102, 11, p. 4153-4162 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  72. Published

    TRPV1: A Potential Therapeutic Target in Type 2 Diabetes and Comorbidities?

    Gram, D. X., Holst, Jens Juul & Szallasi, A., Nov 2017, In: Trends in Molecular Medicine. 23, 11, p. 1002-1013 12 p.

    Research output: Contribution to journalReviewResearchpeer-review

  73. Published

    Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium

    Sharp, G. C., Salas, L. A., Monnereau, C., Allard, C., Yousefi, P., Everson, T. M., Bohlin, J., Xu, Z., Huang, R-C., Reese, S. E., Xu, C-J., Baïz, N., Hoyo, C., Agha, G., Roy, R., Holloway, J. W., Ghantous, A., Merid, S. K., Bakulski, K. M., Küpers, L. K. & 65 others, Zhang, H., Richmond, R. C., Page, C. M., Duijts, L., Lie, R. T., Melton, P. E., Vonk, J. M., Nohr, E. A., Williams-DeVane, C., Huen, K., Rifas-Shiman, S. L., Ruiz-Arenas, C., Gonseth, S., Rezwan, F. I., Herceg, Z., Ekström, S., Croen, L., Falahi, F., Perron, P., Karagas, M. R., Quraishi, B. M., Suderman, M., Magnus, M. C., Jaddoe, V. W. V., Taylor, J. A., Anderson, D., Zhao, S., Smit, H. A., Josey, M. J., Bradman, A., Baccarelli, A. A., Bustamante, M., Håberg, S. E., Pershagen, G., Hertz-Picciotto, I., Newschaffer, C., Corpeleijn, E., Bouchard, L., Lawlor, D. A., Maguire, R. L., Barcellos, L. F., Davey Smith, G., Eskenazi, B., Karmaus, W., Marsit, C. J., Hivert, M., Snieder, H., Fallin, M. D., Melén, E., Munthe-Kaas, M. C., Arshad, H., Wiemels, J. L., Annesi-Maesano, I., Vrijheid, M., Oken, E., Holland, N., Murphy, S. K., Sørensen, Thorkild I.A., Koppelman, G. H., Newnham, J. P., Wilcox, A. J., Nystad, W., London, S. J., Felix, J. F. & Relton, C. L., 15 Oct 2017, In: Human Molecular Genetics. 26, 20, p. 4067-4085 19 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  74. Published

    Anti-inflammatory effects of active commuting and leisure time exercise in overweight and obese women and men: A randomized controlled trial

    Gram, A. S., Bladbjerg, E., Quist, Jonas Salling, Blond, Martin Bæk, Rosenkilde, M. & Stallknecht, Bente Merete, Oct 2017, In: Atherosclerosis. 265, p. 318-324 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. Published

    Bidirectional manipulation of gene expression in adipocytes using CRISPRa and siRNA

    Lundh, M., Plucinska, Kaja, Isidor, Marie Sophie, Petersen, P. S. S. & Emanuelli, Brice, Oct 2017, In: Molecular Metabolism. 6, 10, p. 1313-1320 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  76. Published

    Childhood body mass index and risk of adult pancreatic cancer

    Nogueira, L., Stolzenberg-Solomon, R., Gamborg, Michael Orland, Sørensen, Thorkild I.A. & Baker, J. L., Oct 2017, In: Current Opinion in Clinical Nutrition and Metabolic Care. 1, 10, 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  77. Published

    Defects in α-Cell Function in Patients With Diabetes Due to Chronic Pancreatitis Compared With Patients With Type 2 Diabetes and Healthy Individuals

    Mumme, L., Breuer, T. G. K., Rohrer, S., Schenker, N., Menge, B. A., Holst, Jens Juul, Nauck, M. A. & Meier, J. J., Oct 2017, In: Diabetes Care. 40, 10, p. 1314-1322 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts

    Silventoinen, K., Jelenkovic, A., Latvala, A., Sund, R., Yokoyama, Y., Ullemar, V., Almqvist, C., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Kandler, C., Honda, C., Inui, F., Iwatani, Y., Watanabe, M., Rebato, E., Stazi, M. A., Fagnani, C., Brescianini, S., Hur, Y-M. & 81 others, Jeong, H., Cutler, T. L., Hopper, J. L., Busjahn, A., Saudino, K. J., Ji, F., Ning, F., Pang, Z., Rose, R. J., Koskenvuo, M., Heikkilae, K., Cozen, W., Hwang, A. E., Mack, T. M., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Sung, J., Kim, J., Lee, J., Lee, S., Nelson, T. L., Whitfield, K. E., Tan, Q., Zhang, D., Llewellyn, C. H., Fisher, A., Burt, S. A., Klump, K. L., Knafo-Noam, A., Mankuta, D., Abramson, L., Medland, S. E., Martin, N. G., Montgomery, G. W., Magnusson, P. K. E., Pedersen, N. L., Aslan, A. K. D., Corley, R. P., Huibregtse, B. M., OEncel, S. Y., Aliev, F., Krueger, R. F., Mcgue, M., Pahlen, S., Willemsen, G., Bartels, M., Van Beijsterveldt, C. E. M., Silberg, J. L., Eaves, L. J., Maes, H. H., Harris, J. R., Brandt, I., Nilsen, T. S., Rasmussen, F., Tynelius, P., Baker, L. A., Tuvblad, C., Ordonana, J. R., Sanchez-Romera, J. F., Colodro-Conde, L., Gatz, M., Butler, D. A., Lichtenstein, P., Goldberg, J. H., Harden, K. P., Tucker-Drob, E. M., Duncan, G. E., Buchwald, D., Tarnoki, A. D., Tarnoki, D. L., Franz, C. E., Kremen, W. S., Lyons, M. J., Maia, J. A., Freitas, D. L., Turkheimer, E., Sørensen, Thorkild I.A., Boomsma, D. I. & Kaprio, J., Oct 2017, In: Twin Research and Human Genetics. 20, 5, p. 395-405 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. Published

    Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease

    Zhao, W., Rasheed, A., Tikkanen, E., Lee, J-J., Butterworth, A. S., Howson, J. M. M., Assimes, T. L., Chowdhury, R., Orho-Melander, M., Damrauer, S., Small, A., Asma, S., Imamura, M., Yamauch, T., Chambers, J. C., Chen, P., Sapkota, B. R., Shah, N., Jabeen, S., Surendran, P. & 31 others, Lu, Y., Zhang, W., Imran, A., Abbas, S., Majeed, F., Trindade, K., Qamar, N., Mallick, N. H., Yaqoob, Z., Saghir, T., Rizvi, S. N. H., Memon, A., Rasheed, S. Z., Memon, F., Mehmood, K., Ahmed, N., Qureshi, I. H., Tanveer-Us-Salam, Iqbal, W., Malik, U., Mehra, N., Kuo, J. Z., Sheu, W. H., Guo, X., Hsiung, C. A., Juang, J. J., Nordestgaard, Børge, Tybjærg-Hansen, Anne, Benn, Marianne, Frikke-Schmidt, Ruth & CHD Exome+ Consortium, C. E. C., Oct 2017, In: Nature Genetics. 49, 10, p. 1450-1457 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  80. Published

    Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition

    Kootte, R. S., Levin, E., Salojärvi, J., Smits, L. P., Hartstra, A. V., Udayappan, S. D., Hermes, G., Bouter, K. E., Koopen, A. M., Holst, J. J., Knop, F. K., Blaak, E. E., Zhao, J., Smidt, H., Harms, A. C., Hankemeijer, T., Bergman, J. J. G. H. M., Romijn, H. A., Schaap, F. G., Olde Damink, S. W. M. & 8 others, Ackermans, M. T., Dallinga-Thie, G. M., Zoetendal, E., de Vos, W. M., Serlie, M. J., Stroes, E. S. G., Groen, A. K. & Nieuwdorp, M., Oct 2017, In: Cell Metabolism. 26, 4, p. 611-619.e6 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  81. Published

    Mathematical Modelling of Glucose-Dependent Insulinotropic Polypeptide and Glucagon-like Peptide-1 following Ingestion of Glucose

    Røge, R. M., Bagger, J. I., Alskär, O., Kristensen, N. R., Klim, S., Holst, Jens Juul, Ingwersen, S. H., Karlsson, M. O., Knop, Filip Krag, Vilsbøll, Tina & Kjellsson, M. C., Oct 2017, In: Basic & Clinical Pharmacology & Toxicology. 121, 4, p. 290-297 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  82. Published

    New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals

    Kraja, A. T., Cook, J. P., Warren, H. R., Surendran, P., Liu, C., Evangelou, E., Manning, A. K., Grarup, N., Drenos, F., Sim, X., Smith, A. V., Amin, N., Blakemore, A. I. F., Bork-Jensen, J., Brandslund, I., Farmaki, A. E., Fava, C., Ferreira, T., Herzig, K. H., Giri, A. & 31 others, Giulianini, F., Grove, M. L., Guo, X., Harris, S. E., Have, C. T., Havulinna, A. S., Zhang, H., Jørgensen, M. E., Käräjämäki, A. M., Kooperberg, C., Linneberg, Allan René, Little, L., Liu, Y., Bonnycastle, L. L., Lu, Y., Mägi, R., Mahajan, A., Malerba, G., Marioni, R. E., Mei, H., Menni, C., Morrison, A. C., Padmanabhan, S., Palmas, W., Poveda, A., Rauramaa, R., Rayner, N. W., Riaz, M., Hansen, Torben, Pedersen, Oluf Borbye & behalf of the CHARGE EXOME BP, CHD Exome+, Exome BP, GoT2D:T2DGenes Consortia, The UK Biobank Cardio-Metabolic Traits Consortium Blood Pressure Working Group, B. O. T. C. E. B. C. E. E. B. G. C. T. U. B. C. T. C. B. P. W. G., Oct 2017, In: Circulation: Cardiovascular Genetics. 10, 5, 9 p., e001778.

    Research output: Contribution to journalJournal articleResearchpeer-review

  83. Published

    New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individuals

    Kraja, A. T., Cook, J. P., Warren, H. R., Surendran, P., Liu, C., Evangelou, E., Manning, A. K., Grarup, N., Drenos, F., Sim, X., Smith, A. V., Amin, N., Blakemore, A. I. F., Bork-Jensen, J., Brandslund, I., Farmaki, A-E., Fava, C., Ferreira, T., Herzig, K-H., Giri, A. & 122 others, Giulianini, F., Grove, M. L., Guo, X., Harris, S. E., Have, C. T., Havulinna, A. S., Zhang, H., Jørgensen, M. E., Karajamaki, A., Kooperberg, C., Linneberg, Allan René, Little, L., Liu, Y., Bonnycastle, L. L., Lu, Y., Magi, R., Mahajan, A., Malerba, G., Marioni, R. E., Mei, H., Menni, C., Morrison, A. C., Padmanabhan, S., Palmas, W., Poveda, A., Rauramaa, R., Rayner, N. W., Riaz, M., Rice, K., Richard, M. A., Smith, J. A., Southam, L., Stancakova, A., Stirrups, K. E., Tragante, V., Tuomi, T., Tzoulald, I., V Varga, Tibor, Weiss, S., Yiorkas, A. M., Young, R., Zhang, W., Barnes, M. R., Cabrera, C. P., Gao, H., Boehnke, M., Boerwinkle, E., Chambers, J. C., Connell, J. M., Christensen, C. K., de Boer, R. A., Deary, I. J., Dedoussis, G., Deloukas, P., Dominiczak, A. F., Dorr, M., Joehanes, R., Edwards, T. L., Esko, T., Fornage, M., Franceschini, N., Franks, P. W., Gambaro, G., Groop, L., Hallmans, G., Hansen, Torben, Hayward, C., Heikki, O., Ingelsson, E., Tuomilehto, J., Jarvelin, M., Kardia, S. L. R., Karpe, F., Kooner, J. S., Lakka, T. A., Langenberg, C., Lind, L., Loos, Ruth, Laakso, M., McCarthy, M. I., Melander, O., Mohlke, K. L., Moris, A. P., Palmer, C. N. A., Pedersen, Oluf Borbye, Polasek, O., Poulter, N. R., Province, M. A., Psaty, B. M., Ridker, P. M., Rotter, J. I., Rudan, I., Salomaa, V., Samani, N. J., Sever, P. J., Skaaby, T., Stafford, J. M., Starr, J. M., van der Harst, P., van der Meer, P., van Duijn, C. M., Vergnaud, A., Gudnason, V., Wareham, N. J., Wilson, J. G., Willer, C. J., Witte, D. R., Zeggini, E., Saleheen, D., Butterworth, A. S., Danesh, J., Asselbergs, F. W., Wain, L. V., Ehret, G. B., Chasman, D. I., Caulfield, M. J., Elliott, P., Lindgren, C. M., Levy, D., Newton-Cheh, C., Munroe, P. B. & Howson, J. M. M., Oct 2017, In: Circulation: Cardiovascular Genetics. 10, 5

    Research output: Contribution to journalJournal articleResearchpeer-review

  84. Published

    Reductions in blood pressure during a community-based overweight and obesity treatment in children and adolescents with prehypertension and hypertension

    Mollerup, P. M., Lausten-Thomsen, U., Fonvig, Cilius Esmann, Baker, J. L. & Holm, Jens-Christian, Oct 2017, In: Journal of Human Hypertension. 31, p. 640-646 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  85. Published

    Short-term effects of a low carbohydrate diet on glycaemic variables and cardiovascular risk markers in patients with type 1 diabetes: A randomized open-label crossover trial

    Ranjan, A., Schmidt, S., Damm-Frydenberg, C., Holst, Jens Juul, Madsbad, Sten & Nørgaard, Kirsten, Oct 2017, In: Diabetes, Obesity and Metabolism. 19, 10, p. 1479-1484

    Research output: Contribution to journalJournal articleResearchpeer-review

  86. Published

    Why is it so difficult to measure glucagon-like peptide-1 in a mouse?

    Windeløv, Johanne Agerlin, Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Jepsen, Sara Lind, Hornburg, D., Pedersen, Jens, Jensen, E. P., Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Ørgaard, A., Deacon, Carolyn F., Mann, Matthias, Kissow, Hannelouise, Hartmann, Bolette & Holst, Jens Juul, Oct 2017, In: Diabetologia. 60, 10, p. 2066-2075 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  87. Published

    Complete Genome Sequences of emm111 Type Streptococcus pyogenes Strain GUR, with Antitumor Activity, and Its Derivative Strain GURSA1 with an Inactivated emm Gene

    Suvorova, M. A., Tsapieva, A. N., Bak, Emilie Glad, Chereshnev, V. A., Kiseleva, E. P., Suvorov, A. N. & Arumugam, Mani, 21 Sep 2017, In: Genome Announcements. 5, 38, 2 p., e00939-17.

    Research output: Contribution to journalJournal articleResearch

  88. Published

    A functional IFN-λ4-generating DNA polymorphism could protect older asthmatic women from aeroallergen sensitization and associate with clinical features of asthma

    Chinnaswamy, S., Wardzynska, A., Pawelczyk, M., Makowska, J., Skaaby, T., Mercader, J. M., Ahluwalia, T. S., Grarup, N., Guindo-Martinez, M., Bisgaard, H., Torrents, D., Linneberg, Allan René, Bønnelykke, Klaus & Kowalski, M. L., 5 Sep 2017, In: Scientific Reports. 7, 1, p. 1-11 11 p., 10500.

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. Published

    A sandwich ELISA for measurement of the primary glucagon-like peptide-1 metabolite

    Albrechtsen, Nicolai Jacob Wewer, Asmar, A., Jensen, F., Törang, S., Simonsen, L., Kuhre, Rune Ehrenreich, Asmar, M., Veedfald, Simon, Plamboeck, A., Knop, Filip Krag, Vilsbøll, Tina, Madsbad, Sten, Nauck, M. A., Deacon, Carolyn F., Bülow, J., Holst, Jens Juul & Hartmann, Bolette, 1 Sep 2017, In: American Journal of Physiology: Endocrinology and Metabolism. 313, 3, p. E284-E291

    Research output: Contribution to journalJournal articleResearchpeer-review

  90. Published

    A urinary proteome-based classifier for the early detection of decline in glomerular filtration

    Pontillo, C., Jacobs, L., Staessen, J. A., Schanstra, J. P., Rossing, Peter, Heerspink, H. J. L., Siwy, J., Mullen, W., Vlahou, A., Mischak, H., Vanholder, R., Zürbig, P. & Jankowski, J., 1 Sep 2017, In: Nephrology, Dialysis, Transplantation. 32, 9, p. 1510-1516 7 p., gfw239.

    Research output: Contribution to journalJournal articleResearchpeer-review

  91. Published

    Assembly and analysis of 100 full MHC haplotypes from the Danish population

    Jensen, J. M., Villesen, P., Friborg, R. M., Mailund, T., Besenbacher, S., Sørensen, L. M., Petersen, B., Sibbesen, J. A., Liu, S., Skov, L., Belling, K. G., Have, C. T., Izarzugaza, J. M. G., Grosjean, M., Bork-Jensen, J., Grove, J., Als, T. D., Huang, S., Chang, Y., Xu, R. & 39 others, Ye, W., Rao, J., Guo, X., Sun, J., Cao, H., Ye, C., Beusekom, J. V., Espeseth, T., Flindt, E., Halager, A. E., Hellard, S. L., Hultman, C. M., Lescai, F., Li, S., Lund, O., Løngren, P., Matey-Hernandez, M. L., Mors, O., Pedersen, C. N. S., Sicheritz-Pontén, T., Sullivan, P., Syed, A., Westergaard, D., Yadav, R., Li, N., Xu, X., Hansen, Torben, Bolund, L., Krogh, Anders, Sørensen, Thorkild I.A., Pedersen, Oluf Borbye, Gupta, R., Rasmussen, Simon, Børglum, A. D., Wang, J., Eiberg, Hans Rudolf Lytchoff, Kristiansen, Karsten, Brunak, Søren & Schierup, M. H., Sep 2017, In: Genome Research. 27, 9, p. 1597-1607 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  92. Published

    Cell-Free DNA in Metastatic Colorectal Cancer: A Systematic Review and Meta-Analysis

    Spindler, K. G., Boysen, A. K., Pallisgård, N., Johansen, Julia Sidenius, Tabernero, J., Sørensen, M. M., Jensen, B. V., Hansen, Torben, Sefrioui, D., Andersen, R. F., Brandslund, I. & Jakobsen, A., Sep 2017, In: Oncologist. 22, 9, p. 1049-1055 7 p.

    Research output: Contribution to journalReviewResearchpeer-review

  93. Published

    Diabetes-associated microbiota in fa/fa rats is modified by Roux-en-Y gastric bypass

    Arora, Tulika, Seyfried, F., Docherty, N. G., Tremaroli, V., le Roux, C. W., Perkins, R. & Bäckhed, F., Sep 2017, In: I S M E Journal. 11, 9, p. 2035-2046 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  94. Published

    High-Intensity Interval Training, Appetite, and Reward Value of Food in the Obese

    Martins, C., Aschehoug, I., Ludviksen, M., Holst, Jens Juul, Finlayson, G., Wisloff, U., Morgan, L., King, N. & Kulseng, B., Sep 2017, In: Medicine and Science in Sports and Exercise. 49, 9, p. 1851-1858 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  95. Published

    NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program

    Hiraike, Y., Waki, H., Yu, J., Nakamura, M., Miyake, K., Nagano, G., Nakaki, R., Suzuki, K., Kobayashi, H., Yamamoto, S., Sun, W., Aoyama, T., Hirota, Y., Ohno, H., Oki, K., Yoneda, M., White, A. P., Tseng, Y-H., Cypess, A. M., Larsen, T. J. & 6 others, Jespersen, N. Z., Schéele, Camilla Charlotte Nielsen, Tsutsumi, S., Aburatani, H., Yamauchi, T. & Kadowaki, T., Sep 2017, In: Nature Cell Biology. 19, 9, p. 1081-1092 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  96. Published

    Signaling Pathways as Potential Therapeutic Targets in Hepatocarcinogenesis

    Yılmaz, Y., Güneş, A., Topel, Hande & Atabey, N., Sep 2017, In: Journal of Gastrointestinal Cancer. 48, 3, p. 225-237 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  97. Published

    The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor

    Asmar, M., Asmar, A., Simonsen, L., Gasbjerg, Lærke Smidt, wbf943, wbf943, Rosenkilde, Mette, Hartmann, Bolette, Dela, Flemming, Holst, Jens Juul & Bülow, J., Sep 2017, In: Diabetes. 66, 9, p. 2363-2371 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Published

    The role of somatostatin in GLP-1-induced inhibition of glucagon secretion in mice

    Ørgaard, A. & Holst, Jens Juul, Sep 2017, In: Diabetologia. 60, 9, p. 1731-1739 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  99. Published

    To see and then to act, that is the challenge

    Sørensen, Thorkild I.A., Sep 2017, In: European Journal of Epidemiology. 32, 9, p. 737-739 3 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  100. Published

    Alcohol consumption and its interaction with adiposity-associated genetic variants in relation to subsequent changes in waist circumference and body weight

    Rohde, J. F., Ängquist, Lars, Larsen, S. C., Tolstrup, J. S., Husemoen, L. L. N., Linneberg, Allan René, Toft, Ulla Marie Nørgaard, Overvad, K., Halkjær, J., Tjønneland, A., Hansen, Torben, Pedersen, Oluf Borbye, Sørensen, Thorkild I.A. & Heitmann, Berit, 25 Aug 2017, In: Nutrition Journal. 16, 11 p., 51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  101. Published

    Pancreatic and Intestinal Function Post Roux-en-Y Gastric Bypass Surgery for Obesity

    O'Keefe, S. J. D., Rakitt, T., Ou, J., El Hajj, I. I., Blaney, E., Vipperla, K., Holst, Jens Juul & Rehlfeld, J., 3 Aug 2017, In: Clinical and Translational Gastroenterology. 8, 11 p., e112.

    Research output: Contribution to journalJournal articleResearchpeer-review

  102. Published

    1H MRS Assessment of Hepatic Fat Content. Comparison Between Normal- and Excess-weight Children and Adolescents

    Chabanova, E., Fonvig, Cilius Esmann, Bøjsøe, C., Holm, Jens-Christian & Thomsen, Henrik S., Aug 2017, In: Academic Radiology. 24, 8, p. 982-987 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review