Novo Nordisk Foundation Center for Basic Metabolic Research

High-Throughput UHPLC-MS to Screen Metabolites in Feces for Gut Metabolic Health

de Zawadzki, A., Thiele, M., Suvitaival, T., Wretlind, A., Kim, M., Ali, M., Bjerre, A. F., Stahr, K., Mattila, I., Hansen, Torben, Krag, A. & Legido-Quigley, C., 2022, In: Metabolites. 12, 3, 16 p., 211.

Research output: Contribution to journal › Journal article › Research › peer-review

High-dose vitamin D supplementation in pregnancy and 25(OH)D sufficiency in childhood reduce the risk of fractures and improve bone mineralization in childhood: Follow-up of a randomized clinical trial

Brustad, N., Chawes, Bo Lund Krogsgaard, Thorsen, Jonathan Jan Ilve, Krakauer, M., Lasky-Su, J., Weiss, S. T., Stokholm, J., Bønnelykke, Klaus & Bisgaard, H., 2022, In: EClinicalMedicine. 43, 10 p., 101254.

Research output: Contribution to journal › Journal article › Research › peer-review

High-fat diet exacerbates cognitive and metabolic abnormalities in neuronal BACE1 knock-in mice - partial prevention by Fenretinide

Plucinska, Kaja, Mody, N., Dekeryte, R., Shearer, K., Mcilroy, G. D., Delibegovic, M. & Platt, B., 2022, In: Nutritional Neuroscience. 25, 4, p. 719-736 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

High-intensity interval training remodels the proteome and acetylome of human skeletal muscle

Hostrup, Morten, Lemminger, A. K., Stocks, Ben Nicholas, Gonzalez-Franquesa, A., Larsen, Jeppe Kjærgaard, Prats Quesada, Júlia, Thomassen, Martin, Weinert, B. T., Bangsbo, Jens & Deshmukh, Atul Shahaji, 2022, In: eLife. 11, 37 p., 69802.

Research output: Contribution to journal › Journal article › Research › peer-review

Himalayan bacterial endophytes enhance microalgal cell numbers and chlorophyll content in synthetic co-culture

Sonowal, S., Palani, Nagendra Prasad, Ahmed, R., Debbarma, J., Chikkaputtaiah, C., Basar, E. & Velmurugan, N., 2022, In: Journal of Applied Phycology. 34, 5, p. 2383-2400

Research output: Contribution to journal › Journal article › Research › peer-review

Hindbrain circuits in the control of eating behaviour and energy balance

Cheng, W., Gordian, D., Ludwig, M. Q., Pers, Tune H, Seeley, R. J. & Myers, M. G., 2022, In: Nature Metabolism. 4, 7, p. 826-835 10 p.

Research output: Contribution to journal › Review › Research › peer-review

Human visceral and subcutaneous adipose stem and progenitor cells retain depot-specific adipogenic properties during obesity

Mathur, N., Severinsen, M. C. K., Jensen, M. E., Naver, L., Schrölkamp, Maren, Laye, M. J., Watt, M. J., Nielsen, S., Krogh-Madsen, Rikke, Pedersen, Bente Klarlund & Schéele, Camilla Charlotte Nielsen, 2022, In: Frontiers in Cell and Developmental Biology. 10, 12 p., 983899.

Research output: Contribution to journal › Journal article › Research › peer-review

Hyperglucagonemia in pediatric adiposity associates with cardiometabolic risk factors but not hyperglycemia

Stinson, Sara, Jonsson, Anna Elisabet, Alzola, I. F. D. R., Lund, Morten Asp Vonsild, Frithioff-Bøjsøe, C., Holm, L. A., Fonvig, Cilius Esmann, Pedersen, Oluf Borbye, Ängquist, Lars, Sørensen, Thorkild I.A., Holst, Jens Juul, Christiansen, M., Holm, Jens-Christian, Hartmann, Bolette & Hansen, Torben, 2022, In: Journal of Clinical Endocrinology and Metabolism. 107, 6, p. 1569–1576

Research output: Contribution to journal › Journal article › Research › peer-review

Hyperinsulinemia Is Highly Associated With Markers of Hepatocytic Senescence in Two Independent Cohorts

Meijnikman, A. S., van Olden, C. C., Aydin, Ö., Herrema, H., Kaminska, D., Lappa, D., Männistö, V., Tremaroli, V., Olofsson, L. E., de Brauw, M., van de Laar, A., Verheij, J., Gerdes, V. E. A., Schwartz, T. W., Nielsen, J., Bäckhed, F., Pajukanta, P., Pihlajamäki, J., Tchkonia, T., Kirkland, J. L. & 3 others, Kuipers, F., Nieuwdorp, M. & Groen, A. K., 2022, In: Diabetes. 71, 9, p. 1929-1936 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Hypoglycaemia and rebound hyperglycaemia increase left ventricular systolic function in patients with type 1 diabetes

Andreasen, C. R., Andersen, A., Hagelqvist, P. G., Lauritsen, J. V., Jørgensen, P. G., Engberg, S., Faber, Jens, Hartmann, Bolette, Pedersen-Bjergaard, Ulrik, Knop, Filip Krag & Vilsbøll, Tina, 2022, In: Diabetes, Obesity and Metabolism. 24, 10, p. 2027-2037

Research output: Contribution to journal › Journal article › Research › peer-review

Illumination of the endogenous insulin-regulated TBC1D4 interactome in human skeletal muscle

Larsen, Jeppe Kjærgaard, Larsen, Magnus Romme, Birk, Jesper Bratz, Steenberg, D. E., Hingst, J. R., Højlund, K., Chadt, A., Al-Hasani, H., Deshmukh, Atul Shahaji, Wojtaszewski, Jørgen F P & Kjøbsted, Rasmus, 2022, In: Diabetes. 71, 5, p. 906-920

Research output: Contribution to journal › Journal article › Research › peer-review

Immune Cells in Thermogenic Adipose Depots: The Essential but Complex Relationship: Immunomodulation of Thermogenic Fat Depots

Agueda Oyarzabal, Marina & Emanuelli, Brice, 2022, In: Frontiers in Endocrinology. 13, 9 p., 839360.

Research output: Contribution to journal › Review › Research › peer-review

Impact of polymorphism in the β₂-receptor gene on metabolic responses to repeated hypoglycaemia in healthy humans

Rokamp, K. Z., Holst, Jens Juul, Olsen, N. V., Dela, Flemming, Secher, Niels H., Juul, Anders, Faber, Jens, Wiberg, S., Thorsteinsson, B. & Pedersen-Bjergaard, Ulrik, 2022, In: Journal of Clinical Endocrinology and Metabolism. 107, 8, p. e3194–e3205 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Impaired phosphocreatine metabolism in white adipocytes promotes inflammation

Maqdasy, S., Lecoutre, S., Renzi, G., Frendo-Cumbo, S., Rizo-Roca, D., Moritz, Thomas, Juvany, M., Hodek, O., Gao, H., Couchet, M., Witting, M., Kerr, A., Bergo, M. O., Choudhury, R. P., Aouadi, M., Zierath, Juleen R, Krook, A., Mejhert, N. & Rydén, M., 2022, In: Nature Metabolism. 4, p. 190-202

Research output: Contribution to journal › Journal article › Research › peer-review

Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism

Belda, E., Voland, L., Tremaroli, V., Falony, G., Adriouch, S., Assmann, K. E., Prifiti, E., Aron-Wisnewsky, J., Debedat, J., Le Roy, T., Nielsen, T., Amouyal, C., Andre, S., Andreelli, F., Blueher, M., Chakaroun, R., Chilloux, J., Coelho, L. P., Dao, M. C., Das, P. & 42 others, Fellahi, S., Forslund, S., Galleron, N., Hansen, T. H., Holmes, B., Ji, B., Pedersen, H. K., Phuong Le, Le Chatelier, E., Lewinter, C., Manneras-Holm, L., Marquet, F., Myridakis, A., Pelloux, V., Pons, N., Quinquis, B., Rouault, C., Roume, H., Salem, J., Sokolovska, N., Søndertoft, N. B., Touch, S., Vieira-Silva, S., Galan, P., Holst, Jens Juul, Gøtze, J. P., Køber, Lars Valeur, drb459, drb459, Hansen, Torben, Hercberg, S., Oppert, J., Nielsen, J., Letunic, I., Dumas, M., Stumvoll, M., Pedersen, Oluf Borbye, Bork, P., Ehrlich, S. D., Zucker, J., Baeckhed, F., Raes, J. & Clement, K., 2022, In: Gut. 71, 12, p. 2463-2480 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Kanoni, S., Graham, S. E., Wang, Y., Surakka, I., Ramdas, S., Zhu, X., Clarke, S. L., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K. H. H., Ntalla, I., Hui, Q., Klarin, D., Hilliard, A. T., Wang, Z., Xue, C. & 519 others, Thorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Hwang, M. Y., Han, S., Akiyama, M., Sakaue, S., Terao, C., Kanai, M., Zhou, W., Brumpton, B. M., Rasheed, H., Havulinna, A. S., Veturi, Y., Pacheco, J. A., Rosenthal, E. A., Lingren, T., Feng, Q. P., Kullo, I. J., Narita, A., Takayama, J., Martin, H. C., Hunt, K. A., Trivedi, B., Haessler, J., Giulianini, F., Bradford, Y., Miller, J. E., Campbell, A., Lin, K., Millwood, I. Y., Rasheed, A., Hindy, G., Faul, J. D., Zhao, W., Weir, D. R., Turman, C., Huang, H., Graff, M., Choudhury, A., Sengupta, D., Mahajan, A., Brown, M. R., Zhang, W., Yu, K., Schmidt, E. M., Pandit, A., Gustafsson, S., Yin, X., Luan, J., Zhao, J. H., Matsuda, F., Jang, H. M., Yoon, K., Medina-Gomez, C., Pitsillides, A., Hottenga, J. J., Wood, A. R., Ji, Y., Gao, Z., Haworth, S., Yousri, N. A., Mitchell, R. E., Chai, J. F., Aadahl, Mette, Bjerregaard, A. A., Yao, J., Manichaikul, A., Hwu, C. M., Hung, Y. J., Warren, H. R., Ramirez, J., Bork-Jensen, J., Kårhus, L. L., Goel, A., Sabater-Lleal, M., Noordam, R., Mauro, P., Matteo, F., McDaid, A. F., Marques-Vidal, P., Wielscher, M., Trompet, S., Sattar, N., Møllehave, L. T., Munz, M., Zeng, L., Huang, J., Yang, B., Poveda, A., Kurbasic, A., Lamina, C., Forer, L., Scholz, M., Galesloot, T. E., Bradfield, J. P., Ruotsalainen, S. E., Daw, E., Zmuda, J. M., Mitchell, J. S., Fuchsberger, C., Christensen, H., Brody, J. A., Vazquez-Moreno, M., Feitosa, M. F., Wojczynski, M. K., Wang, Z., Preuss, M. H., Mangino, M., Christofidou, P., Verweij, N., Benjamins, J. W., Engmann, J., Tsao, N. L., Verma, A., Slieker, R. C., Lo, K. S., Zilhao, N. R., Le, P., Kleber, M. E., Delgado, G. E., Huo, S., Ikeda, D. D., Iha, H., Yang, J., Liu, J., Demirkan, A., Leonard, H. L., Marten, J., Frank, M., Schmidt, B., Smyth, L. J., Cañadas-Garre, M., Wang, C., Nakatochi, M., Wong, A., Hutri-Kähönen, N., Sim, X., Xia, R., Huerta-Chagoya, A., Fernandez-Lopez, J. C., Lyssenko, V., Nongmaithem, S. S., Bayyana, S., Stringham, H. M., Irvin, M. R., Oldmeadow, C., Kim, H. N., Ryu, S., Timmers, P. R. H. J., Arbeeva, L., Dorajoo, R., Lange, L. A., Prasad, G., Lorés-Motta, L., Pauper, M., Long, J., Li, X., Theusch, E., Takeuchi, F., Spracklen, C. N., Loukola, A., Bollepalli, S., Warner, S. C., Wang, Y. X., Wei, W. B., Nutile, T., Ruggiero, D., Sung, Y. J., Chen, S., Liu, F., Yang, J., Kentistou, K. A., Banas, B., Nardone, G. G., Meidtner, K., Bielak, L. F., Smith, J. A., Hebbar, P., Farmaki, A. E., Hofer, E., Lin, M., Concas, M. P., Vaccargiu, S., van der Most, P. J., Pitkänen, N., Cade, B. E., van der Laan, S. W., Chitrala, K. N., Weiss, S., Bentley, A. R., Doumatey, A. P., Adeyemo, A. A., Lee, J. Y., Petersen, E. R. B., Nielsen, A. A., Choi, H. S., Nethander, M., Freitag-Wolf, S., Southam, L., Rayner, N. W., Wang, C. A., Lin, S. Y., Wang, J. S., Couture, C., Lyytikäinen, L. P., Nikus, K., Cuellar-Partida, G., Vestergaard, H., Hidalgo, B., Giannakopoulou, O., Cai, Q., Obura, M. O., van Setten, J., Li, X., Liang, J., Tang, H., Terzikhan, N., Shin, J. H., Jackson, R. D., Reiner, A. P., Martin, L. W., Chen, Z., Li, L., Kawaguchi, T., Thiery, J., Bis, J. C., Launer, L. J., Li, H., Nalls, M. A., Raitakari, O. T., Ichihara, S., Wild, S. H., Nelson, C. P., Campbell, H., Jäger, S., Nabika, T., Al-Mulla, F., Niinikoski, H., Braund, P. S., Kolcic, I., Kovacs, P., Giardoglou, T., Katsuya, T., de Kleijn, D., de Borst, G. J., Kim, E. K., Adams, H. H. H., Ikram, M. A., Zhu, X., Asselbergs, F. W., Kraaijeveld, A. O., Beulens, J. W. J., Shu, X. O., Rallidis, L. S., Pedersen, Oluf Borbye, Hansen, Torben, Mitchell, P., Hewitt, A. W., Kähönen, M., Pérusse, L., Bouchard, C., Tönjes, A., Chen, Y. D. I., Pennell, C. E., Mori, T. A., Lieb, W., Franke, A., Ohlsson, C., Mellström, D., Cho, Y. S., Lee, H., Yuan, J. M., Koh, W. P., Rhee, S. Y., Woo, J. T., Heid, I. M., Stark, K. J., Zimmermann, M. E., Völzke, H., Homuth, G., Evans, M. K., Zonderman, A. B., Polasek, O., Pasterkamp, G., Hoefer, I. E., Redline, S., Pahkala, K., Oldehinkel, A. J., Snieder, H., Biino, G., Schmidt, R., Schmidt, H., Bandinelli, S., Dedoussis, G., Thanaraj, T. A., Kardia, S. L. R., Peyser, P. A., Kato, N., Schulze, M. B., Girotto, G., Böger, C. A., Jung, B., Joshi, P. K., Bennett, D. A., De Jager, P. L., Lu, X., Mamakou, V., Brown, M., Caulfield, M. J., Munroe, P. B., Guo, X., Ciullo, M., Jonas, J. B., Samani, N. J., Kaprio, J., Pajukanta, P., Tusié-Luna, T., Aguilar-Salinas, C. A., Adair, L. S., Bechayda, S. A., de Silva, H. J., Wickremasinghe, A. R., Krauss, R. M., Wu, J. Y., Zheng, W., Hollander, A. I., Bharadwaj, D., Correa, A., Wilson, J. G., Lind, L., Heng, C. K., Nelson, A. E., Golightly, Y. M., Wilson, J. F., Penninx, B., Kim, H. L., Attia, J., Scott, R. J., Rao, D. C., Arnett, D. K., Hunt, S. C., Walker, M., Koistinen, H. A., Chandak, G. R., Mercader, J. M., Costanzo, M. C., Jang, D., Burtt, N. P., Villalpando, C. G., Orozco, L., Fornage, M., Tai, E., van Dam, R. M., Lehtimäki, T., Chaturvedi, N., Yokota, M., Liu, J., Reilly, D. F., McKnight, A. J., Kee, F., Jöckel, K. H., McCarthy, M. I., Palmer, C. N. A., Vitart, V., Hayward, C., Simonsick, E., van Duijn, C. M., Jin, Z. B., Qu, J., Hishigaki, H., Lin, X., März, W., Gudnason, V., Tardif, J. C., Lettre, G., Hart, L. M. T., Elders, P. J. M., Damrauer, S. M., Kumari, M., Kivimaki, M., van der Harst, P., Spector, T. D., Loos, Ruth, Province, M. A., Parra, E. J., Cruz, M., Psaty, B. M., Brandslund, I., Pramstaller, P. P., Rotimi, C. N., Christensen, K., Ripatti, S., Widén, E., Hakonarson, H., Grant, S. F. A., Kiemeney, L. A. L. M., de Graaf, J., Loeffler, M., Kronenberg, F., Gu, D., Erdmann, J., Schunkert, H., Franks, P. W., Linneberg, Allan René, Jukema, J. W., Khera, A. V., Männikkö, M., Jarvelin, M. R., Kutalik, Z., Francesco, C., Mook-Kanamori, D. O., van Dijk, K. W., Watkins, H., Strachan, D. P., Grarup, N., Sever, P., Poulter, N., Chuang, L. M., Rotter, J. I., Dantoft, T. M., Karpe, F., Neville, M. J., Timpson, N. J., Cheng, C. Y., Wong, T. Y., Khor, C. C., Li, H., Sabanayagam, C., Peters, A., Gieger, C., Hattersley, A. T., Pedersen, N. L., Magnusson, P. K. E., Boomsma, D. I., Willemsen, A. H. M., Cupples, L., van Meurs, J. B. J., Ghanbari, M., Gordon-Larsen, P., Huang, W., Kim, Y. J., Tabara, Y., Wareham, N. J., Langenberg, C., Zeggini, E., Kuusisto, J., Laakso, M., Ingelsson, E., Abecasis, G., Chambers, J. C., Kooner, J. S., de Vries, P. S., Morrison, A. C., Hazelhurst, S., Ramsay, M., North, K. E., Daviglus, M., Kraft, P., Martin, N. G., Whitfield, J. B., Abbas, S., Saleheen, D., Walters, R. G., Holmes, M. V., Black, C., Smith, B. H., Baras, A., Justice, A. E., Buring, J. E., Ridker, P. M., Chasman, D. I., Kooperberg, C., Tamiya, G., Yamamoto, M., van Heel, D. A., Trembath, R. C., Wei, W. Q., Jarvik, G. P., Namjou, B., Hayes, M. G., Ritchie, M. D., Jousilahti, P., Salomaa, V., Hveem, K., Åsvold, B. O., Kubo, M., Kamatani, Y., Okada, Y., Murakami, Y., Kim, B. J., Thorsteinsdottir, U., Stefansson, K., Zhang, J., Chen, Y., Ho, Y. L., Lynch, J. A., Rader, D. J., Tsao, P. S., Chang, K. M., Cho, K., O'Donnell, C. J., Gaziano, J. M., Wilson, P. W. F., Frayling, T. M., Hirschhorn, J. N., Kathiresan, S., Mohlke, K. L., Sun, Y. V., Morris, A. P., Boehnke, M., Brown, C. D., Natarajan, P., Deloukas, P., Willer, C. J., Assimes, T. L. & Peloso, G. M., 2022, In: Genome Biology. 23, 1, 42 p., 268.

Research output: Contribution to journal › Journal article › Research › peer-review

Increased liver fat associates with severe metabolic perturbations in low birth weight men

Brøns, C., Thuesen, Anne Cathrine Baun, Elingaard-Larsen, L. O., Justesen, L., Jensen, Rasmus Tanderup, Henriksen, Nicolai Stevns, Juel, H. B., Størling, Joachim, Ried-Larsen, M., Sparks, L. M., van Hall, Gerrit, Danielsen, E. R., Hansen, Torben & Vaag, Allan, 2022, In: European Journal of Endocrinology. 186, 5, p. 511-521 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration

Pedersen, J. S., Rygg, M. O., Chrøis, K., Sustarsic, E. G., Gerhart-Hines, Zach, Wever Albrechtsen, N. J., Serizawa, R. R., Kristiansen, V. B., Basse, A. L., Boilesen, Astrid Elisabeth Bruun, Olsen, B. H., Hansen, Torben, Gluud, Lise Lotte, Madsbad, Sten, Larsen, S., Bendtsen, Flemming & Dela, Flemming, 2022, In: Nature Communications. 13, 15 p., 2931.

Research output: Contribution to journal › Journal article › Research › peer-review

Insulin resistance rewires the metabolic gene program and glucose utilization in human white adipocytes

Isidor, Marie Sophie, Dong, W., Servin-Uribe, R. I., Villarroel, J., Altıntaş, Ali, Ayala-Sumuano, J. T., Varela-Echavarría, A., Barrès, Romain, Stephanopoulos, G., Macotela, Y. & Emanuelli, Brice, 2022, In: International Journal of Obesity. 46, 3, p. 535-543

Research output: Contribution to journal › Journal article › Research › peer-review

Integrated Liver and Plasma Proteomics in Obese Mice Reveals Complex Metabolic Regulation

Stocks, Ben Nicholas, Gonzalez-Franquesa, A., Borg, M. L., Björnholm, M., Niu, Lili, Zierath, Juleen R & Deshmukh, Atul Shahaji, 2022, In: Molecular and Cellular Proteomics. 21, 3, 19 p., 100207.

Research output: Contribution to journal › Journal article › Research › peer-review

Interactions of physical activity, muscular fitness, adiposity, and genetic risk for NAFLD

Schnurr, T. M., Katz, S. F., Justesen, Johanne Marie, O'Sullivan, J. W., Saliba-Gustafsson, P., Assimes, T. L., Carcamo-Orive, I., Ahmed, A., Ashley, E. A., Hansen, Torben & Knowles, J. W., 2022, In: Hepatology Communications. 6, 7, p. 1516-1526

Research output: Contribution to journal › Journal article › Research › peer-review

Intravenous nicotinamide riboside elevates mouse skeletal muscle NAD⁺ without impacting respiratory capacity or insulin sensitivity

Damgaard, Mads Vargas, Nielsen, Thomas Svava, Basse, A. L., Chubanava, Sabina, Trost, K., Moritz, Thomas, Dellinger, R. W., Larsen, Steen & Treebak, Jonas Thue, 2022, In: iScience. 25, 2, 21 p., 103863.

Research output: Contribution to journal › Journal article › Research › peer-review

Investigating the roles of hyperglycaemia, hyperinsulinaemia and elevated free fatty acids in cardiac function in patients with type 2 diabetes via treatment with insulin compared with empagliflozin: Protocol for the HyperCarD2 randomised, crossover trial

Thirumathyam, R., Richter, Erik A., Goetze, Jens P. , Fenger, M., van Hall, Gerrit, Dixen, Ulrik, Holst, Jens Juul, Madsbad, Sten, Vejlstrup, N., Madsen, Per & Jørgensen, N. B., 2022, In: B M J Open. 12, 8, 10 p., e054100.

Research output: Contribution to journal › Journal article › Research › peer-review

Isolation and Characterization of Human Brown Adipocytes

Schéele, Camilla Charlotte Nielsen, Henriksen, T. I. & Nielsen, S., 2022, In: Methods in Molecular Biology. 2448, p. 217-234 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Jan Fahrenkrug (6/6 1947 – 10/11 2021)

Rehfeld, Jens Frederik, Hannibal, Jens, Holst, Jens Juul, Hökfelt, T., de Muckadell, O. B. S. & Schwartz, Thue W., 2022, In: Peptides. 150, 170771.

Research output: Contribution to journal › Editorial › Research