Novo Nordisk Foundation Center for Basic Metabolic Research

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  1. 2022
  2. Published

    Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation

    Solomon, O., Huen, K., Yousefi, P., Küpers, L. K., González, J. R., Suderman, M., Reese, S. E., Page, C. M., Gruzieva, O., Rzehak, P., Gao, L., Bakulski, K. M., Novoloaca, A., Allard, C., Pappa, I., Llambrich, M., Vives, M., Jima, D. D., Kvist, T., Baccarelli, A. & 65 others, White, C., Rezwan, F. I., Sharp, G. C., Tindula, G., Bergström, A., Grote, V., Dou, J. F., Isaevska, E., Magnus, M. C., Corpeleijn, E., Perron, P., Jaddoe, V. W. V., Nohr, E. A., Maitre, L., Foraster, M., Hoyo, C., Håberg, S. E., Lahti, J., DeMeo, D. L., Zhang, H., Karmaus, W., Kull, I., Koletzko, B., Feinberg, J. I., Gagliardi, L., Bouchard, L., Ramlau-Hansen, C. H., Tiemeier, H., Santorelli, G., Maguire, R. L., Czamara, D., Litonjua, A. A., Langhendries, J. P., Plusquin, M., Lepeule, J., Binder, E. B., Verduci, E., Dwyer, T., Carracedo, Á., Ferre, N., Eskenazi, B., Kogevinas, M., Nawrot, T. S., Munthe-Kaas, M. C., Herceg, Z., Relton, C., Melén, E., Gruszfeld, D., Breton, C., Fallin, M. D., Ghantous, A., Nystad, W., Heude, B., Snieder, H., Hivert, M. F., Felix, J. F., Sørensen, Thorkild I.A., Bustamante, M., Murphy, S. K., Raikkönen, K., Oken, E., Holloway, J. W., Arshad, S. H., London, S. J. & Holland, N., 2022, In: Mutation Research - Reviews in Mutation Research. 789, 108415.

    Research output: Contribution to journal › Review › Research › peer-review

  3. Published

    Metabolic and Genetic Risk Factors Are the Strongest Predictors of Severity of Alcohol-Related Liver Fibrosis

    Israelsen, M., Juel, H. B., Detlefsen, S., Madsen, B. S., Rasmussen, D. N., Larsen, T. R., Kjærgaard, M., Fernandes Jensen, M. J., Stender, S., Hansen, Torben, Krag, A., Thiele, M. & GALAXY and MicrobLiver consortiak, G. A. M. C., 2022, In: Clinical Gastroenterology and Hepatology. 20, 8, p. 1784-1794.e9 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Metabolic control of arginine and ornithine levels paces the progression of leaf senescence

    Liebsch, D., Juvany, M., Li, Z., Wang, H., Ziolkowska, A., Chrobok, D., Boussardon, C., Wen, X., Law, S. R., Janečková, H., Brouwer, B., Lindén, P., Delhomme, N., Stenlund, H., Moritz, Thomas, Gardeström, P., Guo, H. & Keech, O., 2022, In: Plant Physiology. 189, 4, p. 1943-1960

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Metabolite G-protein coupled receptor signaling: Potential regulation of eicosanoids

    Tang, X., Hou, Y., Schwartz, Thue W. & Haeggström, J. Z., 2022, In: Biochemical Pharmacology. 204, 7 p., 115208.

    Research output: Contribution to journal › Review › Research › peer-review

  6. Published

    Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease

    Talmor-Barkan, Y., Bar, N., Shaul, A. A., Shahaf, N., Godneva, A., Bussi, Y., Lotan-Pompan, M., Weinberger, A., Shechter, A., Chezar-Azerrad, C., Arow, Z., Hammer, Y., Chechi, K., Forslund, S. K., Fromentin, S., Dumas, M. E., Ehrlich, S. D., Pedersen, Oluf Borbye, Kornowski, R. & Segal, E., 2022, In: Nature Medicine. 28, 2, p. 295-302 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Metagenomic evidence for co-occurrence of antibiotic, biocide and metal resistance genes in pigs

    Li, Xuan Ji, Rensing, C., Vestergaard, G., Arumugam, Mani, Nesme, Joseph, Gupta, S., Brejnrod, A. D. & Sørensen, Søren Johannes, 2022, In: Environment International. 158, 10 p., 106899.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Methods in Bioarchaeology: What’s New in Profiling an Individual Inside and Out

    Freiwald, C., Belanich, Jonathan Robert & Rand, A., 2022, The Routledge Handbook of Mesoamerican Bioarchaeology. Tieslar, V. (ed.). Routledge, p. 577-600 24 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  9. Published

    MicroRNAs in non-alcoholic fatty liver disease: Progress and perspectives

    Hochreuter, Mette Yde, Dall, M., Treebak, Jonas Thue & Barrès, Romain, 2022, In: Molecular Metabolism. 65, 17 p., 101581.

    Research output: Contribution to journal › Review › Research › peer-review

  10. Published

    Microbiome and metabolome features of the cardiometabolic disease spectrum

    Fromentin, S., Forslund, S. K., Chechi, K., Aron-Wisnewsky, J., Chakaroun, R., Nielsen, T., Tremaroli, V., Ji, B., Prifti, E., Myridakis, A., Chilloux, J., Andrikopoulos, P., Fan, Y., Olanipekun, M. T., Alves, R., Adiouch, S., Bar, N., Talmor-Barkan, Y., Belda, E., Caesar, R. & 44 others, Coelho, L. P., Falony, G., Fellahi, S., Galan, P., Galleron, N., Helft, G., Hoyles, L., Isnard, R., Le Chatelier, E., Julienne, H., Olsson, L., Pedersen, H. K., Pons, N., Quinquis, B., Rouault, C., Roume, H., Salem, J. E., Schmidt, T. S. B., Vieira-Silva, S., Li, P., Zimmermann-Kogadeeva, M., Lewinter, C., Søndertoft, N. B., Hansen, T. H., Gauguier, D., Gøtze, J. P., Køber, Lars Valeur, Kornowski, R., drb459, drb459, Hansen, Torben, Zucker, J. D., Hercberg, S., Letunic, I., Bäckhed, F., Oppert, J. M., Nielsen, J., Raes, J., Bork, P., Stumvoll, M., Segal, E., Clément, K., Dumas, M. E., Ehrlich, S. D. & Pedersen, Oluf Borbye, 2022, In: Nature Medicine. 28, 2, p. 303-314

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Microbiome-derived ethanol in nonalcoholic fatty liver disease

    Meijnikman, A. S., Davids, M., Herrema, H., Aydin, O., Tremaroli, V., Rios-Morales, M., Levels, H., Bruin, S., de Brauw, M., Verheij, J., Kemper, M., Holleboom, A. G., Tushuizen, M. E., Schwartz, T. W., Nielsen, J., Brandjes, D., Dirinck, E., Weyler, J., Verrijken, A., De Block, C. E. M. & 7 others, Vonghia, L., Francque, S., Beuers, U., Gerdes, V. E. A., Bäckhed, F., Groen, A. K. & Nieuwdorp, M., 2022, In: Nature Medicine. 28, p. 2100-2106

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Mild Cognitive Impairment Is Associated with Poorer Nutritional Status on Hospital Admission and after Discharge in Acutely Hospitalized Older Patients

    Bornæs, O., Andersen, A. L., Houlind, Morten Baltzer, Kallemose, T., Tavenier, J., Aharaz, A., Nielsen, Rikke Linnemann, Jørgensen, L. M., Beck, A. M., Andersen, Ove, Petersen, Janne & Pedersen, Mette Merete, 2022, In: Geriatrics (Switzerland). 7, 5, 16 p., 95.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Mixed-mode chromatography-mass spectrometry enables targeted and untargeted screening of carboxylic acids in biological samples

    Hodek, O., Argemi Muntadas, Lidia, Khan, Adnan & Moritz, Thomas, 2022, In: Analytical Methods. 14, 10, p. 1015-1022 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Modeling the early stages of Alzheimer's disease by administering intracerebroventricular injections of human native A beta oligomers to rats

    Baerends, E., Soud, K., Folke, J., Pedersen, A., Henmar, S., Konrad, Lisa, Lycas, M. D., Mori, Yuki, Pakkenberg, B., Woldbye, David Paul Drucker, Dmytriyeva, O. & Pankratova, Stanislava, 2022, In: Acta Neuropathologica Communications. 10, 1, 21 p., 113.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Modulation of gut microbiota by Mantequilla and Melipona honeys decrease low-grade inflammation caused by high fructose corn syrup or sucrose in rats

    Coutiño-Hernández, D., Sánchez-Tapia, M., Leal-Vega, F., Bobadilla del Valle, M., Ledezma, H., Cervantes, R., Pedraza-Chaverri, J., Granados-Portillo, O., Díaz, D., Antunes-Ricardo, M., Gutiérrez-Uribe, J., Maya, Otoniel, Olin-Sandoval, V., Tovar, A. R. & Torres, N., 2022, In: Food Research International. 151, 13 p., 110856.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Molecular Insights into the Role of Pathogenic nsSNPs in GRIN2B Gene Provoking Neurodevelopmental Disorders

    Shah, A. A., Amjad, M., Hassan, J. U., Ullah, A., Mahmood, A., Deng, H., Ali, Y., Gul, F. & Xia, K., 2022, In: Genes. 13, 8, 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Molecular and in vivo phenotyping of missense variants of the human glucagon receptor

    van der Velden, W. J. C., Lindquist, Peter, Madsen, Jakob Sture, Stassen, R. H. M. J., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Hauser, Alexander Sebastian & Rosenkilde, M. M., 2022, In: Journal of Biological Chemistry. 298, 2, 101413.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Monogenic diabetes variants in Emirati women with gestational diabetes are associated with risk of non-autoimmune diabetes within 5 years after pregnancy

    Daggag, H., Gjesing, A. P., Mohammad, A., Ängquist, Lars, Shobi, B., Antony, S., Haj, D., Al Tikriti, A., Buckley, A., Hansen, Torben & Barakat, M. T., 2022, In: Metabolism open. 16, 7 p., 100213.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

    Mahajan, A., Spracklen, C. N., Zhang, W., Ng, M. C. Y., Petty, L. E., Kitajima, H., Yu, G. Z., Rüeger, S., Speidel, L., Kim, Y. J., Horikoshi, M., Mercader, J. M., Taliun, D., Moon, S., Kwak, S-H., Robertson, N. R., Rayner, N. W., Loh, M., Kim, B-J., Chiou, J. & 31 others, Miguel-Escalada, I., Della Briotta Parolo, P., Lin, K., Bragg, F., Preuss, M. H., Takeuchi, F., Nano, J., Guo, X., Lamri, A., Nakatochi, M., Scott, R. A., Lee, J., Huerta-Chagoya, A., Graff, M., Chai, J., Parra, E. J., Yao, J., Bielak, L. F., Grarup, N., Chen, W., Bork-Jensen, J., Islam, M. T., Jørgensen, M. E., Jørgensen, T., Linneberg, Allan René, Witte, D. R., Lind, L., Loos, Ruth, Hansen, Torben, Pedersen, Oluf Borbye & FinnGen, F., 2022, In: Nature Genetics. 54, 5, p. 560-572 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Multi-component prime-boost Chlamydia trachomatis vaccination regimes induce antibody and T cell responses and accelerate clearance of infection in a non-human primate model

    Lorenzen, E., Contreras, V., Olsen, A. W., Andersen, P., Desjardins, D., Rosenkrands, I., Juel, H. B., Delache, B., Langlois, S., Delaugerre, C., Joubert, C., Dereuddre-Bosquet, N., Bébéar, C., De Barbeyrac, B., Touati, A., McKay, P. F., Shattock, R. J., Le Grand, R., Follmann, F. & Dietrich, J., 2022, In: Frontiers in Immunology. 13, 13 p., 1057375.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Multiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health

    Marabita, F., James, T., Karhu, A., Virtanen, H., Kettunen, K., Stenlund, H., Boulund, F., Hellström, C., Neiman, M., Mills, R., Perheentupa, T., Laivuori, H., Helkkula, P., Byrne, M., Jokinen, I., Honko, H., Kallonen, A., Ermes, M., Similä, H., Lindholm, M. & 9 others, Widén, E., Ripatti, S., Perälä-Heape, M., Engstrand, L., Nilsson, P., Moritz, Thomas, Miettinen, T., Sallinen, R. & Kallioniemi, O., 2022, In: Cell Systems. 13, 3, p. 241-255.e7

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Multiomics signatures of type 1 diabetes with and without albuminuria

    Clos-Garcia, M., Ahluwalia, Tarun Veer Singh, Winther, S. A., Henriksen, P., Ali, M., Fan, Yong, Stankevic, Evelina, Lyu, Liwei, Vogt, J. K., Hansen, Torben, Legido-Quigley, C., Rossing, Peter & Pedersen, Oluf Borbye, 2022, In: Frontiers in Endocrinology. 13, 17 p., 1015557.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of GLP-2 receptor selectivity towards more GLP-1 receptor interaction

    Gabe, M. B. N., Gasbjerg, Lærke Smidt, Gadgaard, S., Lindquist, Peter, Holst, Jens Juul & Rosenkilde, Mette, 2022, In: British Journal of Pharmacology. 179, 18, p. 4473-4485

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    NAD+ and NAFLD - Caution, Causality, and Careful Optimism

    Dall, M., Hassing, Anna Skab & Treebak, Jonas Thue, 2022, In: The Journal of Physiology. 600, 5, p. 1135-1154

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite–binding site

    Sanders, M. J., Ratinaud, Y., Neopane, K., Bonhoure, N., Day, E. A., Ciclet, O., Lassueur, S., Pinta, M. N., Deak, M., Brinon, B., Christen, S., Steinberg, G. R., Barron, D. & Sakamoto, Kei, 2022, In: Journal of Biological Chemistry. 298, 5, 15 p., 101852.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Neonatal Anthropometrics and Obesity Treatment Response in Children and Adolescents

    Lausten-Thomsen, U., Lund, Morten Asp Vonsild, Stinson, Sara, Frithioff-Bøjsøe, C., Holm, L. A., Baker, J. L., Fonvig, Cilius Esmann, Christiansen, M., Ängquist, Lars, Hansen, Torben & Holm, Jens-Christian, 2022, In: Journal of Pediatrics. 242, p. 74-78.e2 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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