- 2014
- Published
New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors
Liebscher, I., Ackley, B., Araç, D., Ariestanti, D. M., Aust, G., Bae, B., Bista, B. R., Bridges, J. P., Duman, J. G., Engel, F. B., Giera, S., Goffinet, A. M., Hall, R. A., Hamann, J., Hartmann, N., Lin, H-H., Liu, M., Luo, R., Mogha, A., Monk, K. R. & 12 others, , Dec 2014, In: Annals of the New York Academy of Sciences. 1333, p. 43-64 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
On the role of gallbladder emptying and incretin hormones for nutrient-mediated TSH suppression in patients with type 2 diabetes
Sonne, David Peick, Lund, Asger Bach, Faber, J., Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Dec 2014, In: Endocrine Connections. 3, 4, p. 193-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers
Taylor, A. E., Morris, R. W., Fluharty, M. E., Bjorngaard, J. H., Åsvold, B. O., Gabrielsen, M. E., Campbell, A., Marioni, R., Kumari, M., Hällfors, J., Männistö, S., Marques-Vidal, P., Kaakinen, M., Cavadino, A., Postmus, I., Husemoen, L. L. N., Skaaby, T., Ahluwalia, T. V. S., Treur, J. L., Willemsen, G. & 44 others, , Dec 2014, In: P L o S Genetics. 10, 12, p. 1-6 6 p., e1004799.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural basis for constitutive activity and agonist-induced activation of the enteroendocrine fat sensor GPR119
Engelstoft, M. S., Norn, C., Pedersen, M. H., Holliday, N. D., Elster, L., Lehmann, J., Jones, R. M., Frimurer, Thomas Michael & Schwartz, Thue W., Dec 2014, In: British Journal of Pharmacology. 171, 24, p. 5774-89 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The absence of GH signaling affects the susceptibility to high-fat diet-induced hypothalamic inflammation in male mice
Baquedano, E., Ruiz-Lopez, A. M., Sustarsic, E. G., Herpy, J., List, E. O., Chowen, J. A., Frago, L. M., Kopchick, J. J. & Argente, J., Dec 2014, In: Endocrinology. 155, 12, p. 4856-67 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The interleukin-1 receptor antagonist anakinra improves first-phase insulin secretion and insulinogenic index in subjects with impaired glucose tolerance
van Poppel, P. C. M., van Asseldonk, E. J. P., Holst, Jens Juul, Vilsbøll, Tina, Netea, M. G. & Tack, C. J., Dec 2014, In: Diabetes, Obesity and Metabolism. 16, 12, p. 1269-73 5 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Therapies for inter-relating diabetes and obesity - GLP-1 and obesity
Iepsen, E. P. W., Torekov, Signe Sørensen & Holst, Jens Juul, Dec 2014, In: Expert Opinion on Pharmacotherapy. 15, 17, p. 2487-500 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Physiological and Pathological Impact of Blood Sampling by Retro-Bulbar Sinus Puncture and Facial Vein Phlebotomy in Laboratory Mice
Teilmann, A. C., Nygaard Madsen, A., Holst, Birgitte, Hau, Jann, Rozell, B. & Abelson, Klas, 26 Nov 2014, In: PloS one. 9, 11, p. 1-19 19 p., e113225.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Circadian enhancers coordinate multiple phases of rhythmic gene transcription in vivo
Fang, B., Everett, L. J., Jager, J., Briggs, E., Armour, S. M., Feng, D., Roy, A., Gerhart-Hines, Zach, Sun, Z. & Lazar, M. A., 20 Nov 2014, In: Cell. 159, 5, p. 1140-1152 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genomet og diabetes
Allin, K. H., Hansen, Torben & Pedersen, Oluf Borbye, 10 Nov 2014, In: Ugeskrift for Laeger. 176, 23, p. 2176-2179 V06140337.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucose-dependent insulinotropic polypeptide inhibits bone resorption in humans
Nissen, A., Christensen, Mikkel Bring, Knop, Filip Krag, Vilsbøll, T., Holst, Jens Juul & Hartmann, Bolette, Nov 2014, In: The Journal of clinical endocrinology and metabolism. 99, 11, p. E2325-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of fetal and neonatal environment on beta cell function and development of diabetes
Nielsen, Jens Høiriis, Haase, T. N., Jaksch, C., Nalla, A., Søstrup, B., Nalla, A. A., Larsen, L., Rasmussen, M., Dalgaard, L. T., Gaarn, L. W., Thams, P., Kofod, H. & Billestrup, Nils, Nov 2014, In: Acta Obstetricia et Gynecologica Scandinavica. 93, 11, p. 1109-22 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The potential role of inhibitor of differentiation-3 in human adipose tissue remodeling and metabolic health
Svendstrup, M. & drb459, drb459, Nov 2014, In: Molecular Genetics and Metabolism. 113, 3, p. 149-154 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLP-1 as a Mediator in the Remission of Type 2 Diabetes After Gastric Bypass and Sleeve Gastrectomy Surgery
Madsbad, Sten & Holst, Jens Juul, Oct 2014, In: Diabetes. 63, 10, p. 3172-4 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Postprandial gallbladder emptying in patients with type 2 diabetes: potential implications for bile-induced secretion of glucagon-like peptide 1
Sonne, David Peick, Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Oct 2014, In: European Journal of Endocrinology. 171, 4, p. 407-419 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression
Agudelo, L. Z., Femenía, T., Orhan, F., Porsmyr-Palmertz, M., Goiny, M., Martinez-Redondo, V., Correia, J. C., Izadi, M., Bhat, M., Schuppe-Koistinen, I., Pettersson, A. T., Ferreira, D. M. S., Krook, A., Barrès, Romain, Zierath, Juleen R, Erhardt, S., Lindskog, M. & Ruas, J. L., 25 Sep 2014, In: Cell. 159, 1, p. 33-45 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Does prenatal exposure to vitamin D-fortified margarine and milk alter birth weight? A societal experiment
Jensen, C. B., Berentzen, T. L., Gamborg, Michael Orland, Sørensen, Thorkild I.A. & Heitmann, B. L., 14 Sep 2014, In: British Journal of Nutrition. 112, 5, p. 785-793 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Altered DNA Methylation and Differential Expression of Genes Influencing Metabolism and Inflammation in Adipose Tissue From Subjects With Type 2 Diabetes
Nilsson, E., Jansson, P. A., Perfilyev, A., Volkov, P., Pedersen, M., Svensson, M. K., Poulsen, P., Ribel-Madsen, R., Pedersen, N. L., Almgren, P., Fadista, J., Rönn, T., Pedersen, Bente Klarlund, Schéele, Camilla Charlotte Nielsen, Vaag, Allan & Ling, C., Sep 2014, In: Diabetes. 63, 9, p. 2962-2976 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study
Vimaleswaran, K. S., Cavadino, A., Berry, D. J., Jorde, R., Dieffenbach, A. K., Lu, C., Alves, A. C., Heerspink, H. J. L., Tikkanen, E., Eriksson, J., Wong, A., Mangino, M., Jablonski, K. A., Nolte, I. M., Houston, D. K., Ahluwalia, T. V. S., van der Most, P. J., Pasko, D., Zgaga, L., Thiering, E. & 31 others, , Sep 2014, In: The Lancet Diabetes & Endocrinology. 2, 9, p. 719-729 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DNA methylation is altered in B and NK lymphocytes in obese and type 2 diabetic human
Simar, D., Versteyhe, S., Donkin, I., Liu, J., Hesson, L., Nylander, V. C., Fossum, A. & Barrès, Romain, Sep 2014, In: Metabolism. 63, 9Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide association analyses identify variants in developmental genes associated with hypospadias
Geller, F., Feenstra, B., Carstensen, L., Pers, Tune H, van Rooij, I. A. L. M., Korberg, I. B., Choudhry, S., Karjalainen, J. M., Schnack, T. H., Hollegaard, M. V., Feitz, W. F. J., Roeleveld, N., Hougaard, D. M., Hirschhorn, J. N., Franke, L., Baskin, L. S., Nordenskjold, A., van der Zanden, L. F. M. & Melbye, M., Sep 2014, In: Nature Genetics. 46, 9, p. 957-+Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucometabolic hormones and cardiovascular risk markers in antipsychotic-treated patients
Ebdrup, Bjørn, Knop, Filip Krag, Madsen, A., Mortensen, H. B., Søgaard, B., Holst, Jens Juul, Szecsi, P. B. & Lublin, H., Sep 2014, In: Journal of Clinical Psychiatry. 75, 9, p. e899-905 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Obesity: Global trends in the prevalence of overweight and obesity
Morgen, C. S. & Sørensen, Thorkild I.A., Sep 2014, In: Nature Reviews Endocrinology. 10, 9, p. 513-514 2 p.Research output: Contribution to journal › Comment/debate › Research
- Published
Safety and efficacy of liraglutide in patients with type 2 diabetes and end-stage renal disease: an investigator-initiated, randomised, placebo-controlled trial
Idorn, T., Knop, Filip Krag, Jorgensen, M. B., Jensen, T., Resuli, M., Hansen, P. M., Christensen, Karl Bang, Holst, Jens Juul, Hornum, M. & Feldt-Rasmussen, B., Sep 2014, In: Diabetologia. 57, 1 supplement, p. S370-S371 909.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
The use of double-balloon enteroscopy in retrieving mucosal biopsies from the entire human gastrointestinal tract
Rhee, N. A., Vilmann, Peter, Hassan, H., Hendel, J. W., Holst, Jens Juul, Vilsbøll, T. & Knop, Filip Krag, Sep 2014, In: Scandinavian Journal of Gastroenterology. 49, 9, p. 1143-1149 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of high-fat diet on rat myometrium during pregnancy-isolated myometrial mitochondria are not affected
Gam, C. M. B. F., Mortensen, Ole Hartvig, Qvortrup, Klaus, Damm, Peter & Quistorff, B., 21 Aug 2014, In: Pflügers Archiv - European Journal of Physiology. 467, 7, p. 1539-1549 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tarmbakterier kan have betydning for overvægt i barnealderen
Fonvig, C. E., Pihl, A. F., Hansen, Torben, Pedersen, Oluf Borbye & Holm, Jens-Christian, 18 Aug 2014, In: Ugeskrift for Laeger. 176, p. 2-6 5 p., V03140171.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age
Deelen, J., Beekman, M., Uh, H-W., Broer, L., Ayers, K. L., Tan, Q., Kamatani, Y., Bennet, A. M., Tamm, R., Trompet, S., Guðbjartsson, D. F., Flachsbart, F., Rose, G., Viktorin, A., Fischer, K., Nygaard, M., Cordell, H. J., Crocco, P., van den Akker, E. B., Böhringer, S. & 67 others, , 15 Aug 2014, In: Human Molecular Genetics. 23, 16, p. 4420-4432 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals
Qi, Q., Oskari Kilpeläinen, T., Downer, M. K., Tanaka, T., Smith, C. E., Sluijs, I., Sonestedt, E., Chu, A. Y., Renström, F., Lin, X., Angquist, L. H., Huang, J., Liu, Z., Li, Y., Asif Ali, M., Xu, M., Ahluwalia, T. V. S., Boer, J. M. A., Chen, P., Daimon, M. & 89 others, , 7 Aug 2014, In: Human Molecular Genetics. 23, 25, p. 6961-6972 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glycerol-3-phosphate acyltransferase-4-deficient mice are protected from diet-induced insulin resistance by the enhanced association of mTOR and rictor
Zhang, C., Cooper, D. E., Grevengoed, Trisha Jean, Li, L. O., Klett, E. L., Eaton, J. M., Harris, T. E. & Coleman, R. A., 1 Aug 2014, In: American Journal of Physiology: Endocrinology and Metabolism. 307, 3, p. E305-15Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Environmental factors affecting the expression of type IV pilus genes as well as piliation of Thermus thermophilus
Salzer, R., Kern, T., Joos, F. & Averhoff, B., Aug 2014, In: FEMS Microbiology Letters. 357, 1, p. 56-62 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional body composition and related aspects in research on obesity and cachexia: report on the 12th Stock Conference held on 6 and 7 September 2013 in Hamburg, Germany
Müller, M. J., Baracos, V., Bosy-Westphal, A., Dulloo, A. G., Eckel, J., Fearon, K. C. H., Hall, K. D., Pietrobelli, A., Sørensen, Thorkild I.A., Speakman, J., Trayhurn, P., Visser, M. & Heymsfield, S. B., Aug 2014, In: Obesity Reviews. 15, 8, p. 640-656 17 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond
Grarup, N., Sandholt, C. H., Hansen, Torben & Pedersen, Oluf Borbye, Aug 2014, In: Diabetologia. 57, 8, p. 1528-41 14 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
High saturated fatty acid intake induces insulin secretion by elevating gastric inhibitory polypeptide levels in healthy individuals
Itoh, K., Moriguchi, R., Yamada, Y., Fujita, M., Yamato, T., Oumi, M., Holst, Jens Juul & Seino, Y., Aug 2014, In: Nutrition Research. 34, 8, p. 653-60 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and Type 2 diabetes susceptibility
Guigas, B., de Leeuw van Weenen, J. E., van Leeuwen, N., Simonis-Bik, A. M., van Haeften, T. W., Nijpels, G., Houwing-Duistermaat, J. J., Beekman, M., Deelen, J., Havekes, L. M., Penninx, B. W. J. H., Vogelzangs, N., van 't Riet, E., Dehghan, A., Hofman, A., Witteman, J. C., Uitterlinden, A. G., Grarup, N., Jørgensen, T., Witte, D. R. & 15 others, , Aug 2014, In: Diabetic Medicine. 31, 8, p. 1001-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Timing of motor milestones achievement and development of overweight in childhood: a study within the Danish National Birth Cohort
Morgen, C. S., Nybo Andersen, Anne-Marie, Due, P., Neelon, S. B., Gamborg, Michael Orland & Sørensen, Thorkild I.A., Aug 2014, In: Pediatric Obesity. 9, 4, p. 239-48 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dynamic epigenetic responses to muscle contraction
Rasmussen, M., Zierath, Juleen R & Barrès, Romain, 19 Jul 2014, In: Drug Discovery Today. 19, 7, p. 1010-4 5 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Identification and characterization of human brown adipose tissue (BAT) content and metabolism in adults using [18F]-FDG PET/MR – a pilot study
Johannesen, H. H., Löfgren, J., Donkin, I., Hansen, A. E., Loft, A., Højgaard, Liselotte & Kjær, Andreas, Jul 2014, In: E J N M M I Physics. 1, Suppl 1, 3 p., A68.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
META-Life: Biotechnologies, Synthetic Biology, Alife and the Arts
Bureaud, A. (ed.), Malina, R. (ed.) & Whiteley, Louise (ed.), Jul 2014, (Leonardo).Research output: Book/Report › Book › Research › peer-review
- Published
Mapping Substance P Binding Sites on the Neurokinin-1 Receptor Using Genetic Incorporation of a Photoreactive Amino Acid
Valentin-Hansen, L., Park, M., Huber, T., Grunbeck, A., Naganathan, S., Schwartz, Thue W. & Sakmar, T. P., 27 Jun 2014, In: The Journal of Biological Chemistry. 289, 26, p. 18045-54 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stimulation of intestinal growth and function with DPP-IV inhibition in a mouse short bowel syndrome model
Sueyoshi, R., Ignatoski, K. M. W., Okawada, M., Hartmann, Bolette, Holst, Jens Juul & Teitelbaum, D. H., 26 Jun 2014, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 307, 4, p. G410-19 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The impact of dipeptidyl peptidase 4 inhibition on incretin effect, glucose tolerance, and gastrointestinal-mediated glucose disposal in healthy subjects
Rhee, N. A., Østoft, S. H., Holst, Jens Juul, Deacon, Carolyn F., Vilsbøll, T. & Knop, Filip Krag, 16 Jun 2014, In: European Journal of Endocrinology. 171, 3, p. 353-362 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucose-Lowering Effects and Low Risk of Hypoglycemia in Patients With Maturity-Onset Diabetes of the Young When Treated With a GLP-1 Receptor Agonist: A Double-Blind, Randomized, Crossover Trial
Ostoft, S. H., Bagger, J. I., Hansen, Torben, Pedersen, Oluf Borbye, Faber, Jens, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, T., 14 Jun 2014, In: Diabetes Care. 37, 7, p. 1797-1805 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Incretin secretion: direct mechanisms
Balk-Møller, E., Holst, Jens Juul & Kuhre, Rune Ehrenreich, 12 Jun 2014, Diapedia: The living textbook of diabetes. European Association for the Study of Diabetes (EASD), p. 1-3 3 p.Research output: Chapter in Book/Report/Conference proceeding › Encyclopedia chapter › Communication
- Published
The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
Perry, R. J., Samuel, V. T., Petersen, K. M. F. & Shulmann, G. I., 5 Jun 2014, In: Nature. 510, p. 84-91 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hyperglucagonaemia analysed by glucagon sandwich ELISA: nonspecific interference or truly elevated levels?
Albrechtsen, Nicolai Jacob Wewer, Hartmann, Bolette, Veedfald, Simon, Windeløv, Johanne Agerlin, Plamboeck, A., Bojsen-Møller, K. N., Idorn, T., Feldt-Rasmussen, Bo, Knop, Filip Krag, Vilsbøll, T., Madsbad, Sten, Deacon, Carolyn F. & Holst, Jens Juul, 3 Jun 2014, In: Diabetologia. 57, 9, p. 1919-1926 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chronic glucocorticoid treatment increases de novo lipogenesis in visceral adipose tissue
Vienberg, S. G. & Björnholm, M., Jun 2014, In: Acta Physiologica (Print). 211, 2, p. 257-9 3 p.Research output: Contribution to journal › Editorial › Research › peer-review
- Published
Deficiency of cardiac Acyl-CoA synthetase-1 induces diastolic dysfunction, but pathologic hypertrophy is reversed by rapamycin
Paul, D. S., Grevengoed, Trisha Jean, Pascual, F., Ellis, J. M., Willis, M. S. & Coleman, R. A., Jun 2014, In: B B A - Reviews on Cancer. 1841, 6, p. 880-7 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease
Nielsen, Thomas Svava, Jessen, N., Jørgensen, J. O. L., Møller, N. & Lund, S., Jun 2014, In: Journal of Molecular Endocrinology. 52, 3, p. R199-R222 24 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Glucose Stimulates GLP-1 Secretion from Isolated Perfused Rat Small Intestine by SGLT1 and GLUT2 Mediated Uptake, Causing V-gated Calcium Channel Activation
Kuhre, Rune Ehrenreich, Frost, C. R., Svendsen, B. & Holst, Jens Juul, Jun 2014, In: Diabetes. 63, suppl 1, p. A491 1 p., Abstract no 1915-P.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Natural selection affects multiple aspects of genetic variation at putatively peutral sites across the human genome
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Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets
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The isoenzyme pattern of LDH does not play a physiological role; except perhaps during fast transitions in energy metabolism
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Determinants of plasma levels of proglucagon and the metabolic impact of glucagon receptor signalling: a UK Biobank study
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The interplay between birth weight and obesity in determining childhood and adolescent cardiometabolic risk
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Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment
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