Novo Nordisk Foundation Center for Basic Metabolic Research

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  1. 2005
  2. Published

    The functional Thr130Ile and Val255Met polymorphisms of the hepatocyte nuclear factor-4alpha (HNF4A): gene associations with type 2 diabetes or altered beta-cell function among Danes

    Ek, J., Rose, C. S., Jensen, D. P., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Pedersen, Oluf Borbye & Hansen, Torben, 2005, In: Journal of Clinical Endocrinology and Metabolism. 90, 5, p. 3054-9 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    The prevalence of the metabolic syndrome in a danish population of women with previous gestational diabetes mellitus is three-fold higher than in the general population

    Lauenborg, J., Mathiesen, Elisabeth, Hansen, Torben, Glümer, C., Jørgensen, T., Borch-Johnsen, K., Hornnes, P., Pedersen, Oluf Borbye & Damm, Peter, 2005, In: Journal of Clinical Endocrinology and Metabolism. 90, 7, p. 4004-10 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    alpha 2-AMPK knockout abolishes AICAR but not exercise training-induced GLUT4 and HKII protein expression in mouse skeletal muscle

    Jørgensen, Solvejg, Treebak, Jonas Thue, Viollet, B., Andreelli, F., Schjerling, Peter, Vaulont, S., Wojtaszewski, Jørgen F P & Richter, Erik A., 2005, In: FASEB Journal.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. 2004
  6. Published

    Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus

    Lauenborg, J., Damm, Peter, Ek, J., Glümer, C., Jørgensen, Tina, Borch-Johnsen, K., Vestergaard, H., Hornnes, P., Pedersen, Oluf Borbye & Hansen, Torben, Dec 2004, In: Diabetic Medicine. 21, 12, p. 1310-5 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    The potential role of SOCS-3 in the interleukin-1beta-induced desensitization of insulin signaling in pancreatic beta-cells

    Emanuelli, Brice, Glondu, M., Filloux, C., Peraldi, P. & Van Obberghen, E., Dec 2004, In: Diabetes. 53 Suppl 3, p. S97-S103

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Plasma GLP-2 levels and intestinal markers in the juvenile pig during intestinal adaptation: effects of different diet regimens

    Paris, M. C., Fuller, P. J., Carstensen, Bendix, Nagy, E., Taylor, R. G., Sourial, M., Holst, Jens Juul, Hartmann, Bolette & Binesm, J. E., Oct 2004, In: Digestive Diseases and Sciences. 49, 10, p. 1688-95 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Glucagon-like peptide 2 (GLP-2) accelerates the growth of colonic neoplasms in mice

    Thulesen, J., Hartmann, Bolette, Hare, K. J., Kissow, Hannelouise, Ørskov, Cathrine, Holst, Jens Juul & Poulsen, Steen Seier, Aug 2004, In: Gut. 53, 8, p. 1145-1150 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    The independent effect of type 2 diabetes mellitus on ischemic heart disease, stroke, and death: a population-based study of 13,000 men and women with 20 years of follow-up

    Almdal, Thomas Peter, Scharling, H., Jensen, J. S. & drb459, drb459, 12 Jul 2004, In: J A M A Internal Medicine. 164, 13, p. 1422-6 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Characterization of RNA interference in rat PC12 cells: requirement of GERp95

    Thonberg, H., Schéele, Camilla Charlotte Nielsen, Dahlgren, C. & Wahlestedt, C., 11 Jun 2004, In: Molecular Cell Biology Research Communications. 318, 4, p. 927-34 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Transcriptional profiling of extracellular amino acid sensing in Saccharomyces cerevisiae and the role of Stp 1 p and Stp2p

    Eckert-Boulet, N., Nielsen, P. S., Friis, Carsten, Moreira dos Santos, M., Nielsen, J., Kielland-Brandt, M. C. & Regenberg, Birgitte, 1 Jun 2004, In: Yeast. 21, 8, p. 635-648 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Onset of small intestinal atrophy is associated with reduced intestinal blood flow in TPN-fed neonatal piglets

    Niinikoski, H., Stoll, B., Guan, X., Kansagra, K., Lambert, B. D., Stephens, J., Hartmann, Bolette, Holst, Jens Juul & Burrin, D. G., Jun 2004, In: Journal of Nutrition. 134, 6, p. 1467-74 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Glucagon-like peptide-1 secretion is influenced by perfusate glucose concentration and by a feedback mechanism involving somatostatin in isolated perfused porcine ileum

    Hansen, L., Hartmann, Bolette, Mineo, H. & Holst, Jens Juul, 15 Apr 2004, In: Regulatory Peptides. 118, 1-2, p. 11-8 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Keeping hens in tents - Experiences from the first year

    Forkman, Björn, Andersen, Daniel Bjørklund, Hindrup, B. & Horsted, K., Apr 2004, In: British Poultry Science. 45, SUPPL. 1, p. S37-S38

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Alteration in insulin action: role of IRS-1 serine phosphorylation in the retroregulation of insulin signalling

    Tanti, J. F., Gual, P., Grémeaux, T., Gonzalez, T., Barrès, Romain & Le Marchand-Brustel, Y., Feb 2004, In: Annales d'Endocrinologie. 65, 1, p. 43-8 6 p.

    Research output: Contribution to journal › Journal article › Communication

  17. Published

    Using importance sampling to improve simulation in linkage analysis

    Ängquist, Lars & Hössjer, O., 1 Jan 2004, In: Statistical Applications in Genetics and Molecular Biology. 3, 1, 5.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Increased mortality in patients hospitalized with primary hyperparathyroidism during the period 1977-1993 in Denmark

    Øgard, C. G., Engholm, G., Almdal, Thomas Peter & drb459, drb459, Jan 2004, In: World Journal of Surgery. 28, 1, p. 108-11 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    A common polymorphism in the promoter of the IGF-I gene associates with increased fasting serum triglyceride levels in glucose-tolerant subjects

    Nielsen, E. D., Hansen, L., Lajer, M., Andersen, K. L., Echwald, S. M., Urhammer, S. A., Hansen, Torben & Pedersen, Oluf Borbye, 2004, In: Clinical Biochemistry. 37, 8, p. 660-5 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    A novel syndrome of autosomal-dominant hyperinsulinemic hypoglycemia linked to a mutation in the human insulin receptor gene

    Højlund, K., Hansen, Torben, Lajer, M., Henriksen, J. E., Levin, K., Lindholm, J., Pedersen, Oluf Borbye & Beck-Nielsen, H., 2004, In: Diabetes. 53, 6, p. 1592-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    A pseudo-sequence method for comparing 7TM receptors with respect to the physicochemical properties of their binding sites

    Frimurer, Thomas Michael, Ulven, Trond, Högberg, T. & Elling, C. E., 2004, Patent No. WO 2004/079625

    Research output: Patent

  22. Published

    Cyclic Quinoline compounds for use in MCH receptor related disorders

    Frimurer, Thomas Michael, Ulven, Trond, Högberg, T., Nørregaard, P. K., Little, P. B. & Receveur, J., 2004, Patent No. WO 2004/052371

    Research output: Patent

  23. Published

    EMPRR: A high-dimensional EM-based piecewise regression algorithm

    Arumugam, Mani & Scott, S. D., 2004, Proceedings of the 2004 International Conference on Machine Learning and Applications, ICMLA '04. Kantardzic, M., Nasraoui, O. & Milanova, M. (eds.). p. 264-271 8 p. (Proceedings of the 2004 International Conference on Machine Learning and Applications, ICMLA '04).

    Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

  24. Published

    Expression profiling of insulin action in human myotubes: induction of inflammatory and pro-angiogenic pathways in relationship with glycogen synthesis and type 2 diabetes

    Hansen, L., Gaster, M., Oakeley, E. J., Brusgaard, K., Damsgaard Nielsen, E., Beck-Nielsen, H., Pedersen, Oluf Borbye & Hemmings, B. A., 2004, In: Biochemical and Biophysical Research Communications. 323, 2, p. 685-95 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Facilitated processing of visual stimuli associated with the body

    Whiteley, Louise, Kennett, S., Taylor-Clarke, M. & Haggard, P., 2004, In: Perception. 33, 3, p. 307-14 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Genome sequence of the Brown Norway rat yields insights into mammalian evolution

    Gibbs, R. A., Weinstock, G. M., Metzker, M. L., Muzny, D. M., Sodergren, E. J., Scherer, S., Scott, G., Steffen, D., Worley, K. C., Burch, P. E., Okwuonu, G., Hines, S., Lewis, L., DeRamo, C., Delgado, O., Dugan-Rocha, S., Miner, G., Morgan, M., Hawes, A., Gill, R. & 31 others, Celera, Holt, R. A., Adams, M. D., Amanatides, P. G., Baden-Tillson, H., Barnstead, M., Chin, S., Evans, C. A., Ferriera, S., Fosler, C., Glodek, A., Gu, Z., Jennings, D., Kraft, C. L., Nguyen, T., Pfannkoch, C. M., Sitter, C., Sutton, G. G., Venter, J. C., Woodage, T., Smith, D., Lee, H., Gustafson, E., Cahill, P., Kana, A., Doucette-Stamm, L., Weinstock, K., Fechtel, K., Weiss, R. B., Arumugam, Mani & Rat Genome Sequencing Project Consortium, R. G. S. P. C., 2004, In: Nature. 428, 6982, p. 493-521 29 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Grey-box modelling of pharmacokinetic/pharmacodynamic systems

    Tornøe, C. W., Jacobsen, Judith Lone, Pedersen, Oluf Borbye, Hansen, Torben & Madsen, H. T., 2004, In: Journal of Pharmacokinetics and Pharmacodynamics. 31, 5, p. 401-17 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Handlingsplan om diabetes

    Pedersen, Oluf Borbye, 2004, In: Ugeskrift for Laeger. 166, 12, p. 1099

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Identification of rat genes by TWINSCAN gene prediction, RT-PCR, and direct sequencing

    Wu, J. Q., Shteynberg, D., Arumugam, Mani, Gibbs, R. A. & Brent, M. R., 2004, In: Genome Research. 14, 4, p. 665-71 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Increasing incidence of diabetes after gestational diabetes: a long-term follow-up in a Danish population

    Lauenborg, J., Hansen, Torben, Jensen, D. M., drb459, drb459, Mølsted-Pedersen, L., Hornnes, P., Locht, H., Pedersen, Oluf Borbye & Damm, Peter, 2004, In: Diabetes Care. 27, 5, p. 1194-9 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Intensive integrated therapy of type 2 diabetes: implications for long-term prognosis

    Gaede, P. & Pedersen, Oluf Borbye, 2004, In: Diabetes. 53 Suppl 3, p. S39-47

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Maturity-onset diabetes of the young with end-stage nephropathy: a new indication for simultaneous pancreas and kidney transplantation?

    Saudek, F., Pruhová, S., Boucek, P., Lebl, J., Adamec, M., Ek, J., Pedersen, Oluf Borbye & Hansen, Torben, 2004, In: Transplantation. 77, 8, p. 1298-301 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Mutation analysis of NR0B2 among 1545 Danish men identifies a novel c.278G>A (p.G93D) variant with reduced functional activity

    Echwald, S. M., Andersen, K. L., Sørensen, Thorkild I.A., Larsen, L. H., Andersen, T., Tonooka, N., Tomura, H., Takeda, J. & Pedersen, Oluf Borbye, 2004, In: Human Mutation. 24, 5, p. 381-387 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Quinoline compounds for use in MCH receptor related disorders

    Frimurer, Thomas Michael, Ulven, Trond, Högberg, T., Nørregaard, P. K., Little, P. B. & Receveur, J., 2004, Patent No. WO 2004/052370

    Research output: Patent

  35. Published

    Remission to normoalbuminuria during multifactorial treatment preserves kidney function in patients with type 2 diabetes and microalbuminuria

    Gaede, P., Tarnow, L., Vedel, P., Parving, H. & Pedersen, Oluf Borbye, 2004, In: Nephrology, Dialysis, Transplantation. 19, 11, p. 2784-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Target intervention against multiple-risk markers to reduce cardiovascular disease in patients with type 2 diabetes

    Gaede, P. & Pedersen, Oluf Borbye, 2004, In: Annals of Medicine. 36, 5, p. 355-66 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Variation in the interleukin-6 receptor gene associates with type 2 diabetes in Danish whites

    Hamid, Y. H., Urhammer, S. A., Jensen, D. P., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Hansen, Torben & Pedersen, Oluf Borbye, 2004, In: Diabetes. 53, 12, p. 3342-5 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. 2003
  39. Published

    Fatty acid-induced insulin resistance: role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling

    Le Marchand-Brustel, Y., Gual, P., Grémeaux, T., Gonzalez, T., Barrès, Romain & Tanti, J., Dec 2003, In: Biochemical Society Transactions. 31, Pt 6, p. 1152-6 5 p.

    Research output: Contribution to journal › Journal article › Communication

  40. Published

    Peripheral administration of GLP-2 to humans has no effect on gastric emptying or satiety

    Schmidt, P. T., Näslund, E., Grybäck, P., Jacobsson, H., Hartmann, Bolette, Holst, Jens Juul & Hellström, P. M., 15 Nov 2003, In: Regulatory Peptides. 116, 1-3, p. 21-5 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes

    Gual, P., Gonzalez, T., Grémeaux, T., Barrès, Romain, Le Marchand-Brustel, Y. & Tanti, J., 18 Jul 2003, In: Journal of Biological Chemistry. 278, 29, p. 26550-7 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    GLP-2-mediated up-regulation of intestinal blood flow and glucose uptake is nitric oxide-dependent in TPN-fed piglets 1

    Guan, X., Stoll, B., Lu, X., Tappenden, K. A., Holst, Jens Juul, Hartmann, Bolette & Burrin, D. G., Jul 2003, In: Gastroenterology. 125, 1, p. 136-47 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Introduction of enteral food increases plasma GLP-2 and decreases GLP-2 receptor mRNA abundance during pig development

    Petersen, Y. M., Hartmann, Bolette, Holst, Jens Juul, Le Huerou-Luron, I., Bjørnvad, Charlotte Reinhard & Sangild, Per Torp, Jun 2003, In: Journal of Nutrition. 133, 6, p. 1781-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females

    Kristiansen, O. P., Nolsøe, R. L., Larsen, L., Gjesing, A. M. P., Johannesen, J., Larsen, Z. M. E., Lykkesfeldt, A. E., Karlsen, A. E., Pociot, Flemming, Mandrup-Poulsen, Thomas & DIEGG, D., 15 May 2003, In: Human Molecular Genetics. 12, 10, p. 1101-10 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    No effect of physiological concentrations of glucagon-like peptide-2 on appetite and energy intake in normal weight subjects

    Sørensen, L. B., Flint, A., Raben, Anne, Hartmann, Bolette, Holst, Jens Juul & Astrup, A., Apr 2003, In: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 27, 4, p. 450-6 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Activity-induced and developmental downregulation of the Nogo receptor

    Josephson, A., Trifunovski, A., Schéele, Camilla Charlotte Nielsen, Widenfalk, J., Wahlestedt, C., Brené, S., Olson, L. & Spenger, C., Mar 2003, In: Cell and Tissue Research. 311, 3, p. 333-42 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    The 5-HT1A serotonin receptor is located on calbindin- and parvalbumin-containing neurons in the rat brain

    Aznar, S., Qian, Z., Shah, R., Kornum, Birgitte Rahbek & Knudsen, Gitte Moos, 3 Jan 2003, In: Brain Research. 959, 1, p. 58-67 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians

    Muller, Y. L., Bogardus, C., Pedersen, Oluf Borbye & Baier, L., 2003, In: Diabetes. 52, 3, p. 895-8 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    A genome-wide scan in families with maturity-onset diabetes of the young: evidence for further genetic heterogeneity

    Frayling, T. M., Lindgren, C. M., Chevre, J. C., Menzel, S., Wishart, M., Benmezroua, Y., Brown, A., Evans, J. C., Rao, P. S., Dina, C., Lecoeur, C., Kanninen, T., Almgren, P., Bulman, M. P., Wang, Y., Mills, J., Wright-Pascoe, R., Mahtani, M. M., Prisco, F., Costa, A. & 9 others, Cognet, I., Hansen, Torben, Pedersen, Oluf Borbye, Ellard, S., Tuomi, T., Groop, L. C., Froguel, P., Hattersley, A. T. & Vaxillaire, M., 2003, In: Diabetes. 52, 3, p. 872-81 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Evidence for an association between the Leu162Val polymorphism of the PPARalpha gene and decreased fasting serum triglyceride levels in glucose tolerant subjects

    Nielsen, E. D., Hansen, L., Echwald, S. M., Drivsholm, Thomas, Borch-Johnsen, K., Ekstrøm, C. T., Hansen, Torben & Pedersen, Oluf Borbye, 2003, In: Pharmacogenetics and Genomics. 13, 7, p. 417-23 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Impact of low-dose acetylsalicylic acid on kidney function in type 2 diabetic patients with elevated urinary albumin excretion rate

    Gaede, P., Hansen, H. P., Parving, H. & Pedersen, Oluf Borbye, 2003, In: Nephrology, Dialysis, Transplantation. 18, 3, p. 539-42 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Impact of two common polymorphisms in the PPARgamma gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: thrifty genotype, thrifty phenotype, or both?

    Poulsen, P., Andersen, G., Fenger, M., Hansen, Torben, Echwald, S. M., Vølund, A., Beck-Nielsen, H., Pedersen, Oluf Borbye & Vaag, Allan, 2003, In: Diabetes. 52, 1, p. 194-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Injected TFF1 and TFF3 bind to TFF2-immunoreactive cells in the gastrointestinal tract in rats

    Poulsen, Steen Seier, Thulesen, J., Hartmann, Bolette, Kissow, Hannelouise, Nexø, E. & Thim, L., 2003, In: Regulatory Peptides. 115, 2, p. 91-99 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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