1H MRS Assessment of Hepatic Fat Content. Comparison Between Normal- and Excess-weight Children and Adolescents

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

1H MRS Assessment of Hepatic Fat Content. Comparison Between Normal- and Excess-weight Children and Adolescents. / Chabanova, Elizaveta; Fonvig, Cilius Esmann; Bøjsøe, Christine; Holm, Jens Christian; Thomsen, Henrik S.

In: Academic Radiology, Vol. 24, No. 8, 08.2017, p. 982-987.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Chabanova, E, Fonvig, CE, Bøjsøe, C, Holm, JC & Thomsen, HS 2017, '1H MRS Assessment of Hepatic Fat Content. Comparison Between Normal- and Excess-weight Children and Adolescents', Academic Radiology, vol. 24, no. 8, pp. 982-987. https://doi.org/10.1016/j.acra.2017.02.010

APA

Chabanova, E., Fonvig, C. E., Bøjsøe, C., Holm, J. C., & Thomsen, H. S. (2017). 1H MRS Assessment of Hepatic Fat Content. Comparison Between Normal- and Excess-weight Children and Adolescents. Academic Radiology, 24(8), 982-987. https://doi.org/10.1016/j.acra.2017.02.010

Vancouver

Chabanova E, Fonvig CE, Bøjsøe C, Holm JC, Thomsen HS. 1H MRS Assessment of Hepatic Fat Content. Comparison Between Normal- and Excess-weight Children and Adolescents. Academic Radiology. 2017 Aug;24(8):982-987. https://doi.org/10.1016/j.acra.2017.02.010

Author

Chabanova, Elizaveta ; Fonvig, Cilius Esmann ; Bøjsøe, Christine ; Holm, Jens Christian ; Thomsen, Henrik S. / 1H MRS Assessment of Hepatic Fat Content. Comparison Between Normal- and Excess-weight Children and Adolescents. In: Academic Radiology. 2017 ; Vol. 24, No. 8. pp. 982-987.

Bibtex

@article{4b27d29bb7bc40908895e83b4a90b80d,
title = "1H MRS Assessment of Hepatic Fat Content. Comparison Between Normal- and Excess-weight Children and Adolescents",
abstract = "Rationale and Objectives: The purpose of the present study was to obtain a cutoff value of liver fat content for the diagnosis of hepatic steatosis by comparing magnetic resonance (MR) spectroscopy results in children and adolescents with normal and excess weight. Materials and Methods: The study included 420 children and adolescents (91 normal-weight, 99 overweight, and 230 obese) 8-18 years of age. Proton magnetic resonance spectroscopy was performed with a 3T MR system using point resolved spectroscopy sequence with series echo times. Results: The mean absolute mass concentration of liver fat was obtained: 0.5 ± 0.04% in normal-weight boys; 0.5 ± 0.03% in normal-weight girls; 0.9 ± 0.16% in boys with overweight; 1.1 ± 0.24% in girls with overweight; 1.7 ± 0.24% in boys with obesity; and 1.4 ± 0.21% in girls with obesity.The cutoff value of absolute mass concentration of liver fat for hepatic steatosis was found to be 1.5%. Based on this cutoff value, hepatic steatosis was diagnosed in 16% of boys with overweight, 11% of girls with overweight, 32% of boys with obesity, and 27% of girls with obesity. Conclusions: Proton magnetic resonance spectroscopy was successfully applied to obtain the cutoff value of absolute mass concentration of liver fat for the diagnosis of hepatic steatosis in children and adolescents. Children and adolescents with obesity have higher risk of hepatic steatosis than their peers with overweight.",
keywords = "Adolescents, Children, Magnetic resonance, Obesity, Spectroscopy, Steatosis",
author = "Elizaveta Chabanova and Fonvig, {Cilius Esmann} and Christine B{\o}js{\o}e and Holm, {Jens Christian} and Thomsen, {Henrik S.}",
year = "2017",
month = aug,
doi = "10.1016/j.acra.2017.02.010",
language = "English",
volume = "24",
pages = "982--987",
journal = "Academic Radiology",
issn = "1076-6332",
publisher = "Elsevier",
number = "8",

}

RIS

TY - JOUR

T1 - 1H MRS Assessment of Hepatic Fat Content. Comparison Between Normal- and Excess-weight Children and Adolescents

AU - Chabanova, Elizaveta

AU - Fonvig, Cilius Esmann

AU - Bøjsøe, Christine

AU - Holm, Jens Christian

AU - Thomsen, Henrik S.

PY - 2017/8

Y1 - 2017/8

N2 - Rationale and Objectives: The purpose of the present study was to obtain a cutoff value of liver fat content for the diagnosis of hepatic steatosis by comparing magnetic resonance (MR) spectroscopy results in children and adolescents with normal and excess weight. Materials and Methods: The study included 420 children and adolescents (91 normal-weight, 99 overweight, and 230 obese) 8-18 years of age. Proton magnetic resonance spectroscopy was performed with a 3T MR system using point resolved spectroscopy sequence with series echo times. Results: The mean absolute mass concentration of liver fat was obtained: 0.5 ± 0.04% in normal-weight boys; 0.5 ± 0.03% in normal-weight girls; 0.9 ± 0.16% in boys with overweight; 1.1 ± 0.24% in girls with overweight; 1.7 ± 0.24% in boys with obesity; and 1.4 ± 0.21% in girls with obesity.The cutoff value of absolute mass concentration of liver fat for hepatic steatosis was found to be 1.5%. Based on this cutoff value, hepatic steatosis was diagnosed in 16% of boys with overweight, 11% of girls with overweight, 32% of boys with obesity, and 27% of girls with obesity. Conclusions: Proton magnetic resonance spectroscopy was successfully applied to obtain the cutoff value of absolute mass concentration of liver fat for the diagnosis of hepatic steatosis in children and adolescents. Children and adolescents with obesity have higher risk of hepatic steatosis than their peers with overweight.

AB - Rationale and Objectives: The purpose of the present study was to obtain a cutoff value of liver fat content for the diagnosis of hepatic steatosis by comparing magnetic resonance (MR) spectroscopy results in children and adolescents with normal and excess weight. Materials and Methods: The study included 420 children and adolescents (91 normal-weight, 99 overweight, and 230 obese) 8-18 years of age. Proton magnetic resonance spectroscopy was performed with a 3T MR system using point resolved spectroscopy sequence with series echo times. Results: The mean absolute mass concentration of liver fat was obtained: 0.5 ± 0.04% in normal-weight boys; 0.5 ± 0.03% in normal-weight girls; 0.9 ± 0.16% in boys with overweight; 1.1 ± 0.24% in girls with overweight; 1.7 ± 0.24% in boys with obesity; and 1.4 ± 0.21% in girls with obesity.The cutoff value of absolute mass concentration of liver fat for hepatic steatosis was found to be 1.5%. Based on this cutoff value, hepatic steatosis was diagnosed in 16% of boys with overweight, 11% of girls with overweight, 32% of boys with obesity, and 27% of girls with obesity. Conclusions: Proton magnetic resonance spectroscopy was successfully applied to obtain the cutoff value of absolute mass concentration of liver fat for the diagnosis of hepatic steatosis in children and adolescents. Children and adolescents with obesity have higher risk of hepatic steatosis than their peers with overweight.

KW - Adolescents

KW - Children

KW - Magnetic resonance

KW - Obesity

KW - Spectroscopy

KW - Steatosis

U2 - 10.1016/j.acra.2017.02.010

DO - 10.1016/j.acra.2017.02.010

M3 - Journal article

C2 - 28462823

AN - SCOPUS:85018750193

VL - 24

SP - 982

EP - 987

JO - Academic Radiology

JF - Academic Radiology

SN - 1076-6332

IS - 8

ER -

ID: 178736781