A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. / Feng, Dan; Liu, Tao; Sun, Zheng; Bugge, Anne Skovsø; Mullican, Shannon E; Alenghat, Theresa; Liu, X Shirley; Lazar, Mitchell A.

In: Science (New York, N.Y.), Vol. 331, No. 6022, 11.03.2011, p. 1315-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Feng, D, Liu, T, Sun, Z, Bugge, AS, Mullican, SE, Alenghat, T, Liu, XS & Lazar, MA 2011, 'A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism', Science (New York, N.Y.), vol. 331, no. 6022, pp. 1315-9. https://doi.org/10.1126/science.1198125

APA

Feng, D., Liu, T., Sun, Z., Bugge, A. S., Mullican, S. E., Alenghat, T., Liu, X. S., & Lazar, M. A. (2011). A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science (New York, N.Y.), 331(6022), 1315-9. https://doi.org/10.1126/science.1198125

Vancouver

Feng D, Liu T, Sun Z, Bugge AS, Mullican SE, Alenghat T et al. A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science (New York, N.Y.). 2011 Mar 11;331(6022):1315-9. https://doi.org/10.1126/science.1198125

Author

Feng, Dan ; Liu, Tao ; Sun, Zheng ; Bugge, Anne Skovsø ; Mullican, Shannon E ; Alenghat, Theresa ; Liu, X Shirley ; Lazar, Mitchell A. / A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. In: Science (New York, N.Y.). 2011 ; Vol. 331, No. 6022. pp. 1315-9.

Bibtex

@article{581199a81f63489484d4abb96a141416,
title = "A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism",
abstract = "Disruption of the circadian clock exacerbates metabolic diseases, including obesity and diabetes. We show that histone deacetylase 3 (HDAC3) recruitment to the genome displays a circadian rhythm in mouse liver. Histone acetylation is inversely related to HDAC3 binding, and this rhythm is lost when HDAC3 is absent. Although amounts of HDAC3 are constant, its genomic recruitment in liver corresponds to the expression pattern of the circadian nuclear receptor Rev-erbα. Rev-erbα colocalizes with HDAC3 near genes regulating lipid metabolism, and deletion of HDAC3 or Rev-erbα in mouse liver causes hepatic steatosis. Thus, genomic recruitment of HDAC3 by Rev-erbα directs a circadian rhythm of histone acetylation and gene expression required for normal hepatic lipid homeostasis.",
keywords = "Animals, Binding Sites, Chromatin Immunoprecipitation, Chronobiology Disorders, Circadian Clocks, Circadian Rhythm, DNA, Epigenesis, Genetic, Fatty Liver, Gene Expression Regulation, Genome, Histone Deacetylases, Histones, Homeostasis, Lipid Metabolism, Lipogenesis, Liver, Mice, Mice, Inbred C57BL, Mice, Knockout, Molecular Sequence Data, Nuclear Receptor Co-Repressor 1, Nuclear Receptor Subfamily 1, Group D, Member 1, RNA Polymerase II, Up-Regulation",
author = "Dan Feng and Tao Liu and Zheng Sun and Bugge, {Anne Skovs{\o}} and Mullican, {Shannon E} and Theresa Alenghat and Liu, {X Shirley} and Lazar, {Mitchell A}",
year = "2011",
month = mar,
day = "11",
doi = "10.1126/science.1198125",
language = "English",
volume = "331",
pages = "1315--9",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6022",

}

RIS

TY - JOUR

T1 - A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism

AU - Feng, Dan

AU - Liu, Tao

AU - Sun, Zheng

AU - Bugge, Anne Skovsø

AU - Mullican, Shannon E

AU - Alenghat, Theresa

AU - Liu, X Shirley

AU - Lazar, Mitchell A

PY - 2011/3/11

Y1 - 2011/3/11

N2 - Disruption of the circadian clock exacerbates metabolic diseases, including obesity and diabetes. We show that histone deacetylase 3 (HDAC3) recruitment to the genome displays a circadian rhythm in mouse liver. Histone acetylation is inversely related to HDAC3 binding, and this rhythm is lost when HDAC3 is absent. Although amounts of HDAC3 are constant, its genomic recruitment in liver corresponds to the expression pattern of the circadian nuclear receptor Rev-erbα. Rev-erbα colocalizes with HDAC3 near genes regulating lipid metabolism, and deletion of HDAC3 or Rev-erbα in mouse liver causes hepatic steatosis. Thus, genomic recruitment of HDAC3 by Rev-erbα directs a circadian rhythm of histone acetylation and gene expression required for normal hepatic lipid homeostasis.

AB - Disruption of the circadian clock exacerbates metabolic diseases, including obesity and diabetes. We show that histone deacetylase 3 (HDAC3) recruitment to the genome displays a circadian rhythm in mouse liver. Histone acetylation is inversely related to HDAC3 binding, and this rhythm is lost when HDAC3 is absent. Although amounts of HDAC3 are constant, its genomic recruitment in liver corresponds to the expression pattern of the circadian nuclear receptor Rev-erbα. Rev-erbα colocalizes with HDAC3 near genes regulating lipid metabolism, and deletion of HDAC3 or Rev-erbα in mouse liver causes hepatic steatosis. Thus, genomic recruitment of HDAC3 by Rev-erbα directs a circadian rhythm of histone acetylation and gene expression required for normal hepatic lipid homeostasis.

KW - Animals

KW - Binding Sites

KW - Chromatin Immunoprecipitation

KW - Chronobiology Disorders

KW - Circadian Clocks

KW - Circadian Rhythm

KW - DNA

KW - Epigenesis, Genetic

KW - Fatty Liver

KW - Gene Expression Regulation

KW - Genome

KW - Histone Deacetylases

KW - Histones

KW - Homeostasis

KW - Lipid Metabolism

KW - Lipogenesis

KW - Liver

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Molecular Sequence Data

KW - Nuclear Receptor Co-Repressor 1

KW - Nuclear Receptor Subfamily 1, Group D, Member 1

KW - RNA Polymerase II

KW - Up-Regulation

U2 - 10.1126/science.1198125

DO - 10.1126/science.1198125

M3 - Journal article

C2 - 21393543

VL - 331

SP - 1315

EP - 1319

JO - Science

JF - Science

SN - 0036-8075

IS - 6022

ER -

ID: 137667625