A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism

Research output: Contribution to journalJournal articleResearchpeer-review

  • Dan Feng
  • Tao Liu
  • Zheng Sun
  • Anne Skovsø Bugge
  • Shannon E Mullican
  • Theresa Alenghat
  • X Shirley Liu
  • Mitchell A Lazar

Disruption of the circadian clock exacerbates metabolic diseases, including obesity and diabetes. We show that histone deacetylase 3 (HDAC3) recruitment to the genome displays a circadian rhythm in mouse liver. Histone acetylation is inversely related to HDAC3 binding, and this rhythm is lost when HDAC3 is absent. Although amounts of HDAC3 are constant, its genomic recruitment in liver corresponds to the expression pattern of the circadian nuclear receptor Rev-erbα. Rev-erbα colocalizes with HDAC3 near genes regulating lipid metabolism, and deletion of HDAC3 or Rev-erbα in mouse liver causes hepatic steatosis. Thus, genomic recruitment of HDAC3 by Rev-erbα directs a circadian rhythm of histone acetylation and gene expression required for normal hepatic lipid homeostasis.

Original languageEnglish
JournalScience (New York, N.Y.)
Volume331
Issue number6022
Pages (from-to)1315-9
Number of pages5
ISSN0036-8075
DOIs
Publication statusPublished - 11 Mar 2011

    Research areas

  • Animals, Binding Sites, Chromatin Immunoprecipitation, Chronobiology Disorders, Circadian Clocks, Circadian Rhythm, DNA, Epigenesis, Genetic, Fatty Liver, Gene Expression Regulation, Genome, Histone Deacetylases, Histones, Homeostasis, Lipid Metabolism, Lipogenesis, Liver, Mice, Mice, Inbred C57BL, Mice, Knockout, Molecular Sequence Data, Nuclear Receptor Co-Repressor 1, Nuclear Receptor Subfamily 1, Group D, Member 1, RNA Polymerase II, Up-Regulation

ID: 137667625