A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B
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A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. / Yamauchi, Toshimasa; Hara, Kazuo; Maeda, Shiro; Yasuda, Kazuki; Takahashi, Atsushi; Horikoshi, Momoko; Nakamura, Masahiro; Fujita, Hayato; Grarup, Niels; Cauchi, Stephane; Ng, Daniel P K; Ma, Ronald C W; Tsunoda, Tatsuhiko; Kubo, Michiaki; Watada, Hirotaka; Maegawa, Hiroshi; Okada-Iwabu, Miki; Iwabu, Masato; Shojima, Nobuhiro; Shin, Hyoung Doo; Andersen, Gitte; Witte, Daniel R; Jørgensen, Torben; Lauritzen, Torsten; Sandbæk, Annelli; Hansen, Torben; Ohshige, Toshihiko; Omori, Shintaro; Saito, Ikuo; Kaku, Kohei; Hirose, Hiroshi; So, Wing-Yee; Beury, Delphine; Chan, Juliana C N; Park, Kyong Soo; Tai, E Shyong; Ito, Chikako; Tanaka, Yasushi; Kashiwagi, Atsunori; Kawamori, Ryuzo; Kasuga, Masato; Froguel, Philippe; Pedersen, Oluf; Kamatani, Naoyuki; Nakamura, Yusuke; Kadowaki, Takashi.
In: Nature Genetics, Vol. 42, No. 10, 01.10.2010, p. 864-8.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B
AU - Yamauchi, Toshimasa
AU - Hara, Kazuo
AU - Maeda, Shiro
AU - Yasuda, Kazuki
AU - Takahashi, Atsushi
AU - Horikoshi, Momoko
AU - Nakamura, Masahiro
AU - Fujita, Hayato
AU - Grarup, Niels
AU - Cauchi, Stephane
AU - Ng, Daniel P K
AU - Ma, Ronald C W
AU - Tsunoda, Tatsuhiko
AU - Kubo, Michiaki
AU - Watada, Hirotaka
AU - Maegawa, Hiroshi
AU - Okada-Iwabu, Miki
AU - Iwabu, Masato
AU - Shojima, Nobuhiro
AU - Shin, Hyoung Doo
AU - Andersen, Gitte
AU - Witte, Daniel R
AU - Jørgensen, Torben
AU - Lauritzen, Torsten
AU - Sandbæk, Annelli
AU - Hansen, Torben
AU - Ohshige, Toshihiko
AU - Omori, Shintaro
AU - Saito, Ikuo
AU - Kaku, Kohei
AU - Hirose, Hiroshi
AU - So, Wing-Yee
AU - Beury, Delphine
AU - Chan, Juliana C N
AU - Park, Kyong Soo
AU - Tai, E Shyong
AU - Ito, Chikako
AU - Tanaka, Yasushi
AU - Kashiwagi, Atsunori
AU - Kawamori, Ryuzo
AU - Kasuga, Masato
AU - Froguel, Philippe
AU - Pedersen, Oluf
AU - Kamatani, Naoyuki
AU - Nakamura, Yusuke
AU - Kadowaki, Takashi
PY - 2010/10/1
Y1 - 2010/10/1
N2 - We conducted a genome-wide association study of type 2 diabetes (T2D) using 459,359 SNPs in a Japanese population with a three-stage study design (stage 1, 4,470 cases and 3,071 controls; stage 2, 2,886 cases and 3,087 controls; stage 3, 3,622 cases and 2,356 controls). We identified new associations in UBE2E2 on chromosome 3 and in C2CD4A-C2CD4B on chromosome 15 at genome-wide significant levels (rs7612463 in UBE2E2, combined P = 2.27 × 10¿¿; rs7172432 in C2CD4A-C2CD4B, combined P = 3.66 × 10¿¿). The association of these two loci with T2D was replicated in other east Asian populations. In the European populations, the C2CD4A-C2CD4B locus was significantly associated with T2D, and a combined analysis of all populations gave P = 8.78 × 10¿¹4, whereas the UBE2E2 locus did not show association to T2D. In conclusion, we identified two new loci at UBE2E2 and C2CD4A-C2CD4B associated with susceptibility to T2D.
AB - We conducted a genome-wide association study of type 2 diabetes (T2D) using 459,359 SNPs in a Japanese population with a three-stage study design (stage 1, 4,470 cases and 3,071 controls; stage 2, 2,886 cases and 3,087 controls; stage 3, 3,622 cases and 2,356 controls). We identified new associations in UBE2E2 on chromosome 3 and in C2CD4A-C2CD4B on chromosome 15 at genome-wide significant levels (rs7612463 in UBE2E2, combined P = 2.27 × 10¿¿; rs7172432 in C2CD4A-C2CD4B, combined P = 3.66 × 10¿¿). The association of these two loci with T2D was replicated in other east Asian populations. In the European populations, the C2CD4A-C2CD4B locus was significantly associated with T2D, and a combined analysis of all populations gave P = 8.78 × 10¿¹4, whereas the UBE2E2 locus did not show association to T2D. In conclusion, we identified two new loci at UBE2E2 and C2CD4A-C2CD4B associated with susceptibility to T2D.
KW - Asian Continental Ancestry Group
KW - Case-Control Studies
KW - Chromosomes, Human, Pair 15
KW - Chromosomes, Human, Pair 3
KW - Diabetes Mellitus, Type 2
KW - Genetic Predisposition to Disease
KW - Genome, Human
KW - Genome-Wide Association Study
KW - Genotype
KW - Humans
KW - Polymorphism, Single Nucleotide
KW - Transcription Factors
KW - Ubiquitin-Conjugating Enzymes
U2 - 10.1038/ng.660
DO - 10.1038/ng.660
M3 - Journal article
C2 - 20818381
VL - 42
SP - 864
EP - 868
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 10
ER -
ID: 33508665