A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians. / Muller, Yunhua Li; Bogardus, Clifton; Pedersen, Oluf; Baier, Leslie.

In: Diabetes, Vol. 52, No. 3, 2003, p. 895-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Muller, YL, Bogardus, C, Pedersen, O & Baier, L 2003, 'A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians', Diabetes, vol. 52, no. 3, pp. 895-8.

APA

Muller, Y. L., Bogardus, C., Pedersen, O., & Baier, L. (2003). A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians. Diabetes, 52(3), 895-8.

Vancouver

Muller YL, Bogardus C, Pedersen O, Baier L. A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians. Diabetes. 2003;52(3):895-8.

Author

Muller, Yunhua Li ; Bogardus, Clifton ; Pedersen, Oluf ; Baier, Leslie. / A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians. In: Diabetes. 2003 ; Vol. 52, No. 3. pp. 895-8.

Bibtex

@article{30d6348ac28d4431a09153ba1f6fde4d,
title = "A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians",
abstract = "Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) is a transcriptional coactivator of peroxisome proliferator-activated receptor gamma and alpha, which play important roles in adipogenesis and lipid metabolism. A single nucleotide polymorphism within the coding region of the PGC-1 gene predicts a glycine to serine substitution at amino acid 482 and has been associated with type 2 diabetes in a Danish population. In this study, we examined whether this Gly482Ser polymorphism is associated with type 2 diabetes or obesity, or metabolic predictors of these diseases, in Pima Indians. There was no association of the Gly482Ser polymorphism with either type 2 diabetes or BMI (n = 984). However, among nondiabetic Pima Indians (n = 183-201), those with the Gly/Gly genotype had a lower mean insulin secretory response to intravenous and oral glucose and a lower mean rate of lipid oxidation (over 24 h in a respiratory chamber) despite a larger mean subcutaneous abdominal adipocyte size and a higher mean plasma free fatty acid concentration. These data indicate that the Gly482Ser missense polymorphism in PGC-1 has metabolic consequences on lipid metabolism that could influence insulin secretion.",
keywords = "Adipocytes, Adipose Tissue, Adult, Alleles, Blood Glucose, Body Composition, Body Mass Index, Cell Size, Diabetes Mellitus, Type 2, Female, Gene Frequency, Glycine, Humans, Indians, North American, Insulin, Lipid Peroxidation, Longitudinal Studies, Male, Mutation, Missense, Obesity, Sequence Analysis, DNA, Serine, Transcription Factors",
author = "Muller, {Yunhua Li} and Clifton Bogardus and Oluf Pedersen and Leslie Baier",
year = "2003",
language = "English",
volume = "52",
pages = "895--8",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "3",

}

RIS

TY - JOUR

T1 - A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians

AU - Muller, Yunhua Li

AU - Bogardus, Clifton

AU - Pedersen, Oluf

AU - Baier, Leslie

PY - 2003

Y1 - 2003

N2 - Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) is a transcriptional coactivator of peroxisome proliferator-activated receptor gamma and alpha, which play important roles in adipogenesis and lipid metabolism. A single nucleotide polymorphism within the coding region of the PGC-1 gene predicts a glycine to serine substitution at amino acid 482 and has been associated with type 2 diabetes in a Danish population. In this study, we examined whether this Gly482Ser polymorphism is associated with type 2 diabetes or obesity, or metabolic predictors of these diseases, in Pima Indians. There was no association of the Gly482Ser polymorphism with either type 2 diabetes or BMI (n = 984). However, among nondiabetic Pima Indians (n = 183-201), those with the Gly/Gly genotype had a lower mean insulin secretory response to intravenous and oral glucose and a lower mean rate of lipid oxidation (over 24 h in a respiratory chamber) despite a larger mean subcutaneous abdominal adipocyte size and a higher mean plasma free fatty acid concentration. These data indicate that the Gly482Ser missense polymorphism in PGC-1 has metabolic consequences on lipid metabolism that could influence insulin secretion.

AB - Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) is a transcriptional coactivator of peroxisome proliferator-activated receptor gamma and alpha, which play important roles in adipogenesis and lipid metabolism. A single nucleotide polymorphism within the coding region of the PGC-1 gene predicts a glycine to serine substitution at amino acid 482 and has been associated with type 2 diabetes in a Danish population. In this study, we examined whether this Gly482Ser polymorphism is associated with type 2 diabetes or obesity, or metabolic predictors of these diseases, in Pima Indians. There was no association of the Gly482Ser polymorphism with either type 2 diabetes or BMI (n = 984). However, among nondiabetic Pima Indians (n = 183-201), those with the Gly/Gly genotype had a lower mean insulin secretory response to intravenous and oral glucose and a lower mean rate of lipid oxidation (over 24 h in a respiratory chamber) despite a larger mean subcutaneous abdominal adipocyte size and a higher mean plasma free fatty acid concentration. These data indicate that the Gly482Ser missense polymorphism in PGC-1 has metabolic consequences on lipid metabolism that could influence insulin secretion.

KW - Adipocytes

KW - Adipose Tissue

KW - Adult

KW - Alleles

KW - Blood Glucose

KW - Body Composition

KW - Body Mass Index

KW - Cell Size

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Gene Frequency

KW - Glycine

KW - Humans

KW - Indians, North American

KW - Insulin

KW - Lipid Peroxidation

KW - Longitudinal Studies

KW - Male

KW - Mutation, Missense

KW - Obesity

KW - Sequence Analysis, DNA

KW - Serine

KW - Transcription Factors

M3 - Journal article

C2 - 12606537

VL - 52

SP - 895

EP - 898

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 3

ER -

ID: 38454540