Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice

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Standard

Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. / Livanos, Alexandra E; Greiner, Thomas U; Vangay, Pajau; Pathmasiri, Wimal; Stewart, Delisha; McRitchie, Susan; Li, Huilin; Chung, Jennifer; Sohn, Jiho; Kim, Sara; Gao, Zhan; Barber, Cecily; Kim, Joanne; Ng, Sandy; Rogers, Arlin B; Sumner, Susan; Zhang, Xue-Song; Cadwell, Ken; Knights, Dan; Alekseyenko, Alexander; Bäckhed, Gert Fredrik; Blaser, Martin J.

In: Nature Microbiology, Vol. 1, No. 11, 16140, 22.08.2016, p. 1-13.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Livanos, AE, Greiner, TU, Vangay, P, Pathmasiri, W, Stewart, D, McRitchie, S, Li, H, Chung, J, Sohn, J, Kim, S, Gao, Z, Barber, C, Kim, J, Ng, S, Rogers, AB, Sumner, S, Zhang, X-S, Cadwell, K, Knights, D, Alekseyenko, A, Bäckhed, GF & Blaser, MJ 2016, 'Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice', Nature Microbiology, vol. 1, no. 11, 16140, pp. 1-13. https://doi.org/10.1038/nmicrobiol.2016.140

APA

Livanos, A. E., Greiner, T. U., Vangay, P., Pathmasiri, W., Stewart, D., McRitchie, S., Li, H., Chung, J., Sohn, J., Kim, S., Gao, Z., Barber, C., Kim, J., Ng, S., Rogers, A. B., Sumner, S., Zhang, X-S., Cadwell, K., Knights, D., ... Blaser, M. J. (2016). Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Nature Microbiology, 1(11), 1-13. [16140]. https://doi.org/10.1038/nmicrobiol.2016.140

Vancouver

Livanos AE, Greiner TU, Vangay P, Pathmasiri W, Stewart D, McRitchie S et al. Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Nature Microbiology. 2016 Aug 22;1(11):1-13. 16140. https://doi.org/10.1038/nmicrobiol.2016.140

Author

Livanos, Alexandra E ; Greiner, Thomas U ; Vangay, Pajau ; Pathmasiri, Wimal ; Stewart, Delisha ; McRitchie, Susan ; Li, Huilin ; Chung, Jennifer ; Sohn, Jiho ; Kim, Sara ; Gao, Zhan ; Barber, Cecily ; Kim, Joanne ; Ng, Sandy ; Rogers, Arlin B ; Sumner, Susan ; Zhang, Xue-Song ; Cadwell, Ken ; Knights, Dan ; Alekseyenko, Alexander ; Bäckhed, Gert Fredrik ; Blaser, Martin J. / Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. In: Nature Microbiology. 2016 ; Vol. 1, No. 11. pp. 1-13.

Bibtex

@article{7e1863b711ca4a5f81aed3cf7c766501,
title = "Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice",
abstract = "The early life microbiome plays important roles in host immunological and metabolic development. Because the incidence of type 1 diabetes (T1D) has been increasing substantially in recent decades, we hypothesized that early-life antibiotic use alters gut microbiota, which predisposes to disease. Using non-obese diabetic mice that are genetically susceptible to T1D, we examined the effects of exposure to either continuous low-dose antibiotics or pulsed therapeutic antibiotics (PAT) early in life, mimicking childhood exposures. We found that in mice receiving PAT, T1D incidence was significantly higher, and microbial community composition and structure differed compared with controls. In pre-diabetic male PAT mice, the intestinal lamina propria had lower Th17 and Treg proportions and intestinal SAA expression than in controls, suggesting key roles in transducing the altered microbiota signals. PAT affected microbial lipid metabolism and host cholesterol biosynthetic gene expression. These findings show that early-life antibiotic treatments alter the gut microbiota and its metabolic capacities, intestinal gene expression and T-cell populations, accelerating T1D onset in non-obese diabetic mice.",
author = "Livanos, {Alexandra E} and Greiner, {Thomas U} and Pajau Vangay and Wimal Pathmasiri and Delisha Stewart and Susan McRitchie and Huilin Li and Jennifer Chung and Jiho Sohn and Sara Kim and Zhan Gao and Cecily Barber and Joanne Kim and Sandy Ng and Rogers, {Arlin B} and Susan Sumner and Xue-Song Zhang and Ken Cadwell and Dan Knights and Alexander Alekseyenko and B{\"a}ckhed, {Gert Fredrik} and Blaser, {Martin J}",
year = "2016",
month = aug,
day = "22",
doi = "10.1038/nmicrobiol.2016.140",
language = "English",
volume = "1",
pages = "1--13",
journal = "Nature Microbiology",
issn = "2058-5276",
publisher = "nature publishing group",
number = "11",

}

RIS

TY - JOUR

T1 - Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice

AU - Livanos, Alexandra E

AU - Greiner, Thomas U

AU - Vangay, Pajau

AU - Pathmasiri, Wimal

AU - Stewart, Delisha

AU - McRitchie, Susan

AU - Li, Huilin

AU - Chung, Jennifer

AU - Sohn, Jiho

AU - Kim, Sara

AU - Gao, Zhan

AU - Barber, Cecily

AU - Kim, Joanne

AU - Ng, Sandy

AU - Rogers, Arlin B

AU - Sumner, Susan

AU - Zhang, Xue-Song

AU - Cadwell, Ken

AU - Knights, Dan

AU - Alekseyenko, Alexander

AU - Bäckhed, Gert Fredrik

AU - Blaser, Martin J

PY - 2016/8/22

Y1 - 2016/8/22

N2 - The early life microbiome plays important roles in host immunological and metabolic development. Because the incidence of type 1 diabetes (T1D) has been increasing substantially in recent decades, we hypothesized that early-life antibiotic use alters gut microbiota, which predisposes to disease. Using non-obese diabetic mice that are genetically susceptible to T1D, we examined the effects of exposure to either continuous low-dose antibiotics or pulsed therapeutic antibiotics (PAT) early in life, mimicking childhood exposures. We found that in mice receiving PAT, T1D incidence was significantly higher, and microbial community composition and structure differed compared with controls. In pre-diabetic male PAT mice, the intestinal lamina propria had lower Th17 and Treg proportions and intestinal SAA expression than in controls, suggesting key roles in transducing the altered microbiota signals. PAT affected microbial lipid metabolism and host cholesterol biosynthetic gene expression. These findings show that early-life antibiotic treatments alter the gut microbiota and its metabolic capacities, intestinal gene expression and T-cell populations, accelerating T1D onset in non-obese diabetic mice.

AB - The early life microbiome plays important roles in host immunological and metabolic development. Because the incidence of type 1 diabetes (T1D) has been increasing substantially in recent decades, we hypothesized that early-life antibiotic use alters gut microbiota, which predisposes to disease. Using non-obese diabetic mice that are genetically susceptible to T1D, we examined the effects of exposure to either continuous low-dose antibiotics or pulsed therapeutic antibiotics (PAT) early in life, mimicking childhood exposures. We found that in mice receiving PAT, T1D incidence was significantly higher, and microbial community composition and structure differed compared with controls. In pre-diabetic male PAT mice, the intestinal lamina propria had lower Th17 and Treg proportions and intestinal SAA expression than in controls, suggesting key roles in transducing the altered microbiota signals. PAT affected microbial lipid metabolism and host cholesterol biosynthetic gene expression. These findings show that early-life antibiotic treatments alter the gut microbiota and its metabolic capacities, intestinal gene expression and T-cell populations, accelerating T1D onset in non-obese diabetic mice.

U2 - 10.1038/nmicrobiol.2016.140

DO - 10.1038/nmicrobiol.2016.140

M3 - Journal article

C2 - 27782139

VL - 1

SP - 1

EP - 13

JO - Nature Microbiology

JF - Nature Microbiology

SN - 2058-5276

IS - 11

M1 - 16140

ER -

ID: 173290713