Association between obesity and asthma in a twin cohort

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Association between obesity and asthma in a twin cohort. / Thomsen, SF; Ulrik, Charlotte Suppli; Kyvik, KO; Sørensen, Thorkild I.A.; Posthuma, D; Skadhauge, LR; Steffensen, I; Backer, V.

In: Allergy. European Journal of Allergy and Clinical Immunology, Vol. 62, No. 10, 2007, p. 1199-1204.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Thomsen, SF, Ulrik, CS, Kyvik, KO, Sørensen, TIA, Posthuma, D, Skadhauge, LR, Steffensen, I & Backer, V 2007, 'Association between obesity and asthma in a twin cohort', Allergy. European Journal of Allergy and Clinical Immunology, vol. 62, no. 10, pp. 1199-1204. https://doi.org/10.1111/j.1398-9995.2007.01480.x

APA

Thomsen, SF., Ulrik, C. S., Kyvik, KO., Sørensen, T. I. A., Posthuma, D., Skadhauge, LR., Steffensen, I., & Backer, V. (2007). Association between obesity and asthma in a twin cohort. Allergy. European Journal of Allergy and Clinical Immunology, 62(10), 1199-1204. https://doi.org/10.1111/j.1398-9995.2007.01480.x

Vancouver

Thomsen SF, Ulrik CS, Kyvik KO, Sørensen TIA, Posthuma D, Skadhauge LR et al. Association between obesity and asthma in a twin cohort. Allergy. European Journal of Allergy and Clinical Immunology. 2007;62(10):1199-1204. https://doi.org/10.1111/j.1398-9995.2007.01480.x

Author

Thomsen, SF ; Ulrik, Charlotte Suppli ; Kyvik, KO ; Sørensen, Thorkild I.A. ; Posthuma, D ; Skadhauge, LR ; Steffensen, I ; Backer, V. / Association between obesity and asthma in a twin cohort. In: Allergy. European Journal of Allergy and Clinical Immunology. 2007 ; Vol. 62, No. 10. pp. 1199-1204.

Bibtex

@article{5a2f689020ec11ddbc23000ea68e967b,
title = "Association between obesity and asthma in a twin cohort",
abstract = "Background: Obesity is linked to asthma in a yet poorly understood manner. We examined the relationship between obesity and asthma in a population-based sample of twins.Methods: From the cohorts born between 1953 and 1982, who were enrolled in The Danish Twin Registry, a total of 29 183 twin individuals participated in a nationwide questionnaire study, where data on height, weight and asthma were collected. Latent factor models of genetic and environmental effects were fitted using maximum likelihood methods.Results: The age-adjusted risk of asthma was increased both in obese females, OR = 1.96 (1.45-2.64), P = 0.001 and in obese males, OR = 1.59 (1.08-2.33), P = 0.02. According to best-fitting models, the heritability for obesity was 81% in males and 92% in females, whereas the heritability for asthma was 78% and 68% in males and females respectively. The age-adjusted genetic liabilities to obesity and asthma were significantly correlated only in females, r = 0.28 (0.16-0.38).Conclusions: Obese subjects have an increased risk for asthma, which in females seems partly because of common genes.",
author = "SF Thomsen and Ulrik, {Charlotte Suppli} and KO Kyvik and S{\o}rensen, {Thorkild I.A.} and D Posthuma and LR Skadhauge and I Steffensen and V Backer",
year = "2007",
doi = "http://dx.doi.org/10.1111/j.1398-9995.2007.01480.x",
language = "English",
volume = "62",
pages = "1199--1204",
journal = "Allergy: European Journal of Allergy and Clinical Immunology",
issn = "0105-4538",
publisher = "Wiley Online",
number = "10",

}

RIS

TY - JOUR

T1 - Association between obesity and asthma in a twin cohort

AU - Thomsen, SF

AU - Ulrik, Charlotte Suppli

AU - Kyvik, KO

AU - Sørensen, Thorkild I.A.

AU - Posthuma, D

AU - Skadhauge, LR

AU - Steffensen, I

AU - Backer, V

PY - 2007

Y1 - 2007

N2 - Background: Obesity is linked to asthma in a yet poorly understood manner. We examined the relationship between obesity and asthma in a population-based sample of twins.Methods: From the cohorts born between 1953 and 1982, who were enrolled in The Danish Twin Registry, a total of 29 183 twin individuals participated in a nationwide questionnaire study, where data on height, weight and asthma were collected. Latent factor models of genetic and environmental effects were fitted using maximum likelihood methods.Results: The age-adjusted risk of asthma was increased both in obese females, OR = 1.96 (1.45-2.64), P = 0.001 and in obese males, OR = 1.59 (1.08-2.33), P = 0.02. According to best-fitting models, the heritability for obesity was 81% in males and 92% in females, whereas the heritability for asthma was 78% and 68% in males and females respectively. The age-adjusted genetic liabilities to obesity and asthma were significantly correlated only in females, r = 0.28 (0.16-0.38).Conclusions: Obese subjects have an increased risk for asthma, which in females seems partly because of common genes.

AB - Background: Obesity is linked to asthma in a yet poorly understood manner. We examined the relationship between obesity and asthma in a population-based sample of twins.Methods: From the cohorts born between 1953 and 1982, who were enrolled in The Danish Twin Registry, a total of 29 183 twin individuals participated in a nationwide questionnaire study, where data on height, weight and asthma were collected. Latent factor models of genetic and environmental effects were fitted using maximum likelihood methods.Results: The age-adjusted risk of asthma was increased both in obese females, OR = 1.96 (1.45-2.64), P = 0.001 and in obese males, OR = 1.59 (1.08-2.33), P = 0.02. According to best-fitting models, the heritability for obesity was 81% in males and 92% in females, whereas the heritability for asthma was 78% and 68% in males and females respectively. The age-adjusted genetic liabilities to obesity and asthma were significantly correlated only in females, r = 0.28 (0.16-0.38).Conclusions: Obese subjects have an increased risk for asthma, which in females seems partly because of common genes.

U2 - http://dx.doi.org/10.1111/j.1398-9995.2007.01480.x

DO - http://dx.doi.org/10.1111/j.1398-9995.2007.01480.x

M3 - Journal article

VL - 62

SP - 1199

EP - 1204

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

SN - 0105-4538

IS - 10

ER -

ID: 4043124