Associations of genetic determinants of serum vitamin B12 and folate concentrations with hay fever and asthma: a Mendelian randomization meta-analysis
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Associations of genetic determinants of serum vitamin B12 and folate concentrations with hay fever and asthma : a Mendelian randomization meta-analysis. / Skaaby, Tea; Taylor, Amy E.; Jacobsen, Rikke K.; Møllehave, Line T.; Friedrich, Nele; Thuesen, Betina H.; Shabanzadeh, Daniel Mønsted; Paternoster, Lavinia; Völker, Uwe; Nauck, Matthias; Völzke, Henry; Munafò, Marcus; Hansen, Torben; Pedersen, Oluf; Jørgensen, Torben; Grarup, Niels; Linneberg, Allan.
In: European Journal of Clinical Nutrition, Vol. 72, No. 2, 2018, p. 264–271.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Associations of genetic determinants of serum vitamin B12 and folate concentrations with hay fever and asthma
T2 - a Mendelian randomization meta-analysis
AU - Skaaby, Tea
AU - Taylor, Amy E.
AU - Jacobsen, Rikke K.
AU - Møllehave, Line T.
AU - Friedrich, Nele
AU - Thuesen, Betina H.
AU - Shabanzadeh, Daniel Mønsted
AU - Paternoster, Lavinia
AU - Völker, Uwe
AU - Nauck, Matthias
AU - Völzke, Henry
AU - Munafò, Marcus
AU - Hansen, Torben
AU - Pedersen, Oluf
AU - Jørgensen, Torben
AU - Grarup, Niels
AU - Linneberg, Allan
PY - 2018
Y1 - 2018
N2 - Background/objectives: Studies of the effect of vitamin B12 and folate on the risk of asthma and hay fever have shown inconsistent results that may be biased by reverse causation and confounding. We used a Mendelian randomization approach to examine a potential causal effect of vitamin B12 and folate on hay fever, asthma, and selected biomarkers of allergy by using 11 vitamin B12-associated single-nucleotide polymorphisms (SNPs) and 2 folate-associated SNPs as unconfounded markers. Subjects/methods: We included 162,736 participants from 9 population-based studies including the UK Biobank. Results were combined in instrumental variable and meta-analyses and effects expressed as odds ratios (ORs) or estimates with 95% confidence interval (CI). Results: Using genetic proxies for B12 and folate, instrumental variable analyses did not show evidence for associations between serum B12 and hay fever: OR = 1.02 (95% CI: 0.98, 1.05), asthma: OR = 0.99 (95% CI: 0.95, 1.04), allergic sensitization: OR = 1.02 (95% CI: 0.74, 1.40), or change in serum IgE: 10.0% (95% CI: −9.6%, 29.6%) per 100 pg/ml B12. Similarly, there was no evidence for association between serum folate and hay fever: OR = 0.74 (95% CI: 0.45, 1.21), asthma: OR = 0.80 (95% CI: 0.43, 1.49), or allergic sensitization: OR = 1.92 (95% CI: 0.11, 33.45), but there was a statistically significant association with change in serum IgE: 2.0% (95% CI: 0.43%, 3.58%) per 0.1 ng/ml serum folate. Conclusions: Our results did not support the hypothesis that levels of vitamin B12 and folate are causally related to hay fever, asthma, or biomarkers of allergy, but we found evidence of a positive association between serum folate and serum total IgE.
AB - Background/objectives: Studies of the effect of vitamin B12 and folate on the risk of asthma and hay fever have shown inconsistent results that may be biased by reverse causation and confounding. We used a Mendelian randomization approach to examine a potential causal effect of vitamin B12 and folate on hay fever, asthma, and selected biomarkers of allergy by using 11 vitamin B12-associated single-nucleotide polymorphisms (SNPs) and 2 folate-associated SNPs as unconfounded markers. Subjects/methods: We included 162,736 participants from 9 population-based studies including the UK Biobank. Results were combined in instrumental variable and meta-analyses and effects expressed as odds ratios (ORs) or estimates with 95% confidence interval (CI). Results: Using genetic proxies for B12 and folate, instrumental variable analyses did not show evidence for associations between serum B12 and hay fever: OR = 1.02 (95% CI: 0.98, 1.05), asthma: OR = 0.99 (95% CI: 0.95, 1.04), allergic sensitization: OR = 1.02 (95% CI: 0.74, 1.40), or change in serum IgE: 10.0% (95% CI: −9.6%, 29.6%) per 100 pg/ml B12. Similarly, there was no evidence for association between serum folate and hay fever: OR = 0.74 (95% CI: 0.45, 1.21), asthma: OR = 0.80 (95% CI: 0.43, 1.49), or allergic sensitization: OR = 1.92 (95% CI: 0.11, 33.45), but there was a statistically significant association with change in serum IgE: 2.0% (95% CI: 0.43%, 3.58%) per 0.1 ng/ml serum folate. Conclusions: Our results did not support the hypothesis that levels of vitamin B12 and folate are causally related to hay fever, asthma, or biomarkers of allergy, but we found evidence of a positive association between serum folate and serum total IgE.
U2 - 10.1038/s41430-017-0037-2
DO - 10.1038/s41430-017-0037-2
M3 - Journal article
C2 - 29249824
AN - SCOPUS:85038071914
VL - 72
SP - 264
EP - 271
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
SN - 0954-3007
IS - 2
ER -
ID: 188443073