Bifidobacteria or fiber protects against diet-induced microbiota-mediated colonic mucus deterioration

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Bifidobacteria or fiber protects against diet-induced microbiota-mediated colonic mucus deterioration. / Schroeder, Bjoern O; Birchenough, George M H; Ståhlman, Marcus; Arike, Liisa; Johansson, Malin E V; Hansson, Gunnar C; Bäckhed, Fredrik.

In: Cell Host & Microbe, Vol. 23, No. 1, 2018, p. 27-40 + e1-e7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Schroeder, BO, Birchenough, GMH, Ståhlman, M, Arike, L, Johansson, MEV, Hansson, GC & Bäckhed, F 2018, 'Bifidobacteria or fiber protects against diet-induced microbiota-mediated colonic mucus deterioration', Cell Host & Microbe, vol. 23, no. 1, pp. 27-40 + e1-e7. https://doi.org/10.1016/j.chom.2017.11.004

APA

Schroeder, B. O., Birchenough, G. M. H., Ståhlman, M., Arike, L., Johansson, M. E. V., Hansson, G. C., & Bäckhed, F. (2018). Bifidobacteria or fiber protects against diet-induced microbiota-mediated colonic mucus deterioration. Cell Host & Microbe, 23(1), 27-40 + e1-e7. https://doi.org/10.1016/j.chom.2017.11.004

Vancouver

Schroeder BO, Birchenough GMH, Ståhlman M, Arike L, Johansson MEV, Hansson GC et al. Bifidobacteria or fiber protects against diet-induced microbiota-mediated colonic mucus deterioration. Cell Host & Microbe. 2018;23(1):27-40 + e1-e7. https://doi.org/10.1016/j.chom.2017.11.004

Author

Schroeder, Bjoern O ; Birchenough, George M H ; Ståhlman, Marcus ; Arike, Liisa ; Johansson, Malin E V ; Hansson, Gunnar C ; Bäckhed, Fredrik. / Bifidobacteria or fiber protects against diet-induced microbiota-mediated colonic mucus deterioration. In: Cell Host & Microbe. 2018 ; Vol. 23, No. 1. pp. 27-40 + e1-e7.

Bibtex

@article{907001e8829b4b47929604cbcac93dc7,
title = "Bifidobacteria or fiber protects against diet-induced microbiota-mediated colonic mucus deterioration",
abstract = "Diet strongly affects gut microbiota composition, and gut bacteria can influence the colonic mucus layer, a physical barrier that separates trillions of gut bacteria from the host. However, the interplay between a Western style diet (WSD), gut microbiota composition, and the intestinal mucus layer is less clear. Here we show that mice fed a WSD have an altered colonic microbiota composition that causes increased penetrability and a reduced growth rate of the inner mucus layer. Both barrier defects can be prevented by transplanting microbiota from chow-fed mice. In addition, we found that administration of Bifidobacterium longum was sufficient to restore mucus growth, whereas administration of the fiber inulin prevented increased mucus penetrability in WSD-fed mice. We hypothesize that the presence of distinct bacteria is crucial for proper mucus function. If confirmed in humans, these findings may help to better understand diseases with an affected mucus layer, such as ulcerative colitis.",
keywords = "Journal Article",
author = "Schroeder, {Bjoern O} and Birchenough, {George M H} and Marcus St{\aa}hlman and Liisa Arike and Johansson, {Malin E V} and Hansson, {Gunnar C} and Fredrik B{\"a}ckhed",
note = "Copyright {\textcopyright} 2017 Elsevier Inc. All rights reserved.",
year = "2018",
doi = "10.1016/j.chom.2017.11.004",
language = "English",
volume = "23",
pages = "27--40 + e1--e7",
journal = "Cell Host & Microbe",
issn = "1931-3128",
publisher = "Cell Press",
number = "1",

}

RIS

TY - JOUR

T1 - Bifidobacteria or fiber protects against diet-induced microbiota-mediated colonic mucus deterioration

AU - Schroeder, Bjoern O

AU - Birchenough, George M H

AU - Ståhlman, Marcus

AU - Arike, Liisa

AU - Johansson, Malin E V

AU - Hansson, Gunnar C

AU - Bäckhed, Fredrik

N1 - Copyright © 2017 Elsevier Inc. All rights reserved.

PY - 2018

Y1 - 2018

N2 - Diet strongly affects gut microbiota composition, and gut bacteria can influence the colonic mucus layer, a physical barrier that separates trillions of gut bacteria from the host. However, the interplay between a Western style diet (WSD), gut microbiota composition, and the intestinal mucus layer is less clear. Here we show that mice fed a WSD have an altered colonic microbiota composition that causes increased penetrability and a reduced growth rate of the inner mucus layer. Both barrier defects can be prevented by transplanting microbiota from chow-fed mice. In addition, we found that administration of Bifidobacterium longum was sufficient to restore mucus growth, whereas administration of the fiber inulin prevented increased mucus penetrability in WSD-fed mice. We hypothesize that the presence of distinct bacteria is crucial for proper mucus function. If confirmed in humans, these findings may help to better understand diseases with an affected mucus layer, such as ulcerative colitis.

AB - Diet strongly affects gut microbiota composition, and gut bacteria can influence the colonic mucus layer, a physical barrier that separates trillions of gut bacteria from the host. However, the interplay between a Western style diet (WSD), gut microbiota composition, and the intestinal mucus layer is less clear. Here we show that mice fed a WSD have an altered colonic microbiota composition that causes increased penetrability and a reduced growth rate of the inner mucus layer. Both barrier defects can be prevented by transplanting microbiota from chow-fed mice. In addition, we found that administration of Bifidobacterium longum was sufficient to restore mucus growth, whereas administration of the fiber inulin prevented increased mucus penetrability in WSD-fed mice. We hypothesize that the presence of distinct bacteria is crucial for proper mucus function. If confirmed in humans, these findings may help to better understand diseases with an affected mucus layer, such as ulcerative colitis.

KW - Journal Article

U2 - 10.1016/j.chom.2017.11.004

DO - 10.1016/j.chom.2017.11.004

M3 - Journal article

C2 - 29276171

VL - 23

SP - 27-40 + e1-e7

JO - Cell Host & Microbe

JF - Cell Host & Microbe

SN - 1931-3128

IS - 1

ER -

ID: 189862747