Birthweight, Childhood Body Mass Index, Height and Growth, and Risk of Polycystic Ovary Syndrome
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Birthweight, Childhood Body Mass Index, Height and Growth, and Risk of Polycystic Ovary Syndrome. / Aarestrup, J.; Pedersen, D. C.; Thomas, P. E.; Glintborg, D.; Holm, Jens-Christian; Bjerregaard, L. G.; Baker, Jennifer L.
In: Obesity Facts, Vol. 14, No. 3, 2021, p. 283-290.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Birthweight, Childhood Body Mass Index, Height and Growth, and Risk of Polycystic Ovary Syndrome
AU - Aarestrup, J.
AU - Pedersen, D. C.
AU - Thomas, P. E.
AU - Glintborg, D.
AU - Holm, Jens-Christian
AU - Bjerregaard, L. G.
AU - Baker, Jennifer L.
PY - 2021
Y1 - 2021
N2 - Introduction: Adult obesity is linked with polycystic ovary syndrome (PCOS), but the importance of body size at ages before PCOS is diagnosed is unknown. Objective: To investigate associations between a woman's own birthweight, childhood body mass index (BMI), height and growth patterns in relation to her risk of PCOS. Methods: We included 65,665 girls from the Copenhagen School Health Records Register, born in the period 1960-1996, with information on birthweight and measured weight and height at the ages of 7-13 years. Overweight was defined using International Obesity Task Force (IOTF) criteria. From the Danish National Patient Register, 606 women aged 15-50 years were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated by Cox regression analysis. Results: Birthweight was not associated with PCOS. At the age of 7-13 years, girls with overweight had a higher risk of developing PCOS than girls without overweight; HR 2.83 (95% CI 2.34-3.42) at age 7 years and 2.99 (95% CI 2.38-3.76) at age 13 years. Furthermore, girls with overweight at both 7 and 13 years had a higher risk of developing PCOS than girls without overweight or overweight at only one age. Height was positively associated with PCOS risk at all ages. Girls who were persistently tall or changed from tall to average height had a higher risk of developing PCOS than girls with average height growth. Conclusion: Overweight and tall stature in childhood are positively associated with PCOS risk, but birthweight is not.
AB - Introduction: Adult obesity is linked with polycystic ovary syndrome (PCOS), but the importance of body size at ages before PCOS is diagnosed is unknown. Objective: To investigate associations between a woman's own birthweight, childhood body mass index (BMI), height and growth patterns in relation to her risk of PCOS. Methods: We included 65,665 girls from the Copenhagen School Health Records Register, born in the period 1960-1996, with information on birthweight and measured weight and height at the ages of 7-13 years. Overweight was defined using International Obesity Task Force (IOTF) criteria. From the Danish National Patient Register, 606 women aged 15-50 years were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated by Cox regression analysis. Results: Birthweight was not associated with PCOS. At the age of 7-13 years, girls with overweight had a higher risk of developing PCOS than girls without overweight; HR 2.83 (95% CI 2.34-3.42) at age 7 years and 2.99 (95% CI 2.38-3.76) at age 13 years. Furthermore, girls with overweight at both 7 and 13 years had a higher risk of developing PCOS than girls without overweight or overweight at only one age. Height was positively associated with PCOS risk at all ages. Girls who were persistently tall or changed from tall to average height had a higher risk of developing PCOS than girls with average height growth. Conclusion: Overweight and tall stature in childhood are positively associated with PCOS risk, but birthweight is not.
KW - Polycystic ovary syndrome
KW - Birthweight
KW - Body height
KW - Body weights and measures
KW - Child
KW - NATIONWIDE POPULATION
KW - WOMEN
KW - OBESITY
KW - PATHOPHYSIOLOGY
KW - EPIDEMIOLOGY
KW - ASSOCIATIONS
KW - OVERWEIGHT
KW - ADULTHOOD
KW - DISEASE
KW - CANCER
U2 - 10.1159/000515294
DO - 10.1159/000515294
M3 - Journal article
C2 - 33979806
VL - 14
SP - 283
EP - 290
JO - Obesity Facts
JF - Obesity Facts
SN - 1662-4025
IS - 3
ER -
ID: 270549774