Calcium sensing in exocytosis
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Calcium sensing in exocytosis. / Gustavsson, Natalia; Wu, Bingbing; Han, Weiping.
In: Advances in Experimental Medicine and Biology, Vol. 740, 2012, p. 731-57.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Calcium sensing in exocytosis
AU - Gustavsson, Natalia
AU - Wu, Bingbing
AU - Han, Weiping
PY - 2012
Y1 - 2012
N2 - Neurotransmitters, neuropeptides and hormones are released through regulated exocytosis of synaptic vesicles and large dense core vesicles. This complex and highly regulated process is orchestrated by SNAREs and their associated proteins. The triggering signal for regulated exocytosis is usually an increase in intracellular calcium levels. Besides the triggering role, calcium signaling modulates the precise amount and kinetics of vesicle release. Thus, it is a central question to understand the molecular machineries responsible for calcium sensing in exocytosis. Here we provide an overview of our current understanding of calcium sensing in neurotransmitter release and hormone secretion.
AB - Neurotransmitters, neuropeptides and hormones are released through regulated exocytosis of synaptic vesicles and large dense core vesicles. This complex and highly regulated process is orchestrated by SNAREs and their associated proteins. The triggering signal for regulated exocytosis is usually an increase in intracellular calcium levels. Besides the triggering role, calcium signaling modulates the precise amount and kinetics of vesicle release. Thus, it is a central question to understand the molecular machineries responsible for calcium sensing in exocytosis. Here we provide an overview of our current understanding of calcium sensing in neurotransmitter release and hormone secretion.
KW - Amino Acid Sequence
KW - Animals
KW - Calcium
KW - Calcium Signaling
KW - Exocytosis
KW - Hormones
KW - Humans
KW - Molecular Sequence Data
KW - Neuropeptides
KW - Neurotransmitter Agents
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
KW - Review
U2 - 10.1007/978-94-007-2888-2_32
DO - 10.1007/978-94-007-2888-2_32
M3 - Journal article
C2 - 22453967
VL - 740
SP - 731
EP - 757
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
SN - 0065-2598
ER -
ID: 172513325