Calcium sensing in exocytosis
Research output: Contribution to journal › Journal article › Research › peer-review
Neurotransmitters, neuropeptides and hormones are released through regulated exocytosis of synaptic vesicles and large dense core vesicles. This complex and highly regulated process is orchestrated by SNAREs and their associated proteins. The triggering signal for regulated exocytosis is usually an increase in intracellular calcium levels. Besides the triggering role, calcium signaling modulates the precise amount and kinetics of vesicle release. Thus, it is a central question to understand the molecular machineries responsible for calcium sensing in exocytosis. Here we provide an overview of our current understanding of calcium sensing in neurotransmitter release and hormone secretion.
Original language | English |
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Book series | Advances in Experimental Medicine and Biology |
Volume | 740 |
Pages (from-to) | 731-57 |
Number of pages | 27 |
ISSN | 0065-2598 |
DOIs | |
Publication status | Published - 2012 |
- Amino Acid Sequence, Animals, Calcium, Calcium Signaling, Exocytosis, Hormones, Humans, Molecular Sequence Data, Neuropeptides, Neurotransmitter Agents, Journal Article, Research Support, Non-U.S. Gov't, Review
Research areas
ID: 172513325