Calcium-sensing beyond neurotransmitters: functions of synaptotagmins in neuroendocrine and endocrine secretion

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Calcium-sensing beyond neurotransmitters : functions of synaptotagmins in neuroendocrine and endocrine secretion. / Gustavsson, Natalia; Han, Weiping.

In: Bioscience Reports, Vol. 29, No. 4, 08.2009, p. 245-59.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gustavsson, N & Han, W 2009, 'Calcium-sensing beyond neurotransmitters: functions of synaptotagmins in neuroendocrine and endocrine secretion', Bioscience Reports, vol. 29, no. 4, pp. 245-59. https://doi.org/10.1042/BSR20090031

APA

Gustavsson, N., & Han, W. (2009). Calcium-sensing beyond neurotransmitters: functions of synaptotagmins in neuroendocrine and endocrine secretion. Bioscience Reports, 29(4), 245-59. https://doi.org/10.1042/BSR20090031

Vancouver

Gustavsson N, Han W. Calcium-sensing beyond neurotransmitters: functions of synaptotagmins in neuroendocrine and endocrine secretion. Bioscience Reports. 2009 Aug;29(4):245-59. https://doi.org/10.1042/BSR20090031

Author

Gustavsson, Natalia ; Han, Weiping. / Calcium-sensing beyond neurotransmitters : functions of synaptotagmins in neuroendocrine and endocrine secretion. In: Bioscience Reports. 2009 ; Vol. 29, No. 4. pp. 245-59.

Bibtex

@article{60f637cbbbf24f449fb967a317d9ceb3,
title = "Calcium-sensing beyond neurotransmitters: functions of synaptotagmins in neuroendocrine and endocrine secretion",
abstract = "Neurotransmitters, neuropeptides and hormones are released through the regulated exocytosis of SVs (synaptic vesicles) and LDCVs (large dense-core vesicles), a process that is controlled by calcium. Synaptotagmins are a family of type 1 membrane proteins that share a common domain structure. Most synaptotagmins are located in brain and endocrine cells, and some of these synaptotagmins bind to phospholipids and calcium at levels that trigger regulated exocytosis of SVs and LDCVs. This led to the proposed synaptotagmin-calcium-sensor paradigm, that is, members of the synaptotagmin family function as calcium sensors for the regulated exocytosis of neurotransmitters, neuropeptides and hormones. Here, we provide an overview of the synaptotagmin family, and review the recent mouse genetic studies aimed at understanding the functions of synaptotagmins in neurotransmission and endocrine-hormone secretion. Also, we discuss potential roles of synaptotagmins in non-traditional endocrine systems.",
keywords = "Animals, Calcium, Endocrine System, Exocytosis, Mice, Neurosecretory Systems, Neurotransmitter Agents, Synaptotagmins, Journal Article, Research Support, Non-U.S. Gov't, Review",
author = "Natalia Gustavsson and Weiping Han",
year = "2009",
month = aug,
doi = "10.1042/BSR20090031",
language = "English",
volume = "29",
pages = "245--59",
journal = "Bioscience Reports",
issn = "0144-8463",
publisher = "Portland Press Ltd.",
number = "4",

}

RIS

TY - JOUR

T1 - Calcium-sensing beyond neurotransmitters

T2 - functions of synaptotagmins in neuroendocrine and endocrine secretion

AU - Gustavsson, Natalia

AU - Han, Weiping

PY - 2009/8

Y1 - 2009/8

N2 - Neurotransmitters, neuropeptides and hormones are released through the regulated exocytosis of SVs (synaptic vesicles) and LDCVs (large dense-core vesicles), a process that is controlled by calcium. Synaptotagmins are a family of type 1 membrane proteins that share a common domain structure. Most synaptotagmins are located in brain and endocrine cells, and some of these synaptotagmins bind to phospholipids and calcium at levels that trigger regulated exocytosis of SVs and LDCVs. This led to the proposed synaptotagmin-calcium-sensor paradigm, that is, members of the synaptotagmin family function as calcium sensors for the regulated exocytosis of neurotransmitters, neuropeptides and hormones. Here, we provide an overview of the synaptotagmin family, and review the recent mouse genetic studies aimed at understanding the functions of synaptotagmins in neurotransmission and endocrine-hormone secretion. Also, we discuss potential roles of synaptotagmins in non-traditional endocrine systems.

AB - Neurotransmitters, neuropeptides and hormones are released through the regulated exocytosis of SVs (synaptic vesicles) and LDCVs (large dense-core vesicles), a process that is controlled by calcium. Synaptotagmins are a family of type 1 membrane proteins that share a common domain structure. Most synaptotagmins are located in brain and endocrine cells, and some of these synaptotagmins bind to phospholipids and calcium at levels that trigger regulated exocytosis of SVs and LDCVs. This led to the proposed synaptotagmin-calcium-sensor paradigm, that is, members of the synaptotagmin family function as calcium sensors for the regulated exocytosis of neurotransmitters, neuropeptides and hormones. Here, we provide an overview of the synaptotagmin family, and review the recent mouse genetic studies aimed at understanding the functions of synaptotagmins in neurotransmission and endocrine-hormone secretion. Also, we discuss potential roles of synaptotagmins in non-traditional endocrine systems.

KW - Animals

KW - Calcium

KW - Endocrine System

KW - Exocytosis

KW - Mice

KW - Neurosecretory Systems

KW - Neurotransmitter Agents

KW - Synaptotagmins

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1042/BSR20090031

DO - 10.1042/BSR20090031

M3 - Journal article

C2 - 19500075

VL - 29

SP - 245

EP - 259

JO - Bioscience Reports

JF - Bioscience Reports

SN - 0144-8463

IS - 4

ER -

ID: 172513234