Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity
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Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity. / Zhang, Guojie; Cowled, Christopher; Shi, Zhengli; Huang, Zhiyong; Bishop-Lilly, Kimberly A.; Fang, Xiaodong; Wynne, James W.; Xiong, Zhiqiang; Baker, Michelle L.; Zhao, Wei; Tachedjian, Mary; Zhu, Yabing; Zhou, Peng; Jiang, Xuanting; Ng, Justin; Yang, Lan; Wu, Lijun; Xiao, Jin; Feng, Yue; Chen, Yuanxin; Sun, Xiaoqing; Zhang, Yong; Marsh, Glenn A.; Crameri, Gary; Broder, Christopher C.; Frey, Kenneth G.; Wang, Lin-Fa; Wang, Jun.
In: Science (New York, N.Y.), Vol. 339, No. 6118, 2013.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity
AU - Zhang, Guojie
AU - Cowled, Christopher
AU - Shi, Zhengli
AU - Huang, Zhiyong
AU - Bishop-Lilly, Kimberly A.
AU - Fang, Xiaodong
AU - Wynne, James W.
AU - Xiong, Zhiqiang
AU - Baker, Michelle L.
AU - Zhao, Wei
AU - Tachedjian, Mary
AU - Zhu, Yabing
AU - Zhou, Peng
AU - Jiang, Xuanting
AU - Ng, Justin
AU - Yang, Lan
AU - Wu, Lijun
AU - Xiao, Jin
AU - Feng, Yue
AU - Chen, Yuanxin
AU - Sun, Xiaoqing
AU - Zhang, Yong
AU - Marsh, Glenn A.
AU - Crameri, Gary
AU - Broder, Christopher C.
AU - Frey, Kenneth G.
AU - Wang, Lin-Fa
AU - Wang, Jun
PY - 2013
Y1 - 2013
N2 - Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related bat species, fruit bat Pteropus alecto and insectivorous Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor-¿B pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution.
AB - Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related bat species, fruit bat Pteropus alecto and insectivorous Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor-¿B pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution.
U2 - 10.1126/science.1230835
DO - 10.1126/science.1230835
M3 - Journal article
C2 - 23258410
VL - 339
JO - Science
JF - Science
SN - 0036-8075
IS - 6118
ER -
ID: 43544019