Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health. / Bui, Thi Phuong Nam; Mannerås-Holm, Louise; Puschmann, Robert; Wu, Hao; Troise, Antonio Dario; Nijsse, Bart; Boeren, Sjef; Bäckhed, Fredrik; Fiedler, Dorothea; deVos, Willem M.

In: Nature Communications, Vol. 12, No. 1, 4798, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bui, TPN, Mannerås-Holm, L, Puschmann, R, Wu, H, Troise, AD, Nijsse, B, Boeren, S, Bäckhed, F, Fiedler, D & deVos, WM 2021, 'Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health', Nature Communications, vol. 12, no. 1, 4798. https://doi.org/10.1038/s41467-021-25081-w

APA

Bui, T. P. N., Mannerås-Holm, L., Puschmann, R., Wu, H., Troise, A. D., Nijsse, B., Boeren, S., Bäckhed, F., Fiedler, D., & deVos, W. M. (2021). Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health. Nature Communications, 12(1), [4798]. https://doi.org/10.1038/s41467-021-25081-w

Vancouver

Bui TPN, Mannerås-Holm L, Puschmann R, Wu H, Troise AD, Nijsse B et al. Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health. Nature Communications. 2021;12(1). 4798. https://doi.org/10.1038/s41467-021-25081-w

Author

Bui, Thi Phuong Nam ; Mannerås-Holm, Louise ; Puschmann, Robert ; Wu, Hao ; Troise, Antonio Dario ; Nijsse, Bart ; Boeren, Sjef ; Bäckhed, Fredrik ; Fiedler, Dorothea ; deVos, Willem M. / Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health. In: Nature Communications. 2021 ; Vol. 12, No. 1.

Bibtex

@article{8dff32bbad1a4aef887941418084a9d5,
title = "Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health",
abstract = "We describe the anaerobic conversion of inositol stereoisomers to propionate and acetate by the abundant intestinal genus Anaerostipes. A inositol pathway was elucidated by nuclear magnetic resonance using [13C]-inositols, mass spectrometry and proteogenomic analyses in A. rhamnosivorans, identifying 3-oxoacid CoA transferase as a key enzyme involved in both 3-oxopropionyl-CoA and propionate formation. This pathway also allowed conversion of phytate-derived inositol into propionate as shown with [13C]-phytate in fecal samples amended with A. rhamnosivorans. Metabolic and (meta)genomic analyses explained the adaptation of Anaerostipes spp. to inositol-containing substrates and identified a propionate-production gene cluster to be inversely associated with metabolic biomarkers in (pre)diabetes cohorts. Co-administration of myo-inositol with live A. rhamnosivorans in western-diet fed mice reduced fasting-glucose levels comparing to heat-killed A. rhamnosivorans after 6-weeks treatment. Altogether, these data suggest a potential beneficial role for intestinal Anaerostipes spp. in promoting host health.",
author = "Bui, {Thi Phuong Nam} and Louise Manner{\aa}s-Holm and Robert Puschmann and Hao Wu and Troise, {Antonio Dario} and Bart Nijsse and Sjef Boeren and Fredrik B{\"a}ckhed and Dorothea Fiedler and deVos, {Willem M.}",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2021",
doi = "10.1038/s41467-021-25081-w",
language = "English",
volume = "12",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health

AU - Bui, Thi Phuong Nam

AU - Mannerås-Holm, Louise

AU - Puschmann, Robert

AU - Wu, Hao

AU - Troise, Antonio Dario

AU - Nijsse, Bart

AU - Boeren, Sjef

AU - Bäckhed, Fredrik

AU - Fiedler, Dorothea

AU - deVos, Willem M.

N1 - Publisher Copyright: © 2021, The Author(s).

PY - 2021

Y1 - 2021

N2 - We describe the anaerobic conversion of inositol stereoisomers to propionate and acetate by the abundant intestinal genus Anaerostipes. A inositol pathway was elucidated by nuclear magnetic resonance using [13C]-inositols, mass spectrometry and proteogenomic analyses in A. rhamnosivorans, identifying 3-oxoacid CoA transferase as a key enzyme involved in both 3-oxopropionyl-CoA and propionate formation. This pathway also allowed conversion of phytate-derived inositol into propionate as shown with [13C]-phytate in fecal samples amended with A. rhamnosivorans. Metabolic and (meta)genomic analyses explained the adaptation of Anaerostipes spp. to inositol-containing substrates and identified a propionate-production gene cluster to be inversely associated with metabolic biomarkers in (pre)diabetes cohorts. Co-administration of myo-inositol with live A. rhamnosivorans in western-diet fed mice reduced fasting-glucose levels comparing to heat-killed A. rhamnosivorans after 6-weeks treatment. Altogether, these data suggest a potential beneficial role for intestinal Anaerostipes spp. in promoting host health.

AB - We describe the anaerobic conversion of inositol stereoisomers to propionate and acetate by the abundant intestinal genus Anaerostipes. A inositol pathway was elucidated by nuclear magnetic resonance using [13C]-inositols, mass spectrometry and proteogenomic analyses in A. rhamnosivorans, identifying 3-oxoacid CoA transferase as a key enzyme involved in both 3-oxopropionyl-CoA and propionate formation. This pathway also allowed conversion of phytate-derived inositol into propionate as shown with [13C]-phytate in fecal samples amended with A. rhamnosivorans. Metabolic and (meta)genomic analyses explained the adaptation of Anaerostipes spp. to inositol-containing substrates and identified a propionate-production gene cluster to be inversely associated with metabolic biomarkers in (pre)diabetes cohorts. Co-administration of myo-inositol with live A. rhamnosivorans in western-diet fed mice reduced fasting-glucose levels comparing to heat-killed A. rhamnosivorans after 6-weeks treatment. Altogether, these data suggest a potential beneficial role for intestinal Anaerostipes spp. in promoting host health.

U2 - 10.1038/s41467-021-25081-w

DO - 10.1038/s41467-021-25081-w

M3 - Journal article

C2 - 34376656

AN - SCOPUS:85112085987

VL - 12

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 4798

ER -

ID: 276655143