Defects in α-Cell Function in Patients With Diabetes Due to Chronic Pancreatitis Compared With Patients With Type 2 Diabetes and Healthy Individuals

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Defects in α-Cell Function in Patients With Diabetes Due to Chronic Pancreatitis Compared With Patients With Type 2 Diabetes and Healthy Individuals. / Mumme, Lena; Breuer, Thomas G K; Rohrer, Stephan; Schenker, Nina; Menge, Björn A; Holst, Jens J; Nauck, Michael A; Meier, Juris J.

In: Diabetes Care, Vol. 40, No. 10, 10.2017, p. 1314-1322.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Mumme, L, Breuer, TGK, Rohrer, S, Schenker, N, Menge, BA, Holst, JJ, Nauck, MA & Meier, JJ 2017, 'Defects in α-Cell Function in Patients With Diabetes Due to Chronic Pancreatitis Compared With Patients With Type 2 Diabetes and Healthy Individuals', Diabetes Care, vol. 40, no. 10, pp. 1314-1322. https://doi.org/10.2337/dc17-0792

APA

Mumme, L., Breuer, T. G. K., Rohrer, S., Schenker, N., Menge, B. A., Holst, J. J., Nauck, M. A., & Meier, J. J. (2017). Defects in α-Cell Function in Patients With Diabetes Due to Chronic Pancreatitis Compared With Patients With Type 2 Diabetes and Healthy Individuals. Diabetes Care, 40(10), 1314-1322. https://doi.org/10.2337/dc17-0792

Vancouver

Mumme L, Breuer TGK, Rohrer S, Schenker N, Menge BA, Holst JJ et al. Defects in α-Cell Function in Patients With Diabetes Due to Chronic Pancreatitis Compared With Patients With Type 2 Diabetes and Healthy Individuals. Diabetes Care. 2017 Oct;40(10):1314-1322. https://doi.org/10.2337/dc17-0792

Author

Mumme, Lena ; Breuer, Thomas G K ; Rohrer, Stephan ; Schenker, Nina ; Menge, Björn A ; Holst, Jens J ; Nauck, Michael A ; Meier, Juris J. / Defects in α-Cell Function in Patients With Diabetes Due to Chronic Pancreatitis Compared With Patients With Type 2 Diabetes and Healthy Individuals. In: Diabetes Care. 2017 ; Vol. 40, No. 10. pp. 1314-1322.

Bibtex

@article{eeab1ddaa16249d5bd8631f1d60d1413,
title = "Defects in α-Cell Function in Patients With Diabetes Due to Chronic Pancreatitis Compared With Patients With Type 2 Diabetes and Healthy Individuals",
abstract = "OBJECTIVE: Diabetes frequently develops in patients with chronic pancreatitis. We examined the alterations in the glucagon response to hypoglycemia and to oral glucose administration in patients with diabetes due to chronic pancreatitis.RESEARCH DESIGN AND METHODS: Ten patients with diabetes secondary to chronic pancreatitis were compared with 13 patients with type 2 diabetes and 10 healthy control subjects. A stepwise hypoglycemic clamp and an oral glucose tolerance test (OGTT) were performed.RESULTS: Glucose levels during the OGTT were higher in patients with diabetes and chronic pancreatitis and lower in control subjects (P< 0.0001). Insulin and C-peptide levels were reduced, and the glucose-induced suppression of glucagon was impaired in both groups with diabetes (allP< 0.0001 vs. control subjects). During hypoglycemia, glucagon concentrations were reduced in patients with chronic pancreatitis and with type 2 diabetes (P< 0.05). The increase in glucagon during the clamp was inversely related to the glucose-induced glucagon suppression and positively related to β-cell function. Growth hormone responses to hypoglycemia were lower in patients with type 2 diabetes (P= 0.0002) but not in patients with chronic pancreatitis.CONCLUSIONS: α-Cell responses to oral glucose ingestion and to hypoglycemia are disturbed in patients with diabetes and chronic pancreatitis and in patients with type 2 diabetes. The similarities between these defects suggest a common etiology.",
author = "Lena Mumme and Breuer, {Thomas G K} and Stephan Rohrer and Nina Schenker and Menge, {Bj{\"o}rn A} and Holst, {Jens J} and Nauck, {Michael A} and Meier, {Juris J}",
note = "{\textcopyright} 2017 by the American Diabetes Association.",
year = "2017",
month = oct,
doi = "10.2337/dc17-0792",
language = "English",
volume = "40",
pages = "1314--1322",
journal = "Diabetes Care",
issn = "0149-5992",
publisher = "American Diabetes Association",
number = "10",

}

RIS

TY - JOUR

T1 - Defects in α-Cell Function in Patients With Diabetes Due to Chronic Pancreatitis Compared With Patients With Type 2 Diabetes and Healthy Individuals

AU - Mumme, Lena

AU - Breuer, Thomas G K

AU - Rohrer, Stephan

AU - Schenker, Nina

AU - Menge, Björn A

AU - Holst, Jens J

AU - Nauck, Michael A

AU - Meier, Juris J

N1 - © 2017 by the American Diabetes Association.

PY - 2017/10

Y1 - 2017/10

N2 - OBJECTIVE: Diabetes frequently develops in patients with chronic pancreatitis. We examined the alterations in the glucagon response to hypoglycemia and to oral glucose administration in patients with diabetes due to chronic pancreatitis.RESEARCH DESIGN AND METHODS: Ten patients with diabetes secondary to chronic pancreatitis were compared with 13 patients with type 2 diabetes and 10 healthy control subjects. A stepwise hypoglycemic clamp and an oral glucose tolerance test (OGTT) were performed.RESULTS: Glucose levels during the OGTT were higher in patients with diabetes and chronic pancreatitis and lower in control subjects (P< 0.0001). Insulin and C-peptide levels were reduced, and the glucose-induced suppression of glucagon was impaired in both groups with diabetes (allP< 0.0001 vs. control subjects). During hypoglycemia, glucagon concentrations were reduced in patients with chronic pancreatitis and with type 2 diabetes (P< 0.05). The increase in glucagon during the clamp was inversely related to the glucose-induced glucagon suppression and positively related to β-cell function. Growth hormone responses to hypoglycemia were lower in patients with type 2 diabetes (P= 0.0002) but not in patients with chronic pancreatitis.CONCLUSIONS: α-Cell responses to oral glucose ingestion and to hypoglycemia are disturbed in patients with diabetes and chronic pancreatitis and in patients with type 2 diabetes. The similarities between these defects suggest a common etiology.

AB - OBJECTIVE: Diabetes frequently develops in patients with chronic pancreatitis. We examined the alterations in the glucagon response to hypoglycemia and to oral glucose administration in patients with diabetes due to chronic pancreatitis.RESEARCH DESIGN AND METHODS: Ten patients with diabetes secondary to chronic pancreatitis were compared with 13 patients with type 2 diabetes and 10 healthy control subjects. A stepwise hypoglycemic clamp and an oral glucose tolerance test (OGTT) were performed.RESULTS: Glucose levels during the OGTT were higher in patients with diabetes and chronic pancreatitis and lower in control subjects (P< 0.0001). Insulin and C-peptide levels were reduced, and the glucose-induced suppression of glucagon was impaired in both groups with diabetes (allP< 0.0001 vs. control subjects). During hypoglycemia, glucagon concentrations were reduced in patients with chronic pancreatitis and with type 2 diabetes (P< 0.05). The increase in glucagon during the clamp was inversely related to the glucose-induced glucagon suppression and positively related to β-cell function. Growth hormone responses to hypoglycemia were lower in patients with type 2 diabetes (P= 0.0002) but not in patients with chronic pancreatitis.CONCLUSIONS: α-Cell responses to oral glucose ingestion and to hypoglycemia are disturbed in patients with diabetes and chronic pancreatitis and in patients with type 2 diabetes. The similarities between these defects suggest a common etiology.

U2 - 10.2337/dc17-0792

DO - 10.2337/dc17-0792

M3 - Journal article

C2 - 28751547

VL - 40

SP - 1314

EP - 1322

JO - Diabetes Care

JF - Diabetes Care

SN - 0149-5992

IS - 10

ER -

ID: 191386451