Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella. / Kovatcheva-Datchary, Petia; Nilsson, Anne; Akrami, Rozita; Lee, Ying Shiuan; De Vadder, Filipe; Arora, Tulika; Hallen, Anna; Martens, Eric; Björck, Inger; Bäckhed, Gert Fredrik.

In: Cell Metabolism, Vol. 22, No. 6, 01.12.2015, p. 971-82.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kovatcheva-Datchary, P, Nilsson, A, Akrami, R, Lee, YS, De Vadder, F, Arora, T, Hallen, A, Martens, E, Björck, I & Bäckhed, GF 2015, 'Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella', Cell Metabolism, vol. 22, no. 6, pp. 971-82. https://doi.org/10.1016/j.cmet.2015.10.001

APA

Kovatcheva-Datchary, P., Nilsson, A., Akrami, R., Lee, Y. S., De Vadder, F., Arora, T., Hallen, A., Martens, E., Björck, I., & Bäckhed, G. F. (2015). Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella. Cell Metabolism, 22(6), 971-82. https://doi.org/10.1016/j.cmet.2015.10.001

Vancouver

Kovatcheva-Datchary P, Nilsson A, Akrami R, Lee YS, De Vadder F, Arora T et al. Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella. Cell Metabolism. 2015 Dec 1;22(6):971-82. https://doi.org/10.1016/j.cmet.2015.10.001

Author

Kovatcheva-Datchary, Petia ; Nilsson, Anne ; Akrami, Rozita ; Lee, Ying Shiuan ; De Vadder, Filipe ; Arora, Tulika ; Hallen, Anna ; Martens, Eric ; Björck, Inger ; Bäckhed, Gert Fredrik. / Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella. In: Cell Metabolism. 2015 ; Vol. 22, No. 6. pp. 971-82.

Bibtex

@article{15e57e9494204f9597086d74e5e0d652,
title = "Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella",
abstract = "The gut microbiota plays an important role in human health by interacting with host diet, but there is substantial inter-individual variation in the response to diet. Here we compared the gut microbiota composition of healthy subjects who exhibited improved glucose metabolism following 3-day consumption of barley kernel-based bread (BKB) with those who responded least to this dietary intervention. The Prevotella/Bacteroides ratio was higher in responders than non-responders after BKB. Metagenomic analysis showed that the gut microbiota of responders was enriched in Prevotella copri and had increased potential to ferment complex polysaccharides after BKB. Finally, germ-free mice transplanted with microbiota from responder human donors exhibited improved glucose metabolism and increased abundance of Prevotella and liver glycogen content compared with germ-free mice that received non-responder microbiota. Our findings indicate that Prevotella plays a role in the BKB-induced improvement in glucose metabolism observed in certain individuals, potentially by promoting increased glycogen storage.",
author = "Petia Kovatcheva-Datchary and Anne Nilsson and Rozita Akrami and Lee, {Ying Shiuan} and {De Vadder}, Filipe and Tulika Arora and Anna Hallen and Eric Martens and Inger Bj{\"o}rck and B{\"a}ckhed, {Gert Fredrik}",
note = "Copyright {\textcopyright} 2015 Elsevier Inc. All rights reserved.",
year = "2015",
month = dec,
day = "1",
doi = "10.1016/j.cmet.2015.10.001",
language = "English",
volume = "22",
pages = "971--82",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella

AU - Kovatcheva-Datchary, Petia

AU - Nilsson, Anne

AU - Akrami, Rozita

AU - Lee, Ying Shiuan

AU - De Vadder, Filipe

AU - Arora, Tulika

AU - Hallen, Anna

AU - Martens, Eric

AU - Björck, Inger

AU - Bäckhed, Gert Fredrik

N1 - Copyright © 2015 Elsevier Inc. All rights reserved.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - The gut microbiota plays an important role in human health by interacting with host diet, but there is substantial inter-individual variation in the response to diet. Here we compared the gut microbiota composition of healthy subjects who exhibited improved glucose metabolism following 3-day consumption of barley kernel-based bread (BKB) with those who responded least to this dietary intervention. The Prevotella/Bacteroides ratio was higher in responders than non-responders after BKB. Metagenomic analysis showed that the gut microbiota of responders was enriched in Prevotella copri and had increased potential to ferment complex polysaccharides after BKB. Finally, germ-free mice transplanted with microbiota from responder human donors exhibited improved glucose metabolism and increased abundance of Prevotella and liver glycogen content compared with germ-free mice that received non-responder microbiota. Our findings indicate that Prevotella plays a role in the BKB-induced improvement in glucose metabolism observed in certain individuals, potentially by promoting increased glycogen storage.

AB - The gut microbiota plays an important role in human health by interacting with host diet, but there is substantial inter-individual variation in the response to diet. Here we compared the gut microbiota composition of healthy subjects who exhibited improved glucose metabolism following 3-day consumption of barley kernel-based bread (BKB) with those who responded least to this dietary intervention. The Prevotella/Bacteroides ratio was higher in responders than non-responders after BKB. Metagenomic analysis showed that the gut microbiota of responders was enriched in Prevotella copri and had increased potential to ferment complex polysaccharides after BKB. Finally, germ-free mice transplanted with microbiota from responder human donors exhibited improved glucose metabolism and increased abundance of Prevotella and liver glycogen content compared with germ-free mice that received non-responder microbiota. Our findings indicate that Prevotella plays a role in the BKB-induced improvement in glucose metabolism observed in certain individuals, potentially by promoting increased glycogen storage.

U2 - 10.1016/j.cmet.2015.10.001

DO - 10.1016/j.cmet.2015.10.001

M3 - Journal article

C2 - 26552345

VL - 22

SP - 971

EP - 982

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 6

ER -

ID: 150712409