Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

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Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals. / Winkler, Thomas W.; Rasheed, Humaira; Teumer, Alexander; Gorski, Mathias; Rowan, Bryce X; Stanzick, Kira J; Thomas, Laurent F; Tin, Adrienne; Hoppmann, Anselm; Chu, Audrey Y; Tayo, Bamidele; Thio, Chris H L; Cusi, Daniele; Chai, Jin-Fang; Sieber, Karsten B; Horn, Katrin; Li, Man; Scholz, Markus; Cocca, Massimiliano; Wuttke, Matthias; van der Most, Peter J; Yang, Qiong; Ghasemi, Sahar; Nutile, Teresa; Li, Yong; Pontali, Giulia; Günther, Felix; Dehghan, Abbas; Correa, Adolfo; Parsa, Afshin; Feresin, Agnese; de Vries, Aiko P J; Zonderman, Alan B; Smith, Albert V; Oldehinkel, Albertine J; De Grandi, Alessandro; Rosenkranz, Alexander R; Franke, Andre; Teren, Andrej; Metspalu, Andres; Hicks, Andrew A; Morris, Andrew P; Tönjes, Anke; Morgan, Anna; Podgornaia, Anna I; Christensen, Kaare; Lind, Lars; Kovacs, Peter; Rossing, Peter; Loos, Ruth J.F.; LifeLines Cohort Study.

In: Communications Biology , Vol. 5, 2022, p. 580.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Winkler, TW, Rasheed, H, Teumer, A, Gorski, M, Rowan, BX, Stanzick, KJ, Thomas, LF, Tin, A, Hoppmann, A, Chu, AY, Tayo, B, Thio, CHL, Cusi, D, Chai, J-F, Sieber, KB, Horn, K, Li, M, Scholz, M, Cocca, M, Wuttke, M, van der Most, PJ, Yang, Q, Ghasemi, S, Nutile, T, Li, Y, Pontali, G, Günther, F, Dehghan, A, Correa, A, Parsa, A, Feresin, A, de Vries, APJ, Zonderman, AB, Smith, AV, Oldehinkel, AJ, De Grandi, A, Rosenkranz, AR, Franke, A, Teren, A, Metspalu, A, Hicks, AA, Morris, AP, Tönjes, A, Morgan, A, Podgornaia, AI, Christensen, K, Lind, L, Kovacs, P, Rossing, P, Loos, RJF & LifeLines Cohort Study 2022, 'Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals', Communications Biology , vol. 5, pp. 580. https://doi.org/10.1038/s42003-022-03448-z

APA

Winkler, T. W., Rasheed, H., Teumer, A., Gorski, M., Rowan, B. X., Stanzick, K. J., Thomas, L. F., Tin, A., Hoppmann, A., Chu, A. Y., Tayo, B., Thio, C. H. L., Cusi, D., Chai, J-F., Sieber, K. B., Horn, K., Li, M., Scholz, M., Cocca, M., ... LifeLines Cohort Study (2022). Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals. Communications Biology , 5, 580. https://doi.org/10.1038/s42003-022-03448-z

Vancouver

Winkler TW, Rasheed H, Teumer A, Gorski M, Rowan BX, Stanzick KJ et al. Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals. Communications Biology . 2022;5:580. https://doi.org/10.1038/s42003-022-03448-z

Author

Winkler, Thomas W. ; Rasheed, Humaira ; Teumer, Alexander ; Gorski, Mathias ; Rowan, Bryce X ; Stanzick, Kira J ; Thomas, Laurent F ; Tin, Adrienne ; Hoppmann, Anselm ; Chu, Audrey Y ; Tayo, Bamidele ; Thio, Chris H L ; Cusi, Daniele ; Chai, Jin-Fang ; Sieber, Karsten B ; Horn, Katrin ; Li, Man ; Scholz, Markus ; Cocca, Massimiliano ; Wuttke, Matthias ; van der Most, Peter J ; Yang, Qiong ; Ghasemi, Sahar ; Nutile, Teresa ; Li, Yong ; Pontali, Giulia ; Günther, Felix ; Dehghan, Abbas ; Correa, Adolfo ; Parsa, Afshin ; Feresin, Agnese ; de Vries, Aiko P J ; Zonderman, Alan B ; Smith, Albert V ; Oldehinkel, Albertine J ; De Grandi, Alessandro ; Rosenkranz, Alexander R ; Franke, Andre ; Teren, Andrej ; Metspalu, Andres ; Hicks, Andrew A ; Morris, Andrew P ; Tönjes, Anke ; Morgan, Anna ; Podgornaia, Anna I ; Christensen, Kaare ; Lind, Lars ; Kovacs, Peter ; Rossing, Peter ; Loos, Ruth J.F. ; LifeLines Cohort Study. / Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals. In: Communications Biology . 2022 ; Vol. 5. pp. 580.

Bibtex

@article{238d4ce35b8e4649b18186d0d27faff5,
title = "Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals",
abstract = "Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (nDM = 178,691, nnoDM = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.",
keywords = "Creatinine, Diabetes Mellitus, Diabetic Nephropathies/genetics, Genome-Wide Association Study, Glomerular Filtration Rate/genetics, Humans, Kidney",
author = "Winkler, {Thomas W.} and Humaira Rasheed and Alexander Teumer and Mathias Gorski and Rowan, {Bryce X} and Stanzick, {Kira J} and Thomas, {Laurent F} and Adrienne Tin and Anselm Hoppmann and Chu, {Audrey Y} and Bamidele Tayo and Thio, {Chris H L} and Daniele Cusi and Jin-Fang Chai and Sieber, {Karsten B} and Katrin Horn and Man Li and Markus Scholz and Massimiliano Cocca and Matthias Wuttke and {van der Most}, {Peter J} and Qiong Yang and Sahar Ghasemi and Teresa Nutile and Yong Li and Giulia Pontali and Felix G{\"u}nther and Abbas Dehghan and Adolfo Correa and Afshin Parsa and Agnese Feresin and {de Vries}, {Aiko P J} and Zonderman, {Alan B} and Smith, {Albert V} and Oldehinkel, {Albertine J} and {De Grandi}, Alessandro and Rosenkranz, {Alexander R} and Andre Franke and Andrej Teren and Andres Metspalu and Hicks, {Andrew A} and Morris, {Andrew P} and Anke T{\"o}njes and Anna Morgan and Podgornaia, {Anna I} and Kaare Christensen and Lars Lind and Peter Kovacs and Peter Rossing and Loos, {Ruth J.F.} and {LifeLines Cohort Study}",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
doi = "10.1038/s42003-022-03448-z",
language = "English",
volume = "5",
pages = "580",
journal = "Communications Biology",
issn = "2399-3642",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

AU - Winkler, Thomas W.

AU - Rasheed, Humaira

AU - Teumer, Alexander

AU - Gorski, Mathias

AU - Rowan, Bryce X

AU - Stanzick, Kira J

AU - Thomas, Laurent F

AU - Tin, Adrienne

AU - Hoppmann, Anselm

AU - Chu, Audrey Y

AU - Tayo, Bamidele

AU - Thio, Chris H L

AU - Cusi, Daniele

AU - Chai, Jin-Fang

AU - Sieber, Karsten B

AU - Horn, Katrin

AU - Li, Man

AU - Scholz, Markus

AU - Cocca, Massimiliano

AU - Wuttke, Matthias

AU - van der Most, Peter J

AU - Yang, Qiong

AU - Ghasemi, Sahar

AU - Nutile, Teresa

AU - Li, Yong

AU - Pontali, Giulia

AU - Günther, Felix

AU - Dehghan, Abbas

AU - Correa, Adolfo

AU - Parsa, Afshin

AU - Feresin, Agnese

AU - de Vries, Aiko P J

AU - Zonderman, Alan B

AU - Smith, Albert V

AU - Oldehinkel, Albertine J

AU - De Grandi, Alessandro

AU - Rosenkranz, Alexander R

AU - Franke, Andre

AU - Teren, Andrej

AU - Metspalu, Andres

AU - Hicks, Andrew A

AU - Morris, Andrew P

AU - Tönjes, Anke

AU - Morgan, Anna

AU - Podgornaia, Anna I

AU - Christensen, Kaare

AU - Lind, Lars

AU - Kovacs, Peter

AU - Rossing, Peter

AU - Loos, Ruth J.F.

AU - LifeLines Cohort Study

N1 - © 2022. The Author(s).

PY - 2022

Y1 - 2022

N2 - Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (nDM = 178,691, nnoDM = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.

AB - Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (nDM = 178,691, nnoDM = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.

KW - Creatinine

KW - Diabetes Mellitus

KW - Diabetic Nephropathies/genetics

KW - Genome-Wide Association Study

KW - Glomerular Filtration Rate/genetics

KW - Humans

KW - Kidney

U2 - 10.1038/s42003-022-03448-z

DO - 10.1038/s42003-022-03448-z

M3 - Journal article

C2 - 35697829

VL - 5

SP - 580

JO - Communications Biology

JF - Communications Biology

SN - 2399-3642

ER -

ID: 311338757