Discovery and uses of pegvisomant: A growth hormone antagonist

Research output: Contribution to journal › Review › Research › peer-review

Standard

Discovery and uses of pegvisomant : A growth hormone antagonist. / Berryman, Darlene E.; Palmer, Amanda J.; Gosney, Elahu S.; Swaminathan, Svetha; DeSantis, Dave; Kopchick, John J.

In: Endokrynologia Polska, Vol. 58, No. 4, 01.12.2007, p. 322-329.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Berryman, DE, Palmer, AJ, Gosney, ES, Swaminathan, S, DeSantis, D & Kopchick, JJ 2007, 'Discovery and uses of pegvisomant: A growth hormone antagonist', Endokrynologia Polska, vol. 58, no. 4, pp. 322-329.

APA

Berryman, D. E., Palmer, A. J., Gosney, E. S., Swaminathan, S., DeSantis, D., & Kopchick, J. J. (2007). Discovery and uses of pegvisomant: A growth hormone antagonist. Endokrynologia Polska, 58(4), 322-329.

Vancouver

Berryman DE, Palmer AJ, Gosney ES, Swaminathan S, DeSantis D, Kopchick JJ. Discovery and uses of pegvisomant: A growth hormone antagonist. Endokrynologia Polska. 2007 Dec 1;58(4):322-329.

Author

Berryman, Darlene E. ; Palmer, Amanda J. ; Gosney, Elahu S. ; Swaminathan, Svetha ; DeSantis, Dave ; Kopchick, John J. / Discovery and uses of pegvisomant : A growth hormone antagonist. In: Endokrynologia Polska. 2007 ; Vol. 58, No. 4. pp. 322-329.

Bibtex

@article{1451435090b74198921a6ea353d3aac4,
title = "Discovery and uses of pegvisomant: A growth hormone antagonist",
abstract = "Growth hormone (GH) is a well established participant in several complex physiological processes including growth, differentiation, and metabolism. Recombinant human GH is a drug that has been approved for use for several clinical conditions where the action of GH is diminished or completely lacking. Thus there is considerable interest in developing novel drugs that modify the function of GH. Only in the last several decades have the detailed structural features of GH along with its interaction with its receptor been elucidated. In this review we summarise the basic structural and functional properties of GH, its receptor and their interaction. In addition, we discuss the discovery and development of an effective GH receptor antagonist, pegvisomant, and summarise potential therapeutic uses of this drug.",
keywords = "Growth hormone, Growth hormone receptor, Growth hormone receptor antagonist",
author = "Berryman, {Darlene E.} and Palmer, {Amanda J.} and Gosney, {Elahu S.} and Svetha Swaminathan and Dave DeSantis and Kopchick, {John J.}",
year = "2007",
month = dec,
day = "1",
language = "English",
volume = "58",
pages = "322--329",
journal = "Endokrynologia Polska",
issn = "0423-104X",
publisher = "Via Medica",
number = "4",

}

RIS

TY - JOUR

T1 - Discovery and uses of pegvisomant

T2 - A growth hormone antagonist

AU - Berryman, Darlene E.

AU - Palmer, Amanda J.

AU - Gosney, Elahu S.

AU - Swaminathan, Svetha

AU - DeSantis, Dave

AU - Kopchick, John J.

PY - 2007/12/1

Y1 - 2007/12/1

N2 - Growth hormone (GH) is a well established participant in several complex physiological processes including growth, differentiation, and metabolism. Recombinant human GH is a drug that has been approved for use for several clinical conditions where the action of GH is diminished or completely lacking. Thus there is considerable interest in developing novel drugs that modify the function of GH. Only in the last several decades have the detailed structural features of GH along with its interaction with its receptor been elucidated. In this review we summarise the basic structural and functional properties of GH, its receptor and their interaction. In addition, we discuss the discovery and development of an effective GH receptor antagonist, pegvisomant, and summarise potential therapeutic uses of this drug.

AB - Growth hormone (GH) is a well established participant in several complex physiological processes including growth, differentiation, and metabolism. Recombinant human GH is a drug that has been approved for use for several clinical conditions where the action of GH is diminished or completely lacking. Thus there is considerable interest in developing novel drugs that modify the function of GH. Only in the last several decades have the detailed structural features of GH along with its interaction with its receptor been elucidated. In this review we summarise the basic structural and functional properties of GH, its receptor and their interaction. In addition, we discuss the discovery and development of an effective GH receptor antagonist, pegvisomant, and summarise potential therapeutic uses of this drug.

KW - Growth hormone

KW - Growth hormone receptor

KW - Growth hormone receptor antagonist

UR - http://www.scopus.com/inward/record.url?scp=38449118318&partnerID=8YFLogxK

M3 - Review

C2 - 18058724

AN - SCOPUS:38449118318

VL - 58

SP - 322

EP - 329

JO - Endokrynologia Polska

JF - Endokrynologia Polska

SN - 0423-104X

IS - 4

ER -

ID: 202371937