Discovery and uses of pegvisomant: A growth hormone antagonist

Research output: Contribution to journalReviewResearchpeer-review

  • Darlene E. Berryman
  • Amanda J. Palmer
  • Elahu S. Gosney
  • Svetha Swaminathan
  • Dave DeSantis
  • John J. Kopchick

Growth hormone (GH) is a well established participant in several complex physiological processes including growth, differentiation, and metabolism. Recombinant human GH is a drug that has been approved for use for several clinical conditions where the action of GH is diminished or completely lacking. Thus there is considerable interest in developing novel drugs that modify the function of GH. Only in the last several decades have the detailed structural features of GH along with its interaction with its receptor been elucidated. In this review we summarise the basic structural and functional properties of GH, its receptor and their interaction. In addition, we discuss the discovery and development of an effective GH receptor antagonist, pegvisomant, and summarise potential therapeutic uses of this drug.

Original languageEnglish
JournalEndokrynologia Polska
Volume58
Issue number4
Pages (from-to)322-329
Number of pages8
ISSN0423-104X
Publication statusPublished - 1 Dec 2007

    Research areas

  • Growth hormone, Growth hormone receptor, Growth hormone receptor antagonist

ID: 202371937