TY - JOUR

T1 - Effects of delayed-release olive oil and hydrolyzed pine nut oil on glucose tolerance, incretin secretion and appetite in humans

AU - Sørensen, Karina V.

AU - Kaspersen, Mads H.

AU - Ekberg, Jeppe H.

AU - Bauer-Brandl, Annette

AU - Ulven, Trond

AU - Højlund, Kurt

N1 - Funding Information: This research was funded by the Danish Research Council for Strategic Research (grant 11-116196) and Innovation Fund Denmark (grant 0603-00452B). In addition, Odense University Hospital, the Region of Southern Denmark, the University of Southern Denmark (SDU2020) and the Ingemann O. Bucks fund supplied financial support.We thank Lone Hansen and Charlotte B?tchi?r Olsen for technical assistance. The study was a part of the FFARMED project lead by Professor Trond Ulven (http://ffarmed.dk/, 27.09.21). We thank the entire project group for valuable inputs and discussions throughout the process. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021

Y1 - 2021

N2 - Background: To investigate the potential synergistic effects of olive oil releasing 2oleoylglycerol and hydrolyzed pine nut oil containing 20% pinolenic acid on GLP-1 secretion, glucose tolerance, insulin secretion and appetite in healthy individuals, when delivered to the small intestine as potential agonists of GPR119, FFA1 and FFA4. Methods: Nine overweight/obese individuals completed three 6-h oral glucose tolerance tests (OGTTs) in a crossover design. At-30 min, participants consumed either: no oil, 6 g of hydrolyzed pine nut oil (PNO-FFA), or a combination of 3 g hydrolyzed pine nut oil and 3 g olive oil (PNO-OO) in delayed-release capsules. Repeated measures of glucose, insulin, C-peptide, GLP-1, GIP, ghrelin, subjective appetite and gastrointestinal tolerability were done. Results: PNO-FFA augmented GLP-1 secretion from 0–360 min compared to no oil and PNO-OO (p < 0.01). GIP secretion was increased from 240–360 min after both PNO-FFA and PNO-OO versus no oil (p < 0.01). Both oil treatments suppressed subjective appetite by reducing hunger and prospective food consumption and increasing satiety (p < 0.05). Conclusions: In support of previous findings, 6 g of delayed-release hydrolyzed pine nut oil enhanced postprandial GLP-1 secretion and reduced appetite. However, no synergistic effect of combining hydrolyzed pine nut oil and olive oil on GLP-1 secretion was observed. These results need further evaluation in long-term studies including effects on bodyweight and insulin sensitivity.

AB - Background: To investigate the potential synergistic effects of olive oil releasing 2oleoylglycerol and hydrolyzed pine nut oil containing 20% pinolenic acid on GLP-1 secretion, glucose tolerance, insulin secretion and appetite in healthy individuals, when delivered to the small intestine as potential agonists of GPR119, FFA1 and FFA4. Methods: Nine overweight/obese individuals completed three 6-h oral glucose tolerance tests (OGTTs) in a crossover design. At-30 min, participants consumed either: no oil, 6 g of hydrolyzed pine nut oil (PNO-FFA), or a combination of 3 g hydrolyzed pine nut oil and 3 g olive oil (PNO-OO) in delayed-release capsules. Repeated measures of glucose, insulin, C-peptide, GLP-1, GIP, ghrelin, subjective appetite and gastrointestinal tolerability were done. Results: PNO-FFA augmented GLP-1 secretion from 0–360 min compared to no oil and PNO-OO (p < 0.01). GIP secretion was increased from 240–360 min after both PNO-FFA and PNO-OO versus no oil (p < 0.01). Both oil treatments suppressed subjective appetite by reducing hunger and prospective food consumption and increasing satiety (p < 0.05). Conclusions: In support of previous findings, 6 g of delayed-release hydrolyzed pine nut oil enhanced postprandial GLP-1 secretion and reduced appetite. However, no synergistic effect of combining hydrolyzed pine nut oil and olive oil on GLP-1 secretion was observed. These results need further evaluation in long-term studies including effects on bodyweight and insulin sensitivity.

KW - 2-oleoylglycerol

KW - Appetite

KW - G-protein-coupled receptors

KW - Glucose tolerance

KW - Incretins

KW - Olive oil

KW - Pine nut oil

KW - Pinolenic acid

U2 - 10.3390/nu13103407

DO - 10.3390/nu13103407

M3 - Journal article

C2 - 34684407

AN - SCOPUS:85115798979

VL - 13

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 10

M1 - 3407

ER -