Enteroendocrine cell types revisited
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Enteroendocrine cell types revisited. / Engelstoft, Maja S; Egerod, Kristoffer Lihme; Lund, Mari L; Schwartz, Thue W.
In: Current Opinion in Pharmacology, Vol. 13, No. 6, 12.2013, p. 912-21.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Enteroendocrine cell types revisited
AU - Engelstoft, Maja S
AU - Egerod, Kristoffer Lihme
AU - Lund, Mari L
AU - Schwartz, Thue W
N1 - Copyright © 2013 Elsevier Ltd. All rights reserved.
PY - 2013/12
Y1 - 2013/12
N2 - The GI-tract is profoundly involved in the control of metabolism through peptide hormones secreted from enteroendocrine cells scattered throughout the gut mucosa. A large number of recently generated transgenic reporter mice have allowed for direct characterization of biochemical and cell biological properties of these previously highly elusive enteroendocrine cells. In particular the surprisingly broad co-expression of six functionally related hormones in the intestinal enteroendocrine cells indicates that it should be possible to control not only the hormone secretion but also the type and number of enteroendocrine cells. However, this will require a more deep understanding of the factors controlling differentiation, gene expression and specification of the enteroendocrine cells during their weekly renewal from progenitor cells in the crypts of the mucosa.
AB - The GI-tract is profoundly involved in the control of metabolism through peptide hormones secreted from enteroendocrine cells scattered throughout the gut mucosa. A large number of recently generated transgenic reporter mice have allowed for direct characterization of biochemical and cell biological properties of these previously highly elusive enteroendocrine cells. In particular the surprisingly broad co-expression of six functionally related hormones in the intestinal enteroendocrine cells indicates that it should be possible to control not only the hormone secretion but also the type and number of enteroendocrine cells. However, this will require a more deep understanding of the factors controlling differentiation, gene expression and specification of the enteroendocrine cells during their weekly renewal from progenitor cells in the crypts of the mucosa.
KW - Animals
KW - Enteroendocrine Cells
KW - Gastrointestinal Hormones
KW - Humans
KW - Intestinal Mucosa
KW - Intestines
U2 - 10.1016/j.coph.2013.09.018
DO - 10.1016/j.coph.2013.09.018
M3 - Journal article
C2 - 24140256
VL - 13
SP - 912
EP - 921
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
SN - 1471-4892
IS - 6
ER -
ID: 117973306