Estimates of insulin sensitivity and β-cell function in children and adolescents with and without components of the metabolic syndrome

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Estimates of insulin sensitivity and β-cell function in children and adolescents with and without components of the metabolic syndrome. / Frithioff-Bøjsøe, Christine; Trier, Cæcilie; Esmann Fonvig, Cilius; Nissen, Anne; Kloppenborg, Julie Tonsgaard; Mollerup, Pernille Maria; Bjerrum, Poul Jannik; Pedersen, Oluf; Hansen, Torben; Holm, Jens-Christian.

In: Pediatric Endocrinology, Diabetes and Metabolism, Vol. 23, No. 3, 2017, p. 122-129.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Frithioff-Bøjsøe, C, Trier, C, Esmann Fonvig, C, Nissen, A, Kloppenborg, JT, Mollerup, PM, Bjerrum, PJ, Pedersen, O, Hansen, T & Holm, J-C 2017, 'Estimates of insulin sensitivity and β-cell function in children and adolescents with and without components of the metabolic syndrome', Pediatric Endocrinology, Diabetes and Metabolism, vol. 23, no. 3, pp. 122-129. https://doi.org/10.18544/PEDM-23.03.0083

APA

Frithioff-Bøjsøe, C., Trier, C., Esmann Fonvig, C., Nissen, A., Kloppenborg, J. T., Mollerup, P. M., Bjerrum, P. J., Pedersen, O., Hansen, T., & Holm, J-C. (2017). Estimates of insulin sensitivity and β-cell function in children and adolescents with and without components of the metabolic syndrome. Pediatric Endocrinology, Diabetes and Metabolism, 23(3), 122-129. https://doi.org/10.18544/PEDM-23.03.0083

Vancouver

Frithioff-Bøjsøe C, Trier C, Esmann Fonvig C, Nissen A, Kloppenborg JT, Mollerup PM et al. Estimates of insulin sensitivity and β-cell function in children and adolescents with and without components of the metabolic syndrome. Pediatric Endocrinology, Diabetes and Metabolism. 2017;23(3):122-129. https://doi.org/10.18544/PEDM-23.03.0083

Author

Frithioff-Bøjsøe, Christine ; Trier, Cæcilie ; Esmann Fonvig, Cilius ; Nissen, Anne ; Kloppenborg, Julie Tonsgaard ; Mollerup, Pernille Maria ; Bjerrum, Poul Jannik ; Pedersen, Oluf ; Hansen, Torben ; Holm, Jens-Christian. / Estimates of insulin sensitivity and β-cell function in children and adolescents with and without components of the metabolic syndrome. In: Pediatric Endocrinology, Diabetes and Metabolism. 2017 ; Vol. 23, No. 3. pp. 122-129.

Bibtex

@article{ef02b814f16241f7a730565b83443bef,
title = "Estimates of insulin sensitivity and β-cell function in children and adolescents with and without components of the metabolic syndrome",
abstract = "INTRODUCTION: The accumulation of components of the metabolic syndrome (MetS) is associated with a disturbed glucose metabolism in obese children.AIM OF STUDY: The aim of the present study was to evaluate the association between MetS and estimates of insulin sensitivity and β-cell function obtained from oral glucose tolerance test (OGTT)-derived indices in lean and obese children.MATERIAL AND METHODS: A 2-hour OGTT was administered in 83 children aged 7-17 years. 47 children were obese and recruited from a childhood obesity clinic and 36 were lean age- and sex-matched controls. Surrogate measures of insulin sensitivity and β-cell function were assessed by the OGTT-derived indices: the Matsuda index, the insulinogenic index, and the oral disposition index. The severity of MetS was assessed by measures of waist circumference, blood pressure, and fasting levels of triglycerides, high-density lipoprotein cholesterol, and glucose.RESULTS: The 83 children were allocated to one of three groups according to the number of components of MetS: the median body mass index standard deviation score was 0.2 (range -0.6-2.9) in the low MetS risk group (n=36), 2.8 (0.1-4.1) in the high MetS risk group (n=25), and 2.9 (2.1-4.4) in the MetS group (n=22). An increasing number of MetS components were associated with a lower insulin sensitivity and an altered β-cell function according to the Matsuda index (p<0.0001), the insulinogenic index (p<0.0001), and the oral disposition index (p=0.005).CONCLUSIONS: Children burdened by the accumulation of components of MetS exhibited a disturbed glucose metabolism as expressed by lowered peripheral insulin sensitivity and β-cell function.",
author = "Christine Frithioff-B{\o}js{\o}e and C{\ae}cilie Trier and {Esmann Fonvig}, Cilius and Anne Nissen and Kloppenborg, {Julie Tonsgaard} and Mollerup, {Pernille Maria} and Bjerrum, {Poul Jannik} and Oluf Pedersen and Torben Hansen and Jens-Christian Holm",
note = "{\textcopyright} Polish Society for Pediatric Endocrinology and Diabetology.",
year = "2017",
doi = "10.18544/PEDM-23.03.0083",
language = "English",
volume = "23",
pages = "122--129",
journal = "Pediatric Endocrinology, Diabetes and Metabolism",
issn = "2081-237X",
publisher = "WydawnictwoCornetis",
number = "3",

}

RIS

TY - JOUR

T1 - Estimates of insulin sensitivity and β-cell function in children and adolescents with and without components of the metabolic syndrome

AU - Frithioff-Bøjsøe, Christine

AU - Trier, Cæcilie

AU - Esmann Fonvig, Cilius

AU - Nissen, Anne

AU - Kloppenborg, Julie Tonsgaard

AU - Mollerup, Pernille Maria

AU - Bjerrum, Poul Jannik

AU - Pedersen, Oluf

AU - Hansen, Torben

AU - Holm, Jens-Christian

N1 - © Polish Society for Pediatric Endocrinology and Diabetology.

PY - 2017

Y1 - 2017

N2 - INTRODUCTION: The accumulation of components of the metabolic syndrome (MetS) is associated with a disturbed glucose metabolism in obese children.AIM OF STUDY: The aim of the present study was to evaluate the association between MetS and estimates of insulin sensitivity and β-cell function obtained from oral glucose tolerance test (OGTT)-derived indices in lean and obese children.MATERIAL AND METHODS: A 2-hour OGTT was administered in 83 children aged 7-17 years. 47 children were obese and recruited from a childhood obesity clinic and 36 were lean age- and sex-matched controls. Surrogate measures of insulin sensitivity and β-cell function were assessed by the OGTT-derived indices: the Matsuda index, the insulinogenic index, and the oral disposition index. The severity of MetS was assessed by measures of waist circumference, blood pressure, and fasting levels of triglycerides, high-density lipoprotein cholesterol, and glucose.RESULTS: The 83 children were allocated to one of three groups according to the number of components of MetS: the median body mass index standard deviation score was 0.2 (range -0.6-2.9) in the low MetS risk group (n=36), 2.8 (0.1-4.1) in the high MetS risk group (n=25), and 2.9 (2.1-4.4) in the MetS group (n=22). An increasing number of MetS components were associated with a lower insulin sensitivity and an altered β-cell function according to the Matsuda index (p<0.0001), the insulinogenic index (p<0.0001), and the oral disposition index (p=0.005).CONCLUSIONS: Children burdened by the accumulation of components of MetS exhibited a disturbed glucose metabolism as expressed by lowered peripheral insulin sensitivity and β-cell function.

AB - INTRODUCTION: The accumulation of components of the metabolic syndrome (MetS) is associated with a disturbed glucose metabolism in obese children.AIM OF STUDY: The aim of the present study was to evaluate the association between MetS and estimates of insulin sensitivity and β-cell function obtained from oral glucose tolerance test (OGTT)-derived indices in lean and obese children.MATERIAL AND METHODS: A 2-hour OGTT was administered in 83 children aged 7-17 years. 47 children were obese and recruited from a childhood obesity clinic and 36 were lean age- and sex-matched controls. Surrogate measures of insulin sensitivity and β-cell function were assessed by the OGTT-derived indices: the Matsuda index, the insulinogenic index, and the oral disposition index. The severity of MetS was assessed by measures of waist circumference, blood pressure, and fasting levels of triglycerides, high-density lipoprotein cholesterol, and glucose.RESULTS: The 83 children were allocated to one of three groups according to the number of components of MetS: the median body mass index standard deviation score was 0.2 (range -0.6-2.9) in the low MetS risk group (n=36), 2.8 (0.1-4.1) in the high MetS risk group (n=25), and 2.9 (2.1-4.4) in the MetS group (n=22). An increasing number of MetS components were associated with a lower insulin sensitivity and an altered β-cell function according to the Matsuda index (p<0.0001), the insulinogenic index (p<0.0001), and the oral disposition index (p=0.005).CONCLUSIONS: Children burdened by the accumulation of components of MetS exhibited a disturbed glucose metabolism as expressed by lowered peripheral insulin sensitivity and β-cell function.

U2 - 10.18544/PEDM-23.03.0083

DO - 10.18544/PEDM-23.03.0083

M3 - Journal article

C2 - 29253032

VL - 23

SP - 122

EP - 129

JO - Pediatric Endocrinology, Diabetes and Metabolism

JF - Pediatric Endocrinology, Diabetes and Metabolism

SN - 2081-237X

IS - 3

ER -

ID: 190848003