FAP finds FGF21 easy to digest
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FAP finds FGF21 easy to digest. / Gillum, Matthew P; Potthoff, Matthew J.
In: Biochemical Journal, Vol. 473, No. 9, 01.05.2016, p. 1125-7.Research output: Contribution to journal › Comment/debate › Research › peer-review
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TY - JOUR
T1 - FAP finds FGF21 easy to digest
AU - Gillum, Matthew P
AU - Potthoff, Matthew J
N1 - © 2016 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Fibroblast growth factor 21 (FGF21) is an endocrine hormone that regulates carbohydrate and lipid metabolism. In humans, circulating FGF21 is inactivated by proteolytic cleavage of its C-terminus, thereby preventing signalling through a receptor complex. The mechanism for this cleavage event and the factors contributing to the post-translational regulation of FGF21 activity has previously been unknown. In a recent issue of the Biochemical Journal, Zhen et al. have identified fibroblast activation protein (FAP) as the endopeptidase responsible for this site-specific cleavage of human FGF21 (hFGF21), and propose that inhibition of FAP may be a therapeutic strategy to increase endogenous levels of active FGF21.
AB - Fibroblast growth factor 21 (FGF21) is an endocrine hormone that regulates carbohydrate and lipid metabolism. In humans, circulating FGF21 is inactivated by proteolytic cleavage of its C-terminus, thereby preventing signalling through a receptor complex. The mechanism for this cleavage event and the factors contributing to the post-translational regulation of FGF21 activity has previously been unknown. In a recent issue of the Biochemical Journal, Zhen et al. have identified fibroblast activation protein (FAP) as the endopeptidase responsible for this site-specific cleavage of human FGF21 (hFGF21), and propose that inhibition of FAP may be a therapeutic strategy to increase endogenous levels of active FGF21.
KW - Journal Article
U2 - 10.1042/BCJ20160004
DO - 10.1042/BCJ20160004
M3 - Comment/debate
C2 - 27118870
VL - 473
SP - 1125
EP - 1127
JO - Biochemical Journal
JF - Biochemical Journal
SN - 0264-6021
IS - 9
ER -
ID: 166944913