TY - JOUR

T1 - From Dietary Fiber to Host Physiology

T2 - Short-Chain Fatty Acids as Key Bacterial Metabolites

AU - Koh, Ara

AU - De Vadder, Filipe

AU - Kovatcheva-Datchary, Petia

AU - Bäckhed, Gert Fredrik

N1 - Copyright © 2016 Elsevier Inc. All rights reserved.

PY - 2016/6/2

Y1 - 2016/6/2

N2 - A compelling set of links between the composition of the gut microbiota, the host diet, and host physiology has emerged. Do these links reflect cause-and-effect relationships, and what might be their mechanistic basis? A growing body of work implicates microbially produced metabolites as crucial executors of diet-based microbial influence on the host. Here, we will review data supporting the diverse functional roles carried out by a major class of bacterial metabolites, the short-chain fatty acids (SCFAs). SCFAs can directly activate G-coupled-receptors, inhibit histone deacetylases, and serve as energy substrates. They thus affect various physiological processes and may contribute to health and disease.

AB - A compelling set of links between the composition of the gut microbiota, the host diet, and host physiology has emerged. Do these links reflect cause-and-effect relationships, and what might be their mechanistic basis? A growing body of work implicates microbially produced metabolites as crucial executors of diet-based microbial influence on the host. Here, we will review data supporting the diverse functional roles carried out by a major class of bacterial metabolites, the short-chain fatty acids (SCFAs). SCFAs can directly activate G-coupled-receptors, inhibit histone deacetylases, and serve as energy substrates. They thus affect various physiological processes and may contribute to health and disease.

KW - Journal Article

KW - Review

U2 - 10.1016/j.cell.2016.05.041

DO - 10.1016/j.cell.2016.05.041

M3 - Journal article

C2 - 27259147

VL - 165

SP - 1332

EP - 1345

JO - Cell

JF - Cell

SN - 0092-8674

IS - 6

ER -