Fructose intervention for 12 weeks does not impair glycemic control or incretin hormone responses during oral glucose or mixed meal tests in obese men
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Fructose intervention for 12 weeks does not impair glycemic control or incretin hormone responses during oral glucose or mixed meal tests in obese men. / Matikainen, N; Söderlund, S; Björnson, E; Bogl, L H; Pietiläinen, K H; Hakkarainen, A; Lundbom, N; Eliasson, B; Räsänen, S M; Rivellese, A; Patti, L; Prinster, A; Riccardi, G; Després, J-P; Alméras, N; Holst, J J; Deacon, C F; Borén, J; Taskinen, M-R.
In: Nutrition, Metabolism & Cardiovascular Diseases, Vol. 27, No. 6, 06.2017, p. 534-542.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Fructose intervention for 12 weeks does not impair glycemic control or incretin hormone responses during oral glucose or mixed meal tests in obese men
AU - Matikainen, N
AU - Söderlund, S
AU - Björnson, E
AU - Bogl, L H
AU - Pietiläinen, K H
AU - Hakkarainen, A
AU - Lundbom, N
AU - Eliasson, B
AU - Räsänen, S M
AU - Rivellese, A
AU - Patti, L
AU - Prinster, A
AU - Riccardi, G
AU - Després, J-P
AU - Alméras, N
AU - Holst, J J
AU - Deacon, C F
AU - Borén, J
AU - Taskinen, M-R
N1 - Copyright © 2017 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
PY - 2017/6
Y1 - 2017/6
N2 - BACKGROUND AND AIMS: Incretin hormones glucagon-like peptide (GLP)-1 and glucose-dependent insulinotropic polypeptide (GIP) are affected early on in the pathogenesis of metabolic syndrome and type 2 diabetes. Epidemiologic studies consistently link high fructose consumption to insulin resistance but whether fructose consumption impairs the incretin response remains unknown.METHODS AND RESULTS: As many as 66 obese (BMI 26-40 kg/m(2)) male subjects consumed fructose-sweetened beverages containing 75 g fructose/day for 12 weeks while continuing their usual lifestyle. Glucose, insulin, GLP-1 and GIP were measured during oral glucose tolerance test (OGTT) and triglycerides (TG), GLP-1, GIP and PYY during a mixed meal test before and after fructose intervention. Fructose intervention did not worsen glucose and insulin responses during OGTT, and GLP-1 and GIP responses during OGTT and fat-rich meal were unchanged. Postprandial TG response increased significantly, p = 0.004, and we observed small but significant increases in weight and liver fat content, but not in visceral or subcutaneous fat depots. However, even the subgroups who gained weight or liver fat during fructose intervention did not worsen their glucose, insulin, GLP-1 or PYY responses. A minor increase in GIP response during OGTT occurred in subjects who gained liver fat (p = 0.049).CONCLUSION: In obese males with features of metabolic syndrome, 12 weeks fructose intervention 75 g/day did not change glucose, insulin, GLP-1 or GIP responses during OGTT or GLP-1, GIP or PYY responses during a mixed meal. Therefore, fructose intake, even accompanied with mild weight gain, increases in liver fat and worsening of postprandial TG profile, does not impair glucose tolerance or gut incretin response to oral glucose or mixed meal challenge.
AB - BACKGROUND AND AIMS: Incretin hormones glucagon-like peptide (GLP)-1 and glucose-dependent insulinotropic polypeptide (GIP) are affected early on in the pathogenesis of metabolic syndrome and type 2 diabetes. Epidemiologic studies consistently link high fructose consumption to insulin resistance but whether fructose consumption impairs the incretin response remains unknown.METHODS AND RESULTS: As many as 66 obese (BMI 26-40 kg/m(2)) male subjects consumed fructose-sweetened beverages containing 75 g fructose/day for 12 weeks while continuing their usual lifestyle. Glucose, insulin, GLP-1 and GIP were measured during oral glucose tolerance test (OGTT) and triglycerides (TG), GLP-1, GIP and PYY during a mixed meal test before and after fructose intervention. Fructose intervention did not worsen glucose and insulin responses during OGTT, and GLP-1 and GIP responses during OGTT and fat-rich meal were unchanged. Postprandial TG response increased significantly, p = 0.004, and we observed small but significant increases in weight and liver fat content, but not in visceral or subcutaneous fat depots. However, even the subgroups who gained weight or liver fat during fructose intervention did not worsen their glucose, insulin, GLP-1 or PYY responses. A minor increase in GIP response during OGTT occurred in subjects who gained liver fat (p = 0.049).CONCLUSION: In obese males with features of metabolic syndrome, 12 weeks fructose intervention 75 g/day did not change glucose, insulin, GLP-1 or GIP responses during OGTT or GLP-1, GIP or PYY responses during a mixed meal. Therefore, fructose intake, even accompanied with mild weight gain, increases in liver fat and worsening of postprandial TG profile, does not impair glucose tolerance or gut incretin response to oral glucose or mixed meal challenge.
KW - Adult
KW - Aged
KW - Beverages
KW - Biomarkers
KW - Blood Glucose
KW - Dietary Carbohydrates
KW - Drinking
KW - Europe
KW - Fructose
KW - Gastrointestinal Hormones
KW - Glucose Tolerance Test
KW - Humans
KW - Insulin
KW - Insulin Resistance
KW - Liver
KW - Male
KW - Metabolic Syndrome X
KW - Middle Aged
KW - Obesity
KW - Postprandial Period
KW - Predictive Value of Tests
KW - Quebec
KW - Time Factors
KW - Triglycerides
KW - Weight Gain
KW - Young Adult
KW - Clinical Trial
KW - Journal Article
KW - Multicenter Study
U2 - 10.1016/j.numecd.2017.03.003
DO - 10.1016/j.numecd.2017.03.003
M3 - Journal article
C2 - 28428027
VL - 27
SP - 534
EP - 542
JO - Nutrition, Metabolism & Cardiovascular Diseases
JF - Nutrition, Metabolism & Cardiovascular Diseases
SN - 0939-4753
IS - 6
ER -
ID: 182973173