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Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. / McLaughlin, Russell L.; Schijven, Dick; Van Rheenen, Wouter; Van Eijk, Kristel R.; O'Brien, Margaret; Kahn, René S.; Ophoff, Roel A.; Goris, An; Bradley, Daniel G.; Al-Chalabi, Ammar; Van Den Berg, Leonard H.; Luykx, Jurjen J.; Hardiman, Orla; Veldink, Jan H.; Shatunov, Aleksey; Dekker, Annelot M.; Diekstra, Frank P.; Pulit, Sara L.; Van Der Spek, Rick A.A.; Van Doormaal, Perry T.C.; Sproviero, William; Jones, Ashley R.; Nicholson, Garth A.; Rowe, Dominic B.; Pamphlett, Roger; Kiernan, Matthew C.; Bauer, Denis; Kahlke, Tim; Williams, Kelly; Eftimov, Filip; Fogh, Isabella; Ticozzi, Nicola; Lin, Kuang; Millecamps, Stephanie; Salachas, Francois; Meininger, Vincent; Carvalho, Mamede De; Pinto, Susana; Mora, Jesus S.; Rojas-Garcyá, Ricardo; Polak, Meraida; Chandran, Siddharthan; Andersen, Peter M.; Pers, Tune H.; Hansen, Mark; Hansen, Thomas; Li, Tao; Olsen, Line; Rasmussen, Henrik B.; Werge, Thomas; Project MinE GWAS Consortium & Schizophrenia Working Group of the Psychiatric Genomics Consortium.
In:
Nature Communications, Vol. 8, 14774, 2017.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
McLaughlin, RL, Schijven, D, Van Rheenen, W, Van Eijk, KR, O'Brien, M, Kahn, RS, Ophoff, RA, Goris, A, Bradley, DG, Al-Chalabi, A, Van Den Berg, LH, Luykx, JJ, Hardiman, O, Veldink, JH, Shatunov, A, Dekker, AM, Diekstra, FP, Pulit, SL, Van Der Spek, RAA, Van Doormaal, PTC, Sproviero, W, Jones, AR, Nicholson, GA, Rowe, DB, Pamphlett, R, Kiernan, MC, Bauer, D, Kahlke, T, Williams, K, Eftimov, F, Fogh, I, Ticozzi, N, Lin, K, Millecamps, S, Salachas, F, Meininger, V, Carvalho, MD, Pinto, S, Mora, JS, Rojas-Garcyá, R, Polak, M, Chandran, S, Andersen, PM
, Pers, TH, Hansen, M, Hansen, T, Li, T, Olsen, L, Rasmussen, HB
, Werge, T & Project MinE GWAS Consortium & Schizophrenia Working Group of the Psychiatric Genomics Consortium 2017, '
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia',
Nature Communications, vol. 8, 14774.
https://doi.org/10.1038/ncomms14774APA
McLaughlin, R. L., Schijven, D., Van Rheenen, W., Van Eijk, K. R., O'Brien, M., Kahn, R. S., Ophoff, R. A., Goris, A., Bradley, D. G., Al-Chalabi, A., Van Den Berg, L. H., Luykx, J. J., Hardiman, O., Veldink, J. H., Shatunov, A., Dekker, A. M., Diekstra, F. P., Pulit, S. L., Van Der Spek, R. A. A., ... Project MinE GWAS Consortium & Schizophrenia Working Group of the Psychiatric Genomics Consortium (2017).
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia.
Nature Communications,
8, [14774].
https://doi.org/10.1038/ncomms14774Vancouver
McLaughlin RL, Schijven D, Van Rheenen W, Van Eijk KR, O'Brien M, Kahn RS et al.
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia.
Nature Communications. 2017;8. 14774.
https://doi.org/10.1038/ncomms14774Author
McLaughlin, Russell L. ; Schijven, Dick ; Van Rheenen, Wouter ; Van Eijk, Kristel R. ; O'Brien, Margaret ; Kahn, René S. ; Ophoff, Roel A. ; Goris, An ; Bradley, Daniel G. ; Al-Chalabi, Ammar ; Van Den Berg, Leonard H. ; Luykx, Jurjen J. ; Hardiman, Orla ; Veldink, Jan H. ; Shatunov, Aleksey ; Dekker, Annelot M. ; Diekstra, Frank P. ; Pulit, Sara L. ; Van Der Spek, Rick A.A. ; Van Doormaal, Perry T.C. ; Sproviero, William ; Jones, Ashley R. ; Nicholson, Garth A. ; Rowe, Dominic B. ; Pamphlett, Roger ; Kiernan, Matthew C. ; Bauer, Denis ; Kahlke, Tim ; Williams, Kelly ; Eftimov, Filip ; Fogh, Isabella ; Ticozzi, Nicola ; Lin, Kuang ; Millecamps, Stephanie ; Salachas, Francois ; Meininger, Vincent ; Carvalho, Mamede De ; Pinto, Susana ; Mora, Jesus S. ; Rojas-Garcyá, Ricardo ; Polak, Meraida ; Chandran, Siddharthan ; Andersen, Peter M. ; Pers, Tune H. ; Hansen, Mark ; Hansen, Thomas ; Li, Tao ; Olsen, Line ; Rasmussen, Henrik B. ; Werge, Thomas ; Project MinE GWAS Consortium & Schizophrenia Working Group of the Psychiatric Genomics Consortium. / Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. In: Nature Communications. 2017 ; Vol. 8.
Bibtex
@article{0616127d899c468c875543d69988616f,
title = "Genetic correlation between amyotrophic lateral sclerosis and schizophrenia",
abstract = "We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P=1 × 10-4) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10-7). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.",
author = "McLaughlin, {Russell L.} and Dick Schijven and {Van Rheenen}, Wouter and {Van Eijk}, {Kristel R.} and Margaret O'Brien and Kahn, {Ren{\'e} S.} and Ophoff, {Roel A.} and An Goris and Bradley, {Daniel G.} and Ammar Al-Chalabi and {Van Den Berg}, {Leonard H.} and Luykx, {Jurjen J.} and Orla Hardiman and Veldink, {Jan H.} and Aleksey Shatunov and Dekker, {Annelot M.} and Diekstra, {Frank P.} and Pulit, {Sara L.} and {Van Der Spek}, {Rick A.A.} and {Van Doormaal}, {Perry T.C.} and William Sproviero and Jones, {Ashley R.} and Nicholson, {Garth A.} and Rowe, {Dominic B.} and Roger Pamphlett and Kiernan, {Matthew C.} and Denis Bauer and Tim Kahlke and Kelly Williams and Filip Eftimov and Isabella Fogh and Nicola Ticozzi and Kuang Lin and Stephanie Millecamps and Francois Salachas and Vincent Meininger and Carvalho, {Mamede De} and Susana Pinto and Mora, {Jesus S.} and Ricardo Rojas-Garcy{\'a} and Meraida Polak and Siddharthan Chandran and Andersen, {Peter M.} and Pers, {Tune H.} and Mark Hansen and Thomas Hansen and Tao Li and Line Olsen and Rasmussen, {Henrik B.} and Thomas Werge and {Project MinE GWAS Consortium & Schizophrenia Working Group of the Psychiatric Genomics Consortium}",
year = "2017",
doi = "10.1038/ncomms14774",
language = "English",
volume = "8",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
}
RIS
TY - JOUR
T1 - Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
AU - McLaughlin, Russell L.
AU - Schijven, Dick
AU - Van Rheenen, Wouter
AU - Van Eijk, Kristel R.
AU - O'Brien, Margaret
AU - Kahn, René S.
AU - Ophoff, Roel A.
AU - Goris, An
AU - Bradley, Daniel G.
AU - Al-Chalabi, Ammar
AU - Van Den Berg, Leonard H.
AU - Luykx, Jurjen J.
AU - Hardiman, Orla
AU - Veldink, Jan H.
AU - Shatunov, Aleksey
AU - Dekker, Annelot M.
AU - Diekstra, Frank P.
AU - Pulit, Sara L.
AU - Van Der Spek, Rick A.A.
AU - Van Doormaal, Perry T.C.
AU - Sproviero, William
AU - Jones, Ashley R.
AU - Nicholson, Garth A.
AU - Rowe, Dominic B.
AU - Pamphlett, Roger
AU - Kiernan, Matthew C.
AU - Bauer, Denis
AU - Kahlke, Tim
AU - Williams, Kelly
AU - Eftimov, Filip
AU - Fogh, Isabella
AU - Ticozzi, Nicola
AU - Lin, Kuang
AU - Millecamps, Stephanie
AU - Salachas, Francois
AU - Meininger, Vincent
AU - Carvalho, Mamede De
AU - Pinto, Susana
AU - Mora, Jesus S.
AU - Rojas-Garcyá, Ricardo
AU - Polak, Meraida
AU - Chandran, Siddharthan
AU - Andersen, Peter M.
AU - Pers, Tune H.
AU - Hansen, Mark
AU - Hansen, Thomas
AU - Li, Tao
AU - Olsen, Line
AU - Rasmussen, Henrik B.
AU - Werge, Thomas
AU - Project MinE GWAS Consortium & Schizophrenia Working Group of the Psychiatric Genomics Consortium
PY - 2017
Y1 - 2017
N2 - We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P=1 × 10-4) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10-7). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.
AB - We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P=1 × 10-4) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10-7). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.
U2 - 10.1038/ncomms14774
DO - 10.1038/ncomms14774
M3 - Journal article
C2 - 28322246
AN - SCOPUS:85016060348
VL - 8
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 14774
ER -
