Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index

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Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. / Freathy, Rachel M; Kazeem, Gbenga R; Morris, Richard W; Johnson, Paul C D; Paternoster, Lavinia; Ebrahim, Shah; Hattersley, Andrew T; Hill, Anita; Hingorani, Aroon D; Holst, Claus; Jefferis, Barbara J; Kring, Sofia I I; Mooser, Vincent; Padmanabhan, Sandosh; Preisig, Martin; Ring, Susan M; Sattar, Naveed; Upton, Mark N; Vollenweider, Peter; Waeber, Gerard; Sørensen, Thorkild I A; Frayling, Timothy M; Watt, Graham; Lawlor, Debbie A; Whincup, Peter H; Tozzi, Federica; Davey Smith, George; Munafò, Marcus.

In: International Journal of Epidemiology, Vol. 40, No. 6, 2011, p. 1617-28.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Freathy, RM, Kazeem, GR, Morris, RW, Johnson, PCD, Paternoster, L, Ebrahim, S, Hattersley, AT, Hill, A, Hingorani, AD, Holst, C, Jefferis, BJ, Kring, SII, Mooser, V, Padmanabhan, S, Preisig, M, Ring, SM, Sattar, N, Upton, MN, Vollenweider, P, Waeber, G, Sørensen, TIA, Frayling, TM, Watt, G, Lawlor, DA, Whincup, PH, Tozzi, F, Davey Smith, G & Munafò, M 2011, 'Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index', International Journal of Epidemiology, vol. 40, no. 6, pp. 1617-28. https://doi.org/10.1093/ije/dyr077, https://doi.org/10.1093/ije/dyr077

APA

Freathy, R. M., Kazeem, G. R., Morris, R. W., Johnson, P. C. D., Paternoster, L., Ebrahim, S., Hattersley, A. T., Hill, A., Hingorani, A. D., Holst, C., Jefferis, B. J., Kring, S. I. I., Mooser, V., Padmanabhan, S., Preisig, M., Ring, S. M., Sattar, N., Upton, M. N., Vollenweider, P., ... Munafò, M. (2011). Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. International Journal of Epidemiology, 40(6), 1617-28. https://doi.org/10.1093/ije/dyr077, https://doi.org/10.1093/ije/dyr077

Vancouver

Freathy RM, Kazeem GR, Morris RW, Johnson PCD, Paternoster L, Ebrahim S et al. Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. International Journal of Epidemiology. 2011;40(6):1617-28. https://doi.org/10.1093/ije/dyr077, https://doi.org/10.1093/ije/dyr077

Author

Freathy, Rachel M ; Kazeem, Gbenga R ; Morris, Richard W ; Johnson, Paul C D ; Paternoster, Lavinia ; Ebrahim, Shah ; Hattersley, Andrew T ; Hill, Anita ; Hingorani, Aroon D ; Holst, Claus ; Jefferis, Barbara J ; Kring, Sofia I I ; Mooser, Vincent ; Padmanabhan, Sandosh ; Preisig, Martin ; Ring, Susan M ; Sattar, Naveed ; Upton, Mark N ; Vollenweider, Peter ; Waeber, Gerard ; Sørensen, Thorkild I A ; Frayling, Timothy M ; Watt, Graham ; Lawlor, Debbie A ; Whincup, Peter H ; Tozzi, Federica ; Davey Smith, George ; Munafò, Marcus. / Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. In: International Journal of Epidemiology. 2011 ; Vol. 40, No. 6. pp. 1617-28.

Bibtex

@article{c572e8dce831449f91066de67a450289,
title = "Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index",
abstract = "Cigarette smoking is associated with lower body mass index (BMI), and a commonly cited reason for unwillingness to quit smoking is a concern about weight gain. Common variation in the CHRNA5-CHRNA3-CHRNB4 gene region (chromosome 15q25) is robustly associated with smoking quantity in smokers, but its association with BMI is unknown. We hypothesized that genotype would accurately reflect smoking exposure and that, if smoking were causally related to weight, it would be associated with BMI in smokers, but not in never smokers.",
author = "Freathy, {Rachel M} and Kazeem, {Gbenga R} and Morris, {Richard W} and Johnson, {Paul C D} and Lavinia Paternoster and Shah Ebrahim and Hattersley, {Andrew T} and Anita Hill and Hingorani, {Aroon D} and Claus Holst and Jefferis, {Barbara J} and Kring, {Sofia I I} and Vincent Mooser and Sandosh Padmanabhan and Martin Preisig and Ring, {Susan M} and Naveed Sattar and Upton, {Mark N} and Peter Vollenweider and Gerard Waeber and S{\o}rensen, {Thorkild I A} and Frayling, {Timothy M} and Graham Watt and Lawlor, {Debbie A} and Whincup, {Peter H} and Federica Tozzi and {Davey Smith}, George and Marcus Munaf{\`o}",
year = "2011",
doi = "10.1093/ije/dyr077",
language = "English",
volume = "40",
pages = "1617--28",
journal = "International Journal of Epidemiology",
issn = "0300-5771",
publisher = "Oxford University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index

AU - Freathy, Rachel M

AU - Kazeem, Gbenga R

AU - Morris, Richard W

AU - Johnson, Paul C D

AU - Paternoster, Lavinia

AU - Ebrahim, Shah

AU - Hattersley, Andrew T

AU - Hill, Anita

AU - Hingorani, Aroon D

AU - Holst, Claus

AU - Jefferis, Barbara J

AU - Kring, Sofia I I

AU - Mooser, Vincent

AU - Padmanabhan, Sandosh

AU - Preisig, Martin

AU - Ring, Susan M

AU - Sattar, Naveed

AU - Upton, Mark N

AU - Vollenweider, Peter

AU - Waeber, Gerard

AU - Sørensen, Thorkild I A

AU - Frayling, Timothy M

AU - Watt, Graham

AU - Lawlor, Debbie A

AU - Whincup, Peter H

AU - Tozzi, Federica

AU - Davey Smith, George

AU - Munafò, Marcus

PY - 2011

Y1 - 2011

N2 - Cigarette smoking is associated with lower body mass index (BMI), and a commonly cited reason for unwillingness to quit smoking is a concern about weight gain. Common variation in the CHRNA5-CHRNA3-CHRNB4 gene region (chromosome 15q25) is robustly associated with smoking quantity in smokers, but its association with BMI is unknown. We hypothesized that genotype would accurately reflect smoking exposure and that, if smoking were causally related to weight, it would be associated with BMI in smokers, but not in never smokers.

AB - Cigarette smoking is associated with lower body mass index (BMI), and a commonly cited reason for unwillingness to quit smoking is a concern about weight gain. Common variation in the CHRNA5-CHRNA3-CHRNB4 gene region (chromosome 15q25) is robustly associated with smoking quantity in smokers, but its association with BMI is unknown. We hypothesized that genotype would accurately reflect smoking exposure and that, if smoking were causally related to weight, it would be associated with BMI in smokers, but not in never smokers.

U2 - 10.1093/ije/dyr077

DO - 10.1093/ije/dyr077

M3 - Journal article

C2 - 21593077

VL - 40

SP - 1617

EP - 1628

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

SN - 0300-5771

IS - 6

ER -

ID: 40207895